YNL311C / SKP2

F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL311C / SKP2

Click on Significant Values for Screen Details ID:SGTC_217|Compound:ketoconazole|FD-Score:3.24|P-value:2.13E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.05|P-value:4.64E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-2.84|P-value:7.64E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:2.85|P-value:9.95E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.07|P-value:4.32E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.06|P-value:3.32E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:2.97|P-value:6.24E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.40|P-value:1.09E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:2.94|P-value:7.06E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-2.86|P-value:7.11E-4 ID:SGTC_1649|Compound:st011737|FD-Score:3.85|P-value:1.34E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.57|P-value:5.21E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-2.84|P-value:7.78E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.48|P-value:7.65E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-2.89|P-value:6.38E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.94|P-value:6.15E-6 ID:SGTC_2095|Compound:5432005|FD-Score:-2.92|P-value:5.62E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.40|P-value:7.81E-5 ID:SGTC_2219|Compound:9098279|FD-Score:3.17|P-value:2.80E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.27|P-value:1.36E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.48|P-value:7.71E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-4.84|P-value:4.04E-8 ID:SGTC_2950|Compound:9072895|FD-Score:4.00|P-value:6.56E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-3.30|P-value:1.19E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.21|P-value:2.42E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.93|P-value:9.17E-6 ID:SGTC_3132|Compound:9126706|FD-Score:3.27|P-value:1.85E-4 ID:SGTC_3153|Compound:9100258|FD-Score:5.09|P-value:1.39E-8 ID:SGTC_3157|Compound:9099274|FD-Score:3.06|P-value:4.50E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-2.86|P-value:7.20E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.24|P-value:2.13E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.05|P-value:4.64E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-2.84|P-value:7.64E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:2.85|P-value:9.95E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.07|P-value:4.32E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.06|P-value:3.32E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:2.97|P-value:6.24E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.40|P-value:1.09E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:2.94|P-value:7.06E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-2.86|P-value:7.11E-4 ID:SGTC_1649|Compound:st011737|FD-Score:3.85|P-value:1.34E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.57|P-value:5.21E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-2.84|P-value:7.78E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.48|P-value:7.65E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-2.89|P-value:6.38E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.94|P-value:6.15E-6 ID:SGTC_2095|Compound:5432005|FD-Score:-2.92|P-value:5.62E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.40|P-value:7.81E-5 ID:SGTC_2219|Compound:9098279|FD-Score:3.17|P-value:2.80E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.27|P-value:1.36E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.48|P-value:7.71E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-4.84|P-value:4.04E-8 ID:SGTC_2950|Compound:9072895|FD-Score:4.00|P-value:6.56E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-3.30|P-value:1.19E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.21|P-value:2.42E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.93|P-value:9.17E-6 ID:SGTC_3132|Compound:9126706|FD-Score:3.27|P-value:1.85E-4 ID:SGTC_3153|Compound:9100258|FD-Score:5.09|P-value:1.39E-8 ID:SGTC_3157|Compound:9099274|FD-Score:3.06|P-value:4.50E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-2.86|P-value:7.20E-4

Top fitness defect scores for YNL311C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3153 9100258 5.09 49.5 µM 1.39E-8 5 1.83E-7
2 SGTC_2950 9072895 4.00 21.5 µM 6.56E-6 37 3.18E-5
3 SGTC_3125 9127534 3.93 49.5 µM 9.17E-6 11 4.22E-5
4 SGTC_1649 st011737 3.85 51.3 µM 1.34E-5 29 5.80E-5
5 SGTC_1674 st016616 3.57 23.6 µM 5.21E-5 40 1.82E-4
6 SGTC_1861 st057647 3.48 17.4 µM 7.65E-5 39 2.52E-4
7 SGTC_2374 9071832 3.48 200.0 µM 7.71E-5 endomembrane recycling 15 2.53E-4
8 SGTC_941 3237-0776 3.40 460.0 µM 1.09E-4 38 3.39E-4
9 SGTC_3132 9126706 3.27 49.5 µM 1.85E-4 52 5.30E-4
10 SGTC_217 ketoconazole 3.24 989.0 nM 2.13E-4 ergosterol depletion effects on membrane 49 5.98E-4
11 SGTC_3069 9117009 3.21 49.5 µM 2.42E-4 60S ribosome export 23 6.65E-4
12 SGTC_2219 9098279 3.17 200.0 µM 2.80E-4 14 7.52E-4
13 SGTC_608 k048-0125 3.07 159.0 µM 4.32E-4 60 0.00108
14 SGTC_3157 9099274 3.06 49.5 µM 4.50E-4 44 0.00112
15 SGTC_234 nsc-17383 3.05 10.7 µM 4.64E-4 ERG2 52 0.00115
16 SGTC_845 0330-0138 2.97 4.5 µM 6.24E-4 58 0.00148
17 SGTC_973 1325-0077 2.94 65.9 µM 7.06E-4 48 0.00164
18 SGTC_559 1550-0661 2.85 158.0 µM 9.95E-4 54 0.00220
19 SGTC_271 rotenone 2.82 740.0 µM 0.00112 91 0.00243
20 SGTC_3228 9131799 2.81 49.5 µM 0.00116 amide catabolism 42 0.00251

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 3.17E-14 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.113 5.53E-11 YMR313C TGL3 hom Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation
0.110 1.64E-10 YPL159C PET20 hom Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome
0.108 3.44E-10 YDR319C_p YFT2_p hom Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens
0.106 8.67E-10 YJR112W NNF1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
0.104 1.65E-9 YJR072C NPA3 het Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
0.104 1.80E-9 YNL004W HRB1 hom Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication
0.098 1.38E-8 YOR144C ELG1 hom Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication
0.094 4.49E-8 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.090 1.91E-7 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.088 3.37E-7 YOR204W DED1 het ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility
0.087 4.77E-7 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.084 1.03E-6 YLR110C CCW12 hom Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication
0.084 1.19E-6 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.081 2.52E-6 YDL124W YDL124W hom NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress