YNL315C / ATP11

Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL315C / ATP11

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.09|P-value:1.92E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.86|P-value:4.44E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:5.29|P-value:5.11E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:4.47|P-value:3.41E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:3.57|P-value:1.70E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.56|P-value:1.73E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:6.23|P-value:1.79E-10 ID:SGTC_149|Compound:3970-0822|FD-Score:4.28|P-value:8.41E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:11.80|P-value:3.38E-33 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.11|P-value:1.77E-5 ID:SGTC_298|Compound:1391-0729|FD-Score:3.65|P-value:1.22E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.17|P-value:7.19E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.77|P-value:7.45E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:3.27|P-value:5.14E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:10.30|P-value:1.64E-25 ID:SGTC_446|Compound:go6976|FD-Score:3.18|P-value:7.08E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.53|P-value:1.68E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.32|P-value:6.93E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.21|P-value:5.55E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:5.03|P-value:2.04E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:5.92|P-value:1.28E-9 ID:SGTC_744|Compound:1594-0068|FD-Score:5.85|P-value:1.95E-9 ID:SGTC_818|Compound:4072-2707|FD-Score:3.55|P-value:1.79E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.57|P-value:1.43E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:15.90|P-value:1.96E-58 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.93|P-value:3.26E-5 ID:SGTC_917|Compound:harmaline|FD-Score:5.75|P-value:3.60E-9 ID:SGTC_957|Compound:1187-1561|FD-Score:3.41|P-value:3.06E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.11|P-value:9.04E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.51|P-value:2.09E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.58|P-value:1.64E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-6.19|P-value:1.78E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.71|P-value:8.80E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:9.14|P-value:1.57E-20 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.12|P-value:1.29E-7 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.27|P-value:8.83E-6 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.38|P-value:3.43E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.40|P-value:3.22E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.62|P-value:1.37E-4 ID:SGTC_1547|Compound:harmine|FD-Score:5.73|P-value:4.01E-9 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.27|P-value:5.18E-4 ID:SGTC_1635|Compound:st007035|FD-Score:12.30|P-value:8.55E-36 ID:SGTC_1641|Compound:st009299|FD-Score:3.57|P-value:1.69E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.48|P-value:2.38E-4 ID:SGTC_1790|Compound:st045711|FD-Score:-4.10|P-value:1.60E-5 ID:SGTC_1798|Compound:st045719|FD-Score:-3.15|P-value:6.86E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.14|P-value:7.00E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.41|P-value:3.12E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:-3.20|P-value:5.82E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.27|P-value:4.48E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.69|P-value:8.78E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-3.14|P-value:7.11E-4 ID:SGTC_2011|Compound:4012611|FD-Score:8.74|P-value:6.30E-19 ID:SGTC_2045|Compound:5106652|FD-Score:3.81|P-value:6.50E-5 ID:SGTC_2136|Compound:5328288|FD-Score:3.90|P-value:4.33E-5 ID:SGTC_2176|Compound:5809774|FD-Score:5.22|P-value:7.37E-8 ID:SGTC_2177|Compound:5811945|FD-Score:4.56|P-value:2.19E-6 ID:SGTC_2284|Compound:7945075|FD-Score:5.74|P-value:3.66E-9 ID:SGTC_2293|Compound:7624732|FD-Score:3.65|P-value:1.23E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.51|P-value:2.10E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.99|P-value:2.56E-7 ID:SGTC_2481|Compound:5478948|FD-Score:4.31|P-value:7.36E-6 ID:SGTC_2482|Compound:5981709|FD-Score:4.13|P-value:1.63E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.35|P-value:6.04E-6 ID:SGTC_2556|Compound:citropten|FD-Score:4.66|P-value:1.35E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.36|P-value:4.81E-6 ID:SGTC_2624|Compound:nerol|FD-Score:4.08|P-value:2.01E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:12.30|P-value:1.18E-35 ID:SGTC_2696|Compound:st077691|FD-Score:3.34|P-value:4.04E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.32|P-value:6.99E-6 ID:SGTC_2748|Compound:diazoxide|FD-Score:4.36|P-value:5.77E-6 ID:SGTC_2836|Compound:9010338|FD-Score:-4.49|P-value:2.56E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-5.45|P-value:1.60E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-3.39|P-value:2.84E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.79|P-value:5.83E-5 ID:SGTC_2925|Compound:9010536|FD-Score:5.17|P-value:9.52E-8 ID:SGTC_2926|Compound:9010726|FD-Score:-4.33|P-value:5.65E-6 ID:SGTC_2931|Compound:9014674|FD-Score:-3.76|P-value:6.78E-5 ID:SGTC_2996|Compound:9066192|FD-Score:3.47|P-value:2.48E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.36|P-value:5.89E-6 ID:SGTC_3025|Compound:9087895|FD-Score:3.09|P-value:9.52E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.21|P-value:5.60E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-4.02|P-value:2.28E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.13|P-value:8.50E-4 ID:SGTC_3144|Compound:9087057|FD-Score:6.06|P-value:5.15E-10 ID:SGTC_3214|Compound:9129694|FD-Score:3.71|P-value:9.49E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.22|P-value:6.18E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.29|P-value:4.19E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.20|P-value:6.57E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.66|P-value:1.16E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.09|P-value:1.92E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.86|P-value:4.44E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:5.29|P-value:5.11E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:4.47|P-value:3.41E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:3.57|P-value:1.70E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.56|P-value:1.73E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:6.23|P-value:1.79E-10 ID:SGTC_149|Compound:3970-0822|FD-Score:4.28|P-value:8.41E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:11.80|P-value:3.38E-33 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.11|P-value:1.77E-5 ID:SGTC_298|Compound:1391-0729|FD-Score:3.65|P-value:1.22E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.17|P-value:7.19E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.77|P-value:7.45E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:3.27|P-value:5.14E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:10.30|P-value:1.64E-25 ID:SGTC_446|Compound:go6976|FD-Score:3.18|P-value:7.08E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.53|P-value:1.68E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.32|P-value:6.93E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.21|P-value:5.55E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:5.03|P-value:2.04E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:5.92|P-value:1.28E-9 ID:SGTC_744|Compound:1594-0068|FD-Score:5.85|P-value:1.95E-9 ID:SGTC_818|Compound:4072-2707|FD-Score:3.55|P-value:1.79E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.57|P-value:1.43E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:15.90|P-value:1.96E-58 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.93|P-value:3.26E-5 ID:SGTC_917|Compound:harmaline|FD-Score:5.75|P-value:3.60E-9 ID:SGTC_957|Compound:1187-1561|FD-Score:3.41|P-value:3.06E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.11|P-value:9.04E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.51|P-value:2.09E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.58|P-value:1.64E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-6.19|P-value:1.78E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.71|P-value:8.80E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:9.14|P-value:1.57E-20 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.12|P-value:1.29E-7 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.27|P-value:8.83E-6 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.38|P-value:3.43E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.40|P-value:3.22E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.62|P-value:1.37E-4 ID:SGTC_1547|Compound:harmine|FD-Score:5.73|P-value:4.01E-9 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.27|P-value:5.18E-4 ID:SGTC_1635|Compound:st007035|FD-Score:12.30|P-value:8.55E-36 ID:SGTC_1641|Compound:st009299|FD-Score:3.57|P-value:1.69E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.48|P-value:2.38E-4 ID:SGTC_1790|Compound:st045711|FD-Score:-4.10|P-value:1.60E-5 ID:SGTC_1798|Compound:st045719|FD-Score:-3.15|P-value:6.86E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.14|P-value:7.00E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.41|P-value:3.12E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:-3.20|P-value:5.82E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.27|P-value:4.48E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.69|P-value:8.78E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-3.14|P-value:7.11E-4 ID:SGTC_2011|Compound:4012611|FD-Score:8.74|P-value:6.30E-19 ID:SGTC_2045|Compound:5106652|FD-Score:3.81|P-value:6.50E-5 ID:SGTC_2136|Compound:5328288|FD-Score:3.90|P-value:4.33E-5 ID:SGTC_2176|Compound:5809774|FD-Score:5.22|P-value:7.37E-8 ID:SGTC_2177|Compound:5811945|FD-Score:4.56|P-value:2.19E-6 ID:SGTC_2284|Compound:7945075|FD-Score:5.74|P-value:3.66E-9 ID:SGTC_2293|Compound:7624732|FD-Score:3.65|P-value:1.23E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.51|P-value:2.10E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.99|P-value:2.56E-7 ID:SGTC_2481|Compound:5478948|FD-Score:4.31|P-value:7.36E-6 ID:SGTC_2482|Compound:5981709|FD-Score:4.13|P-value:1.63E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.35|P-value:6.04E-6 ID:SGTC_2556|Compound:citropten|FD-Score:4.66|P-value:1.35E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.36|P-value:4.81E-6 ID:SGTC_2624|Compound:nerol|FD-Score:4.08|P-value:2.01E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:12.30|P-value:1.18E-35 ID:SGTC_2696|Compound:st077691|FD-Score:3.34|P-value:4.04E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.32|P-value:6.99E-6 ID:SGTC_2748|Compound:diazoxide|FD-Score:4.36|P-value:5.77E-6 ID:SGTC_2836|Compound:9010338|FD-Score:-4.49|P-value:2.56E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-5.45|P-value:1.60E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-3.39|P-value:2.84E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.79|P-value:5.83E-5 ID:SGTC_2925|Compound:9010536|FD-Score:5.17|P-value:9.52E-8 ID:SGTC_2926|Compound:9010726|FD-Score:-4.33|P-value:5.65E-6 ID:SGTC_2931|Compound:9014674|FD-Score:-3.76|P-value:6.78E-5 ID:SGTC_2996|Compound:9066192|FD-Score:3.47|P-value:2.48E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.36|P-value:5.89E-6 ID:SGTC_3025|Compound:9087895|FD-Score:3.09|P-value:9.52E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.21|P-value:5.60E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-4.02|P-value:2.28E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.13|P-value:8.50E-4 ID:SGTC_3144|Compound:9087057|FD-Score:6.06|P-value:5.15E-10 ID:SGTC_3214|Compound:9129694|FD-Score:3.71|P-value:9.49E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.22|P-value:6.18E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.29|P-value:4.19E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.20|P-value:6.57E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.66|P-value:1.16E-4

Top fitness defect scores for YNL315C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_880 0833-0487 15.90 87.2 µM 1.96E-58 mitochondrial processes 1 2.00E-57
2 SGTC_1635 st007035 12.30 42.4 µM 8.55E-36 56 3.27E-35
3 SGTC_2630 antimycin a 12.30 100.0 µM 1.18E-35 mitochondrial processes 2 4.48E-35
4 SGTC_236 1509-0011 11.80 5.3 µM 3.38E-33 153 1.16E-32
5 SGTC_386 1509-0011 10.30 3.1 µM 1.64E-25 41 4.03E-25
6 SGTC_1145 3546-0597 9.14 10.2 µM 1.57E-20 mitochondrial processes 1 3.15E-20
7 SGTC_2011 4012611 8.74 177.0 µM 6.30E-19 mitochondrial processes 1 1.18E-18
8 SGTC_134 0269-0018 6.23 6.9 µM 1.79E-10 79 2.38E-10
9 SGTC_3144 9087057 6.06 49.5 µM 5.15E-10 1 6.74E-10
10 SGTC_614 0462-0418 5.92 107.0 µM 1.28E-9 6 1.64E-9
11 SGTC_744 1594-0068 5.85 283.0 µM 1.95E-9 amide catabolism 4 2.49E-9
12 SGTC_917 harmaline 5.75 728.1 nM 3.60E-9 ergosterol biosynthesis 6 4.56E-9
13 SGTC_2284 7945075 5.74 39.2 µM 3.66E-9 mitochondrial processes 4 4.64E-9
14 SGTC_1547 harmine 5.73 94.2 µM 4.01E-9 ergosterol biosynthesis 20 5.06E-9
15 SGTC_59 0330-0160 5.29 1.3 µM 5.11E-8 51 6.19E-8
16 SGTC_2176 5809774 5.22 34.0 µM 7.37E-8 mitochondrial processes 5 8.88E-8
17 SGTC_2925 9010536 5.17 32.5 µM 9.52E-8 azole & statin 20 1.14E-7
18 SGTC_1188 1403-0014 5.12 4.6 µM 1.29E-7 mitochondrial stress 27 1.54E-7
19 SGTC_607 4491-0986 5.03 66.8 µM 2.04E-7 heme requiring 8 2.42E-7
20 SGTC_2370 9071495 4.99 200.0 µM 2.56E-7 mitochondrial processes 8 3.02E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.473 1.09E-186 YJR121W ATP2 hom Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.436 4.29E-156 YJL180C ATP12 hom Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency
0.394 5.13E-125 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.385 5.60E-119 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.382 4.85E-117 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.379 2.75E-115 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.376 2.60E-113 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.372 1.46E-110 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.364 1.50E-105 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.364 2.03E-105 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.359 1.44E-102 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.357 1.88E-101 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.356 6.00E-101 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.351 5.14E-98 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.348 1.85E-96 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane