YNL316C / PHA2

Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL316C / PHA2

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:4.54|P-value:7.88E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:3.68|P-value:4.91E-5 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.43|P-value:1.40E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:2.94|P-value:8.99E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:4.14|P-value:5.88E-6 ID:SGTC_296|Compound:1222-0039|FD-Score:4.37|P-value:1.93E-6 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.53|P-value:9.25E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.59|P-value:7.16E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.45|P-value:1.30E-6 ID:SGTC_855|Compound:0428-0020|FD-Score:5.22|P-value:1.83E-8 ID:SGTC_919|Compound:tnp00227|FD-Score:4.66|P-value:4.16E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:2.92|P-value:9.62E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.63|P-value:6.20E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.12|P-value:4.75E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:5.66|P-value:1.19E-9 ID:SGTC_1081|Compound:sertraline|FD-Score:3.64|P-value:5.75E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.70|P-value:4.48E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.26|P-value:2.73E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.08|P-value:8.04E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.50|P-value:9.66E-7 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.80|P-value:3.95E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.14|P-value:4.43E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.06|P-value:5.92E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.46|P-value:1.22E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.78|P-value:3.21E-5 ID:SGTC_1653|Compound:st012112|FD-Score:3.77|P-value:3.27E-5 ID:SGTC_1764|Compound:st044502|FD-Score:3.17|P-value:3.91E-4 ID:SGTC_1850|Compound:st056238|FD-Score:4.09|P-value:7.71E-6 ID:SGTC_1912|Compound:st060209|FD-Score:4.65|P-value:4.57E-7 ID:SGTC_2197|Compound:6588183|FD-Score:-3.05|P-value:7.79E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.07|P-value:5.61E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.70|P-value:4.41E-5 ID:SGTC_2282|Compound:7944268|FD-Score:4.42|P-value:1.50E-6 ID:SGTC_2286|Compound:7945697|FD-Score:3.40|P-value:1.55E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.41|P-value:1.52E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.00|P-value:7.34E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.51|P-value:9.95E-5 ID:SGTC_2411|Compound:st077133|FD-Score:4.33|P-value:2.32E-6 ID:SGTC_2444|Compound:5485484|FD-Score:3.03|P-value:6.65E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.40|P-value:1.55E-4 ID:SGTC_2447|Compound:5741742|FD-Score:4.04|P-value:9.52E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.58|P-value:7.64E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.17|P-value:3.85E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.04|P-value:8.09E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.26|P-value:2.75E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.74|P-value:5.01E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.45|P-value:1.31E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.39|P-value:2.19E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.16|P-value:5.18E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.86|P-value:2.21E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.12|P-value:4.78E-4 ID:SGTC_2823|Compound:7987624|FD-Score:5.48|P-value:3.64E-9 ID:SGTC_2833|Compound:9001315|FD-Score:-3.16|P-value:5.18E-4 ID:SGTC_2906|Compound:7926292|FD-Score:4.58|P-value:6.43E-7 ID:SGTC_2981|Compound:9013952|FD-Score:3.05|P-value:6.13E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.17|P-value:3.87E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.61|P-value:6.68E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.23|P-value:3.11E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:4.54|P-value:7.88E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:3.68|P-value:4.91E-5 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.43|P-value:1.40E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:2.94|P-value:8.99E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:4.14|P-value:5.88E-6 ID:SGTC_296|Compound:1222-0039|FD-Score:4.37|P-value:1.93E-6 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.53|P-value:9.25E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.59|P-value:7.16E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.45|P-value:1.30E-6 ID:SGTC_855|Compound:0428-0020|FD-Score:5.22|P-value:1.83E-8 ID:SGTC_919|Compound:tnp00227|FD-Score:4.66|P-value:4.16E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:2.92|P-value:9.62E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.63|P-value:6.20E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.12|P-value:4.75E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:5.66|P-value:1.19E-9 ID:SGTC_1081|Compound:sertraline|FD-Score:3.64|P-value:5.75E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.70|P-value:4.48E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.26|P-value:2.73E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.08|P-value:8.04E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.50|P-value:9.66E-7 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.80|P-value:3.95E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.14|P-value:4.43E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.06|P-value:5.92E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.46|P-value:1.22E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.78|P-value:3.21E-5 ID:SGTC_1653|Compound:st012112|FD-Score:3.77|P-value:3.27E-5 ID:SGTC_1764|Compound:st044502|FD-Score:3.17|P-value:3.91E-4 ID:SGTC_1850|Compound:st056238|FD-Score:4.09|P-value:7.71E-6 ID:SGTC_1912|Compound:st060209|FD-Score:4.65|P-value:4.57E-7 ID:SGTC_2197|Compound:6588183|FD-Score:-3.05|P-value:7.79E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.07|P-value:5.61E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.70|P-value:4.41E-5 ID:SGTC_2282|Compound:7944268|FD-Score:4.42|P-value:1.50E-6 ID:SGTC_2286|Compound:7945697|FD-Score:3.40|P-value:1.55E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.41|P-value:1.52E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.00|P-value:7.34E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.51|P-value:9.95E-5 ID:SGTC_2411|Compound:st077133|FD-Score:4.33|P-value:2.32E-6 ID:SGTC_2444|Compound:5485484|FD-Score:3.03|P-value:6.65E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.40|P-value:1.55E-4 ID:SGTC_2447|Compound:5741742|FD-Score:4.04|P-value:9.52E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.58|P-value:7.64E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.17|P-value:3.85E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.04|P-value:8.09E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.26|P-value:2.75E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.74|P-value:5.01E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.45|P-value:1.31E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.39|P-value:2.19E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.16|P-value:5.18E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.86|P-value:2.21E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.12|P-value:4.78E-4 ID:SGTC_2823|Compound:7987624|FD-Score:5.48|P-value:3.64E-9 ID:SGTC_2833|Compound:9001315|FD-Score:-3.16|P-value:5.18E-4 ID:SGTC_2906|Compound:7926292|FD-Score:4.58|P-value:6.43E-7 ID:SGTC_2981|Compound:9013952|FD-Score:3.05|P-value:6.13E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.17|P-value:3.87E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.61|P-value:6.68E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.23|P-value:3.11E-4

Top fitness defect scores for YNL316C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1064 honokiol 5.66 6.8 µM 1.19E-9 5 7.70E-9
2 SGTC_2823 7987624 5.48 58.4 µM 3.64E-9 7 2.11E-8
3 SGTC_855 0428-0020 5.22 25.0 µM 1.83E-8 Golgi 8 9.12E-8
4 SGTC_919 tnp00227 4.66 403.6 nM 4.16E-7 RNA pol III & RNase P/MRP 18 1.55E-6
5 SGTC_1912 st060209 4.65 90.8 µM 4.57E-7 22 1.69E-6
6 SGTC_2906 7926292 4.58 26.4 µM 6.43E-7 13 2.30E-6
7 SGTC_38 0929-0051 4.54 58.3 µM 7.88E-7 13 2.76E-6
8 SGTC_1370 2001-0092 4.50 44.6 µM 9.66E-7 17 3.32E-6
9 SGTC_576 1073-0113 4.45 22.7 µM 1.30E-6 redox potentiating 53 4.35E-6
10 SGTC_2282 7944268 4.42 200.0 µM 1.50E-6 RPP1 & pyrimidine depletion 19 4.96E-6
11 SGTC_296 1222-0039 4.37 74.9 µM 1.93E-6 8 6.22E-6
12 SGTC_2411 st077133 4.33 39.9 µM 2.32E-6 RNA pol III & RNase P/MRP 21 7.35E-6
13 SGTC_294 k038-0071 4.14 157.0 µM 5.88E-6 ubiquinone biosynthesis & proteasome 57 1.71E-5
14 SGTC_1850 st056238 4.09 17.0 µM 7.71E-6 RPP1 & pyrimidine depletion 16 2.18E-5
15 SGTC_1309 pyrazolanthrone 4.08 13.4 µM 8.04E-6 19 2.27E-5
16 SGTC_2447 5741742 4.04 33.8 µM 9.52E-6 16 2.64E-5
17 SGTC_2717 st081029 3.86 62.3 µM 2.21E-5 20 5.68E-5
18 SGTC_1642 st009582 3.78 77.7 µM 3.21E-5 RPP1 & pyrimidine depletion 19 7.95E-5
19 SGTC_1653 st012112 3.77 65.0 µM 3.27E-5 15 8.08E-5
20 SGTC_2274 7947094 3.70 46.1 µM 4.41E-5 44 1.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.24E-13 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.108 3.83E-10 YPL112C PEX25 hom Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
0.092 9.80E-8 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.085 7.80E-7 YIL023C YKE4 hom Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
0.084 1.10E-6 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.080 3.13E-6 YLR141W RRN5 het Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
0.079 4.14E-6 YPL193W RSA1 hom Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly
0.077 7.70E-6 YPL087W YDC1 hom Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication
0.077 9.09E-6 YLR365W_d YLR365W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
0.074 1.60E-5 YNL170W_d YNL170W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.074 1.64E-5 YJR025C BNA1 hom 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.074 1.72E-5 YBR089C-A NHP6B hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication
0.072 2.80E-5 YER044C-A MEI4 hom Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores
0.070 5.20E-5 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.070 5.33E-5 YJL205C NCE101 hom Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences