YNL322C / KRE1

Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL322C / KRE1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:6.84|P-value:6.02E-12 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.14|P-value:7.07E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.18|P-value:6.18E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:5.38|P-value:5.00E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:3.52|P-value:2.69E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:5.10|P-value:2.31E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:4.82|P-value:9.49E-7 ID:SGTC_154|Compound:3389-1638|FD-Score:4.61|P-value:2.68E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:4.48|P-value:4.84E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.15|P-value:6.82E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.80|P-value:6.18E-7 ID:SGTC_344|Compound:k064-0035|FD-Score:7.49|P-value:5.35E-14 ID:SGTC_353|Compound:1988-1175|FD-Score:4.99|P-value:4.05E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:3.24|P-value:7.24E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:16.70|P-value:1.02E-62 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.73|P-value:1.21E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.59|P-value:2.02E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:7.12|P-value:8.07E-13 ID:SGTC_663|Compound:1486-0733|FD-Score:9.56|P-value:1.01E-21 ID:SGTC_708|Compound:3448-5400|FD-Score:7.22|P-value:3.98E-13 ID:SGTC_721|Compound:1187-1332|FD-Score:4.93|P-value:5.45E-7 ID:SGTC_786|Compound:4544-0069|FD-Score:5.51|P-value:2.48E-8 ID:SGTC_791|Compound:1348-1292|FD-Score:4.03|P-value:3.46E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.74|P-value:1.38E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:5.66|P-value:1.02E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:3.91|P-value:5.89E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:3.19|P-value:8.48E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-3.39|P-value:2.84E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.16|P-value:6.62E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:5.78|P-value:5.18E-9 ID:SGTC_972|Compound:1319-0219|FD-Score:4.86|P-value:7.86E-7 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.23|P-value:1.51E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:6.82|P-value:6.83E-12 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.20|P-value:8.27E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:6.53|P-value:4.82E-11 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.36|P-value:4.77E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.80|P-value:1.03E-6 ID:SGTC_1384|Compound:3089-0840|FD-Score:6.07|P-value:8.94E-10 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.34|P-value:5.10E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.85|P-value:7.35E-5 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.41|P-value:3.91E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.73|P-value:1.19E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.66|P-value:1.54E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.26|P-value:6.68E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.98|P-value:4.41E-5 ID:SGTC_1820|Compound:st053765|FD-Score:3.31|P-value:5.64E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.35|P-value:8.79E-6 ID:SGTC_1939|Compound:st074455|FD-Score:-3.66|P-value:1.04E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.40|P-value:6.85E-6 ID:SGTC_2007|Compound:4011539|FD-Score:15.10|P-value:1.00E-51 ID:SGTC_2009|Compound:4012297|FD-Score:14.20|P-value:8.79E-46 ID:SGTC_2021|Compound:4019055|FD-Score:3.54|P-value:2.46E-4 ID:SGTC_2028|Compound:5153890|FD-Score:6.41|P-value:1.04E-10 ID:SGTC_2055|Compound:5235184|FD-Score:-4.39|P-value:4.55E-6 ID:SGTC_2079|Compound:5212404|FD-Score:-3.25|P-value:4.84E-4 ID:SGTC_2149|Compound:5554786|FD-Score:8.80|P-value:1.12E-18 ID:SGTC_2241|Compound:6772625|FD-Score:3.62|P-value:1.82E-4 ID:SGTC_2272|Compound:7805186|FD-Score:11.70|P-value:1.30E-31 ID:SGTC_2289|Compound:7946404|FD-Score:10.10|P-value:6.11E-24 ID:SGTC_2399|Compound:5884133|FD-Score:16.00|P-value:2.53E-57 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.81|P-value:1.01E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.34|P-value:5.11E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.56|P-value:2.24E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.44|P-value:2.42E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.47|P-value:2.15E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.70|P-value:8.76E-5 ID:SGTC_2699|Compound:st077704|FD-Score:-3.36|P-value:3.21E-4 ID:SGTC_2707|Compound:st078556|FD-Score:4.52|P-value:3.95E-6 ID:SGTC_2825|Compound:7998094|FD-Score:3.89|P-value:6.15E-5 ID:SGTC_2877|Compound:9040724|FD-Score:3.53|P-value:2.55E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.84|P-value:8.38E-7 ID:SGTC_2999|Compound:9069765|FD-Score:3.17|P-value:9.02E-4 ID:SGTC_3092|Compound:9117248|FD-Score:3.22|P-value:7.73E-4 ID:SGTC_3147|Compound:9097027|FD-Score:4.29|P-value:1.12E-5 ID:SGTC_3157|Compound:9099274|FD-Score:3.71|P-value:1.27E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-3.17|P-value:6.42E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:6.84|P-value:6.02E-12 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.14|P-value:7.07E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.18|P-value:6.18E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:5.38|P-value:5.00E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:3.52|P-value:2.69E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:5.10|P-value:2.31E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:4.82|P-value:9.49E-7 ID:SGTC_154|Compound:3389-1638|FD-Score:4.61|P-value:2.68E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:4.48|P-value:4.84E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.15|P-value:6.82E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.80|P-value:6.18E-7 ID:SGTC_344|Compound:k064-0035|FD-Score:7.49|P-value:5.35E-14 ID:SGTC_353|Compound:1988-1175|FD-Score:4.99|P-value:4.05E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:3.24|P-value:7.24E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:16.70|P-value:1.02E-62 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.73|P-value:1.21E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.59|P-value:2.02E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:7.12|P-value:8.07E-13 ID:SGTC_663|Compound:1486-0733|FD-Score:9.56|P-value:1.01E-21 ID:SGTC_708|Compound:3448-5400|FD-Score:7.22|P-value:3.98E-13 ID:SGTC_721|Compound:1187-1332|FD-Score:4.93|P-value:5.45E-7 ID:SGTC_786|Compound:4544-0069|FD-Score:5.51|P-value:2.48E-8 ID:SGTC_791|Compound:1348-1292|FD-Score:4.03|P-value:3.46E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.74|P-value:1.38E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:5.66|P-value:1.02E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:3.91|P-value:5.89E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:3.19|P-value:8.48E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-3.39|P-value:2.84E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.16|P-value:6.62E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:5.78|P-value:5.18E-9 ID:SGTC_972|Compound:1319-0219|FD-Score:4.86|P-value:7.86E-7 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.23|P-value:1.51E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:6.82|P-value:6.83E-12 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.20|P-value:8.27E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:6.53|P-value:4.82E-11 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.36|P-value:4.77E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.80|P-value:1.03E-6 ID:SGTC_1384|Compound:3089-0840|FD-Score:6.07|P-value:8.94E-10 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.34|P-value:5.10E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.85|P-value:7.35E-5 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.41|P-value:3.91E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.73|P-value:1.19E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.66|P-value:1.54E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.26|P-value:6.68E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.98|P-value:4.41E-5 ID:SGTC_1820|Compound:st053765|FD-Score:3.31|P-value:5.64E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.35|P-value:8.79E-6 ID:SGTC_1939|Compound:st074455|FD-Score:-3.66|P-value:1.04E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.40|P-value:6.85E-6 ID:SGTC_2007|Compound:4011539|FD-Score:15.10|P-value:1.00E-51 ID:SGTC_2009|Compound:4012297|FD-Score:14.20|P-value:8.79E-46 ID:SGTC_2021|Compound:4019055|FD-Score:3.54|P-value:2.46E-4 ID:SGTC_2028|Compound:5153890|FD-Score:6.41|P-value:1.04E-10 ID:SGTC_2055|Compound:5235184|FD-Score:-4.39|P-value:4.55E-6 ID:SGTC_2079|Compound:5212404|FD-Score:-3.25|P-value:4.84E-4 ID:SGTC_2149|Compound:5554786|FD-Score:8.80|P-value:1.12E-18 ID:SGTC_2241|Compound:6772625|FD-Score:3.62|P-value:1.82E-4 ID:SGTC_2272|Compound:7805186|FD-Score:11.70|P-value:1.30E-31 ID:SGTC_2289|Compound:7946404|FD-Score:10.10|P-value:6.11E-24 ID:SGTC_2399|Compound:5884133|FD-Score:16.00|P-value:2.53E-57 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.81|P-value:1.01E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.34|P-value:5.11E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.56|P-value:2.24E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.44|P-value:2.42E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.47|P-value:2.15E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.70|P-value:8.76E-5 ID:SGTC_2699|Compound:st077704|FD-Score:-3.36|P-value:3.21E-4 ID:SGTC_2707|Compound:st078556|FD-Score:4.52|P-value:3.95E-6 ID:SGTC_2825|Compound:7998094|FD-Score:3.89|P-value:6.15E-5 ID:SGTC_2877|Compound:9040724|FD-Score:3.53|P-value:2.55E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.84|P-value:8.38E-7 ID:SGTC_2999|Compound:9069765|FD-Score:3.17|P-value:9.02E-4 ID:SGTC_3092|Compound:9117248|FD-Score:3.22|P-value:7.73E-4 ID:SGTC_3147|Compound:9097027|FD-Score:4.29|P-value:1.12E-5 ID:SGTC_3157|Compound:9099274|FD-Score:3.71|P-value:1.27E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-3.17|P-value:6.42E-4

Top fitness defect scores for YNL322C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_390 dec-rvkr-cmk 16.70 16.7 µM 1.02E-62 calcium & mitochondrial duress 1 3.77E-63
2 SGTC_2399 5884133 16.00 200.0 µM 2.53E-57 cell wall signaling 4 9.81E-58
3 SGTC_2007 4011539 15.10 71.8 µM 1.00E-51 cell wall signaling 6 4.10E-52
4 SGTC_2009 4012297 14.20 12.1 µM 8.79E-46 cell wall signaling 6 3.82E-46
5 SGTC_2272 7805186 11.70 180.0 µM 1.30E-31 cell wall signaling 3 6.63E-32
6 SGTC_2289 7946404 10.10 165.1 µM 6.11E-24 8 3.43E-24
7 SGTC_663 1486-0733 9.56 13.9 µM 1.01E-21 cell wall signaling 13 5.82E-22
8 SGTC_2149 5554786 8.80 194.8 µM 1.12E-18 cell wall signaling 3 6.76E-19
9 SGTC_344 k064-0035 7.49 6.4 µM 5.35E-14 60S ribosome export 1 3.50E-14
10 SGTC_708 3448-5400 7.22 146.0 µM 3.98E-13 5 2.64E-13
11 SGTC_625 k213-0058 7.12 121.0 µM 8.07E-13 translation 21 5.39E-13
12 SGTC_16 erodoxin 6.84 22.8 µM 6.02E-12 unfolded protein response 20 4.09E-12
13 SGTC_1163 k060-0048 6.82 49.9 µM 6.83E-12 1 4.64E-12
14 SGTC_1273 0849-0096 6.53 14.1 µM 4.82E-11 RPP1 & pyrimidine depletion 3 3.33E-11
15 SGTC_2028 5153890 6.41 36.4 µM 1.04E-10 cell wall signaling 9 7.25E-11
16 SGTC_1384 3089-0840 6.07 101.0 µM 8.94E-10 3 6.34E-10
17 SGTC_962 1254-0300 5.78 21.5 µM 5.18E-9 7 3.74E-9
18 SGTC_830 4076-0286 5.66 57.8 µM 1.02E-8 translation 21 7.40E-9
19 SGTC_786 4544-0069 5.51 423.0 µM 2.48E-8 8 1.81E-8
20 SGTC_119 0121-0043 5.38 24.8 µM 5.00E-8 mitochondrial stress 38 3.69E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.417 3.06E-141 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.411 6.23E-137 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.411 8.41E-137 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.382 6.24E-117 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.363 6.57E-105 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.335 7.67E-89 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.333 1.57E-87 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.330 5.87E-86 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.292 6.00E-67 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.289 1.29E-65 YKL096C-B_p YKL096C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.284 1.92E-63 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.284 4.12E-63 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.282 1.38E-62 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.271 2.23E-57 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.253 2.74E-50 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele