YNL333W / SNZ2

Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL333W / SNZ2

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.40|P-value:3.79E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:4.76|P-value:1.06E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:4.59|P-value:2.40E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:5.60|P-value:1.25E-8 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.54|P-value:2.27E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.22|P-value:6.80E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:4.82|P-value:7.86E-7 ID:SGTC_428|Compound:3448-4153|FD-Score:3.34|P-value:4.39E-4 ID:SGTC_476|Compound:mead acid|FD-Score:3.73|P-value:1.03E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.11|P-value:9.61E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.65|P-value:1.36E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:4.27|P-value:1.06E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:5.81|P-value:3.72E-9 ID:SGTC_838|Compound:0109-0203|FD-Score:3.60|P-value:1.70E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.26|P-value:5.82E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.30|P-value:5.01E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.29|P-value:5.60E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.24|P-value:9.14E-8 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.76|P-value:9.19E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.25|P-value:6.07E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.43|P-value:3.38E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.66|P-value:1.44E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.56|P-value:2.07E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.78|P-value:9.04E-5 ID:SGTC_1961|Compound:st076550|FD-Score:3.36|P-value:4.08E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.31|P-value:4.93E-4 ID:SGTC_2145|Compound:5634607|FD-Score:-3.17|P-value:8.55E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.28|P-value:5.40E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.87|P-value:5.83E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.21|P-value:6.82E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-3.77|P-value:9.21E-5 ID:SGTC_2402|Compound:5553605|FD-Score:3.26|P-value:5.85E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-5.03|P-value:3.06E-7 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.36|P-value:4.06E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.82|P-value:7.76E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:5.34|P-value:5.42E-8 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.88|P-value:5.67E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.51|P-value:2.57E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.47|P-value:2.76E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.12|P-value:9.47E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.45|P-value:3.20E-4 ID:SGTC_2942|Compound:9052777|FD-Score:4.65|P-value:1.86E-6 ID:SGTC_2968|Compound:9090663|FD-Score:-4.97|P-value:4.20E-7 ID:SGTC_2972|Compound:9093619|FD-Score:-7.44|P-value:7.61E-14 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.40|P-value:3.79E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:4.76|P-value:1.06E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:4.59|P-value:2.40E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:5.60|P-value:1.25E-8 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.54|P-value:2.27E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.22|P-value:6.80E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:4.82|P-value:7.86E-7 ID:SGTC_428|Compound:3448-4153|FD-Score:3.34|P-value:4.39E-4 ID:SGTC_476|Compound:mead acid|FD-Score:3.73|P-value:1.03E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.11|P-value:9.61E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.65|P-value:1.36E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:4.27|P-value:1.06E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:5.81|P-value:3.72E-9 ID:SGTC_838|Compound:0109-0203|FD-Score:3.60|P-value:1.70E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.26|P-value:5.82E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.30|P-value:5.01E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.29|P-value:5.60E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.24|P-value:9.14E-8 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.76|P-value:9.19E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.25|P-value:6.07E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.43|P-value:3.38E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.66|P-value:1.44E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.56|P-value:2.07E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.78|P-value:9.04E-5 ID:SGTC_1961|Compound:st076550|FD-Score:3.36|P-value:4.08E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.31|P-value:4.93E-4 ID:SGTC_2145|Compound:5634607|FD-Score:-3.17|P-value:8.55E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.28|P-value:5.40E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.87|P-value:5.83E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.21|P-value:6.82E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-3.77|P-value:9.21E-5 ID:SGTC_2402|Compound:5553605|FD-Score:3.26|P-value:5.85E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-5.03|P-value:3.06E-7 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.36|P-value:4.06E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.82|P-value:7.76E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:5.34|P-value:5.42E-8 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.88|P-value:5.67E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.51|P-value:2.57E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.47|P-value:2.76E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.12|P-value:9.47E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.45|P-value:3.20E-4 ID:SGTC_2942|Compound:9052777|FD-Score:4.65|P-value:1.86E-6 ID:SGTC_2968|Compound:9090663|FD-Score:-4.97|P-value:4.20E-7 ID:SGTC_2972|Compound:9093619|FD-Score:-7.44|P-value:7.61E-14

Top fitness defect scores for YNL333W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_781 4335-2806 5.81 94.4 µM 3.72E-9 6 3.13E-9
2 SGTC_75 0159-0059 5.60 199.0 µM 1.25E-8 fatty acid desaturase (OLE1) 8 1.07E-8
3 SGTC_2562 3',7'-dimethoxyflavone 5.34 64.9 µM 5.42E-8 8 4.70E-8
4 SGTC_1118 chelidonine 5.24 707.5 nM 9.14E-8 6 7.96E-8
5 SGTC_305 1682-2595 4.82 20.8 µM 7.86E-7 RNA processing & uracil transport 11 7.01E-7
6 SGTC_69 0096-0274 4.76 206.7 µM 1.06E-6 mitochondrial processes 21 9.49E-7
7 SGTC_2942 9052777 4.65 62.2 µM 1.86E-6 16 1.68E-6
8 SGTC_71 0417-1750 4.59 47.8 µM 2.40E-6 Golgi 30 2.17E-6
9 SGTC_705 1124-0212 4.27 310.0 µM 1.06E-5 8 9.69E-6
10 SGTC_2598 perillyl alcohol 3.88 100.0 µM 5.67E-5 34 5.30E-5
11 SGTC_2307 7538926 3.87 6.3 µM 5.83E-5 45 5.45E-5
12 SGTC_1318 1280-3875 3.76 124.0 µM 9.19E-5 31 8.64E-5
13 SGTC_476 mead acid 3.73 10.0 µM 1.03E-4 5 9.71E-5
14 SGTC_545 4218-0007 3.65 221.0 µM 1.36E-4 35 1.29E-4
15 SGTC_838 0109-0203 3.60 71.4 µM 1.70E-4 24 1.60E-4
16 SGTC_2793 7325131 3.47 81.8 µM 2.76E-4 29 2.62E-4
17 SGTC_2519 cryptotanshinone 3.36 88.0 µM 4.06E-4 heme biosynthesis & mitochondrial translocase 30 3.87E-4
18 SGTC_1961 st076550 3.36 68.7 µM 4.08E-4 26 3.89E-4
19 SGTC_428 3448-4153 3.34 16.5 µM 4.39E-4 TSC3-RPN4 58 4.20E-4
20 SGTC_2081 5214970 3.31 32.3 µM 4.93E-4 48 4.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.01E-15 YDR340W_d YDR340W_d hom Putative protein of unknown function
0.119 4.76E-12 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.114 3.72E-11 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.112 6.62E-11 YJR128W_d YJR128W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
0.109 2.44E-10 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.108 3.84E-10 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.102 3.20E-9 YOR220W RCN2 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress
0.101 5.20E-9 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.094 4.77E-8 YDL214C PRR2 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance
0.093 7.43E-8 YNL334C SNO2 hom Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin
0.092 1.05E-7 YOL024W_p YOL024W_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication
0.088 3.03E-7 YPL127C HHO1 hom Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination
0.085 8.81E-7 YFR028C CDC14 het Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis
0.084 1.18E-6 YKL149C DBR1 hom RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
0.083 1.46E-6 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress