HIPHOP chemogenomics database
YNR004W_p / SWM2 
Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YNR004W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.114 | 4.03E-11 | YGR070W | ROM1 | hom | GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP |
| 0.113 | 6.24E-11 | YIL032C_d | YIL032C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.111 | 1.18E-10 | YKL022C | CDC16 | het | Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation |
| 0.104 | 1.54E-9 | YEL064C | AVT2 | hom | Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters |
| 0.093 | 6.82E-8 | YDR406W | PDR15 | hom | Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element |
| 0.089 | 2.32E-7 | YDR439W | LRS4 | hom | Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation |
| 0.089 | 2.74E-7 | YPL262W | FUM1 | hom | Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria |
| 0.083 | 1.39E-6 | YJL172W | CPS1 | hom | Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions |
| 0.080 | 3.11E-6 | YNL085W | MKT1 | hom | Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress |
| 0.080 | 3.44E-6 | YGR160W_d | YGR160W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.079 | 4.44E-6 | YPR131C | NAT3 | hom | Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met |
| 0.079 | 4.77E-6 | YER016W | BIM1 | hom | Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally |
| 0.077 | 7.96E-6 | YDR281C | PHM6 | hom | Protein of unknown function, expression is regulated by phosphate levels |
| 0.077 | 8.26E-6 | YHL002W | HSE1 | hom | Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes |
| 0.076 | 9.21E-6 | YDR140W | MTQ2 | hom | S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC |