YNL298W / CLA4

Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL298W / CLA4

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.88|P-value:2.99E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:15.00|P-value:2.43E-36 ID:SGTC_12|Compound:0849-0099|FD-Score:4.97|P-value:2.17E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:15.00|P-value:4.87E-36 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.90|P-value:7.18E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.88|P-value:7.59E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:9.20|P-value:1.07E-14 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.44|P-value:6.68E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.88|P-value:6.10E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:4.08|P-value:4.28E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.08|P-value:4.27E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.45|P-value:1.31E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:8.88|P-value:8.53E-14 ID:SGTC_210|Compound:3551-0445|FD-Score:13.00|P-value:1.02E-27 ID:SGTC_212|Compound:3807-4682|FD-Score:9.16|P-value:1.42E-14 ID:SGTC_268|Compound:camptothecin|FD-Score:14.40|P-value:2.32E-33 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.08|P-value:2.17E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.41|P-value:7.37E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:7.48|P-value:2.88E-10 ID:SGTC_354|Compound:2783-3500|FD-Score:5.80|P-value:8.76E-7 ID:SGTC_360|Compound:0957-0399|FD-Score:3.91|P-value:7.08E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.90|P-value:7.11E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:6.84|P-value:7.58E-9 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.98|P-value:5.70E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:8.27|P-value:3.49E-12 ID:SGTC_540|Compound:1187-0821|FD-Score:4.14|P-value:3.56E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.94|P-value:3.39E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:4.72|P-value:5.40E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.69|P-value:7.08E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:5.46|P-value:3.46E-6 ID:SGTC_589|Compound:1227-0070|FD-Score:10.30|P-value:7.33E-18 ID:SGTC_594|Compound:1487-1584|FD-Score:35.10|P-value:8.10E-191 ID:SGTC_612|Compound:0302-0167|FD-Score:3.86|P-value:8.08E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.28|P-value:6.89E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:4.73|P-value:5.15E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:5.80|P-value:8.61E-7 ID:SGTC_785|Compound:1270-0111|FD-Score:-4.16|P-value:1.70E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:12.00|P-value:6.66E-24 ID:SGTC_879|Compound:0831-1030|FD-Score:4.17|P-value:3.24E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:10.30|P-value:4.14E-18 ID:SGTC_897|Compound:1000-0139|FD-Score:8.78|P-value:1.54E-13 ID:SGTC_951|Compound:1171-0579|FD-Score:8.93|P-value:6.30E-14 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.25|P-value:7.80E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.91|P-value:7.03E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.31|P-value:2.06E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.78|P-value:4.28E-5 ID:SGTC_1433|Compound:4060-0023|FD-Score:4.68|P-value:6.14E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.99|P-value:5.45E-4 ID:SGTC_1522|Compound:st012842|FD-Score:6.36|P-value:7.55E-8 ID:SGTC_1568|Compound:digitonin|FD-Score:5.61|P-value:1.92E-6 ID:SGTC_1604|Compound:st002052|FD-Score:4.02|P-value:5.03E-4 ID:SGTC_1608|Compound:st001473|FD-Score:5.03|P-value:1.75E-5 ID:SGTC_1617|Compound:st002906|FD-Score:4.02|P-value:5.10E-4 ID:SGTC_1643|Compound:st009866|FD-Score:16.80|P-value:3.64E-45 ID:SGTC_1661|Compound:st013063|FD-Score:3.82|P-value:8.95E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.85|P-value:8.23E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.02|P-value:4.98E-4 ID:SGTC_1719|Compound:st032227|FD-Score:7.71|P-value:8.55E-11 ID:SGTC_1720|Compound:st037298|FD-Score:-5.77|P-value:3.88E-7 ID:SGTC_1745|Compound:st081495|FD-Score:5.84|P-value:7.15E-7 ID:SGTC_1773|Compound:st048542|FD-Score:18.90|P-value:1.10E-56 ID:SGTC_1845|Compound:st056753|FD-Score:5.44|P-value:3.71E-6 ID:SGTC_1941|Compound:st076221|FD-Score:-3.79|P-value:5.22E-4 ID:SGTC_1950|Compound:st077106|FD-Score:5.36|P-value:4.99E-6 ID:SGTC_2035|Compound:5154463|FD-Score:7.44|P-value:3.60E-10 ID:SGTC_2045|Compound:5106652|FD-Score:-3.74|P-value:6.04E-4 ID:SGTC_2058|Compound:5236698|FD-Score:13.60|P-value:6.63E-30 ID:SGTC_2065|Compound:5221596|FD-Score:4.96|P-value:2.24E-5 ID:SGTC_2084|Compound:5306078|FD-Score:3.93|P-value:6.68E-4 ID:SGTC_2089|Compound:5281248|FD-Score:16.40|P-value:7.47E-43 ID:SGTC_2110|Compound:5483698|FD-Score:5.63|P-value:1.72E-6 ID:SGTC_2111|Compound:5486399|FD-Score:5.36|P-value:5.13E-6 ID:SGTC_2141|Compound:5621638|FD-Score:3.94|P-value:6.46E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.35|P-value:7.81E-8 ID:SGTC_2225|Compound:6654152|FD-Score:6.07|P-value:2.69E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.08|P-value:4.16E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:14.80|P-value:1.62E-35 ID:SGTC_2289|Compound:7946404|FD-Score:7.05|P-value:2.77E-9 ID:SGTC_2313|Compound:7726885|FD-Score:6.11|P-value:2.27E-7 ID:SGTC_2323|Compound:6148992|FD-Score:11.20|P-value:4.64E-21 ID:SGTC_2405|Compound:ticlatone|FD-Score:11.40|P-value:1.25E-21 ID:SGTC_2408|Compound:sulbentine|FD-Score:8.48|P-value:9.90E-13 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.06|P-value:2.33E-4 ID:SGTC_2430|Compound:5571206|FD-Score:13.20|P-value:1.96E-28 ID:SGTC_2479|Compound:5617353|FD-Score:4.37|P-value:1.71E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.70|P-value:5.68E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.90|P-value:1.29E-5 ID:SGTC_2537|Compound:larixol|FD-Score:-4.80|P-value:1.89E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.60|P-value:1.91E-22 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:6.48|P-value:4.23E-8 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-4.12|P-value:1.93E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.63|P-value:8.46E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.94|P-value:3.36E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-4.42|P-value:7.13E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.93|P-value:6.54E-4 ID:SGTC_2892|Compound:9047358|FD-Score:-3.92|P-value:3.58E-4 ID:SGTC_2910|Compound:7948405|FD-Score:4.40|P-value:1.56E-4 ID:SGTC_2912|Compound:7964298|FD-Score:12.50|P-value:1.21E-25 ID:SGTC_2947|Compound:9072639|FD-Score:4.18|P-value:3.13E-4 ID:SGTC_2952|Compound:9073731|FD-Score:6.01|P-value:3.58E-7 ID:SGTC_2980|Compound:9014342|FD-Score:4.06|P-value:4.50E-4 ID:SGTC_3058|Compound:9093861|FD-Score:6.41|P-value:5.91E-8 ID:SGTC_3062|Compound:9077494|FD-Score:13.40|P-value:3.97E-29 ID:SGTC_3120|Compound:9124077|FD-Score:9.22|P-value:9.67E-15 ID:SGTC_3137|Compound:9097352|FD-Score:-3.66|P-value:7.81E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.80|P-value:9.56E-4 ID:SGTC_3282|Compound:9108498|FD-Score:10.80|P-value:1.71E-19 ID:SGTC_3288|Compound:9119690|FD-Score:13.20|P-value:1.32E-28 ID:SGTC_3294|Compound:9122953|FD-Score:5.52|P-value:2.68E-6 ID:SGTC_3304|Compound:9125678|FD-Score:7.89|P-value:3.04E-11 ID:SGTC_3312|Compound:9133330|FD-Score:-4.28|P-value:1.14E-4 ID:SGTC_3317|Compound:9138495|FD-Score:8.07|P-value:1.12E-11 ID:SGTC_3323|Compound:9138564|FD-Score:-4.07|P-value:2.27E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.88|P-value:2.99E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:15.00|P-value:2.43E-36 ID:SGTC_12|Compound:0849-0099|FD-Score:4.97|P-value:2.17E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:15.00|P-value:4.87E-36 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.90|P-value:7.18E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.88|P-value:7.59E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:9.20|P-value:1.07E-14 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.44|P-value:6.68E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.88|P-value:6.10E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:4.08|P-value:4.28E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.08|P-value:4.27E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.45|P-value:1.31E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:8.88|P-value:8.53E-14 ID:SGTC_210|Compound:3551-0445|FD-Score:13.00|P-value:1.02E-27 ID:SGTC_212|Compound:3807-4682|FD-Score:9.16|P-value:1.42E-14 ID:SGTC_268|Compound:camptothecin|FD-Score:14.40|P-value:2.32E-33 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.08|P-value:2.17E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.41|P-value:7.37E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:7.48|P-value:2.88E-10 ID:SGTC_354|Compound:2783-3500|FD-Score:5.80|P-value:8.76E-7 ID:SGTC_360|Compound:0957-0399|FD-Score:3.91|P-value:7.08E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.90|P-value:7.11E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:6.84|P-value:7.58E-9 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.98|P-value:5.70E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:8.27|P-value:3.49E-12 ID:SGTC_540|Compound:1187-0821|FD-Score:4.14|P-value:3.56E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.94|P-value:3.39E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:4.72|P-value:5.40E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.69|P-value:7.08E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:5.46|P-value:3.46E-6 ID:SGTC_589|Compound:1227-0070|FD-Score:10.30|P-value:7.33E-18 ID:SGTC_594|Compound:1487-1584|FD-Score:35.10|P-value:8.10E-191 ID:SGTC_612|Compound:0302-0167|FD-Score:3.86|P-value:8.08E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.28|P-value:6.89E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:4.73|P-value:5.15E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:5.80|P-value:8.61E-7 ID:SGTC_785|Compound:1270-0111|FD-Score:-4.16|P-value:1.70E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:12.00|P-value:6.66E-24 ID:SGTC_879|Compound:0831-1030|FD-Score:4.17|P-value:3.24E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:10.30|P-value:4.14E-18 ID:SGTC_897|Compound:1000-0139|FD-Score:8.78|P-value:1.54E-13 ID:SGTC_951|Compound:1171-0579|FD-Score:8.93|P-value:6.30E-14 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.25|P-value:7.80E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.91|P-value:7.03E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.31|P-value:2.06E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.78|P-value:4.28E-5 ID:SGTC_1433|Compound:4060-0023|FD-Score:4.68|P-value:6.14E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.99|P-value:5.45E-4 ID:SGTC_1522|Compound:st012842|FD-Score:6.36|P-value:7.55E-8 ID:SGTC_1568|Compound:digitonin|FD-Score:5.61|P-value:1.92E-6 ID:SGTC_1604|Compound:st002052|FD-Score:4.02|P-value:5.03E-4 ID:SGTC_1608|Compound:st001473|FD-Score:5.03|P-value:1.75E-5 ID:SGTC_1617|Compound:st002906|FD-Score:4.02|P-value:5.10E-4 ID:SGTC_1643|Compound:st009866|FD-Score:16.80|P-value:3.64E-45 ID:SGTC_1661|Compound:st013063|FD-Score:3.82|P-value:8.95E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.85|P-value:8.23E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.02|P-value:4.98E-4 ID:SGTC_1719|Compound:st032227|FD-Score:7.71|P-value:8.55E-11 ID:SGTC_1720|Compound:st037298|FD-Score:-5.77|P-value:3.88E-7 ID:SGTC_1745|Compound:st081495|FD-Score:5.84|P-value:7.15E-7 ID:SGTC_1773|Compound:st048542|FD-Score:18.90|P-value:1.10E-56 ID:SGTC_1845|Compound:st056753|FD-Score:5.44|P-value:3.71E-6 ID:SGTC_1941|Compound:st076221|FD-Score:-3.79|P-value:5.22E-4 ID:SGTC_1950|Compound:st077106|FD-Score:5.36|P-value:4.99E-6 ID:SGTC_2035|Compound:5154463|FD-Score:7.44|P-value:3.60E-10 ID:SGTC_2045|Compound:5106652|FD-Score:-3.74|P-value:6.04E-4 ID:SGTC_2058|Compound:5236698|FD-Score:13.60|P-value:6.63E-30 ID:SGTC_2065|Compound:5221596|FD-Score:4.96|P-value:2.24E-5 ID:SGTC_2084|Compound:5306078|FD-Score:3.93|P-value:6.68E-4 ID:SGTC_2089|Compound:5281248|FD-Score:16.40|P-value:7.47E-43 ID:SGTC_2110|Compound:5483698|FD-Score:5.63|P-value:1.72E-6 ID:SGTC_2111|Compound:5486399|FD-Score:5.36|P-value:5.13E-6 ID:SGTC_2141|Compound:5621638|FD-Score:3.94|P-value:6.46E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.35|P-value:7.81E-8 ID:SGTC_2225|Compound:6654152|FD-Score:6.07|P-value:2.69E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.08|P-value:4.16E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:14.80|P-value:1.62E-35 ID:SGTC_2289|Compound:7946404|FD-Score:7.05|P-value:2.77E-9 ID:SGTC_2313|Compound:7726885|FD-Score:6.11|P-value:2.27E-7 ID:SGTC_2323|Compound:6148992|FD-Score:11.20|P-value:4.64E-21 ID:SGTC_2405|Compound:ticlatone|FD-Score:11.40|P-value:1.25E-21 ID:SGTC_2408|Compound:sulbentine|FD-Score:8.48|P-value:9.90E-13 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.06|P-value:2.33E-4 ID:SGTC_2430|Compound:5571206|FD-Score:13.20|P-value:1.96E-28 ID:SGTC_2479|Compound:5617353|FD-Score:4.37|P-value:1.71E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.70|P-value:5.68E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.90|P-value:1.29E-5 ID:SGTC_2537|Compound:larixol|FD-Score:-4.80|P-value:1.89E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.60|P-value:1.91E-22 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:6.48|P-value:4.23E-8 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-4.12|P-value:1.93E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.63|P-value:8.46E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.94|P-value:3.36E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-4.42|P-value:7.13E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.93|P-value:6.54E-4 ID:SGTC_2892|Compound:9047358|FD-Score:-3.92|P-value:3.58E-4 ID:SGTC_2910|Compound:7948405|FD-Score:4.40|P-value:1.56E-4 ID:SGTC_2912|Compound:7964298|FD-Score:12.50|P-value:1.21E-25 ID:SGTC_2947|Compound:9072639|FD-Score:4.18|P-value:3.13E-4 ID:SGTC_2952|Compound:9073731|FD-Score:6.01|P-value:3.58E-7 ID:SGTC_2980|Compound:9014342|FD-Score:4.06|P-value:4.50E-4 ID:SGTC_3058|Compound:9093861|FD-Score:6.41|P-value:5.91E-8 ID:SGTC_3062|Compound:9077494|FD-Score:13.40|P-value:3.97E-29 ID:SGTC_3120|Compound:9124077|FD-Score:9.22|P-value:9.67E-15 ID:SGTC_3137|Compound:9097352|FD-Score:-3.66|P-value:7.81E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.80|P-value:9.56E-4 ID:SGTC_3282|Compound:9108498|FD-Score:10.80|P-value:1.71E-19 ID:SGTC_3288|Compound:9119690|FD-Score:13.20|P-value:1.32E-28 ID:SGTC_3294|Compound:9122953|FD-Score:5.52|P-value:2.68E-6 ID:SGTC_3304|Compound:9125678|FD-Score:7.89|P-value:3.04E-11 ID:SGTC_3312|Compound:9133330|FD-Score:-4.28|P-value:1.14E-4 ID:SGTC_3317|Compound:9138495|FD-Score:8.07|P-value:1.12E-11 ID:SGTC_3323|Compound:9138564|FD-Score:-4.07|P-value:2.27E-4

Top fitness defect scores for YNL298W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_594 1487-1584 35.10 10.8 µM 8.10E-191 1 7.03E-271
2 SGTC_1773 st048542 18.90 73.6 µM 1.10E-56 1 2.85E-80
3 SGTC_1643 st009866 16.80 20.2 µM 3.64E-45 3 7.03E-64
4 SGTC_2089 5281248 16.40 129.7 µM 7.47E-43 superoxide 1 1.37E-60
5 SGTC_9 0092-0002 15.00 10.4 µM 2.43E-36 1 2.56E-51
6 SGTC_29 0299-0004 15.00 13.0 µM 4.87E-36 1 6.91E-51
7 SGTC_2233 sulbentine 14.80 40.4 µM 1.62E-35 3 3.83E-50
8 SGTC_268 camptothecin 14.40 39.6 µM 2.32E-33 DNA damage response 3 4.48E-47
9 SGTC_2058 5236698 13.60 133.0 µM 6.63E-30 2 3.75E-42
10 SGTC_3062 9077494 13.40 49.5 µM 3.97E-29 mitochondrial response to ROS 1 4.80E-41
11 SGTC_3288 9119690 13.20 36.2 µM 1.32E-28 1 2.64E-40
12 SGTC_2430 5571206 13.20 200.0 µM 1.96E-28 4 4.66E-40
13 SGTC_210 3551-0445 13.00 56.8 µM 1.02E-27 11 4.92E-39
14 SGTC_2912 7964298 12.50 10.9 µM 1.21E-25 cell wall 8 4.38E-36
15 SGTC_871 0574-0004 12.00 149.0 µM 6.66E-24 5 1.33E-33
16 SGTC_2582 agaric acid 11.60 100.0 µM 1.91E-22 redox potentiating 43 1.59E-31
17 SGTC_2405 ticlatone 11.40 3.5 µM 1.25E-21 9 2.30E-30
18 SGTC_2323 6148992 11.20 148.3 µM 4.64E-21 2 1.50E-29
19 SGTC_3282 9108498 10.80 15.5 µM 1.71E-19 4 2.55E-27
20 SGTC_885 0865-0106 10.30 16.8 µM 4.14E-18 TSC3-RPN4 3 2.40E-25

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.571 2.55E-288 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.339 5.85E-91 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.307 8.86E-74 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.287 1.97E-64 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.276 1.85E-59 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.271 3.35E-57 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.248 4.97E-48 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.230 2.08E-41 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.207 1.20E-33 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.196 1.94E-30 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.192 4.59E-29 YMR185W RTP1 het Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene
0.181 4.44E-26 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.179 1.36E-25 YJR018W_d YJR018W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.179 1.75E-25 YNL216W RAP1 het Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)
0.175 1.90E-24 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance