YNL288W / CAF40

Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL288W / CAF40

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:6.06|P-value:2.21E-9 ID:SGTC_146|Compound:3448-8650|FD-Score:6.69|P-value:4.61E-11 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.57|P-value:2.93E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.88|P-value:8.45E-5 ID:SGTC_237|Compound:nikkomycin|FD-Score:5.74|P-value:1.36E-8 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.27|P-value:7.57E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:7.82|P-value:1.91E-14 ID:SGTC_528|Compound:3492-0019|FD-Score:6.87|P-value:1.41E-11 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.94|P-value:9.31E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.60|P-value:2.60E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.86|P-value:1.23E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:7.03|P-value:5.03E-12 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.31|P-value:7.05E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.38|P-value:5.26E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.33|P-value:6.12E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.47|P-value:4.19E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.11|P-value:2.82E-12 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.26|P-value:1.81E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.45|P-value:4.10E-4 ID:SGTC_1706|Compound:st031321|FD-Score:-3.26|P-value:8.33E-4 ID:SGTC_1712|Compound:st032288|FD-Score:8.40|P-value:2.06E-16 ID:SGTC_1844|Compound:rapamycin|FD-Score:9.57|P-value:9.70E-21 ID:SGTC_2030|Compound:5175110|FD-Score:5.13|P-value:3.28E-7 ID:SGTC_2083|Compound:5306046|FD-Score:4.05|P-value:4.29E-5 ID:SGTC_2150|Compound:5556613|FD-Score:4.16|P-value:2.72E-5 ID:SGTC_2157|Compound:5649910|FD-Score:3.51|P-value:3.31E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.87|P-value:8.58E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.90|P-value:8.53E-5 ID:SGTC_2340|Compound:7987427|FD-Score:4.16|P-value:2.74E-5 ID:SGTC_2511|Compound:berberine|FD-Score:3.86|P-value:8.96E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:-4.18|P-value:2.78E-5 ID:SGTC_2556|Compound:citropten|FD-Score:3.20|P-value:9.43E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.69|P-value:2.78E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.94|P-value:7.44E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.64|P-value:2.27E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.57|P-value:4.65E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.35|P-value:6.17E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.37|P-value:4.93E-13 ID:SGTC_2688|Compound:kanamycin b|FD-Score:12.30|P-value:6.61E-33 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.42|P-value:4.97E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.47|P-value:3.81E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.77|P-value:1.40E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.28|P-value:7.28E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:8.93|P-value:2.66E-18 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.20|P-value:2.61E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.54|P-value:2.99E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.45|P-value:8.11E-6 ID:SGTC_2878|Compound:9043973|FD-Score:3.39|P-value:5.08E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.47|P-value:7.27E-6 ID:SGTC_2905|Compound:7799065|FD-Score:-3.35|P-value:6.30E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.46|P-value:3.91E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-4.73|P-value:2.59E-6 ID:SGTC_3037|Compound:9091026|FD-Score:5.02|P-value:5.83E-7 ID:SGTC_3140|Compound:9094243|FD-Score:3.51|P-value:3.33E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.30|P-value:7.32E-4 ID:SGTC_3250|Compound:9135583|FD-Score:-3.89|P-value:9.05E-5 ID:SGTC_3311|Compound:9131146|FD-Score:5.47|P-value:5.71E-8 ID:SGTC_3321|Compound:9137793|FD-Score:4.94|P-value:8.57E-7 ID:SGTC_3322|Compound:9139058|FD-Score:3.65|P-value:1.99E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.61|P-value:2.27E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.06|P-value:2.21E-9 ID:SGTC_146|Compound:3448-8650|FD-Score:6.69|P-value:4.61E-11 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.57|P-value:2.93E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.88|P-value:8.45E-5 ID:SGTC_237|Compound:nikkomycin|FD-Score:5.74|P-value:1.36E-8 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.27|P-value:7.57E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:7.82|P-value:1.91E-14 ID:SGTC_528|Compound:3492-0019|FD-Score:6.87|P-value:1.41E-11 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.94|P-value:9.31E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.60|P-value:2.60E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.86|P-value:1.23E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:7.03|P-value:5.03E-12 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.31|P-value:7.05E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.38|P-value:5.26E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.33|P-value:6.12E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.47|P-value:4.19E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.11|P-value:2.82E-12 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.26|P-value:1.81E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.45|P-value:4.10E-4 ID:SGTC_1706|Compound:st031321|FD-Score:-3.26|P-value:8.33E-4 ID:SGTC_1712|Compound:st032288|FD-Score:8.40|P-value:2.06E-16 ID:SGTC_1844|Compound:rapamycin|FD-Score:9.57|P-value:9.70E-21 ID:SGTC_2030|Compound:5175110|FD-Score:5.13|P-value:3.28E-7 ID:SGTC_2083|Compound:5306046|FD-Score:4.05|P-value:4.29E-5 ID:SGTC_2150|Compound:5556613|FD-Score:4.16|P-value:2.72E-5 ID:SGTC_2157|Compound:5649910|FD-Score:3.51|P-value:3.31E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.87|P-value:8.58E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.90|P-value:8.53E-5 ID:SGTC_2340|Compound:7987427|FD-Score:4.16|P-value:2.74E-5 ID:SGTC_2511|Compound:berberine|FD-Score:3.86|P-value:8.96E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:-4.18|P-value:2.78E-5 ID:SGTC_2556|Compound:citropten|FD-Score:3.20|P-value:9.43E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.69|P-value:2.78E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.94|P-value:7.44E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.64|P-value:2.27E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.57|P-value:4.65E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.35|P-value:6.17E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.37|P-value:4.93E-13 ID:SGTC_2688|Compound:kanamycin b|FD-Score:12.30|P-value:6.61E-33 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.42|P-value:4.97E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.47|P-value:3.81E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.77|P-value:1.40E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.28|P-value:7.28E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:8.93|P-value:2.66E-18 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.20|P-value:2.61E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.54|P-value:2.99E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.45|P-value:8.11E-6 ID:SGTC_2878|Compound:9043973|FD-Score:3.39|P-value:5.08E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.47|P-value:7.27E-6 ID:SGTC_2905|Compound:7799065|FD-Score:-3.35|P-value:6.30E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.46|P-value:3.91E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-4.73|P-value:2.59E-6 ID:SGTC_3037|Compound:9091026|FD-Score:5.02|P-value:5.83E-7 ID:SGTC_3140|Compound:9094243|FD-Score:3.51|P-value:3.33E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.30|P-value:7.32E-4 ID:SGTC_3250|Compound:9135583|FD-Score:-3.89|P-value:9.05E-5 ID:SGTC_3311|Compound:9131146|FD-Score:5.47|P-value:5.71E-8 ID:SGTC_3321|Compound:9137793|FD-Score:4.94|P-value:8.57E-7 ID:SGTC_3322|Compound:9139058|FD-Score:3.65|P-value:1.99E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.61|P-value:2.27E-4

Top fitness defect scores for YNL288W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 12.30 96.7 µM 6.61E-33 calcium & mitochondrial duress 10 5.29E-35
2 SGTC_1844 rapamycin 9.57 4.0 nM 9.70E-21 42 5.25E-22
3 SGTC_2776 terbinafine 8.93 19.9 µM 2.66E-18 cell wall signaling 14 2.11E-19
4 SGTC_1712 st032288 8.40 53.4 µM 2.06E-16 calcium & mitochondrial duress 37 2.19E-17
5 SGTC_514 4466-0038 7.82 2.6 nM 1.91E-14 cell wall 44 2.75E-15
6 SGTC_2679 rapamycin 7.37 1.0 nM 4.93E-13 48 8.83E-14
7 SGTC_1597 7-benzyloxygramine 7.11 47.5 µM 2.82E-12 calcium & mitochondrial duress 37 5.68E-13
8 SGTC_916 4466-0038 7.03 42.0 nM 5.03E-12 cell wall 18 1.05E-12
9 SGTC_528 3492-0019 6.87 172.0 µM 1.41E-11 calcium & mitochondrial duress 98 3.15E-12
10 SGTC_146 3448-8650 6.69 53.1 µM 4.61E-11 NEO1-PIK1 44 1.12E-11
11 SGTC_58 0957-0393 6.06 9.0 µM 2.21E-9 cell wall 213 6.94E-10
12 SGTC_237 nikkomycin 5.74 200.0 µM 1.36E-8 RSC complex & mRNA processing 5 4.81E-9
13 SGTC_3311 9131146 5.47 2.9 µM 5.71E-8 cell wall 71 2.22E-8
14 SGTC_2030 5175110 5.13 200.0 µM 3.28E-7 Golgi 13 1.43E-7
15 SGTC_3037 9091026 5.02 49.5 µM 5.83E-7 NEO1-PIK1 75 2.64E-7
16 SGTC_3321 9137793 4.94 26.8 µM 8.57E-7 cell wall 44 3.97E-7
17 SGTC_770 0389-1121 4.86 67.2 µM 1.23E-6 RPP1 & pyrimidine depletion 12 5.84E-7
18 SGTC_2561 acetosyringone 4.69 100.0 µM 2.78E-6 11 1.39E-6
19 SGTC_2619 obliquin 4.57 87.9 µM 4.65E-6 cell wall 114 2.40E-6
20 SGTC_2896 9052656 4.47 71.4 µM 7.27E-6 endomembrane recycling 83 3.87E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.287 1.79E-64 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.287 1.19E-64 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.281 7.83E-62 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.270 3.78E-57 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.264 1.10E-54 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.264 1.75E-54 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.258 5.78E-52 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.248 2.36E-48 YKR095W MLP1 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
0.248 4.39E-48 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.247 6.06E-48 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.243 3.09E-46 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.243 3.17E-46 YKL053W_d YKL053W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1
0.236 8.85E-44 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.232 3.26E-42 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.231 5.17E-42 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability