YNL289W / PCL1

Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL289W / PCL1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.29|P-value:7.91E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.93|P-value:8.22E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:10.80|P-value:5.17E-25 ID:SGTC_65|Compound:0798-0905|FD-Score:3.69|P-value:2.01E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.40|P-value:6.65E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.54|P-value:3.45E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.14|P-value:3.67E-5 ID:SGTC_271|Compound:rotenone|FD-Score:5.37|P-value:1.41E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.46|P-value:4.55E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.94|P-value:9.89E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:3.60|P-value:2.77E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:4.46|P-value:9.90E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.26|P-value:2.81E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:5.10|P-value:5.41E-7 ID:SGTC_522|Compound:1273-0010|FD-Score:4.34|P-value:1.66E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.63|P-value:2.53E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-4.71|P-value:4.21E-6 ID:SGTC_738|Compound:1315-0003|FD-Score:-3.87|P-value:1.31E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-4.51|P-value:1.01E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.80|P-value:1.37E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.30|P-value:2.47E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.70|P-value:2.38E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.72|P-value:3.16E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.34|P-value:6.86E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.36|P-value:1.50E-5 ID:SGTC_1782|Compound:st039423|FD-Score:-3.40|P-value:6.63E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.81|P-value:1.30E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.46|P-value:4.50E-4 ID:SGTC_1980|Compound:st071811|FD-Score:4.11|P-value:4.07E-5 ID:SGTC_1988|Compound:st071872|FD-Score:5.09|P-value:5.52E-7 ID:SGTC_1991|Compound:st073000|FD-Score:4.48|P-value:8.83E-6 ID:SGTC_2006|Compound:4011487|FD-Score:-3.39|P-value:6.85E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.55|P-value:8.62E-6 ID:SGTC_2133|Compound:5320837|FD-Score:3.58|P-value:3.03E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.94|P-value:8.16E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.77|P-value:1.71E-8 ID:SGTC_2448|Compound:5185112|FD-Score:-4.27|P-value:2.77E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.25|P-value:9.01E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.30|P-value:1.98E-7 ID:SGTC_3045|Compound:9092950|FD-Score:4.16|P-value:3.44E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.28|P-value:8.15E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.29|P-value:7.91E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.93|P-value:8.22E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:10.80|P-value:5.17E-25 ID:SGTC_65|Compound:0798-0905|FD-Score:3.69|P-value:2.01E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.40|P-value:6.65E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.54|P-value:3.45E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.14|P-value:3.67E-5 ID:SGTC_271|Compound:rotenone|FD-Score:5.37|P-value:1.41E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.46|P-value:4.55E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.94|P-value:9.89E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:3.60|P-value:2.77E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:4.46|P-value:9.90E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.26|P-value:2.81E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:5.10|P-value:5.41E-7 ID:SGTC_522|Compound:1273-0010|FD-Score:4.34|P-value:1.66E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.63|P-value:2.53E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-4.71|P-value:4.21E-6 ID:SGTC_738|Compound:1315-0003|FD-Score:-3.87|P-value:1.31E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-4.51|P-value:1.01E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.80|P-value:1.37E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.30|P-value:2.47E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.70|P-value:2.38E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.72|P-value:3.16E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.34|P-value:6.86E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.36|P-value:1.50E-5 ID:SGTC_1782|Compound:st039423|FD-Score:-3.40|P-value:6.63E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.81|P-value:1.30E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.46|P-value:4.50E-4 ID:SGTC_1980|Compound:st071811|FD-Score:4.11|P-value:4.07E-5 ID:SGTC_1988|Compound:st071872|FD-Score:5.09|P-value:5.52E-7 ID:SGTC_1991|Compound:st073000|FD-Score:4.48|P-value:8.83E-6 ID:SGTC_2006|Compound:4011487|FD-Score:-3.39|P-value:6.85E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.55|P-value:8.62E-6 ID:SGTC_2133|Compound:5320837|FD-Score:3.58|P-value:3.03E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.94|P-value:8.16E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.77|P-value:1.71E-8 ID:SGTC_2448|Compound:5185112|FD-Score:-4.27|P-value:2.77E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.25|P-value:9.01E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.30|P-value:1.98E-7 ID:SGTC_3045|Compound:9092950|FD-Score:4.16|P-value:3.44E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.28|P-value:8.15E-4

Top fitness defect scores for YNL289W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 10.80 9.0 µM 5.17E-25 cell wall 69 2.59E-27
2 SGTC_2286 7945697 5.77 125.0 µM 1.71E-8 16 3.88E-9
3 SGTC_271 rotenone 5.37 740.0 µM 1.41E-7 7 3.92E-8
4 SGTC_2567 aureobasidin a 5.30 60.0 nM 1.98E-7 55 5.69E-8
5 SGTC_519 k048-0011 5.10 62.8 µM 5.41E-7 6 1.71E-7
6 SGTC_1988 st071872 5.09 53.4 µM 5.52E-7 3 1.75E-7
7 SGTC_1150 3909-7983 4.72 10.9 µM 3.16E-6 10 1.19E-6
8 SGTC_1991 st073000 4.48 8.9 µM 8.83E-6 NEO1 62 3.65E-6
9 SGTC_342 k048-0088 4.46 23.3 µM 9.90E-6 RSC & ERG11 11 4.14E-6
10 SGTC_1727 st034309 4.36 9.9 µM 1.50E-5 26 6.53E-6
11 SGTC_522 1273-0010 4.34 11.6 µM 1.66E-5 60S ribosome export 19 7.26E-6
12 SGTC_3045 9092950 4.16 49.5 µM 3.44E-5 13 1.61E-5
13 SGTC_165 k038-0023 4.14 64.4 µM 3.67E-5 ubiquinone biosynthesis & proteasome 71 1.73E-5
14 SGTC_1980 st071811 4.11 45.7 µM 4.07E-5 RPP1 & pyrimidine depletion 13 1.94E-5
15 SGTC_2268 7933382 3.94 153.8 µM 8.16E-5 39 4.15E-5
16 SGTC_54 0159-0055 3.93 9.0 µM 8.22E-5 ERG2 48 4.18E-5
17 SGTC_1792 st045773 3.81 43.6 µM 1.30E-4 31 6.92E-5
18 SGTC_762 1165-0429 3.80 115.0 µM 1.37E-4 TSC3-RPN4 24 7.29E-5
19 SGTC_65 0798-0905 3.69 35.0 µM 2.01E-4 calcium & mitochondrial duress 102 1.11E-4
20 SGTC_669 0108-0021 3.63 26.2 µM 2.53E-4 fatty acid desaturase (OLE1) 101 1.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.269 1.22E-56 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.244 1.64E-46 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.236 8.36E-44 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.232 4.08E-42 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.226 4.30E-40 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.224 2.43E-39 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.212 2.70E-35 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.209 2.56E-34 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.207 1.03E-33 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.206 1.85E-33 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress
0.205 2.70E-33 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.203 1.88E-32 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.201 8.52E-32 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.197 1.27E-30 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.197 1.27E-30 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin