HIPHOP chemogenomics database

YNL334C / SNO2

Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL334C / SNO2

Click on Significant Values for Screen Details

Top fitness defect scores for YNL334C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1585	2',4'-dihydroxychalcone	5.88	10.4 µM	3.52E-9		9	2.11E-9
2	SGTC_69	0096-0274	5.83	206.7 µM	4.50E-9	mitochondrial processes	10	2.72E-9
3	SGTC_1272	0839-0021	5.36	27.0 µM	6.32E-8		8	4.13E-8
4	SGTC_2406	ethylparaben	5.31	405.7 µM	8.35E-8		15	5.50E-8
5	SGTC_119	0121-0043	5.25	24.8 µM	1.17E-7	mitochondrial stress	49	7.75E-8
6	SGTC_1049	3226-0134	4.54	66.0 µM	3.74E-6		18	2.75E-6
7	SGTC_864	0469-0573	4.50	172.0 µM	4.69E-6		10	3.47E-6
8	SGTC_146	3448-8650	4.19	53.1 µM	1.81E-5	NEO1-PIK1	122	1.39E-5
9	SGTC_2178	5812956	4.19	200.0 µM	1.83E-5		10	1.41E-5
10	SGTC_76	0433-0009	4.08	400.3 µM	2.85E-5		12	2.22E-5
11	SGTC_1658	st012944	4.05	20.0 µM	3.31E-5	iron homeostasis	76	2.59E-5
12	SGTC_3057	9095946	4.04	49.5 µM	3.37E-5	Golgi	11	2.64E-5
13	SGTC_1251	0490-5699	4.04	265.0 µM	3.44E-5		30	2.70E-5
14	SGTC_6	0844-0013	3.99	19.8 µM	4.14E-5		83	3.27E-5
15	SGTC_693	4161-2696	3.93	114.0 µM	5.39E-5		11	4.28E-5
16	SGTC_1608	st001473	3.87	40.5 µM	6.76E-5		37	5.40E-5
17	SGTC_71	0417-1750	3.81	47.8 µM	8.68E-5	Golgi	49	6.98E-5
18	SGTC_2801	7907800	3.75	81.8 µM	1.10E-4		35	8.91E-5
19	SGTC_1357	1503-1303	3.73	39.5 µM	1.16E-4		40	9.46E-5
20	SGTC_2795	7780010	3.64	54.5 µM	1.69E-4		42	1.39E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.134	5.98E-15	YNL152W	INN1	het	Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.132	1.68E-14	YMR080C	NAM7	hom	ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.125	4.62E-13	YBL030C	PET9	het	Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
0.116	1.67E-11	YKR059W	TIF1	hom	Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication
0.111	1.06E-10	YPL243W	SRP68	het	Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.102	2.71E-9	YPR022C_p	YPR022C_p	hom	Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.102	2.93E-9	YOR386W	PHR1	hom	DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p
0.102	3.85E-9	YBR087W	RFC5	het	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.098	1.11E-8	YBR242W_p	YBR242W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
0.097	1.92E-8	YPR050C_d	YPR050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
0.095	3.55E-8	YFL044C	OTU1	hom	Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress
0.095	3.64E-8	YDR439W	LRS4	hom	Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.094	5.52E-8	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.093	7.43E-8	YNL333W	SNZ2	hom	Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
0.089	2.28E-7	YNL218W	MGS1	hom	Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress