YNL325C / FIG4

Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL325C / FIG4

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.41|P-value:1.48E-7 ID:SGTC_108|Compound:0509-0257|FD-Score:3.76|P-value:1.86E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.57|P-value:7.46E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.65|P-value:5.30E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.83|P-value:1.41E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.28|P-value:9.45E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.20|P-value:3.50E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:5.53|P-value:7.68E-8 ID:SGTC_660|Compound:4031-1742|FD-Score:3.93|P-value:9.87E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.65|P-value:2.69E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.61|P-value:3.16E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:5.10|P-value:6.75E-7 ID:SGTC_746|Compound:1095-0025|FD-Score:4.45|P-value:1.21E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.85|P-value:1.21E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:7.77|P-value:8.36E-14 ID:SGTC_884|Compound:0851-0618|FD-Score:3.49|P-value:4.72E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:5.12|P-value:5.94E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:4.29|P-value:2.40E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.32|P-value:8.42E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.20|P-value:3.48E-5 ID:SGTC_1903|Compound:st060211|FD-Score:4.05|P-value:6.20E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.67|P-value:2.51E-4 ID:SGTC_1935|Compound:st074532|FD-Score:5.05|P-value:8.29E-7 ID:SGTC_2113|Compound:5491891|FD-Score:-3.70|P-value:2.11E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.64|P-value:2.81E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.93|P-value:9.84E-5 ID:SGTC_2274|Compound:7947094|FD-Score:4.22|P-value:3.18E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.64|P-value:2.78E-4 ID:SGTC_2534|Compound:helenine|FD-Score:4.24|P-value:2.94E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.53|P-value:4.17E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.89|P-value:1.04E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.58|P-value:3.46E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-5.90|P-value:9.74E-9 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.85|P-value:1.23E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-5.67|P-value:3.43E-8 ID:SGTC_2693|Compound:st077581|FD-Score:5.08|P-value:7.15E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.62|P-value:2.82E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.40|P-value:6.41E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.77|P-value:1.77E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.72|P-value:2.15E-4 ID:SGTC_3277|Compound:9138724|FD-Score:4.42|P-value:1.42E-5 ID:SGTC_3278|Compound:9139605|FD-Score:3.91|P-value:1.05E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.36|P-value:1.80E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.41|P-value:1.48E-7 ID:SGTC_108|Compound:0509-0257|FD-Score:3.76|P-value:1.86E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.57|P-value:7.46E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.65|P-value:5.30E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.83|P-value:1.41E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.28|P-value:9.45E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.20|P-value:3.50E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:5.53|P-value:7.68E-8 ID:SGTC_660|Compound:4031-1742|FD-Score:3.93|P-value:9.87E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.65|P-value:2.69E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.61|P-value:3.16E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:5.10|P-value:6.75E-7 ID:SGTC_746|Compound:1095-0025|FD-Score:4.45|P-value:1.21E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.85|P-value:1.21E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:7.77|P-value:8.36E-14 ID:SGTC_884|Compound:0851-0618|FD-Score:3.49|P-value:4.72E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:5.12|P-value:5.94E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:4.29|P-value:2.40E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.32|P-value:8.42E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.20|P-value:3.48E-5 ID:SGTC_1903|Compound:st060211|FD-Score:4.05|P-value:6.20E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.67|P-value:2.51E-4 ID:SGTC_1935|Compound:st074532|FD-Score:5.05|P-value:8.29E-7 ID:SGTC_2113|Compound:5491891|FD-Score:-3.70|P-value:2.11E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.64|P-value:2.81E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.93|P-value:9.84E-5 ID:SGTC_2274|Compound:7947094|FD-Score:4.22|P-value:3.18E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.64|P-value:2.78E-4 ID:SGTC_2534|Compound:helenine|FD-Score:4.24|P-value:2.94E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.53|P-value:4.17E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.89|P-value:1.04E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.58|P-value:3.46E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-5.90|P-value:9.74E-9 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.85|P-value:1.23E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-5.67|P-value:3.43E-8 ID:SGTC_2693|Compound:st077581|FD-Score:5.08|P-value:7.15E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.62|P-value:2.82E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.40|P-value:6.41E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.77|P-value:1.77E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.72|P-value:2.15E-4 ID:SGTC_3277|Compound:9138724|FD-Score:4.42|P-value:1.42E-5 ID:SGTC_3278|Compound:9139605|FD-Score:3.91|P-value:1.05E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.36|P-value:1.80E-5

Top fitness defect scores for YNL325C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_865 0488-0499 7.77 301.0 µM 8.36E-14 2 3.93E-15
2 SGTC_545 4218-0007 5.53 221.0 µM 7.68E-8 9 1.57E-8
3 SGTC_58 0957-0393 5.41 9.0 µM 1.48E-7 cell wall 248 3.23E-8
4 SGTC_893 0958-0369 5.12 48.9 µM 5.94E-7 11 1.51E-7
5 SGTC_739 1486-1183 5.10 203.0 µM 6.75E-7 8 1.74E-7
6 SGTC_2693 st077581 5.08 40.7 µM 7.15E-7 13 1.85E-7
7 SGTC_1935 st074532 5.05 41.6 µM 8.29E-7 9 2.18E-7
8 SGTC_241 5hr heat shock (37°C) + cantharidin 4.65 155.4 µM 5.30E-6 cell wall signaling 52 1.69E-6
9 SGTC_115 0527-0192 4.57 112.0 µM 7.46E-6 48 2.47E-6
10 SGTC_746 1095-0025 4.45 46.6 µM 1.21E-5 RSC & ERG11 10 4.20E-6
11 SGTC_3277 9138724 4.42 49.5 µM 1.42E-5 Golgi 17 5.01E-6
12 SGTC_3293 9120939 4.36 62.0 µM 1.80E-5 13 6.55E-6
13 SGTC_922 1866-0035 4.29 480.0 µM 2.40E-5 excess fatty acid 40 8.97E-6
14 SGTC_2534 helenine 4.24 20.1 µM 2.94E-5 RSC complex & mRNA processing 11 1.12E-5
15 SGTC_2274 7947094 4.22 46.1 µM 3.18E-5 26 1.23E-5
16 SGTC_1199 1638-0010 4.20 4.5 µM 3.48E-5 endomembrane recycling 21 1.35E-5
17 SGTC_459 nigericin 4.20 15.3 µM 3.50E-5 57 1.36E-5
18 SGTC_1903 st060211 4.05 78.3 µM 6.20E-5 26 2.57E-5
19 SGTC_2243 6634756 3.93 200.0 µM 9.84E-5 20 4.27E-5
20 SGTC_660 4031-1742 3.93 102.0 µM 9.87E-5 redox potentiating 49 4.29E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 4.81E-28 YNL324W_d YNL324W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 2.77E-13 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.117 1.05E-11 YGL134W PCL10 hom Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
0.116 1.67E-11 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.114 3.83E-11 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.112 9.48E-11 YOR179C SYC1 hom Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication
0.111 9.98E-11 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.111 1.39E-10 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.110 1.45E-10 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.105 1.10E-9 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.104 1.52E-9 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.103 1.92E-9 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.100 6.91E-9 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.099 8.02E-9 YBR298C MAL31 hom Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C
0.098 1.45E-8 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance