YNL319W_d

Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL319W / YNL319W

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:3.80|P-value:1.65E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.96|P-value:9.08E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.42|P-value:5.83E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.30|P-value:8.71E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:-3.49|P-value:4.64E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.46|P-value:5.16E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.60|P-value:6.92E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:4.34|P-value:2.00E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:5.30|P-value:2.67E-7 ID:SGTC_160|Compound:3453-0671|FD-Score:6.08|P-value:4.47E-9 ID:SGTC_176|Compound:1486-1328|FD-Score:5.45|P-value:1.24E-7 ID:SGTC_382|Compound:3229-0966|FD-Score:4.57|P-value:7.75E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.40|P-value:6.35E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:4.18|P-value:3.93E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:4.00|P-value:7.70E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.83|P-value:1.49E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.86|P-value:1.27E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.37|P-value:6.98E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.58|P-value:3.50E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.65|P-value:2.76E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.09|P-value:5.51E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.50|P-value:9.71E-6 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.32|P-value:8.52E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-3.34|P-value:7.61E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.97|P-value:8.73E-5 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.38|P-value:6.91E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.60|P-value:3.27E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:6.50|P-value:3.96E-10 ID:SGTC_1613|Compound:st002381|FD-Score:4.14|P-value:4.47E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.57|P-value:7.55E-6 ID:SGTC_1667|Compound:st014849|FD-Score:3.51|P-value:4.46E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.36|P-value:7.08E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.39|P-value:1.63E-5 ID:SGTC_1727|Compound:st034309|FD-Score:7.02|P-value:1.53E-11 ID:SGTC_1737|Compound:st035557|FD-Score:3.29|P-value:9.42E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.56|P-value:3.78E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.27|P-value:9.86E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.92|P-value:1.04E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.28|P-value:9.56E-4 ID:SGTC_2008|Compound:4012253|FD-Score:5.02|P-value:1.00E-6 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.69|P-value:2.44E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.99|P-value:8.04E-5 ID:SGTC_2239|Compound:6685329|FD-Score:4.17|P-value:3.96E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.84|P-value:1.42E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.27|P-value:2.74E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-3.60|P-value:3.17E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.33|P-value:2.25E-7 ID:SGTC_2601|Compound:securinine|FD-Score:4.72|P-value:3.96E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.37|P-value:6.98E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:5.08|P-value:7.83E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.82|P-value:1.50E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.49|P-value:4.79E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.74|P-value:3.73E-6 ID:SGTC_2877|Compound:9040724|FD-Score:-3.99|P-value:7.74E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.36|P-value:7.57E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-5.66|P-value:3.95E-8 ID:SGTC_2954|Compound:9074818|FD-Score:-3.67|P-value:2.48E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.56|P-value:3.79E-4 ID:SGTC_3034|Compound:9090421|FD-Score:-3.99|P-value:7.55E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-3.55|P-value:3.76E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.80|P-value:1.65E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.96|P-value:9.08E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.42|P-value:5.83E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.30|P-value:8.71E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:-3.49|P-value:4.64E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.46|P-value:5.16E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.60|P-value:6.92E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:4.34|P-value:2.00E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:5.30|P-value:2.67E-7 ID:SGTC_160|Compound:3453-0671|FD-Score:6.08|P-value:4.47E-9 ID:SGTC_176|Compound:1486-1328|FD-Score:5.45|P-value:1.24E-7 ID:SGTC_382|Compound:3229-0966|FD-Score:4.57|P-value:7.75E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.40|P-value:6.35E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:4.18|P-value:3.93E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:4.00|P-value:7.70E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.83|P-value:1.49E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.86|P-value:1.27E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.37|P-value:6.98E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.58|P-value:3.50E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.65|P-value:2.76E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.09|P-value:5.51E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.50|P-value:9.71E-6 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.32|P-value:8.52E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-3.34|P-value:7.61E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.97|P-value:8.73E-5 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.38|P-value:6.91E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.60|P-value:3.27E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:6.50|P-value:3.96E-10 ID:SGTC_1613|Compound:st002381|FD-Score:4.14|P-value:4.47E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.57|P-value:7.55E-6 ID:SGTC_1667|Compound:st014849|FD-Score:3.51|P-value:4.46E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.36|P-value:7.08E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.39|P-value:1.63E-5 ID:SGTC_1727|Compound:st034309|FD-Score:7.02|P-value:1.53E-11 ID:SGTC_1737|Compound:st035557|FD-Score:3.29|P-value:9.42E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.56|P-value:3.78E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.27|P-value:9.86E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.92|P-value:1.04E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.28|P-value:9.56E-4 ID:SGTC_2008|Compound:4012253|FD-Score:5.02|P-value:1.00E-6 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.69|P-value:2.44E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.99|P-value:8.04E-5 ID:SGTC_2239|Compound:6685329|FD-Score:4.17|P-value:3.96E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.84|P-value:1.42E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.27|P-value:2.74E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-3.60|P-value:3.17E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.33|P-value:2.25E-7 ID:SGTC_2601|Compound:securinine|FD-Score:4.72|P-value:3.96E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.37|P-value:6.98E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:5.08|P-value:7.83E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.82|P-value:1.50E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.49|P-value:4.79E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.74|P-value:3.73E-6 ID:SGTC_2877|Compound:9040724|FD-Score:-3.99|P-value:7.74E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.36|P-value:7.57E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-5.66|P-value:3.95E-8 ID:SGTC_2954|Compound:9074818|FD-Score:-3.67|P-value:2.48E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.56|P-value:3.79E-4 ID:SGTC_3034|Compound:9090421|FD-Score:-3.99|P-value:7.55E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-3.55|P-value:3.76E-4

Top fitness defect scores for YNL319W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1727 st034309 7.02 9.9 µM 1.53E-11 2 1.11E-12
2 SGTC_1587 estradiol valerate 6.50 56.1 µM 3.96E-10 1 4.14E-11
3 SGTC_160 3453-0671 6.08 289.7 µM 4.47E-9 9 6.14E-10
4 SGTC_176 1486-1328 5.45 72.8 µM 1.24E-7 27 2.47E-8
5 SGTC_2566 crystal violet carbinol 5.33 226.0 nM 2.25E-7 16 4.79E-8
6 SGTC_155 k072-0202 5.30 43.6 µM 2.67E-7 7 5.81E-8
7 SGTC_2659 sanguinarine 5.08 24.2 µM 7.83E-7 12 1.92E-7
8 SGTC_2008 4012253 5.02 172.0 µM 1.00E-6 4 2.53E-7
9 SGTC_2870 9038528 4.74 13.0 µM 3.73E-6 10 1.09E-6
10 SGTC_2601 securinine 4.72 100.0 µM 3.96E-6 15 1.16E-6
11 SGTC_150 3970-0969 4.60 77.2 µM 6.92E-6 41 2.16E-6
12 SGTC_1616 st002734 4.57 56.1 µM 7.55E-6 14 2.39E-6
13 SGTC_382 3229-0966 4.57 23.2 µM 7.75E-6 10 2.45E-6
14 SGTC_1724 st037281 4.39 8.3 µM 1.63E-5 33 5.62E-6
15 SGTC_154 3389-1638 4.34 511.1 µM 2.00E-5 17 7.05E-6
16 SGTC_2380 9035439 4.27 200.0 µM 2.74E-5 endomembrane recycling 11 9.98E-6
17 SGTC_734 2023-0417 4.18 80.0 µM 3.93E-5 ergosterol biosynthesis 11 1.49E-5
18 SGTC_2239 6685329 4.17 187.6 µM 3.96E-5 23 1.50E-5
19 SGTC_1613 st002381 4.14 52.1 µM 4.47E-5 19 1.72E-5
20 SGTC_1300 1094-0077 4.09 113.0 µM 5.51E-5 11 2.17E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.55E-8 YER117W RPL23B hom Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication
0.091 1.15E-7 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.088 3.69E-7 YGL080W FMP37 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia
0.082 1.86E-6 YNR048W YNR048W hom Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication
0.078 6.22E-6 YDR370C DXO1 hom Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p
0.077 8.30E-6 YPL220W RPL1A hom Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.077 8.88E-6 YJR036C HUL4 hom Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex
0.071 3.86E-5 YBR047W_p FMP23_p hom Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.069 5.75E-5 YJR012C_p YJR012C_p het Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
0.069 6.67E-5 YLR458W_d YLR458W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
0.068 7.52E-5 YNR043W MVD1 het Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer
0.068 7.93E-5 YMR027W_p YMR027W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene
0.066 1.26E-4 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.066 1.34E-4 YMR261C TPS3 hom Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication
0.064 1.88E-4 YFL019C_d YFL019C_d hom Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene