YNR004W_p / SWM2

Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR004W / SWM2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.70|P-value:1.11E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.21|P-value:5.69E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.45|P-value:2.36E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.62|P-value:1.24E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:8.26|P-value:3.98E-17 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.30|P-value:4.99E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.32|P-value:4.71E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.82|P-value:5.44E-7 ID:SGTC_247|Compound:mechlorethamine|FD-Score:4.24|P-value:8.73E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:3.63|P-value:1.20E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.32|P-value:4.73E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.71|P-value:8.57E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.58|P-value:1.42E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.88|P-value:4.21E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.59|P-value:1.39E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.27|P-value:5.04E-8 ID:SGTC_1136|Compound:pergolide|FD-Score:5.10|P-value:1.28E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.06|P-value:9.41E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:-3.42|P-value:3.25E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.34|P-value:3.53E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.84|P-value:5.08E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:-3.48|P-value:2.61E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.44|P-value:2.47E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-3.76|P-value:8.78E-5 ID:SGTC_1676|Compound:st018489|FD-Score:4.55|P-value:2.05E-6 ID:SGTC_1746|Compound:st038117|FD-Score:3.31|P-value:4.00E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.31|P-value:4.00E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.95|P-value:3.13E-5 ID:SGTC_2085|Compound:5307070|FD-Score:-4.25|P-value:1.11E-5 ID:SGTC_2097|Compound:5376186|FD-Score:3.14|P-value:7.30E-4 ID:SGTC_2108|Compound:5365811|FD-Score:-3.27|P-value:5.53E-4 ID:SGTC_2159|Compound:5658611|FD-Score:4.24|P-value:8.71E-6 ID:SGTC_2170|Compound:morpholine|FD-Score:5.65|P-value:5.58E-9 ID:SGTC_2174|Compound:5790901|FD-Score:-5.23|P-value:8.33E-8 ID:SGTC_2177|Compound:5811945|FD-Score:3.23|P-value:5.34E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.06|P-value:9.52E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.82|P-value:5.39E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.17|P-value:6.54E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.62|P-value:1.20E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.07|P-value:9.14E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.31|P-value:4.74E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.22|P-value:6.63E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.13|P-value:7.39E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.99|P-value:2.64E-5 ID:SGTC_2881|Compound:9058953|FD-Score:-3.23|P-value:6.36E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.25|P-value:4.89E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.23|P-value:6.30E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.61|P-value:1.25E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.48|P-value:2.10E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.77|P-value:8.47E-5 ID:SGTC_3255|Compound:9139072|FD-Score:3.27|P-value:4.61E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.70|P-value:1.11E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.21|P-value:5.69E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.45|P-value:2.36E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.62|P-value:1.24E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:8.26|P-value:3.98E-17 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.30|P-value:4.99E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.32|P-value:4.71E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.82|P-value:5.44E-7 ID:SGTC_247|Compound:mechlorethamine|FD-Score:4.24|P-value:8.73E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:3.63|P-value:1.20E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.32|P-value:4.73E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.71|P-value:8.57E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.58|P-value:1.42E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.88|P-value:4.21E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.59|P-value:1.39E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.27|P-value:5.04E-8 ID:SGTC_1136|Compound:pergolide|FD-Score:5.10|P-value:1.28E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.06|P-value:9.41E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:-3.42|P-value:3.25E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.34|P-value:3.53E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.84|P-value:5.08E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:-3.48|P-value:2.61E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.44|P-value:2.47E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-3.76|P-value:8.78E-5 ID:SGTC_1676|Compound:st018489|FD-Score:4.55|P-value:2.05E-6 ID:SGTC_1746|Compound:st038117|FD-Score:3.31|P-value:4.00E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.31|P-value:4.00E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.95|P-value:3.13E-5 ID:SGTC_2085|Compound:5307070|FD-Score:-4.25|P-value:1.11E-5 ID:SGTC_2097|Compound:5376186|FD-Score:3.14|P-value:7.30E-4 ID:SGTC_2108|Compound:5365811|FD-Score:-3.27|P-value:5.53E-4 ID:SGTC_2159|Compound:5658611|FD-Score:4.24|P-value:8.71E-6 ID:SGTC_2170|Compound:morpholine|FD-Score:5.65|P-value:5.58E-9 ID:SGTC_2174|Compound:5790901|FD-Score:-5.23|P-value:8.33E-8 ID:SGTC_2177|Compound:5811945|FD-Score:3.23|P-value:5.34E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.06|P-value:9.52E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.82|P-value:5.39E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.17|P-value:6.54E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.62|P-value:1.20E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.07|P-value:9.14E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.31|P-value:4.74E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.22|P-value:6.63E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.13|P-value:7.39E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.99|P-value:2.64E-5 ID:SGTC_2881|Compound:9058953|FD-Score:-3.23|P-value:6.36E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.25|P-value:4.89E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.23|P-value:6.30E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.61|P-value:1.25E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.48|P-value:2.10E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.77|P-value:8.47E-5 ID:SGTC_3255|Compound:9139072|FD-Score:3.27|P-value:4.61E-4

Top fitness defect scores for YNR004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_131 0141-0277 8.26 33.9 µM 3.98E-17 2 7.42E-17
2 SGTC_2170 morpholine 5.65 200.0 µM 5.58E-9 2 7.90E-9
3 SGTC_1122 capsaicin 5.27 818.6 nM 5.04E-8 10 6.89E-8
4 SGTC_1136 pergolide 5.10 1.1 µM 1.28E-7 12 1.73E-7
5 SGTC_219 mitoxanthrone 4.82 164.4 µM 5.44E-7 DNA intercalators 30 7.17E-7
6 SGTC_1676 st018489 4.55 23.4 µM 2.05E-6 60S ribosome export 18 2.64E-6
7 SGTC_2159 5658611 4.24 73.8 µM 8.71E-6 6 1.10E-5
8 SGTC_247 mechlorethamine 4.24 29.7 µM 8.73E-6 DNA damage response 10 1.10E-5
9 SGTC_2864 9034755 3.99 47.6 µM 2.64E-5 7 3.27E-5
10 SGTC_2084 5306078 3.95 60.6 µM 3.13E-5 20 3.86E-5
11 SGTC_707 0865-0008 3.88 204.0 µM 4.21E-5 DNA damage response 7 5.17E-5
12 SGTC_1467 k284-1082 3.84 293.0 µM 5.08E-5 19 6.22E-5
13 SGTC_2272 7805186 3.82 180.0 µM 5.39E-5 cell wall signaling 22 6.58E-5
14 SGTC_385 1494-0393 3.71 12.4 µM 8.57E-5 31 1.04E-4
15 SGTC_258 haloperidol 3.63 50.8 µM 1.20E-4 fatty acid desaturase (OLE1) 41 1.44E-4
16 SGTC_2480 5767542 3.62 37.2 µM 1.20E-4 16 1.45E-4
17 SGTC_130 0136-0219 3.62 337.7 µM 1.24E-4 30 1.50E-4
18 SGTC_3085 9117376 3.61 49.5 µM 1.25E-4 20 1.51E-4
19 SGTC_962 1254-0300 3.59 21.5 µM 1.39E-4 34 1.67E-4
20 SGTC_625 k213-0058 3.58 121.0 µM 1.42E-4 translation 137 1.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 4.03E-11 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.113 6.24E-11 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.111 1.18E-10 YKL022C CDC16 het Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
0.104 1.54E-9 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.093 6.82E-8 YDR406W PDR15 hom Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
0.089 2.32E-7 YDR439W LRS4 hom Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.089 2.74E-7 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.083 1.39E-6 YJL172W CPS1 hom Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
0.080 3.11E-6 YNL085W MKT1 hom Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress
0.080 3.44E-6 YGR160W_d YGR160W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.44E-6 YPR131C NAT3 hom Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met
0.079 4.77E-6 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.077 7.96E-6 YDR281C PHM6 hom Protein of unknown function, expression is regulated by phosphate levels
0.077 8.26E-6 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.076 9.21E-6 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC