YNL338W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL338W / YNL338W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.54|P-value:8.09E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.25|P-value:2.81E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:2.90|P-value:9.82E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.18|P-value:3.54E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-4.17|P-value:4.61E-6 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:2.90|P-value:9.91E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-4.97|P-value:6.43E-8 ID:SGTC_749|Compound:1000-0129|FD-Score:2.95|P-value:8.21E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.07|P-value:5.27E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.97|P-value:1.14E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.07|P-value:5.60E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.01|P-value:6.81E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:2.91|P-value:9.64E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.92|P-value:9.67E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.33|P-value:1.89E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.75|P-value:3.33E-5 ID:SGTC_1603|Compound:st002045|FD-Score:3.20|P-value:3.20E-4 ID:SGTC_1607|Compound:st000305|FD-Score:5.03|P-value:4.09E-8 ID:SGTC_1702|Compound:st027038|FD-Score:-3.00|P-value:7.11E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-2.92|P-value:9.79E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.38|P-value:1.59E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.28|P-value:2.37E-4 ID:SGTC_2366|Compound:9070441|FD-Score:2.92|P-value:9.11E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.98|P-value:1.13E-5 ID:SGTC_2413|Compound:inermin|FD-Score:3.78|P-value:2.81E-5 ID:SGTC_2416|Compound:tofa|FD-Score:4.82|P-value:1.43E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:2.96|P-value:7.97E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-5.86|P-value:2.31E-10 ID:SGTC_2620|Compound:irigenin|FD-Score:3.31|P-value:2.07E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.72|P-value:2.49E-7 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:6.72|P-value:3.97E-13 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.70|P-value:4.21E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.78|P-value:2.93E-5 ID:SGTC_2814|Compound:7977482|FD-Score:-4.74|P-value:2.36E-7 ID:SGTC_3167|Compound:9103034|FD-Score:4.28|P-value:2.54E-6 ID:SGTC_3256|Compound:9138902|FD-Score:4.01|P-value:9.73E-6 ID:SGTC_3308|Compound:9128332|FD-Score:3.27|P-value:2.41E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.54|P-value:8.09E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.25|P-value:2.81E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:2.90|P-value:9.82E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.18|P-value:3.54E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-4.17|P-value:4.61E-6 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:2.90|P-value:9.91E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-4.97|P-value:6.43E-8 ID:SGTC_749|Compound:1000-0129|FD-Score:2.95|P-value:8.21E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.07|P-value:5.27E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.97|P-value:1.14E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.07|P-value:5.60E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.01|P-value:6.81E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:2.91|P-value:9.64E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.92|P-value:9.67E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.33|P-value:1.89E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.75|P-value:3.33E-5 ID:SGTC_1603|Compound:st002045|FD-Score:3.20|P-value:3.20E-4 ID:SGTC_1607|Compound:st000305|FD-Score:5.03|P-value:4.09E-8 ID:SGTC_1702|Compound:st027038|FD-Score:-3.00|P-value:7.11E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-2.92|P-value:9.79E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.38|P-value:1.59E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.28|P-value:2.37E-4 ID:SGTC_2366|Compound:9070441|FD-Score:2.92|P-value:9.11E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.98|P-value:1.13E-5 ID:SGTC_2413|Compound:inermin|FD-Score:3.78|P-value:2.81E-5 ID:SGTC_2416|Compound:tofa|FD-Score:4.82|P-value:1.43E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:2.96|P-value:7.97E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-5.86|P-value:2.31E-10 ID:SGTC_2620|Compound:irigenin|FD-Score:3.31|P-value:2.07E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.72|P-value:2.49E-7 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:6.72|P-value:3.97E-13 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.70|P-value:4.21E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.78|P-value:2.93E-5 ID:SGTC_2814|Compound:7977482|FD-Score:-4.74|P-value:2.36E-7 ID:SGTC_3167|Compound:9103034|FD-Score:4.28|P-value:2.54E-6 ID:SGTC_3256|Compound:9138902|FD-Score:4.01|P-value:9.73E-6 ID:SGTC_3308|Compound:9128332|FD-Score:3.27|P-value:2.41E-4

Top fitness defect scores for YNL338W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2633 5,7-dihydroxyisoflavone 6.72 100.0 µM 3.97E-13 4 8.79E-12
2 SGTC_1607 st000305 5.03 50.6 µM 4.09E-8 2 2.40E-7
3 SGTC_2416 tofa 4.82 880.0 nM 1.43E-7 sphingolipid biosynthesis & PDR1 31 7.26E-7
4 SGTC_2621 lithochol-11-enic acid 4.72 100.0 µM 2.49E-7 8 1.19E-6
5 SGTC_3167 9103034 4.28 49.5 µM 2.54E-6 RPP1 & pyrimidine depletion 5 9.31E-6
6 SGTC_3256 9138902 4.01 49.5 µM 9.73E-6 PDR1 1 3.06E-5
7 SGTC_2410 aloe-emodin-8-o-glycoside 3.98 46.3 µM 1.13E-5 mitochondrial processes 30 3.49E-5
8 SGTC_909 3448-9333 3.97 149.0 µM 1.14E-5 17 3.53E-5
9 SGTC_2413 inermin 3.78 26.1 µM 2.81E-5 61 7.83E-5
10 SGTC_6 0844-0013 3.54 19.8 µM 8.09E-5 135 2.00E-4
11 SGTC_2160 5660466 3.38 132.9 µM 1.59E-4 60S ribosome export 33 3.65E-4
12 SGTC_1132 3456-3614 3.33 2.5 µM 1.89E-4 tubulin folding & SWR complex 87 4.27E-4
13 SGTC_2620 irigenin 3.31 100.0 µM 2.07E-4 63 4.62E-4
14 SGTC_2283 7944793 3.28 200.0 µM 2.37E-4 75 5.21E-4
15 SGTC_3308 9128332 3.27 17.6 µM 2.41E-4 plasma membrane duress 109 5.29E-4
16 SGTC_1603 st002045 3.20 67.8 µM 3.20E-4 TSC3-RPN4 40 6.81E-4
17 SGTC_271 rotenone 3.18 740.0 µM 3.54E-4 61 7.44E-4
18 SGTC_778 3456-2434 3.07 196.0 µM 5.27E-4 mitochondrial response to ROS 130 0.00106
19 SGTC_2533 agelasine 2.96 13.7 µM 7.97E-4 ERG2 104 0.00153
20 SGTC_749 1000-0129 2.95 128.0 µM 8.21E-4 amide catabolism 68 0.00157

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 6.21E-27 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.137 1.56E-15 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.134 7.84E-15 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.124 6.68E-13 YDR233C RTN1 hom Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication
0.122 1.13E-12 YIR032C DAL3 hom Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
0.106 7.67E-10 YOL034W SMC5 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
0.105 9.19E-10 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.104 1.58E-9 YER177W BMH1 hom 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.104 1.78E-9 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.095 3.23E-8 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.093 6.41E-8 YGR177C ATF2 hom Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking
0.093 7.77E-8 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.093 7.84E-8 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.092 9.04E-8 YIL127C_p RRT14_p hom Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.092 1.01E-7 YKL123W_d YKL123W_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4