YNL335W_p / DDI3

Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL335W / DDI3

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.64|P-value:1.41E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:5.17|P-value:1.25E-7 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.37|P-value:3.87E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.90|P-value:5.05E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.41|P-value:3.38E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:3.40|P-value:3.55E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.67|P-value:1.28E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.30|P-value:4.96E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.11|P-value:9.59E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.22|P-value:6.71E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.18|P-value:1.53E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.35|P-value:4.16E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.19|P-value:7.33E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.20|P-value:7.12E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.13|P-value:9.04E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.64|P-value:1.42E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.17|P-value:1.61E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.12|P-value:9.17E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:6.16|P-value:4.00E-10 ID:SGTC_1304|Compound:1165-0502|FD-Score:-4.07|P-value:2.43E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.07|P-value:2.47E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.23|P-value:6.34E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:-4.39|P-value:5.92E-6 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.37|P-value:6.71E-6 ID:SGTC_1697|Compound:st025554|FD-Score:7.10|P-value:7.23E-13 ID:SGTC_1710|Compound:st031758|FD-Score:4.39|P-value:6.01E-6 ID:SGTC_1912|Compound:st060209|FD-Score:3.19|P-value:7.30E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.10|P-value:9.88E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.74|P-value:9.74E-5 ID:SGTC_2085|Compound:5307070|FD-Score:4.60|P-value:2.25E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.20|P-value:7.16E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-3.92|P-value:4.55E-5 ID:SGTC_2137|Compound:5261020|FD-Score:-4.11|P-value:2.06E-5 ID:SGTC_2138|Compound:5575593|FD-Score:-3.57|P-value:1.86E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.15|P-value:8.41E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.98|P-value:3.62E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.88|P-value:5.53E-5 ID:SGTC_2368|Compound:9071271|FD-Score:3.19|P-value:7.31E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.27|P-value:5.47E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.61|P-value:1.61E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.67|P-value:1.24E-4 ID:SGTC_2460|Compound:5552655|FD-Score:5.56|P-value:1.51E-8 ID:SGTC_2821|Compound:7996764|FD-Score:-4.89|P-value:5.52E-7 ID:SGTC_2822|Compound:7994718|FD-Score:4.20|P-value:1.43E-5 ID:SGTC_2852|Compound:9023854|FD-Score:-4.74|P-value:1.13E-6 ID:SGTC_2926|Compound:9010726|FD-Score:9.82|P-value:5.88E-23 ID:SGTC_2990|Compound:9074105|FD-Score:3.22|P-value:6.55E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.58|P-value:1.79E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-5.55|P-value:1.58E-8 ID:SGTC_2998|Compound:9066762|FD-Score:-5.54|P-value:1.62E-8 ID:SGTC_3067|Compound:9117431|FD-Score:-3.25|P-value:6.01E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.80|P-value:7.55E-5 ID:SGTC_3148|Compound:9097893|FD-Score:5.83|P-value:3.15E-9 ID:SGTC_3158|Compound:9100007|FD-Score:3.59|P-value:1.69E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.66|P-value:1.29E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.46|P-value:2.84E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.64|P-value:1.41E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:5.17|P-value:1.25E-7 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.37|P-value:3.87E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.90|P-value:5.05E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.41|P-value:3.38E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:3.40|P-value:3.55E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.67|P-value:1.28E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.30|P-value:4.96E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.11|P-value:9.59E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.22|P-value:6.71E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.18|P-value:1.53E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.35|P-value:4.16E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.19|P-value:7.33E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.20|P-value:7.12E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.13|P-value:9.04E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.64|P-value:1.42E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.17|P-value:1.61E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.12|P-value:9.17E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:6.16|P-value:4.00E-10 ID:SGTC_1304|Compound:1165-0502|FD-Score:-4.07|P-value:2.43E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.07|P-value:2.47E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.23|P-value:6.34E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:-4.39|P-value:5.92E-6 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.37|P-value:6.71E-6 ID:SGTC_1697|Compound:st025554|FD-Score:7.10|P-value:7.23E-13 ID:SGTC_1710|Compound:st031758|FD-Score:4.39|P-value:6.01E-6 ID:SGTC_1912|Compound:st060209|FD-Score:3.19|P-value:7.30E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.10|P-value:9.88E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.74|P-value:9.74E-5 ID:SGTC_2085|Compound:5307070|FD-Score:4.60|P-value:2.25E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.20|P-value:7.16E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-3.92|P-value:4.55E-5 ID:SGTC_2137|Compound:5261020|FD-Score:-4.11|P-value:2.06E-5 ID:SGTC_2138|Compound:5575593|FD-Score:-3.57|P-value:1.86E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.15|P-value:8.41E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.98|P-value:3.62E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.88|P-value:5.53E-5 ID:SGTC_2368|Compound:9071271|FD-Score:3.19|P-value:7.31E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.27|P-value:5.47E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.61|P-value:1.61E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.67|P-value:1.24E-4 ID:SGTC_2460|Compound:5552655|FD-Score:5.56|P-value:1.51E-8 ID:SGTC_2821|Compound:7996764|FD-Score:-4.89|P-value:5.52E-7 ID:SGTC_2822|Compound:7994718|FD-Score:4.20|P-value:1.43E-5 ID:SGTC_2852|Compound:9023854|FD-Score:-4.74|P-value:1.13E-6 ID:SGTC_2926|Compound:9010726|FD-Score:9.82|P-value:5.88E-23 ID:SGTC_2990|Compound:9074105|FD-Score:3.22|P-value:6.55E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.58|P-value:1.79E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-5.55|P-value:1.58E-8 ID:SGTC_2998|Compound:9066762|FD-Score:-5.54|P-value:1.62E-8 ID:SGTC_3067|Compound:9117431|FD-Score:-3.25|P-value:6.01E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.80|P-value:7.55E-5 ID:SGTC_3148|Compound:9097893|FD-Score:5.83|P-value:3.15E-9 ID:SGTC_3158|Compound:9100007|FD-Score:3.59|P-value:1.69E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.66|P-value:1.29E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.46|P-value:2.84E-4

Top fitness defect scores for YNL335W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2926 9010726 9.82 65.2 µM 5.88E-23 2 4.43E-23
2 SGTC_1697 st025554 7.10 27.7 µM 7.23E-13 9 6.23E-13
3 SGTC_1292 0kpi-0043 6.16 232.0 µM 4.00E-10 1 3.57E-10
4 SGTC_3148 9097893 5.83 49.5 µM 3.15E-9 13 2.85E-9
5 SGTC_2460 5552655 5.56 174.2 µM 1.51E-8 amide catabolism 12 1.38E-8
6 SGTC_96 0929-0093 5.17 37.3 µM 1.25E-7 calcium & mitochondrial duress 5 1.15E-7
7 SGTC_2085 5307070 4.60 144.1 µM 2.25E-6 superoxide 16 2.11E-6
8 SGTC_1710 st031758 4.39 61.5 µM 6.01E-6 11 5.67E-6
9 SGTC_1599 8-chlro-1-tetrahydronorharmanone 4.37 90.6 µM 6.71E-6 22 6.34E-6
10 SGTC_2822 7994718 4.20 71.4 µM 1.43E-5 13 1.36E-5
11 SGTC_676 falcarinol 4.18 140.0 µM 1.53E-5 48 1.45E-5
12 SGTC_1205 4161-2785 4.17 76.0 µM 1.61E-5 21 1.53E-5
13 SGTC_1416 3966-0321 4.07 25.3 µM 2.47E-5 13 2.35E-5
14 SGTC_2184 6075246 3.98 200.0 µM 3.62E-5 24 3.45E-5
15 SGTC_421 streptovitacin 3.90 30.0 mM 5.05E-5 22 4.82E-5
16 SGTC_2335 9018011 3.88 154.2 µM 5.53E-5 29 5.28E-5
17 SGTC_494 Boc-Gly-Val-Val-CHO 3.67 140.0 µM 1.28E-4 11 1.23E-4
18 SGTC_1203 3992-3522 3.64 103.0 µM 1.42E-4 47 1.36E-4
19 SGTC_2410 aloe-emodin-8-o-glycoside 3.61 46.3 µM 1.61E-4 mitochondrial processes 43 1.55E-4
20 SGTC_3158 9100007 3.59 49.5 µM 1.69E-4 33 1.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.087 5.18E-7 YPL046C ELC1 hom Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair
0.086 5.36E-7 YKR038C KAE1 het Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription
0.083 1.33E-6 YAR029W_p YAR029W_p hom Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.074 2.03E-5 YGR042W YGR042W hom Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress
0.074 2.02E-5 YNR052C POP2 hom RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
0.072 3.09E-5 YLR351C NIT3 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.070 4.47E-5 YIL020C HIS6 hom Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
0.070 5.10E-5 YKR055W RHO4 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
0.068 7.32E-5 YDL068W_d YDL068W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.068 7.81E-5 YBR212W NGR1 hom RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase
0.067 9.23E-5 YNL108C_p YNL108C_p hom Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication
0.065 1.51E-4 YDR104C SPO71 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains
0.065 1.81E-4 YHR074W QNS1 het Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
0.063 2.34E-4 YKL079W SMY1 hom Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
0.063 2.63E-4 YOR321W PMT3 hom Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication