YNL308C / KRI1

Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL308C / KRI1

Click on Significant Values for Screen Details ID:SGTC_97|Compound:0535-0701|FD-Score:3.78|P-value:6.35E-5 ID:SGTC_186|Compound:3455-3465|FD-Score:-4.12|P-value:1.06E-5 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.26|P-value:3.64E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.12|P-value:8.01E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.53|P-value:1.69E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.75|P-value:7.18E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.18|P-value:6.40E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:-4.14|P-value:9.69E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:4.33|P-value:5.48E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:3.31|P-value:4.02E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.15|P-value:7.10E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:4.60|P-value:1.45E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:3.92|P-value:3.47E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:4.23|P-value:8.51E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.23|P-value:8.50E-6 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.84|P-value:4.88E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.15|P-value:5.43E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.30|P-value:4.20E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.02|P-value:8.79E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.78|P-value:6.20E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.33|P-value:3.72E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.17|P-value:6.56E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.34|P-value:3.50E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.25|P-value:4.95E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.40|P-value:2.85E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.50|P-value:1.94E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.79|P-value:6.00E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.07|P-value:9.52E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.81|P-value:5.59E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.13|P-value:7.52E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.20|P-value:5.95E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:6.30|P-value:7.12E-11 ID:SGTC_2467|Compound:5474540|FD-Score:-3.49|P-value:1.53E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.33|P-value:2.86E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.00|P-value:9.41E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:5.89|P-value:1.01E-9 ID:SGTC_2643|Compound:anethole|FD-Score:3.86|P-value:4.56E-5 ID:SGTC_2646|Compound:retinol|FD-Score:3.43|P-value:2.53E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.82|P-value:5.39E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.50|P-value:1.92E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.21|P-value:4.38E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.15|P-value:7.16E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.19|P-value:6.15E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.28|P-value:4.39E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.80|P-value:5.68E-5 ID:SGTC_3179|Compound:9107801|FD-Score:3.55|P-value:1.60E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.12|P-value:7.91E-4 ID:SGTC_3273|Compound:9137859|FD-Score:-3.65|P-value:8.06E-5 ID:SGTC_3278|Compound:9139605|FD-Score:4.44|P-value:3.27E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:3.78|P-value:6.35E-5 ID:SGTC_186|Compound:3455-3465|FD-Score:-4.12|P-value:1.06E-5 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.26|P-value:3.64E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.12|P-value:8.01E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.53|P-value:1.69E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.75|P-value:7.18E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.18|P-value:6.40E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:-4.14|P-value:9.69E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:4.33|P-value:5.48E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:3.31|P-value:4.02E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.15|P-value:7.10E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:4.60|P-value:1.45E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:3.92|P-value:3.47E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:4.23|P-value:8.51E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.23|P-value:8.50E-6 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.84|P-value:4.88E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.15|P-value:5.43E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.30|P-value:4.20E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.02|P-value:8.79E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.78|P-value:6.20E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.33|P-value:3.72E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.17|P-value:6.56E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.34|P-value:3.50E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.25|P-value:4.95E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.40|P-value:2.85E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.50|P-value:1.94E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.79|P-value:6.00E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.07|P-value:9.52E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.81|P-value:5.59E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.13|P-value:7.52E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.20|P-value:5.95E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:6.30|P-value:7.12E-11 ID:SGTC_2467|Compound:5474540|FD-Score:-3.49|P-value:1.53E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.33|P-value:2.86E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.00|P-value:9.41E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:5.89|P-value:1.01E-9 ID:SGTC_2643|Compound:anethole|FD-Score:3.86|P-value:4.56E-5 ID:SGTC_2646|Compound:retinol|FD-Score:3.43|P-value:2.53E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.82|P-value:5.39E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.50|P-value:1.92E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.21|P-value:4.38E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.15|P-value:7.16E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.19|P-value:6.15E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.28|P-value:4.39E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.80|P-value:5.68E-5 ID:SGTC_3179|Compound:9107801|FD-Score:3.55|P-value:1.60E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.12|P-value:7.91E-4 ID:SGTC_3273|Compound:9137859|FD-Score:-3.65|P-value:8.06E-5 ID:SGTC_3278|Compound:9139605|FD-Score:4.44|P-value:3.27E-6

Top fitness defect scores for YNL308C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2131 toluylene red 6.30 5.3 µM 7.12E-11 60S ribosome export 4 1.52E-10 0.28
2 SGTC_2576 guaiol 5.89 23.1 µM 1.01E-9 2 1.93E-9 0.94
3 SGTC_952 1185-0122 4.60 232.0 µM 1.45E-6 2 2.09E-6 0.36
4 SGTC_3278 9139605 4.44 49.5 µM 3.27E-6 7 4.57E-6 0.36
5 SGTC_757 1066-0008 4.33 322.0 µM 5.48E-6 Golgi 1 7.49E-6 0.61
6 SGTC_1032 k061-1018 4.23 98.7 µM 8.50E-6 3 1.14E-5 0.41
7 SGTC_982 1491-0518 4.23 27.5 µM 8.51E-6 3 1.15E-5 0.52
8 SGTC_974 1326-0144 3.92 138.0 µM 3.47E-5 ERG2 7 4.44E-5 0.09
9 SGTC_2643 anethole 3.86 100.0 µM 4.56E-5 3 5.76E-5 0.09
10 SGTC_1112 tnp00069 3.84 1.2 µM 4.88E-5 4 6.16E-5 0.01
11 SGTC_2657 nystatin 3.82 74.4 µM 5.39E-5 4 6.78E-5 0.03
12 SGTC_1956 st077085 3.81 54.0 µM 5.59E-5 2 7.02E-5 0.32
13 SGTC_3002 9075603 3.80 71.4 µM 5.68E-5 6 7.13E-5 0.00
14 SGTC_1754 st042065 3.79 16.1 µM 6.00E-5 NEO1-PIK1 36 7.51E-5 0.07
15 SGTC_1183 1254-0324 3.78 198.0 µM 6.20E-5 3 7.75E-5 0.57
16 SGTC_97 0535-0701 3.78 19.1 µM 6.35E-5 60S ribosome export 11 7.94E-5 0.13
17 SGTC_520 3584-0023 3.75 682.0 µM 7.18E-5 14 8.93E-5 0.17
18 SGTC_3179 9107801 3.55 49.5 µM 1.60E-4 1 1.94E-4 0.28
19 SGTC_420 mitomycin C 3.53 81.9 mM 1.69E-4 5 2.04E-4 0.02
20 SGTC_2718 lomofungin 3.50 53.0 µM 1.92E-4 mitochondrial processes 9 2.31E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 7.98E-9 YIL140W AXL2 hom Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate
0.084 1.28E-6 YIR042C_p YIR042C_p hom Putative protein of unknown function; YIR042C is a non-essential gene
0.078 6.04E-6 YPR111W DBF20 hom Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs
0.075 1.55E-5 YPL048W CAM1 hom Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma
0.072 2.89E-5 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.072 3.10E-5 YGL229C SAP4 hom Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
0.070 4.48E-5 YBL014C RRN6 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.070 5.18E-5 YOL158C ENB1 hom Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
0.070 5.62E-5 YDR408C ADE8 hom Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.069 5.98E-5 YBL035C POL12 het B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
0.069 6.73E-5 YLR282C_d YLR282C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
0.069 7.14E-5 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
0.068 8.07E-5 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.067 1.00E-4 YIL002W-A_p YIL002W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.067 1.14E-4 YIL146C ATG32 hom Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane