YNL306W / MRPS18

Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL306W / MRPS18

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.51|P-value:1.84E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.47|P-value:2.96E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.02|P-value:2.34E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.61|P-value:1.41E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:2.75|P-value:7.32E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-2.70|P-value:7.20E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:2.68|P-value:9.66E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.57|P-value:1.73E-5 ID:SGTC_630|Compound:4356-0227|FD-Score:-2.80|P-value:4.75E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.64|P-value:9.13E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.65|P-value:1.19E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:2.73|P-value:7.92E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.35|P-value:5.15E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:5.11|P-value:1.51E-9 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.86|P-value:2.87E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.81|P-value:5.01E-6 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.05|P-value:2.06E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.03|P-value:1.80E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.77|P-value:6.07E-6 ID:SGTC_1919|Compound:st067113|FD-Score:-2.72|P-value:6.54E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.01|P-value:2.45E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.52|P-value:2.28E-5 ID:SGTC_2204|Compound:7233102|FD-Score:2.68|P-value:9.74E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.68|P-value:7.84E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-2.65|P-value:8.95E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.58|P-value:1.29E-5 ID:SGTC_2369|Compound:9071472|FD-Score:2.72|P-value:8.18E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-2.75|P-value:5.78E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.09|P-value:1.37E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.87|P-value:4.44E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.65|P-value:1.19E-5 ID:SGTC_2505|Compound:galangin|FD-Score:3.95|P-value:2.26E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.03|P-value:2.24E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:2.86|P-value:4.70E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-2.62|P-value:9.91E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.15|P-value:1.05E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:2.87|P-value:4.53E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:2.72|P-value:8.46E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.61|P-value:1.41E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.10|P-value:1.66E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.51|P-value:1.84E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.47|P-value:2.96E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.02|P-value:2.34E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.61|P-value:1.41E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:2.75|P-value:7.32E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-2.70|P-value:7.20E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:2.68|P-value:9.66E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.57|P-value:1.73E-5 ID:SGTC_630|Compound:4356-0227|FD-Score:-2.80|P-value:4.75E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.64|P-value:9.13E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.65|P-value:1.19E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:2.73|P-value:7.92E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.35|P-value:5.15E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:5.11|P-value:1.51E-9 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.86|P-value:2.87E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.81|P-value:5.01E-6 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.05|P-value:2.06E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.03|P-value:1.80E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.77|P-value:6.07E-6 ID:SGTC_1919|Compound:st067113|FD-Score:-2.72|P-value:6.54E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.01|P-value:2.45E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.52|P-value:2.28E-5 ID:SGTC_2204|Compound:7233102|FD-Score:2.68|P-value:9.74E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.68|P-value:7.84E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-2.65|P-value:8.95E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.58|P-value:1.29E-5 ID:SGTC_2369|Compound:9071472|FD-Score:2.72|P-value:8.18E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-2.75|P-value:5.78E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.09|P-value:1.37E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.87|P-value:4.44E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.65|P-value:1.19E-5 ID:SGTC_2505|Compound:galangin|FD-Score:3.95|P-value:2.26E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.03|P-value:2.24E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:2.86|P-value:4.70E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-2.62|P-value:9.91E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.15|P-value:1.05E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:2.87|P-value:4.53E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:2.72|P-value:8.46E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.61|P-value:1.41E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.10|P-value:1.66E-4

Top fitness defect scores for YNL306W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1013 4112-3890 5.11 241.0 µM 1.51E-9 TSC3-RPN4 3 1.65E-7 0.54
2 SGTC_2505 galangin 3.95 7.9 µM 2.26E-6 RPP1 & pyrimidine depletion 7 3.84E-5 0.31
3 SGTC_1017 4239-0030 3.81 168.0 µM 5.01E-6 3 6.96E-5 0.30
4 SGTC_1570 verbenone 3.77 133.0 µM 6.07E-6 5 8.04E-5 0.14
5 SGTC_2504 purpurogallin 3.65 52.3 µM 1.19E-5 RPP1 & pyrimidine depletion 5 1.33E-4 0.10
6 SGTC_795 0685-0265 3.65 78.0 µM 1.19E-5 excess fatty acid 25 1.33E-4 0.03
7 SGTC_2793 7325131 3.61 81.8 µM 1.41E-5 11 1.51E-4 0.25
8 SGTC_152 4469-0003 3.61 551.2 µM 1.41E-5 18 1.51E-4 0.12
9 SGTC_522 1273-0010 3.57 11.6 µM 1.73E-5 60S ribosome export 9 1.76E-4 0.16
10 SGTC_2107 5363541 3.52 170.2 µM 2.28E-5 11 2.17E-4 0.00
11 SGTC_67 0335-0847 3.47 266.0 µM 2.96E-5 ubiquinone biosynthesis & proteasome 30 2.64E-4 0.00
12 SGTC_1010 4112-3296 3.35 15.2 µM 5.15E-5 10 3.99E-4 0.02
13 SGTC_3328 9140624 3.10 29.0 µM 1.66E-4 11 9.66E-4 0.01
14 SGTC_1169 aniline yellow 3.05 25.8 µM 2.06E-4 7 0.00113 0.05
15 SGTC_2550 chrysin dimethyl ether 3.03 71.9 µM 2.24E-4 4 0.00121 0.22
16 SGTC_136 0097-0015 3.02 404.5 µM 2.34E-4 60S ribosome export 15 0.00125 0.11
17 SGTC_1930 st074634 3.01 34.3 µM 2.45E-4 RNA pol III & RNase P/MRP 27 0.00129 0.00
18 SGTC_2491 paeonol 2.87 100.0 µM 4.44E-4 5 0.00203 0.06
19 SGTC_2574 2',4'-dihydroxychalcone 2.87 14.6 µM 4.53E-4 27 0.00206 0.02
20 SGTC_2557 derrustone 2.86 83.8 µM 4.70E-4 12 0.00212 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.17E-19 YJL028W YJL028W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.147 1.04E-17 YNL203C_d YNL203C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.136 2.24E-15 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.136 3.34E-15 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.132 1.37E-14 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.127 1.31E-13 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.119 4.22E-12 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.112 9.25E-11 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.104 1.69E-9 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.102 2.73E-9 YDR344C_d YDR344C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 2.81E-9 YCL049C_p YCL049C_p hom Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene
0.095 3.08E-8 YCR083W TRX3 hom Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p
0.095 3.60E-8 YGR048W UFD1 het Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
0.095 3.74E-8 YKL111C_d YKL111C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1
0.094 5.11E-8 YOR248W_d YOR248W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data