YNL321W / VNX1

Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL321W / VNX1

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:3.71|P-value:2.33E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.64|P-value:2.94E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-4.31|P-value:2.42E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.63|P-value:5.52E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:3.34|P-value:7.97E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-5.43|P-value:1.47E-7 ID:SGTC_949|Compound:1165-0505|FD-Score:-4.06|P-value:6.32E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.95|P-value:9.69E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.68|P-value:2.55E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.56|P-value:4.00E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.16|P-value:5.60E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.98|P-value:8.71E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.10|P-value:5.43E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.64|P-value:3.00E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.80|P-value:1.66E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.41|P-value:6.53E-4 ID:SGTC_1519|Compound:esterone|FD-Score:4.11|P-value:5.15E-5 ID:SGTC_1734|Compound:st037168|FD-Score:-3.45|P-value:5.74E-4 ID:SGTC_1860|Compound:st056228|FD-Score:4.16|P-value:4.36E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.65|P-value:2.85E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.91|P-value:1.14E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.62|P-value:3.22E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-3.32|P-value:8.68E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.80|P-value:1.70E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.42|P-value:6.24E-4 ID:SGTC_2368|Compound:9071271|FD-Score:5.83|P-value:1.90E-8 ID:SGTC_2376|Compound:9072922|FD-Score:-3.41|P-value:6.58E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-4.78|P-value:3.25E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.69|P-value:4.82E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.32|P-value:8.52E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.48|P-value:5.12E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-4.16|P-value:4.33E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.42|P-value:6.13E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-4.66|P-value:5.41E-6 ID:SGTC_2928|Compound:9011484|FD-Score:3.78|P-value:1.81E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.60|P-value:3.39E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.95|P-value:9.50E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.42|P-value:6.24E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.84|P-value:1.47E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.46|P-value:5.49E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.28|P-value:9.94E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.66|P-value:5.54E-6 ID:SGTC_3093|Compound:9117344|FD-Score:3.94|P-value:1.01E-4 ID:SGTC_3214|Compound:9129694|FD-Score:5.57|P-value:7.20E-8 ID:SGTC_55|Compound:0767-0285|FD-Score:3.71|P-value:2.33E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.64|P-value:2.94E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-4.31|P-value:2.42E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.63|P-value:5.52E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:3.34|P-value:7.97E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-5.43|P-value:1.47E-7 ID:SGTC_949|Compound:1165-0505|FD-Score:-4.06|P-value:6.32E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.95|P-value:9.69E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.68|P-value:2.55E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.56|P-value:4.00E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.16|P-value:5.60E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.98|P-value:8.71E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:4.10|P-value:5.43E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.64|P-value:3.00E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.80|P-value:1.66E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.41|P-value:6.53E-4 ID:SGTC_1519|Compound:esterone|FD-Score:4.11|P-value:5.15E-5 ID:SGTC_1734|Compound:st037168|FD-Score:-3.45|P-value:5.74E-4 ID:SGTC_1860|Compound:st056228|FD-Score:4.16|P-value:4.36E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.65|P-value:2.85E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.91|P-value:1.14E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.62|P-value:3.22E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-3.32|P-value:8.68E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.80|P-value:1.70E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.42|P-value:6.24E-4 ID:SGTC_2368|Compound:9071271|FD-Score:5.83|P-value:1.90E-8 ID:SGTC_2376|Compound:9072922|FD-Score:-3.41|P-value:6.58E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-4.78|P-value:3.25E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.69|P-value:4.82E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.32|P-value:8.52E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.48|P-value:5.12E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-4.16|P-value:4.33E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.42|P-value:6.13E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-4.66|P-value:5.41E-6 ID:SGTC_2928|Compound:9011484|FD-Score:3.78|P-value:1.81E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.60|P-value:3.39E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.95|P-value:9.50E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.42|P-value:6.24E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.84|P-value:1.47E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.46|P-value:5.49E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.28|P-value:9.94E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.66|P-value:5.54E-6 ID:SGTC_3093|Compound:9117344|FD-Score:3.94|P-value:1.01E-4 ID:SGTC_3214|Compound:9129694|FD-Score:5.57|P-value:7.20E-8

Top fitness defect scores for YNL321W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2368 9071271 5.83 200.0 µM 1.90E-8 5 2.81E-9
2 SGTC_3214 9129694 5.57 49.5 µM 7.20E-8 6 1.25E-8
3 SGTC_1129 3453-1384 5.16 223.0 µM 5.60E-7 17 1.24E-7
4 SGTC_2553 4-methylesculetin 4.69 85.1 µM 4.82E-6 8 1.38E-6
5 SGTC_3087 9117406 4.66 49.5 µM 5.54E-6 7 1.61E-6
6 SGTC_1860 st056228 4.16 74.6 µM 4.36E-5 15 1.61E-5
7 SGTC_1519 esterone 4.11 74.0 µM 5.15E-5 DNA intercalators 16 1.95E-5
8 SGTC_1278 0874-0585 4.10 172.0 µM 5.43E-5 13 2.06E-5
9 SGTC_1132 3456-3614 3.98 2.5 µM 8.71E-5 tubulin folding & SWR complex 44 3.50E-5
10 SGTC_2986 9022445 3.95 71.4 µM 9.50E-5 15 3.85E-5
11 SGTC_1027 k015-0025 3.95 8.7 µM 9.69E-5 26 3.94E-5
12 SGTC_3093 9117344 3.94 49.5 µM 1.01E-4 60S ribosome export 16 4.11E-5
13 SGTC_1939 st074455 3.91 53.6 µM 1.14E-4 29 4.70E-5
14 SGTC_3034 9090421 3.84 49.5 µM 1.47E-4 60S ribosome export 9 6.25E-5
15 SGTC_1476 4112-3294 3.80 3.3 µM 1.66E-4 60S ribosome export 19 7.20E-5
16 SGTC_2258 7960471 3.80 200.0 µM 1.70E-4 12 7.36E-5
17 SGTC_2928 9011484 3.78 9.8 µM 1.81E-4 heme biosynthesis & mitochondrial translocase 39 7.92E-5
18 SGTC_55 0767-0285 3.71 6.6 µM 2.33E-4 47 1.05E-4
19 SGTC_1060 3448-7350 3.68 82.0 µM 2.55E-4 Golgi 41 1.16E-4
20 SGTC_1892 st058411 3.65 7.4 µM 2.85E-4 36 1.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.092 1.03E-7 YBL035C POL12 het B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
0.088 2.89E-7 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.087 4.04E-7 YBR293W VBA2 hom Permease of basic amino acids in the vacuolar membrane
0.085 9.36E-7 YLR335W NUP2 hom Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
0.084 9.67E-7 YJR134C SGM1 hom Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus
0.083 1.44E-6 YOR285W RDL1 hom Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress
0.083 1.48E-6 YKL096W-A CWP2 hom Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
0.082 1.77E-6 YPL090C RPS6A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication
0.075 1.49E-5 YMR273C ZDS1 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication
0.074 1.81E-5 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.073 2.22E-5 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.073 2.23E-5 YCR003W MRPL32 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.072 2.63E-5 YGL008C PMA1 het Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
0.072 2.64E-5 YKL026C GPX1 hom Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
0.071 4.32E-5 YBR233W PBP2 hom RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress