YNL336W / COS1

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL336W / COS1

Click on Significant Values for Screen Details ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.16|P-value:2.56E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:5.89|P-value:5.12E-9 ID:SGTC_620|Compound:0109-0052|FD-Score:3.26|P-value:7.44E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:3.25|P-value:7.78E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:5.36|P-value:9.00E-8 ID:SGTC_834|Compound:0312-0008|FD-Score:3.36|P-value:5.25E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.20|P-value:8.97E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.68|P-value:1.67E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:4.35|P-value:1.15E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.28|P-value:6.93E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.29|P-value:1.36E-7 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.41|P-value:4.37E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.42|P-value:4.26E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.11|P-value:3.07E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.52|P-value:2.98E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.27|P-value:7.13E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.66|P-value:2.02E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.43|P-value:4.20E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.61|P-value:2.14E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.76|P-value:1.23E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.90|P-value:7.36E-5 ID:SGTC_1850|Compound:st056238|FD-Score:4.04|P-value:4.11E-5 ID:SGTC_1902|Compound:st060212|FD-Score:3.31|P-value:6.16E-4 ID:SGTC_1903|Compound:st060211|FD-Score:4.09|P-value:3.42E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.70|P-value:1.55E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.67|P-value:2.68E-6 ID:SGTC_2457|Compound:5731572|FD-Score:3.33|P-value:5.84E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.45|P-value:8.57E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.21|P-value:9.65E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.43|P-value:4.66E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.84|P-value:9.01E-5 ID:SGTC_2706|Compound:st078239|FD-Score:4.87|P-value:1.05E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.22|P-value:9.60E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.67|P-value:1.99E-4 ID:SGTC_2782|Compound:7736369|FD-Score:5.53|P-value:3.78E-8 ID:SGTC_2784|Compound:7567673|FD-Score:-4.29|P-value:1.67E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-4.23|P-value:2.16E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.58|P-value:2.70E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-3.23|P-value:9.17E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.40|P-value:4.66E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.50|P-value:3.23E-4 ID:SGTC_3012|Compound:9080433|FD-Score:4.72|P-value:2.14E-6 ID:SGTC_3108|Compound:9121785|FD-Score:-3.50|P-value:3.65E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.58|P-value:2.42E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.25|P-value:7.75E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.95|P-value:5.95E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.16|P-value:2.56E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:5.89|P-value:5.12E-9 ID:SGTC_620|Compound:0109-0052|FD-Score:3.26|P-value:7.44E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:3.25|P-value:7.78E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:5.36|P-value:9.00E-8 ID:SGTC_834|Compound:0312-0008|FD-Score:3.36|P-value:5.25E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.20|P-value:8.97E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.68|P-value:1.67E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:4.35|P-value:1.15E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.28|P-value:6.93E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.29|P-value:1.36E-7 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.41|P-value:4.37E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.42|P-value:4.26E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.11|P-value:3.07E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.52|P-value:2.98E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.27|P-value:7.13E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.66|P-value:2.02E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.43|P-value:4.20E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.61|P-value:2.14E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.76|P-value:1.23E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.90|P-value:7.36E-5 ID:SGTC_1850|Compound:st056238|FD-Score:4.04|P-value:4.11E-5 ID:SGTC_1902|Compound:st060212|FD-Score:3.31|P-value:6.16E-4 ID:SGTC_1903|Compound:st060211|FD-Score:4.09|P-value:3.42E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.70|P-value:1.55E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.67|P-value:2.68E-6 ID:SGTC_2457|Compound:5731572|FD-Score:3.33|P-value:5.84E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.45|P-value:8.57E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.21|P-value:9.65E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.43|P-value:4.66E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.84|P-value:9.01E-5 ID:SGTC_2706|Compound:st078239|FD-Score:4.87|P-value:1.05E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.22|P-value:9.60E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.67|P-value:1.99E-4 ID:SGTC_2782|Compound:7736369|FD-Score:5.53|P-value:3.78E-8 ID:SGTC_2784|Compound:7567673|FD-Score:-4.29|P-value:1.67E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-4.23|P-value:2.16E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.58|P-value:2.70E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-3.23|P-value:9.17E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.40|P-value:4.66E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.50|P-value:3.23E-4 ID:SGTC_3012|Compound:9080433|FD-Score:4.72|P-value:2.14E-6 ID:SGTC_3108|Compound:9121785|FD-Score:-3.50|P-value:3.65E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.58|P-value:2.42E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.25|P-value:7.75E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.95|P-value:5.95E-5

Top fitness defect scores for YNL336W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_475 α-linolenic acid 5.89 10.0 µM 5.12E-9 excess fatty acid 5 1.96E-9
2 SGTC_2782 7736369 5.53 71.4 µM 3.78E-8 12 1.63E-8
3 SGTC_792 4534-1957 5.36 155.0 µM 9.00E-8 15 4.07E-8
4 SGTC_1044 1222-0021 5.29 1.8 µM 1.36E-7 heme biosynthesis & mitochondrial translocase 19 6.28E-8
5 SGTC_2706 st078239 4.87 82.5 µM 1.05E-6 1 5.45E-7
6 SGTC_3012 9080433 4.72 71.4 µM 2.14E-6 3 1.16E-6
7 SGTC_2378 9074213 4.67 121.4 µM 2.68E-6 RSC complex & mRNA processing 5 1.48E-6
8 SGTC_982 1491-0518 4.35 27.5 µM 1.15E-5 9 6.84E-6
9 SGTC_464 bw-b 70c 4.16 158.0 µM 2.56E-5 16 1.60E-5
10 SGTC_1317 1273-0028 4.11 910.0 nM 3.07E-5 azole & statin 45 1.94E-5
11 SGTC_1903 st060211 4.09 78.3 µM 3.42E-5 23 2.17E-5
12 SGTC_1850 st056238 4.04 17.0 µM 4.11E-5 RPP1 & pyrimidine depletion 17 2.64E-5
13 SGTC_3325 9138760 3.95 55.2 µM 5.95E-5 Golgi 25 3.90E-5
14 SGTC_1844 rapamycin 3.90 4.0 nM 7.36E-5 162 4.88E-5
15 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.84 70.0 µM 9.01E-5 redox potentiating 79 6.04E-5
16 SGTC_1826 st055655 3.76 41.6 µM 1.23E-4 ERG2 46 8.40E-5
17 SGTC_2185 6113692 3.70 200.0 µM 1.55E-4 ergosterol biosynthesis 21 1.07E-4
18 SGTC_972 1319-0219 3.68 195.0 µM 1.67E-4 40 1.16E-4
19 SGTC_1745 st081495 3.61 74.0 µM 2.14E-4 RNA processing & uracil transport 85 1.50E-4
20 SGTC_3165 9101544 3.58 49.5 µM 2.42E-4 17 1.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.46E-9 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.098 1.18E-8 YPR093C ASR1 hom Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein
0.093 6.31E-8 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.089 2.43E-7 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.088 3.50E-7 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.081 2.66E-6 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.17E-6 YER113C TMN3 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation
0.078 6.72E-6 YHL017W_p YHL017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication
0.077 7.08E-6 YMR129W POM152 hom Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210
0.077 7.51E-6 YAR030C_d YAR030C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
0.076 1.01E-5 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.075 1.23E-5 YNR012W URK1 hom Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP
0.074 1.68E-5 YJL216C IMA5 hom Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose
0.074 1.74E-5 YBL103C RTG3 hom Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
0.072 3.16E-5 YLR357W RSC2 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance