YNL290W / RFC3

Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL290W / RFC3

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.68|P-value:2.23E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:4.55|P-value:2.15E-7 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.24|P-value:1.29E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.20|P-value:1.90E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.97|P-value:5.20E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:5.15|P-value:5.18E-9 ID:SGTC_327|Compound:1273-0057|FD-Score:4.53|P-value:2.32E-7 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.81|P-value:9.08E-6 ID:SGTC_337|Compound:1315-0038|FD-Score:5.87|P-value:3.09E-11 ID:SGTC_339|Compound:3091-4833|FD-Score:-2.90|P-value:5.33E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.25|P-value:1.57E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.29|P-value:1.29E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.58|P-value:3.48E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.72|P-value:1.82E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:2.84|P-value:8.18E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.34|P-value:1.07E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.49|P-value:4.29E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:2.84|P-value:8.17E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.98|P-value:4.78E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:2.83|P-value:8.63E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.93|P-value:5.84E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-3.33|P-value:9.06E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.62|P-value:2.95E-5 ID:SGTC_1632|Compound:st005650|FD-Score:4.16|P-value:1.86E-6 ID:SGTC_1634|Compound:st006576|FD-Score:-2.85|P-value:6.46E-4 ID:SGTC_1638|Compound:st008370|FD-Score:2.97|P-value:4.93E-4 ID:SGTC_1811|Compound:st050069|FD-Score:2.87|P-value:7.38E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-3.07|P-value:2.70E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.15|P-value:2.35E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.50|P-value:5.14E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-2.77|P-value:8.97E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.46|P-value:4.95E-5 ID:SGTC_2160|Compound:5660466|FD-Score:3.06|P-value:3.40E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.34|P-value:8.57E-5 ID:SGTC_2336|Compound:9001819|FD-Score:2.84|P-value:8.21E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.46|P-value:5.02E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.47|P-value:3.36E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.11|P-value:2.76E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.24|P-value:1.62E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.95|P-value:4.44E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.76|P-value:1.51E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-2.76|P-value:9.34E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.62|P-value:2.93E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.77|P-value:1.42E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.05|P-value:3.65E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-3.24|P-value:1.34E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-3.17|P-value:1.79E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-2.91|P-value:5.25E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-2.80|P-value:7.96E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.68|P-value:2.23E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:4.55|P-value:2.15E-7 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.24|P-value:1.29E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.20|P-value:1.90E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.97|P-value:5.20E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:5.15|P-value:5.18E-9 ID:SGTC_327|Compound:1273-0057|FD-Score:4.53|P-value:2.32E-7 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.81|P-value:9.08E-6 ID:SGTC_337|Compound:1315-0038|FD-Score:5.87|P-value:3.09E-11 ID:SGTC_339|Compound:3091-4833|FD-Score:-2.90|P-value:5.33E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.25|P-value:1.57E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.29|P-value:1.29E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.58|P-value:3.48E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.72|P-value:1.82E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:2.84|P-value:8.18E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.34|P-value:1.07E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.49|P-value:4.29E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:2.84|P-value:8.17E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.98|P-value:4.78E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:2.83|P-value:8.63E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.93|P-value:5.84E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-3.33|P-value:9.06E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.62|P-value:2.95E-5 ID:SGTC_1632|Compound:st005650|FD-Score:4.16|P-value:1.86E-6 ID:SGTC_1634|Compound:st006576|FD-Score:-2.85|P-value:6.46E-4 ID:SGTC_1638|Compound:st008370|FD-Score:2.97|P-value:4.93E-4 ID:SGTC_1811|Compound:st050069|FD-Score:2.87|P-value:7.38E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-3.07|P-value:2.70E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.15|P-value:2.35E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.50|P-value:5.14E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-2.77|P-value:8.97E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.46|P-value:4.95E-5 ID:SGTC_2160|Compound:5660466|FD-Score:3.06|P-value:3.40E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.34|P-value:8.57E-5 ID:SGTC_2336|Compound:9001819|FD-Score:2.84|P-value:8.21E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.46|P-value:5.02E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.47|P-value:3.36E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.11|P-value:2.76E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.24|P-value:1.62E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.95|P-value:4.44E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.76|P-value:1.51E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-2.76|P-value:9.34E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.62|P-value:2.93E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.77|P-value:1.42E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.05|P-value:3.65E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-3.24|P-value:1.34E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-3.17|P-value:1.79E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-2.91|P-value:5.25E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-2.80|P-value:7.96E-4

Top fitness defect scores for YNL290W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_337 1315-0038 5.87 354.0 µM 3.09E-11 amide catabolism 1 2.13E-9 1.30
2 SGTC_325 2810-4341 5.15 181.0 µM 5.18E-9 amide catabolism 2 1.34E-7 0.82
3 SGTC_53 0973-0023 4.55 40.0 µM 2.15E-7 RNA processing & uracil transport 7 2.74E-6 0.11
4 SGTC_327 1273-0057 4.53 4.0 µM 2.32E-7 azole & statin 5 2.90E-6 0.12
5 SGTC_2583 asiatic acid 4.47 100.0 µM 3.36E-7 5 3.93E-6 0.21
6 SGTC_1632 st005650 4.16 90.0 µM 1.86E-6 5 1.57E-5 0.11
7 SGTC_853 0419-0306 3.98 21.0 µM 4.78E-6 7 3.39E-5 0.33
8 SGTC_322 k048-0136 3.97 19.3 µM 5.20E-6 RSC & ERG11 10 3.63E-5 0.24
9 SGTC_2871 9038510 3.77 13.0 µM 1.42E-5 5 8.22E-5 0.02
10 SGTC_2794 7785382 3.76 27.3 µM 1.51E-5 14 8.63E-5 0.04
11 SGTC_538 2922-0838 3.72 53.3 µM 1.82E-5 Golgi 6 1.00E-4 0.04
12 SGTC_50 0929-0078 3.68 56.4 µM 2.23E-5 7 1.18E-4 0.06
13 SGTC_2838 9002687 3.62 71.4 µM 2.93E-5 fatty acid desaturase (OLE1) 16 1.48E-4 0.03
14 SGTC_1592 4',5'-dihydroxyflavone 3.62 8.8 µM 2.95E-5 60S ribosome export 9 1.49E-4 0.02
15 SGTC_357 1325-0123 3.58 420.0 µM 3.48E-5 5 1.70E-4 0.37
16 SGTC_1861 st057647 3.50 17.4 µM 5.14E-5 9 2.34E-4 0.10
17 SGTC_657 3534-0529 3.34 86.7 µM 1.07E-4 8 4.26E-4 0.14
18 SGTC_356 1634-0012 3.29 32.5 µM 1.29E-4 11 4.97E-4 0.03
19 SGTC_340 k038-0059 3.25 454.0 µM 1.57E-4 ubiquinone biosynthesis & proteasome 15 5.83E-4 0.12
20 SGTC_2768 sulfasalazine 3.24 50.2 µM 1.62E-4 21 5.96E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 3.22E-15 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.119 5.01E-12 YLR351C NIT3 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.107 5.80E-10 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.096 2.55E-8 YDL078C MDH3 hom Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
0.090 1.80E-7 YDR257C RKM4 hom Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein
0.085 8.89E-7 YDR397C NCB2 het Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
0.085 9.56E-7 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.084 1.09E-6 YKL070W_p YKL070W_p hom Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.083 1.32E-6 YPL199C_p YPL199C_p hom Putative protein of unknown function, predicted to be palmitoylated
0.082 2.12E-6 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.75E-6 YER159C BUR6 het Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
0.080 3.53E-6 YGL102C_d YGL102C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
0.079 4.62E-6 YLR450W HMG2 hom HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at the nuclear periphery upon DNA replication stress
0.076 9.62E-6 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.074 1.87E-5 YOR371C GPB1 hom Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication