YNR007C / ATG3

E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR007C / ATG3

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.61|P-value:1.13E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.07|P-value:8.86E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:11.30|P-value:1.16E-31 ID:SGTC_70|Compound:0141-0289|FD-Score:4.08|P-value:1.53E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.67|P-value:8.79E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.47|P-value:2.40E-6 ID:SGTC_79|Compound:0052-0007|FD-Score:3.08|P-value:8.56E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.34|P-value:4.51E-6 ID:SGTC_95|Compound:0471-0001|FD-Score:4.34|P-value:4.52E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.35|P-value:3.04E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:4.01|P-value:2.06E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:5.64|P-value:3.79E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:4.88|P-value:2.86E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:7.76|P-value:8.42E-16 ID:SGTC_307|Compound:1501-1223|FD-Score:3.55|P-value:1.43E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-5.10|P-value:5.72E-8 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.24|P-value:7.21E-6 ID:SGTC_468|Compound:gf-109203x|FD-Score:4.24|P-value:7.37E-6 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:6.17|P-value:1.24E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:4.93|P-value:2.29E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:6.18|P-value:1.15E-10 ID:SGTC_564|Compound:3555-0129|FD-Score:-3.26|P-value:3.38E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.92|P-value:3.04E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:5.70|P-value:2.56E-9 ID:SGTC_598|Compound:3937-0236|FD-Score:3.25|P-value:4.65E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.35|P-value:3.16E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:4.54|P-value:1.74E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:3.36|P-value:3.06E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:5.25|P-value:3.85E-8 ID:SGTC_774|Compound:k060-0086|FD-Score:3.56|P-value:1.38E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:5.51|P-value:8.03E-9 ID:SGTC_789|Compound:1309-1135|FD-Score:5.16|P-value:6.48E-8 ID:SGTC_818|Compound:4072-2707|FD-Score:4.02|P-value:1.97E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:3.17|P-value:6.06E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.04|P-value:9.71E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.49|P-value:1.86E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.47|P-value:1.46E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.95|P-value:2.77E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.74|P-value:6.17E-7 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.67|P-value:8.78E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.17|P-value:4.66E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.25|P-value:7.09E-6 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.20|P-value:5.57E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.06|P-value:9.17E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.42|P-value:2.41E-4 ID:SGTC_1554|Compound:st069299|FD-Score:5.64|P-value:3.69E-9 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.39|P-value:2.05E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.05|P-value:7.34E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.39|P-value:2.69E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.40|P-value:2.58E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.07|P-value:8.87E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.50|P-value:8.89E-9 ID:SGTC_1749|Compound:st037932|FD-Score:3.69|P-value:8.15E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.04|P-value:7.53E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.17|P-value:4.62E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.09|P-value:8.31E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.21|P-value:5.23E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.27|P-value:4.31E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.25|P-value:3.52E-4 ID:SGTC_1941|Compound:st076221|FD-Score:8.06|P-value:6.46E-17 ID:SGTC_1942|Compound:st076330|FD-Score:-3.58|P-value:9.58E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.79|P-value:5.52E-5 ID:SGTC_2011|Compound:4012611|FD-Score:-3.87|P-value:2.78E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-4.39|P-value:2.46E-6 ID:SGTC_2060|Compound:5238662|FD-Score:3.94|P-value:2.89E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.38|P-value:2.82E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.16|P-value:4.86E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.13|P-value:6.98E-4 ID:SGTC_2367|Compound:9070478|FD-Score:6.93|P-value:5.76E-13 ID:SGTC_2424|Compound:5537928|FD-Score:3.08|P-value:8.36E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.89|P-value:3.47E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.24|P-value:7.34E-6 ID:SGTC_2816|Compound:7982706|FD-Score:-3.54|P-value:1.13E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-4.21|P-value:5.98E-6 ID:SGTC_2942|Compound:9052777|FD-Score:5.05|P-value:1.14E-7 ID:SGTC_2963|Compound:9082507|FD-Score:3.68|P-value:8.74E-5 ID:SGTC_3049|Compound:9092223|FD-Score:4.29|P-value:5.79E-6 ID:SGTC_3087|Compound:9117406|FD-Score:4.07|P-value:1.58E-5 ID:SGTC_3180|Compound:9109287|FD-Score:4.12|P-value:1.27E-5 ID:SGTC_3285|Compound:9112818|FD-Score:5.34|P-value:2.19E-8 ID:SGTC_3288|Compound:9119690|FD-Score:3.75|P-value:6.31E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.01|P-value:2.04E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:3.61|P-value:1.13E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.07|P-value:8.86E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:11.30|P-value:1.16E-31 ID:SGTC_70|Compound:0141-0289|FD-Score:4.08|P-value:1.53E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.67|P-value:8.79E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.47|P-value:2.40E-6 ID:SGTC_79|Compound:0052-0007|FD-Score:3.08|P-value:8.56E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.34|P-value:4.51E-6 ID:SGTC_95|Compound:0471-0001|FD-Score:4.34|P-value:4.52E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.35|P-value:3.04E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:4.01|P-value:2.06E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:5.64|P-value:3.79E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:4.88|P-value:2.86E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:7.76|P-value:8.42E-16 ID:SGTC_307|Compound:1501-1223|FD-Score:3.55|P-value:1.43E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-5.10|P-value:5.72E-8 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.24|P-value:7.21E-6 ID:SGTC_468|Compound:gf-109203x|FD-Score:4.24|P-value:7.37E-6 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:6.17|P-value:1.24E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:4.93|P-value:2.29E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:6.18|P-value:1.15E-10 ID:SGTC_564|Compound:3555-0129|FD-Score:-3.26|P-value:3.38E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.92|P-value:3.04E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:5.70|P-value:2.56E-9 ID:SGTC_598|Compound:3937-0236|FD-Score:3.25|P-value:4.65E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.35|P-value:3.16E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:4.54|P-value:1.74E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:3.36|P-value:3.06E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:5.25|P-value:3.85E-8 ID:SGTC_774|Compound:k060-0086|FD-Score:3.56|P-value:1.38E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:5.51|P-value:8.03E-9 ID:SGTC_789|Compound:1309-1135|FD-Score:5.16|P-value:6.48E-8 ID:SGTC_818|Compound:4072-2707|FD-Score:4.02|P-value:1.97E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:3.17|P-value:6.06E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.04|P-value:9.71E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.49|P-value:1.86E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.47|P-value:1.46E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.95|P-value:2.77E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.74|P-value:6.17E-7 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.67|P-value:8.78E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.17|P-value:4.66E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.25|P-value:7.09E-6 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.20|P-value:5.57E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.06|P-value:9.17E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.42|P-value:2.41E-4 ID:SGTC_1554|Compound:st069299|FD-Score:5.64|P-value:3.69E-9 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.39|P-value:2.05E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.05|P-value:7.34E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.39|P-value:2.69E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.40|P-value:2.58E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.07|P-value:8.87E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.50|P-value:8.89E-9 ID:SGTC_1749|Compound:st037932|FD-Score:3.69|P-value:8.15E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.04|P-value:7.53E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.17|P-value:4.62E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.09|P-value:8.31E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.21|P-value:5.23E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.27|P-value:4.31E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.25|P-value:3.52E-4 ID:SGTC_1941|Compound:st076221|FD-Score:8.06|P-value:6.46E-17 ID:SGTC_1942|Compound:st076330|FD-Score:-3.58|P-value:9.58E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.79|P-value:5.52E-5 ID:SGTC_2011|Compound:4012611|FD-Score:-3.87|P-value:2.78E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-4.39|P-value:2.46E-6 ID:SGTC_2060|Compound:5238662|FD-Score:3.94|P-value:2.89E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.38|P-value:2.82E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.16|P-value:4.86E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.13|P-value:6.98E-4 ID:SGTC_2367|Compound:9070478|FD-Score:6.93|P-value:5.76E-13 ID:SGTC_2424|Compound:5537928|FD-Score:3.08|P-value:8.36E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.89|P-value:3.47E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.24|P-value:7.34E-6 ID:SGTC_2816|Compound:7982706|FD-Score:-3.54|P-value:1.13E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-4.21|P-value:5.98E-6 ID:SGTC_2942|Compound:9052777|FD-Score:5.05|P-value:1.14E-7 ID:SGTC_2963|Compound:9082507|FD-Score:3.68|P-value:8.74E-5 ID:SGTC_3049|Compound:9092223|FD-Score:4.29|P-value:5.79E-6 ID:SGTC_3087|Compound:9117406|FD-Score:4.07|P-value:1.58E-5 ID:SGTC_3180|Compound:9109287|FD-Score:4.12|P-value:1.27E-5 ID:SGTC_3285|Compound:9112818|FD-Score:5.34|P-value:2.19E-8 ID:SGTC_3288|Compound:9119690|FD-Score:3.75|P-value:6.31E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.01|P-value:2.04E-5

Top fitness defect scores for YNR007C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 11.30 9.0 µM 1.16E-31 cell wall 61 4.68E-30
2 SGTC_1941 st076221 8.06 61.8 µM 6.46E-17 sphingolipid biosynthesis & PDR1 20 3.86E-16
3 SGTC_304 1310-0298 7.76 97.0 µM 8.42E-16 cell wall 7 4.37E-15
4 SGTC_2367 9070478 6.93 135.4 µM 5.76E-13 cell wall 4 2.09E-12
5 SGTC_528 3492-0019 6.18 172.0 µM 1.15E-10 calcium & mitochondrial duress 116 3.14E-10
6 SGTC_479 n-linoleoylglycine 6.17 10.0 µM 1.24E-10 1 3.37E-10
7 SGTC_582 0987-0078 5.70 156.0 µM 2.56E-9 calcium & mitochondrial duress 26 5.93E-9
8 SGTC_1554 st069299 5.64 38.7 µM 3.69E-9 3 8.39E-9
9 SGTC_188 3229-0966 5.64 278.5 µM 3.79E-9 11 8.61E-9
10 SGTC_785 1270-0111 5.51 65.3 µM 8.03E-9 3 1.75E-8
11 SGTC_1745 st081495 5.50 74.0 µM 8.89E-9 RNA processing & uracil transport 33 1.93E-8
12 SGTC_3285 9112818 5.34 20.9 µM 2.19E-8 cell wall 12 4.52E-8
13 SGTC_743 1275-0778 5.25 158.0 µM 3.85E-8 excess fatty acid 16 7.73E-8
14 SGTC_789 1309-1135 5.16 70.6 µM 6.48E-8 ERG2 11 1.27E-7
15 SGTC_2942 9052777 5.05 62.2 µM 1.14E-7 10 2.16E-7
16 SGTC_514 4466-0038 4.93 2.6 nM 2.29E-7 cell wall 111 4.20E-7
17 SGTC_268 camptothecin 4.88 39.6 µM 2.86E-7 DNA damage response 50 5.18E-7
18 SGTC_1179 1021-1431 4.74 9.3 µM 6.17E-7 24 1.07E-6
19 SGTC_624 k048-0052 4.54 28.0 µM 1.74E-6 Golgi 9 2.88E-6
20 SGTC_77 0828-0286 4.47 12.5 µM 2.40E-6 TSC3-RPN4 22 3.91E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.344 6.68E-94 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.333 6.69E-88 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.282 3.24E-62 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.265 3.15E-55 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.259 2.35E-52 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.247 8.36E-48 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.244 1.21E-46 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.236 1.13E-43 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.231 7.34E-42 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.225 8.76E-40 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.223 3.33E-39 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.221 1.85E-38 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.220 6.25E-38 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.218 2.25E-37 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.216 8.20E-37 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2