YNL310C / ZIM17

Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL310C / ZIM17

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-3.04|P-value:1.03E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:6.20|P-value:2.21E-14 ID:SGTC_174|Compound:3553-0389|FD-Score:-2.67|P-value:5.71E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.15|P-value:2.12E-7 ID:SGTC_547|Compound:1120-0019|FD-Score:-2.61|P-value:7.13E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:6.15|P-value:3.55E-14 ID:SGTC_705|Compound:1124-0212|FD-Score:3.35|P-value:2.33E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-2.55|P-value:9.19E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-2.64|P-value:6.40E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:2.63|P-value:6.99E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.89|P-value:1.06E-6 ID:SGTC_850|Compound:0388-0143|FD-Score:2.79|P-value:3.39E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:2.89|P-value:2.15E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.46|P-value:1.27E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.58|P-value:8.52E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.08|P-value:8.68E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:2.65|P-value:6.28E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.02|P-value:1.19E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.59|P-value:8.03E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.91|P-value:1.97E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:-2.64|P-value:6.51E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.59|P-value:5.89E-6 ID:SGTC_1363|Compound:1636-0063|FD-Score:-2.55|P-value:9.36E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.56|P-value:7.10E-6 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.93|P-value:1.83E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.09|P-value:8.11E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.71|P-value:4.99E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.74|P-value:2.60E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:2.93|P-value:1.81E-4 ID:SGTC_1604|Compound:st002052|FD-Score:2.57|P-value:8.84E-4 ID:SGTC_1606|Compound:st000094|FD-Score:2.95|P-value:1.68E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.19|P-value:5.08E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.47|P-value:1.18E-5 ID:SGTC_1921|Compound:5740136|FD-Score:2.80|P-value:3.29E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.58|P-value:6.49E-6 ID:SGTC_2112|Compound:5488546|FD-Score:2.87|P-value:2.45E-4 ID:SGTC_2118|Compound:5526350|FD-Score:4.26|P-value:1.05E-7 ID:SGTC_2121|Compound:5257820|FD-Score:2.94|P-value:1.76E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-2.73|P-value:4.35E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.56|P-value:7.43E-6 ID:SGTC_2463|Compound:5473429|FD-Score:3.40|P-value:1.77E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.13|P-value:7.14E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.46|P-value:1.19E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.52|P-value:1.78E-8 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.90|P-value:1.06E-6 ID:SGTC_2788|Compound:5282734|FD-Score:2.94|P-value:1.77E-4 ID:SGTC_2940|Compound:9060638|FD-Score:2.90|P-value:2.12E-4 ID:SGTC_2970|Compound:9090938|FD-Score:2.82|P-value:3.02E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.13|P-value:6.99E-5 ID:SGTC_3210|Compound:9128157|FD-Score:4.35|P-value:5.78E-8 ID:SGTC_3213|Compound:9129884|FD-Score:2.85|P-value:2.66E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-2.83|P-value:2.83E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-4.43|P-value:3.21E-8 ID:SGTC_3270|Compound:9137563|FD-Score:2.86|P-value:2.52E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.04|P-value:1.03E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:6.20|P-value:2.21E-14 ID:SGTC_174|Compound:3553-0389|FD-Score:-2.67|P-value:5.71E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.15|P-value:2.12E-7 ID:SGTC_547|Compound:1120-0019|FD-Score:-2.61|P-value:7.13E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:6.15|P-value:3.55E-14 ID:SGTC_705|Compound:1124-0212|FD-Score:3.35|P-value:2.33E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-2.55|P-value:9.19E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-2.64|P-value:6.40E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:2.63|P-value:6.99E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.89|P-value:1.06E-6 ID:SGTC_850|Compound:0388-0143|FD-Score:2.79|P-value:3.39E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:2.89|P-value:2.15E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.46|P-value:1.27E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.58|P-value:8.52E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.08|P-value:8.68E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:2.65|P-value:6.28E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.02|P-value:1.19E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.59|P-value:8.03E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.91|P-value:1.97E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:-2.64|P-value:6.51E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.59|P-value:5.89E-6 ID:SGTC_1363|Compound:1636-0063|FD-Score:-2.55|P-value:9.36E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.56|P-value:7.10E-6 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.93|P-value:1.83E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.09|P-value:8.11E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.71|P-value:4.99E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.74|P-value:2.60E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:2.93|P-value:1.81E-4 ID:SGTC_1604|Compound:st002052|FD-Score:2.57|P-value:8.84E-4 ID:SGTC_1606|Compound:st000094|FD-Score:2.95|P-value:1.68E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.19|P-value:5.08E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.47|P-value:1.18E-5 ID:SGTC_1921|Compound:5740136|FD-Score:2.80|P-value:3.29E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.58|P-value:6.49E-6 ID:SGTC_2112|Compound:5488546|FD-Score:2.87|P-value:2.45E-4 ID:SGTC_2118|Compound:5526350|FD-Score:4.26|P-value:1.05E-7 ID:SGTC_2121|Compound:5257820|FD-Score:2.94|P-value:1.76E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-2.73|P-value:4.35E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.56|P-value:7.43E-6 ID:SGTC_2463|Compound:5473429|FD-Score:3.40|P-value:1.77E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.13|P-value:7.14E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.46|P-value:1.19E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.52|P-value:1.78E-8 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.90|P-value:1.06E-6 ID:SGTC_2788|Compound:5282734|FD-Score:2.94|P-value:1.77E-4 ID:SGTC_2940|Compound:9060638|FD-Score:2.90|P-value:2.12E-4 ID:SGTC_2970|Compound:9090938|FD-Score:2.82|P-value:3.02E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.13|P-value:6.99E-5 ID:SGTC_3210|Compound:9128157|FD-Score:4.35|P-value:5.78E-8 ID:SGTC_3213|Compound:9129884|FD-Score:2.85|P-value:2.66E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-2.83|P-value:2.83E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-4.43|P-value:3.21E-8 ID:SGTC_3270|Compound:9137563|FD-Score:2.86|P-value:2.52E-4

Top fitness defect scores for YNL310C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_153 4077-0274 6.20 519.7 µM 2.21E-14 2 2.83E-10 0.76
2 SGTC_551 k048-0028 6.15 34.9 µM 3.55E-14 1 3.91E-10 0.79
3 SGTC_3210 9128157 4.35 49.5 µM 5.78E-8 9 6.67E-6 0.03
4 SGTC_2118 5526350 4.26 200.0 µM 1.05E-7 4 1.01E-5 0.20
5 SGTC_2764 methyldopa 3.90 94.7 µM 1.06E-6 5 4.88E-5 0.34
6 SGTC_2311 7694451 3.56 200.0 µM 7.43E-6 14 1.86E-4 8.87E-4
7 SGTC_1888 azatryptophan 3.47 97.5 µM 1.18E-5 4 2.57E-4 0.10
8 SGTC_988 1497-1057 3.46 103.0 µM 1.27E-5 5 2.69E-4 0.31
9 SGTC_2463 5473429 3.40 200.0 µM 1.77E-5 ERG2 8 3.39E-4 0.13
10 SGTC_705 1124-0212 3.35 310.0 µM 2.33E-5 14 4.09E-4 0.04
11 SGTC_1620 st003704 3.19 16.5 µM 5.08E-5 12 7.02E-4 0.07
12 SGTC_3208 9114115 3.13 49.5 µM 6.99E-5 28 8.74E-4 0.01
13 SGTC_2566 crystal violet carbinol 3.13 226.0 nM 7.14E-5 38 8.87E-4 0.02
14 SGTC_1210 3013-0140 3.02 750.0 nM 1.19E-4 8 0.00126 0.04
15 SGTC_1606 st000094 2.95 49.2 µM 1.68E-4 60S ribosome export 20 0.00160 0.13
16 SGTC_2121 5257820 2.94 149.6 µM 1.76E-4 11 0.00166 0.05
17 SGTC_2788 5282734 2.94 71.4 µM 1.77E-4 25 0.00166 0.03
18 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 2.93 19.1 µM 1.81E-4 13 0.00169 0.06
19 SGTC_1383 3049-0032 2.93 20.7 µM 1.83E-4 60S ribosome export 23 0.00170 0.05
20 SGTC_1309 pyrazolanthrone 2.91 13.4 µM 1.97E-4 23 0.00179 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 6.12E-23 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.141 2.38E-16 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.126 2.50E-13 YJR096W YJR096W hom Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.119 4.35E-12 YCR072C RSA4 het WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
0.119 5.06E-12 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.107 4.99E-10 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.107 5.09E-10 YPR201W ARR3 hom Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
0.103 1.88E-9 YDL079C MRK1 hom Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
0.103 1.98E-9 YLR285W NNT1 hom S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination
0.102 2.85E-9 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.102 3.41E-9 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.097 1.90E-8 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.54E-8 YNL339C YRF1-6 hom Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
0.095 3.12E-8 YCR021C HSP30 hom Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
0.094 5.15E-8 YNL085W MKT1 hom Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress