YNR005C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR005C / YNR005C

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:4.70|P-value:1.41E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.38|P-value:4.29E-11 ID:SGTC_73|Compound:0327-0325|FD-Score:4.33|P-value:5.74E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:5.51|P-value:4.74E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:3.63|P-value:5.93E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.70|P-value:4.76E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.33|P-value:5.82E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.25|P-value:9.08E-11 ID:SGTC_525|Compound:k781-2675|FD-Score:5.02|P-value:3.95E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:4.27|P-value:7.20E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:4.16|P-value:1.04E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.22|P-value:8.43E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.88|P-value:2.69E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.97|P-value:1.99E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.95|P-value:2.11E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:5.30|P-value:1.19E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.03|P-value:1.64E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.18|P-value:1.22E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.55|P-value:9.51E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.72|P-value:4.55E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.57|P-value:7.13E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.12|P-value:1.22E-4 ID:SGTC_1605|Compound:st000082|FD-Score:4.28|P-value:6.77E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.63|P-value:6.08E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.28|P-value:1.31E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.51|P-value:4.83E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.90|P-value:1.45E-15 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.76|P-value:1.13E-5 ID:SGTC_2005|Compound:4024620|FD-Score:5.21|P-value:1.79E-6 ID:SGTC_2012|Compound:4023501|FD-Score:3.72|P-value:4.57E-4 ID:SGTC_2148|Compound:5546263|FD-Score:4.05|P-value:1.55E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.54|P-value:7.90E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.11|P-value:1.23E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.70|P-value:8.25E-22 ID:SGTC_2584|Compound:androsterone|FD-Score:4.44|P-value:3.85E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.59|P-value:6.72E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.97|P-value:5.58E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.51|P-value:8.67E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-4.30|P-value:8.12E-5 ID:SGTC_2922|Compound:7999257|FD-Score:3.70|P-value:4.79E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.68|P-value:5.10E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-4.09|P-value:1.68E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-4.13|P-value:1.46E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.88|P-value:2.65E-4 ID:SGTC_3175|Compound:9106517|FD-Score:4.37|P-value:4.87E-5 ID:SGTC_3293|Compound:9120939|FD-Score:-3.98|P-value:2.44E-4 ID:SGTC_3297|Compound:9117502|FD-Score:-3.81|P-value:4.24E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:4.70|P-value:1.41E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.38|P-value:4.29E-11 ID:SGTC_73|Compound:0327-0325|FD-Score:4.33|P-value:5.74E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:5.51|P-value:4.74E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:3.63|P-value:5.93E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.70|P-value:4.76E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.33|P-value:5.82E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.25|P-value:9.08E-11 ID:SGTC_525|Compound:k781-2675|FD-Score:5.02|P-value:3.95E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:4.27|P-value:7.20E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:4.16|P-value:1.04E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.22|P-value:8.43E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.88|P-value:2.69E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.97|P-value:1.99E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.95|P-value:2.11E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:5.30|P-value:1.19E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.03|P-value:1.64E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.18|P-value:1.22E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.55|P-value:9.51E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.72|P-value:4.55E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.57|P-value:7.13E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.12|P-value:1.22E-4 ID:SGTC_1605|Compound:st000082|FD-Score:4.28|P-value:6.77E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.63|P-value:6.08E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.28|P-value:1.31E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.51|P-value:4.83E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.90|P-value:1.45E-15 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.76|P-value:1.13E-5 ID:SGTC_2005|Compound:4024620|FD-Score:5.21|P-value:1.79E-6 ID:SGTC_2012|Compound:4023501|FD-Score:3.72|P-value:4.57E-4 ID:SGTC_2148|Compound:5546263|FD-Score:4.05|P-value:1.55E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.54|P-value:7.90E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.11|P-value:1.23E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.70|P-value:8.25E-22 ID:SGTC_2584|Compound:androsterone|FD-Score:4.44|P-value:3.85E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.59|P-value:6.72E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.97|P-value:5.58E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.51|P-value:8.67E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-4.30|P-value:8.12E-5 ID:SGTC_2922|Compound:7999257|FD-Score:3.70|P-value:4.79E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.68|P-value:5.10E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-4.09|P-value:1.68E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-4.13|P-value:1.46E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.88|P-value:2.65E-4 ID:SGTC_3175|Compound:9106517|FD-Score:4.37|P-value:4.87E-5 ID:SGTC_3293|Compound:9120939|FD-Score:-3.98|P-value:2.44E-4 ID:SGTC_3297|Compound:9117502|FD-Score:-3.81|P-value:4.24E-4

Top fitness defect scores for YNR005C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 10.70 100.0 µM 8.25E-22 redox potentiating 52 3.27E-27
2 SGTC_1844 rapamycin 8.90 4.0 nM 1.45E-15 46 2.86E-19
3 SGTC_2679 rapamycin 5.97 1.0 nM 5.58E-8 77 1.19E-9
4 SGTC_227 fluconazole 5.51 33.5 µM 4.74E-7 azole & statin 47 1.78E-8
5 SGTC_1680 diphenhydramine 5.51 100.0 µM 4.83E-7 NEO1 8 1.83E-8
6 SGTC_1071 trifluoperazine 5.30 6.3 µM 1.19E-6 12 5.68E-8
7 SGTC_1658 st012944 5.28 20.0 µM 1.31E-6 iron homeostasis 41 6.41E-8
8 SGTC_2005 4024620 5.21 188.0 µM 1.79E-6 5 9.55E-8
9 SGTC_525 k781-2675 5.02 26.7 µM 3.95E-6 redox potentiating 32 2.59E-7
10 SGTC_1873 rapamycin 4.76 2.0 nM 1.13E-5 53 9.72E-7
11 SGTC_50 0929-0078 4.70 56.4 µM 1.41E-5 34 1.29E-6
12 SGTC_2584 androsterone 4.44 48.7 µM 3.85E-5 cell wall 96 4.54E-6
13 SGTC_3175 9106517 4.37 49.5 µM 4.87E-5 iron homeostasis 13 6.10E-6
14 SGTC_73 0327-0325 4.33 16.2 µM 5.74E-5 DNA damage response 37 7.50E-6
15 SGTC_358 0075-0058 4.33 9.4 µM 5.82E-5 49 7.62E-6
16 SGTC_1605 st000082 4.28 49.1 µM 6.77E-5 60S ribosome export 9 9.22E-6
17 SGTC_754 3474-0146 4.27 171.0 µM 7.20E-5 copper-dependent oxidative stress 19 9.97E-6
18 SGTC_919 tnp00227 4.22 403.6 nM 8.43E-5 RNA pol III & RNase P/MRP 26 1.21E-5
19 SGTC_817 1391-0715 4.16 46.0 µM 1.04E-4 14 1.57E-5
20 SGTC_1495 4469-0029 4.12 237.0 µM 1.22E-4 102 1.94E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.277 3.24E-60 YKR035W-A DID2 hom Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors
0.244 1.16E-46 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.235 2.05E-43 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.232 2.63E-42 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.231 6.40E-42 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.226 3.83E-40 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.223 8.18E-39 YNR006W VPS27 hom Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.221 2.02E-38 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.215 2.34E-36 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.211 5.30E-35 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.208 3.21E-34 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.207 9.26E-34 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.206 2.41E-33 YKR035C_d OPI8_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A
0.200 1.01E-31 YDL172C_d YDL172C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.197 9.31E-31 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype