HIPHOP chemogenomics database
YNL308C / KRI1 
Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YNL308C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.099 | 7.98E-9 | YIL140W | AXL2 | hom | Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate |
| 0.084 | 1.28E-6 | YIR042C_p | YIR042C_p | hom | Putative protein of unknown function; YIR042C is a non-essential gene |
| 0.078 | 6.04E-6 | YPR111W | DBF20 | hom | Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs |
| 0.075 | 1.55E-5 | YPL048W | CAM1 | hom | Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma |
| 0.072 | 2.89E-5 | YER067W | RGI1 | hom | Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress |
| 0.072 | 3.10E-5 | YGL229C | SAP4 | hom | Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p |
| 0.070 | 4.48E-5 | YBL014C | RRN6 | het | Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p |
| 0.070 | 5.18E-5 | YOL158C | ENB1 | hom | Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment |
| 0.070 | 5.62E-5 | YDR408C | ADE8 | hom | Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway |
| 0.069 | 5.98E-5 | YBL035C | POL12 | het | B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation |
| 0.069 | 6.73E-5 | YLR282C_d | YLR282C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition |
| 0.069 | 7.14E-5 | YGL109W_d | YGL109W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C |
| 0.068 | 8.07E-5 | YGL130W | CEG1 | het | Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide |
| 0.067 | 1.00E-4 | YIL002W-A_p | YIL002W-A_p | hom | Putative protein of unknown function; identified by expression profiling and mass spectrometry |
| 0.067 | 1.14E-4 | YIL146C | ATG32 | hom | Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane |