YNL339C / YRF1-6

Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL339C / YRF1-6

Click on Significant Values for Screen Details ID:SGTC_127|Compound:0180-0333|FD-Score:4.21|P-value:2.69E-6 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.11|P-value:4.21E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:2.88|P-value:8.97E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.13|P-value:3.85E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.54|P-value:6.55E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.33|P-value:1.56E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.75|P-value:2.77E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.63|P-value:4.90E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.41|P-value:9.43E-7 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.47|P-value:8.80E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:6.20|P-value:1.11E-11 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.61|P-value:5.40E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.99|P-value:6.63E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.09|P-value:4.07E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-10.50|P-value:7.82E-30 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.13|P-value:2.18E-11 ID:SGTC_1654|Compound:st012436|FD-Score:4.55|P-value:4.31E-7 ID:SGTC_1824|Compound:st053723|FD-Score:3.49|P-value:7.87E-5 ID:SGTC_1857|Compound:st056007|FD-Score:-2.95|P-value:7.72E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.69|P-value:3.24E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-4.25|P-value:2.47E-6 ID:SGTC_1911|Compound:st060208|FD-Score:-4.09|P-value:5.49E-6 ID:SGTC_2135|Compound:5326629|FD-Score:3.21|P-value:2.61E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.81|P-value:1.90E-5 ID:SGTC_2157|Compound:5649910|FD-Score:2.93|P-value:7.71E-4 ID:SGTC_2183|Compound:6420625|FD-Score:2.92|P-value:7.97E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.21|P-value:2.53E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-3.29|P-value:2.02E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.40|P-value:1.20E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.54|P-value:6.35E-5 ID:SGTC_2523|Compound:spermine|FD-Score:3.20|P-value:2.66E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.34|P-value:1.40E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.55|P-value:4.48E-7 ID:SGTC_2796|Compound:7949634|FD-Score:-3.63|P-value:4.85E-5 ID:SGTC_2803|Compound:7707263|FD-Score:2.90|P-value:8.51E-4 ID:SGTC_2831|Compound:7999036|FD-Score:2.91|P-value:8.11E-4 ID:SGTC_2870|Compound:9038528|FD-Score:5.64|P-value:5.57E-10 ID:SGTC_2919|Compound:7978188|FD-Score:3.79|P-value:2.04E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.06|P-value:4.62E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.49|P-value:6.11E-7 ID:SGTC_3207|Compound:9114163|FD-Score:4.00|P-value:7.65E-6 ID:SGTC_3208|Compound:9114115|FD-Score:4.56|P-value:4.24E-7 ID:SGTC_3295|Compound:9122362|FD-Score:-2.95|P-value:7.65E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.21|P-value:2.69E-6 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.11|P-value:4.21E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:2.88|P-value:8.97E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.13|P-value:3.85E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.54|P-value:6.55E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.33|P-value:1.56E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.75|P-value:2.77E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.63|P-value:4.90E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.41|P-value:9.43E-7 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.47|P-value:8.80E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:6.20|P-value:1.11E-11 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.61|P-value:5.40E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.99|P-value:6.63E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.09|P-value:4.07E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-10.50|P-value:7.82E-30 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.13|P-value:2.18E-11 ID:SGTC_1654|Compound:st012436|FD-Score:4.55|P-value:4.31E-7 ID:SGTC_1824|Compound:st053723|FD-Score:3.49|P-value:7.87E-5 ID:SGTC_1857|Compound:st056007|FD-Score:-2.95|P-value:7.72E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.69|P-value:3.24E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-4.25|P-value:2.47E-6 ID:SGTC_1911|Compound:st060208|FD-Score:-4.09|P-value:5.49E-6 ID:SGTC_2135|Compound:5326629|FD-Score:3.21|P-value:2.61E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.81|P-value:1.90E-5 ID:SGTC_2157|Compound:5649910|FD-Score:2.93|P-value:7.71E-4 ID:SGTC_2183|Compound:6420625|FD-Score:2.92|P-value:7.97E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.21|P-value:2.53E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-3.29|P-value:2.02E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.40|P-value:1.20E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.54|P-value:6.35E-5 ID:SGTC_2523|Compound:spermine|FD-Score:3.20|P-value:2.66E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.34|P-value:1.40E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.55|P-value:4.48E-7 ID:SGTC_2796|Compound:7949634|FD-Score:-3.63|P-value:4.85E-5 ID:SGTC_2803|Compound:7707263|FD-Score:2.90|P-value:8.51E-4 ID:SGTC_2831|Compound:7999036|FD-Score:2.91|P-value:8.11E-4 ID:SGTC_2870|Compound:9038528|FD-Score:5.64|P-value:5.57E-10 ID:SGTC_2919|Compound:7978188|FD-Score:3.79|P-value:2.04E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.06|P-value:4.62E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.49|P-value:6.11E-7 ID:SGTC_3207|Compound:9114163|FD-Score:4.00|P-value:7.65E-6 ID:SGTC_3208|Compound:9114115|FD-Score:4.56|P-value:4.24E-7 ID:SGTC_3295|Compound:9122362|FD-Score:-2.95|P-value:7.65E-4

Top fitness defect scores for YNL339C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1176 0848-0131 6.20 83.3 µM 1.11E-11 Golgi 1 2.91E-10
2 SGTC_2870 9038528 5.64 13.0 µM 5.57E-10 2 8.47E-9
3 SGTC_3208 9114115 4.56 49.5 µM 4.24E-7 24 2.60E-6
4 SGTC_1654 st012436 4.55 41.8 µM 4.31E-7 11 2.64E-6
5 SGTC_2791 5663188 4.55 71.4 µM 4.48E-7 RPP1 & pyrimidine depletion 11 2.73E-6
6 SGTC_3202 9113761 4.49 49.5 µM 6.11E-7 28 3.56E-6
7 SGTC_1166 k206-0078 4.41 225.0 µM 9.43E-7 13 5.19E-6
8 SGTC_2790 5423970 4.34 71.4 µM 1.40E-6 endomembrane recycling 54 7.29E-6
9 SGTC_127 0180-0333 4.21 59.1 µM 2.69E-6 mitochondrial response to ROS 33 1.28E-5
10 SGTC_3207 9114163 4.00 49.5 µM 7.65E-6 29 3.16E-5
11 SGTC_2151 5563267 3.81 85.4 µM 1.90E-5 25 6.95E-5
12 SGTC_2919 7978188 3.79 46.4 µM 2.04E-5 26 7.39E-5
13 SGTC_1908 st060353 3.69 56.5 µM 3.24E-5 RPP1 & pyrimidine depletion 45 1.10E-4
14 SGTC_2434 5670830 3.54 169.9 µM 6.35E-5 39 1.97E-4
15 SGTC_360 0957-0399 3.54 1.0 µM 6.55E-5 cell wall 60 2.03E-4
16 SGTC_1824 st053723 3.49 68.6 µM 7.87E-5 49 2.38E-4
17 SGTC_1167 k781-0610 3.47 148.0 µM 8.80E-5 RNA processing & uracil transport 43 2.62E-4
18 SGTC_2420 aureobasidin a 3.40 50.0 nM 1.20E-4 66 3.42E-4
19 SGTC_884 0851-0618 3.33 334.0 µM 1.56E-4 37 4.29E-4
20 SGTC_2239 6685329 3.21 187.6 µM 2.53E-4 66 6.53E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.321 2.36E-81 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.320 5.83E-81 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.306 2.60E-73 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.294 1.40E-67 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.292 1.34E-66 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.287 8.29E-65 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.281 7.91E-62 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.279 4.60E-61 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.266 1.60E-55 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.257 1.31E-51 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.252 9.27E-50 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.246 2.72E-47 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.244 1.09E-46 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.244 1.55E-46 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.234 1.06E-42 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C