YNL307C / MCK1

Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL307C / MCK1

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:-4.26|P-value:3.84E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:7.29|P-value:1.13E-11 ID:SGTC_134|Compound:0269-0018|FD-Score:4.39|P-value:2.90E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.01|P-value:1.80E-8 ID:SGTC_304|Compound:1310-0298|FD-Score:6.45|P-value:1.64E-9 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.39|P-value:8.05E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.54|P-value:6.20E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.30|P-value:4.25E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:-4.02|P-value:9.56E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:3.87|P-value:2.05E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.77|P-value:2.81E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.45|P-value:6.67E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:5.62|P-value:1.28E-7 ID:SGTC_687|Compound:k029-0044|FD-Score:3.75|P-value:3.03E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:16.30|P-value:4.84E-51 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.44|P-value:6.80E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.23|P-value:4.26E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.62|P-value:4.79E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.78|P-value:2.71E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:6.59|P-value:7.34E-10 ID:SGTC_918|Compound:glabranin|FD-Score:3.51|P-value:6.70E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.82|P-value:2.38E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.28|P-value:4.45E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.46|P-value:6.51E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.49|P-value:7.26E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.60|P-value:1.29E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-4.37|P-value:2.50E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:5.48|P-value:2.52E-7 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.99|P-value:2.49E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.33|P-value:9.67E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.51|P-value:6.78E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-4.07|P-value:7.82E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.55|P-value:5.84E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.68|P-value:9.15E-6 ID:SGTC_1434|Compound:4073-0095|FD-Score:4.22|P-value:5.67E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.83|P-value:1.84E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.82|P-value:1.90E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.86|P-value:2.06E-16 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.40|P-value:7.72E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.80|P-value:5.60E-6 ID:SGTC_1754|Compound:st042065|FD-Score:4.94|P-value:3.06E-6 ID:SGTC_1759|Compound:st043059|FD-Score:4.24|P-value:5.34E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.48|P-value:7.50E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:5.47|P-value:2.69E-7 ID:SGTC_1941|Compound:st076221|FD-Score:5.18|P-value:1.04E-6 ID:SGTC_2004|Compound:4023728|FD-Score:3.46|P-value:7.90E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-3.91|P-value:1.38E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.91|P-value:1.73E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.93|P-value:1.63E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.74|P-value:2.53E-4 ID:SGTC_2175|Compound:5807670|FD-Score:4.59|P-value:1.35E-5 ID:SGTC_2192|Compound:5915882|FD-Score:7.34|P-value:8.06E-12 ID:SGTC_2342|Compound:7990637|FD-Score:4.89|P-value:3.83E-6 ID:SGTC_2351|Compound:9026858|FD-Score:4.21|P-value:5.88E-5 ID:SGTC_2433|Compound:5607874|FD-Score:4.51|P-value:1.83E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:7.08|P-value:4.17E-11 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.45|P-value:6.58E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.69|P-value:3.05E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.98|P-value:1.37E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:6.48|P-value:1.37E-9 ID:SGTC_2610|Compound:ononetin|FD-Score:4.16|P-value:7.14E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.56|P-value:5.65E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.26|P-value:9.02E-18 ID:SGTC_2761|Compound:levamisole|FD-Score:3.50|P-value:6.86E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.37|P-value:8.58E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.97|P-value:1.41E-4 ID:SGTC_2896|Compound:9052656|FD-Score:7.23|P-value:1.64E-11 ID:SGTC_2997|Compound:9067075|FD-Score:4.73|P-value:7.50E-6 ID:SGTC_3074|Compound:9116018|FD-Score:3.40|P-value:9.41E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.66|P-value:4.15E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.97|P-value:1.41E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.78|P-value:2.73E-4 ID:SGTC_3347|Compound:9188721|FD-Score:6.29|P-value:3.97E-9 ID:SGTC_3352|Compound:9151559|FD-Score:-3.34|P-value:9.57E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:-4.26|P-value:3.84E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:7.29|P-value:1.13E-11 ID:SGTC_134|Compound:0269-0018|FD-Score:4.39|P-value:2.90E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.01|P-value:1.80E-8 ID:SGTC_304|Compound:1310-0298|FD-Score:6.45|P-value:1.64E-9 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.39|P-value:8.05E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.54|P-value:6.20E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.30|P-value:4.25E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:-4.02|P-value:9.56E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:3.87|P-value:2.05E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.77|P-value:2.81E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.45|P-value:6.67E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:5.62|P-value:1.28E-7 ID:SGTC_687|Compound:k029-0044|FD-Score:3.75|P-value:3.03E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:16.30|P-value:4.84E-51 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.44|P-value:6.80E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.23|P-value:4.26E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.62|P-value:4.79E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.78|P-value:2.71E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:6.59|P-value:7.34E-10 ID:SGTC_918|Compound:glabranin|FD-Score:3.51|P-value:6.70E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.82|P-value:2.38E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.28|P-value:4.45E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.46|P-value:6.51E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.49|P-value:7.26E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.60|P-value:1.29E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-4.37|P-value:2.50E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:5.48|P-value:2.52E-7 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.99|P-value:2.49E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.33|P-value:9.67E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.51|P-value:6.78E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-4.07|P-value:7.82E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.55|P-value:5.84E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.68|P-value:9.15E-6 ID:SGTC_1434|Compound:4073-0095|FD-Score:4.22|P-value:5.67E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.83|P-value:1.84E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.82|P-value:1.90E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.86|P-value:2.06E-16 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.40|P-value:7.72E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.80|P-value:5.60E-6 ID:SGTC_1754|Compound:st042065|FD-Score:4.94|P-value:3.06E-6 ID:SGTC_1759|Compound:st043059|FD-Score:4.24|P-value:5.34E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.48|P-value:7.50E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:5.47|P-value:2.69E-7 ID:SGTC_1941|Compound:st076221|FD-Score:5.18|P-value:1.04E-6 ID:SGTC_2004|Compound:4023728|FD-Score:3.46|P-value:7.90E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-3.91|P-value:1.38E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.91|P-value:1.73E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.93|P-value:1.63E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.74|P-value:2.53E-4 ID:SGTC_2175|Compound:5807670|FD-Score:4.59|P-value:1.35E-5 ID:SGTC_2192|Compound:5915882|FD-Score:7.34|P-value:8.06E-12 ID:SGTC_2342|Compound:7990637|FD-Score:4.89|P-value:3.83E-6 ID:SGTC_2351|Compound:9026858|FD-Score:4.21|P-value:5.88E-5 ID:SGTC_2433|Compound:5607874|FD-Score:4.51|P-value:1.83E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:7.08|P-value:4.17E-11 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.45|P-value:6.58E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.69|P-value:3.05E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.98|P-value:1.37E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:6.48|P-value:1.37E-9 ID:SGTC_2610|Compound:ononetin|FD-Score:4.16|P-value:7.14E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.56|P-value:5.65E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.26|P-value:9.02E-18 ID:SGTC_2761|Compound:levamisole|FD-Score:3.50|P-value:6.86E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.37|P-value:8.58E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.97|P-value:1.41E-4 ID:SGTC_2896|Compound:9052656|FD-Score:7.23|P-value:1.64E-11 ID:SGTC_2997|Compound:9067075|FD-Score:4.73|P-value:7.50E-6 ID:SGTC_3074|Compound:9116018|FD-Score:3.40|P-value:9.41E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.66|P-value:4.15E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.97|P-value:1.41E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.78|P-value:2.73E-4 ID:SGTC_3347|Compound:9188721|FD-Score:6.29|P-value:3.97E-9 ID:SGTC_3352|Compound:9151559|FD-Score:-3.34|P-value:9.57E-4

Top fitness defect scores for YNL307C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_690 glyoxal 16.30 20.3 µM 4.84E-51 4 6.07E-60
2 SGTC_2688 kanamycin b 9.26 96.7 µM 9.02E-18 calcium & mitochondrial duress 39 1.01E-20
3 SGTC_1687 st020778 8.86 55.4 µM 2.06E-16 57 4.05E-19
4 SGTC_2192 5915882 7.34 198.5 µM 8.06E-12 RNA processing & uracil transport 6 1.05E-13
5 SGTC_87 0100-0052 7.29 35.5 µM 1.13E-11 17 1.56E-13
6 SGTC_2896 9052656 7.23 71.4 µM 1.64E-11 endomembrane recycling 24 2.43E-13
7 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 7.08 3.7 µM 4.17E-11 4 7.29E-13
8 SGTC_863 0466-0191 6.59 129.0 µM 7.34E-10 cell wall 25 2.14E-11
9 SGTC_2584 androsterone 6.48 48.7 µM 1.37E-9 cell wall 47 4.46E-11
10 SGTC_304 1310-0298 6.45 97.0 µM 1.64E-9 cell wall 14 5.52E-11
11 SGTC_3347 9188721 6.29 44.7 µM 3.97E-9 4 1.57E-10
12 SGTC_255 tunicamycin 6.01 200.5 nM 1.80E-8 unfolded protein response 35 9.27E-10
13 SGTC_683 panaxydol 5.62 45.0 µM 1.28E-7 sphingolipid biosynthesis & PDR1 16 9.38E-9
14 SGTC_1261 0712-0010 5.48 12.7 µM 2.52E-7 RNA processing & uracil transport 5 2.08E-8
15 SGTC_1876 myriocin 5.47 605.0 nM 2.69E-7 17 2.24E-8
16 SGTC_1941 st076221 5.18 61.8 µM 1.04E-6 sphingolipid biosynthesis & PDR1 42 1.10E-7
17 SGTC_1263 0774-1208 4.99 64.8 µM 2.49E-6 25 3.09E-7
18 SGTC_1754 st042065 4.94 16.1 µM 3.06E-6 NEO1-PIK1 129 3.93E-7
19 SGTC_2342 7990637 4.89 118.9 µM 3.83E-6 RNA processing & uracil transport 17 5.12E-7
20 SGTC_1745 st081495 4.80 74.0 µM 5.60E-6 RNA processing & uracil transport 46 8.02E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.249 1.14E-48 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.245 5.35E-47 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.209 1.43E-34 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.207 7.62E-34 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.206 1.30E-33 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.198 3.91E-31 YMR275C BUL1 hom Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication
0.192 2.35E-29 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
0.188 3.45E-28 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.186 1.70E-27 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.183 1.26E-26 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.175 1.40E-24 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.172 9.38E-24 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.171 1.94E-23 YJL073W JEM1 hom DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
0.168 9.04E-23 YML113W DAT1 hom DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
0.167 2.66E-22 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA