YNL334C / SNO2

Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL334C / SNO2

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.99|P-value:4.14E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:5.83|P-value:4.50E-9 ID:SGTC_71|Compound:0417-1750|FD-Score:3.81|P-value:8.68E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:4.08|P-value:2.85E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.18|P-value:8.76E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.36|P-value:4.66E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:5.25|P-value:1.17E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:4.19|P-value:1.81E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.63|P-value:1.76E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.93|P-value:5.39E-5 ID:SGTC_707|Compound:0865-0008|FD-Score:3.58|P-value:2.08E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.60|P-value:1.94E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-4.00|P-value:4.21E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:4.50|P-value:4.69E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.54|P-value:3.74E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.04|P-value:3.44E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:5.36|P-value:6.32E-8 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.34|P-value:5.01E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.29|P-value:5.91E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.73|P-value:1.16E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.03|P-value:3.67E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:5.88|P-value:3.52E-9 ID:SGTC_1608|Compound:st001473|FD-Score:3.87|P-value:6.76E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.19|P-value:8.19E-4 ID:SGTC_1653|Compound:st012112|FD-Score:-3.56|P-value:2.30E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.05|P-value:3.31E-5 ID:SGTC_1757|Compound:st041620|FD-Score:3.26|P-value:6.45E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.29|P-value:6.12E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.31|P-value:5.45E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.34|P-value:5.03E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.42|P-value:3.77E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.33|P-value:5.04E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.19|P-value:1.83E-5 ID:SGTC_2334|Compound:9017922|FD-Score:3.23|P-value:7.21E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.31|P-value:8.35E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.30|P-value:5.64E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.16|P-value:9.30E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.32|P-value:5.38E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.39|P-value:4.08E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-6.31|P-value:2.59E-10 ID:SGTC_2789|Compound:5281112|FD-Score:-3.61|P-value:1.95E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.64|P-value:1.69E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.75|P-value:1.10E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.32|P-value:5.24E-4 ID:SGTC_3057|Compound:9095946|FD-Score:4.04|P-value:3.37E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.99|P-value:4.14E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:5.83|P-value:4.50E-9 ID:SGTC_71|Compound:0417-1750|FD-Score:3.81|P-value:8.68E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:4.08|P-value:2.85E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.18|P-value:8.76E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.36|P-value:4.66E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:5.25|P-value:1.17E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:4.19|P-value:1.81E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.63|P-value:1.76E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.93|P-value:5.39E-5 ID:SGTC_707|Compound:0865-0008|FD-Score:3.58|P-value:2.08E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.60|P-value:1.94E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-4.00|P-value:4.21E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:4.50|P-value:4.69E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.54|P-value:3.74E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.04|P-value:3.44E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:5.36|P-value:6.32E-8 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.34|P-value:5.01E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.29|P-value:5.91E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.73|P-value:1.16E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.03|P-value:3.67E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:5.88|P-value:3.52E-9 ID:SGTC_1608|Compound:st001473|FD-Score:3.87|P-value:6.76E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.19|P-value:8.19E-4 ID:SGTC_1653|Compound:st012112|FD-Score:-3.56|P-value:2.30E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.05|P-value:3.31E-5 ID:SGTC_1757|Compound:st041620|FD-Score:3.26|P-value:6.45E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.29|P-value:6.12E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.31|P-value:5.45E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.34|P-value:5.03E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.42|P-value:3.77E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.33|P-value:5.04E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.19|P-value:1.83E-5 ID:SGTC_2334|Compound:9017922|FD-Score:3.23|P-value:7.21E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.31|P-value:8.35E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.30|P-value:5.64E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.16|P-value:9.30E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.32|P-value:5.38E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.39|P-value:4.08E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-6.31|P-value:2.59E-10 ID:SGTC_2789|Compound:5281112|FD-Score:-3.61|P-value:1.95E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.64|P-value:1.69E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.75|P-value:1.10E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.32|P-value:5.24E-4 ID:SGTC_3057|Compound:9095946|FD-Score:4.04|P-value:3.37E-5

Top fitness defect scores for YNL334C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1585 2',4'-dihydroxychalcone 5.88 10.4 µM 3.52E-9 9 2.11E-9
2 SGTC_69 0096-0274 5.83 206.7 µM 4.50E-9 mitochondrial processes 10 2.72E-9
3 SGTC_1272 0839-0021 5.36 27.0 µM 6.32E-8 8 4.13E-8
4 SGTC_2406 ethylparaben 5.31 405.7 µM 8.35E-8 15 5.50E-8
5 SGTC_119 0121-0043 5.25 24.8 µM 1.17E-7 mitochondrial stress 49 7.75E-8
6 SGTC_1049 3226-0134 4.54 66.0 µM 3.74E-6 18 2.75E-6
7 SGTC_864 0469-0573 4.50 172.0 µM 4.69E-6 10 3.47E-6
8 SGTC_146 3448-8650 4.19 53.1 µM 1.81E-5 NEO1-PIK1 122 1.39E-5
9 SGTC_2178 5812956 4.19 200.0 µM 1.83E-5 10 1.41E-5
10 SGTC_76 0433-0009 4.08 400.3 µM 2.85E-5 12 2.22E-5
11 SGTC_1658 st012944 4.05 20.0 µM 3.31E-5 iron homeostasis 76 2.59E-5
12 SGTC_3057 9095946 4.04 49.5 µM 3.37E-5 Golgi 11 2.64E-5
13 SGTC_1251 0490-5699 4.04 265.0 µM 3.44E-5 30 2.70E-5
14 SGTC_6 0844-0013 3.99 19.8 µM 4.14E-5 83 3.27E-5
15 SGTC_693 4161-2696 3.93 114.0 µM 5.39E-5 11 4.28E-5
16 SGTC_1608 st001473 3.87 40.5 µM 6.76E-5 37 5.40E-5
17 SGTC_71 0417-1750 3.81 47.8 µM 8.68E-5 Golgi 49 6.98E-5
18 SGTC_2801 7907800 3.75 81.8 µM 1.10E-4 35 8.91E-5
19 SGTC_1357 1503-1303 3.73 39.5 µM 1.16E-4 40 9.46E-5
20 SGTC_2795 7780010 3.64 54.5 µM 1.69E-4 42 1.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 5.98E-15 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.132 1.68E-14 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.125 4.62E-13 YBL030C PET9 het Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
0.116 1.67E-11 YKR059W TIF1 hom Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication
0.111 1.06E-10 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.102 2.71E-9 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.102 2.93E-9 YOR386W PHR1 hom DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p
0.102 3.85E-9 YBR087W RFC5 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.098 1.11E-8 YBR242W_p YBR242W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
0.097 1.92E-8 YPR050C_d YPR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
0.095 3.55E-8 YFL044C OTU1 hom Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress
0.095 3.64E-8 YDR439W LRS4 hom Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.094 5.52E-8 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.093 7.43E-8 YNL333W SNZ2 hom Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
0.089 2.28E-7 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress