YNL300W_p / TOS6

Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL300W / TOS6

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:4.48|P-value:1.96E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.54|P-value:6.06E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:4.42|P-value:2.47E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.47|P-value:7.12E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.57|P-value:5.16E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:-3.40|P-value:9.43E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.53|P-value:1.58E-5 ID:SGTC_462|Compound:ag-879|FD-Score:4.38|P-value:2.96E-5 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.56|P-value:5.48E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:6.86|P-value:1.56E-10 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.61|P-value:4.58E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:5.99|P-value:1.92E-8 ID:SGTC_538|Compound:2922-0838|FD-Score:3.63|P-value:4.25E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.58|P-value:5.15E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.26|P-value:4.54E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:4.20|P-value:5.79E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.44|P-value:7.90E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.60|P-value:4.82E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:4.21|P-value:5.66E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.14|P-value:1.19E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.83|P-value:2.20E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.84|P-value:4.55E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.40|P-value:9.03E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.91|P-value:1.66E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.44|P-value:7.85E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.46|P-value:7.35E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.60|P-value:4.76E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.55|P-value:5.58E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.50|P-value:6.81E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.40|P-value:8.99E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-4.32|P-value:3.83E-5 ID:SGTC_1861|Compound:st057647|FD-Score:4.23|P-value:5.23E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.48|P-value:7.28E-4 ID:SGTC_1997|Compound:st073024|FD-Score:-3.46|P-value:7.73E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.94|P-value:1.49E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.70|P-value:3.43E-4 ID:SGTC_2149|Compound:5554786|FD-Score:5.32|P-value:5.15E-7 ID:SGTC_2163|Compound:5671233|FD-Score:5.36|P-value:4.46E-7 ID:SGTC_2165|Compound:5727197|FD-Score:4.51|P-value:1.76E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-3.75|P-value:2.95E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.31|P-value:3.80E-5 ID:SGTC_2461|Compound:5755302|FD-Score:-4.59|P-value:1.32E-5 ID:SGTC_2475|Compound:5812728|FD-Score:4.08|P-value:9.19E-5 ID:SGTC_2526|Compound:patulin|FD-Score:3.59|P-value:4.89E-4 ID:SGTC_2556|Compound:citropten|FD-Score:6.09|P-value:1.16E-8 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.39|P-value:9.16E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.69|P-value:8.53E-6 ID:SGTC_2801|Compound:7907800|FD-Score:4.60|P-value:1.21E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.43|P-value:8.16E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.76|P-value:2.75E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.73|P-value:3.05E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.90|P-value:1.79E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.85|P-value:2.03E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:4.48|P-value:1.96E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.54|P-value:6.06E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:4.42|P-value:2.47E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.47|P-value:7.12E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.57|P-value:5.16E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:-3.40|P-value:9.43E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.53|P-value:1.58E-5 ID:SGTC_462|Compound:ag-879|FD-Score:4.38|P-value:2.96E-5 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.56|P-value:5.48E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:6.86|P-value:1.56E-10 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.61|P-value:4.58E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:5.99|P-value:1.92E-8 ID:SGTC_538|Compound:2922-0838|FD-Score:3.63|P-value:4.25E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.58|P-value:5.15E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.26|P-value:4.54E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:4.20|P-value:5.79E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.44|P-value:7.90E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.60|P-value:4.82E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:4.21|P-value:5.66E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.14|P-value:1.19E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.83|P-value:2.20E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.84|P-value:4.55E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.40|P-value:9.03E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.91|P-value:1.66E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.44|P-value:7.85E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.46|P-value:7.35E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.60|P-value:4.76E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.55|P-value:5.58E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.50|P-value:6.81E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.40|P-value:8.99E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-4.32|P-value:3.83E-5 ID:SGTC_1861|Compound:st057647|FD-Score:4.23|P-value:5.23E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.48|P-value:7.28E-4 ID:SGTC_1997|Compound:st073024|FD-Score:-3.46|P-value:7.73E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.94|P-value:1.49E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.70|P-value:3.43E-4 ID:SGTC_2149|Compound:5554786|FD-Score:5.32|P-value:5.15E-7 ID:SGTC_2163|Compound:5671233|FD-Score:5.36|P-value:4.46E-7 ID:SGTC_2165|Compound:5727197|FD-Score:4.51|P-value:1.76E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-3.75|P-value:2.95E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.31|P-value:3.80E-5 ID:SGTC_2461|Compound:5755302|FD-Score:-4.59|P-value:1.32E-5 ID:SGTC_2475|Compound:5812728|FD-Score:4.08|P-value:9.19E-5 ID:SGTC_2526|Compound:patulin|FD-Score:3.59|P-value:4.89E-4 ID:SGTC_2556|Compound:citropten|FD-Score:6.09|P-value:1.16E-8 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.39|P-value:9.16E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.69|P-value:8.53E-6 ID:SGTC_2801|Compound:7907800|FD-Score:4.60|P-value:1.21E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.43|P-value:8.16E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.76|P-value:2.75E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.73|P-value:3.05E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.90|P-value:1.79E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.85|P-value:2.03E-4

Top fitness defect scores for YNL300W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_495 decylubiquinone 6.86 155.0 µM 1.56E-10 copper-dependent oxidative stress 3 3.44E-12
2 SGTC_2556 citropten 6.09 84.6 µM 1.16E-8 3 5.65E-10
3 SGTC_517 1365-0151 5.99 113.0 µM 1.92E-8 11 1.03E-9
4 SGTC_2163 5671233 5.36 125.0 µM 4.46E-7 7 4.26E-8
5 SGTC_2149 5554786 5.32 194.8 µM 5.15E-7 cell wall signaling 12 5.05E-8
6 SGTC_1040 k898-0338 5.14 155.0 µM 1.19E-6 7 1.36E-7
7 SGTC_1107 amlodipine 4.84 47.0 µM 4.55E-6 18 6.63E-7
8 SGTC_2792 7535235 4.69 81.8 µM 8.53E-6 fatty acid desaturase (OLE1) 21 1.39E-6
9 SGTC_2801 7907800 4.60 81.8 µM 1.21E-5 18 2.10E-6
10 SGTC_379 3970-0972 4.53 5.9 µM 1.58E-5 tubulin folding & SWR complex 21 2.88E-6
11 SGTC_2165 5727197 4.51 32.1 µM 1.76E-5 25 3.28E-6
12 SGTC_51 1013-0126 4.48 23.4 µM 1.96E-5 23 3.72E-6
13 SGTC_174 3553-0389 4.42 74.3 µM 2.47E-5 14 4.89E-6
14 SGTC_462 ag-879 4.38 158.0 µM 2.96E-5 20 6.05E-6
15 SGTC_2307 7538926 4.31 6.3 µM 3.80E-5 27 8.11E-6
16 SGTC_740 k014-0057 4.26 261.0 µM 4.54E-5 18 1.00E-5
17 SGTC_1861 st057647 4.23 17.4 µM 5.23E-5 15 1.18E-5
18 SGTC_981 1488-1094 4.21 54.9 µM 5.66E-5 16 1.30E-5
19 SGTC_744 1594-0068 4.20 283.0 µM 5.79E-5 amide catabolism 22 1.33E-5
20 SGTC_2475 5812728 4.08 15.0 µM 9.19E-5 mitochondrial processes 19 2.30E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.80E-9 YOR097C_p YOR097C_p hom Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene
0.094 4.80E-8 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.072 3.21E-5 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.071 3.66E-5 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.071 3.96E-5 YOR355W GDS1 hom Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.071 4.23E-5 YHR085W IPI1 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; IPI1 is an essential gene
0.068 8.59E-5 YOL093W TRM10 hom tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress
0.067 9.76E-5 YOR373W NUD1 het Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance
0.067 1.12E-4 YKL088W CAB3 het Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC
0.066 1.43E-4 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.063 2.53E-4 YOR264W DSE3 hom Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.063 2.69E-4 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.062 3.60E-4 YGL044C RNA15 het Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
0.060 4.57E-4 YGR249W MGA1 hom Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
0.060 4.90E-4 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p