YNR008W / LRO1

Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR008W / LRO1

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.67|P-value:1.11E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.79|P-value:7.02E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.35|P-value:3.88E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:47.30|P-value:0 ID:SGTC_53|Compound:0973-0023|FD-Score:5.99|P-value:7.89E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.13|P-value:7.33E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:7.35|P-value:6.59E-14 ID:SGTC_86|Compound:0417-1630|FD-Score:4.37|P-value:5.50E-6 ID:SGTC_96|Compound:0929-0093|FD-Score:9.20|P-value:9.19E-21 ID:SGTC_115|Compound:0527-0192|FD-Score:18.80|P-value:2.69E-80 ID:SGTC_143|Compound:4032-1194|FD-Score:21.50|P-value:2.14E-104 ID:SGTC_150|Compound:3970-0969|FD-Score:3.27|P-value:5.05E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:4.70|P-value:1.10E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:3.82|P-value:6.09E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:8.30|P-value:2.96E-17 ID:SGTC_198|Compound:3454-2873|FD-Score:3.34|P-value:3.94E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:5.08|P-value:1.56E-7 ID:SGTC_284|Compound:0988-0104|FD-Score:4.31|P-value:7.17E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:9.47|P-value:6.36E-22 ID:SGTC_350|Compound:k064-0020|FD-Score:23.30|P-value:1.45E-122 ID:SGTC_352|Compound:k048-0007|FD-Score:16.10|P-value:7.95E-60 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:25.10|P-value:1.26E-141 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:29.30|P-value:2.06E-192 ID:SGTC_508|Compound:roscovitine|FD-Score:3.23|P-value:5.81E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.85|P-value:5.33E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:5.48|P-value:1.75E-8 ID:SGTC_628|Compound:1636-0253|FD-Score:19.50|P-value:9.40E-87 ID:SGTC_653|Compound:0203-0016|FD-Score:3.61|P-value:1.42E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:7.43|P-value:3.62E-14 ID:SGTC_710|Compound:3448-4187|FD-Score:4.40|P-value:4.81E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:29.00|P-value:2.36E-188 ID:SGTC_759|Compound:3486-0358|FD-Score:5.17|P-value:9.65E-8 ID:SGTC_769|Compound:0302-0231|FD-Score:8.54|P-value:3.56E-18 ID:SGTC_804|Compound:1595-0054|FD-Score:6.09|P-value:4.24E-10 ID:SGTC_823|Compound:0417-1665|FD-Score:4.08|P-value:2.08E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:20.70|P-value:8.58E-97 ID:SGTC_922|Compound:1866-0035|FD-Score:21.40|P-value:5.53E-104 ID:SGTC_979|Compound:1426-2828|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.32|P-value:3.70E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.62|P-value:1.63E-6 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.52|P-value:1.99E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.81|P-value:6.38E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.55|P-value:2.38E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:-6.58|P-value:1.36E-11 ID:SGTC_1163|Compound:k060-0048|FD-Score:5.70|P-value:4.83E-9 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.43|P-value:2.85E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.39|P-value:2.90E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.10|P-value:9.36E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:5.65|P-value:6.46E-9 ID:SGTC_1511|Compound:0906-3109|FD-Score:45.60|P-value:0 ID:SGTC_1619|Compound:st003326|FD-Score:3.56|P-value:1.73E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-4.05|P-value:1.98E-5 ID:SGTC_1815|Compound:st051655|FD-Score:4.05|P-value:2.31E-5 ID:SGTC_1820|Compound:st053765|FD-Score:3.45|P-value:2.60E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.81|P-value:6.45E-5 ID:SGTC_1941|Compound:st076221|FD-Score:14.30|P-value:1.00E-47 ID:SGTC_1953|Compound:st076800|FD-Score:4.74|P-value:9.29E-7 ID:SGTC_2067|Compound:5224629|FD-Score:3.62|P-value:1.38E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.96|P-value:2.86E-5 ID:SGTC_2071|Compound:5230951|FD-Score:-3.98|P-value:2.66E-5 ID:SGTC_2086|Compound:5274770|FD-Score:3.12|P-value:8.63E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-3.31|P-value:3.89E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.52|P-value:2.05E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.51|P-value:2.10E-4 ID:SGTC_2393|Compound:9031399|FD-Score:4.10|P-value:1.87E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.23|P-value:5.91E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.86|P-value:1.77E-9 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.96|P-value:3.38E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.12|P-value:8.63E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.30|P-value:4.62E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.33|P-value:9.15E-11 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.02|P-value:2.66E-5 ID:SGTC_2840|Compound:9008771|FD-Score:-3.17|P-value:6.41E-4 ID:SGTC_2858|Compound:9025781|FD-Score:21.80|P-value:1.17E-107 ID:SGTC_2956|Compound:9076196|FD-Score:3.81|P-value:6.28E-5 ID:SGTC_2962|Compound:9082311|FD-Score:4.72|P-value:1.01E-6 ID:SGTC_3022|Compound:9087993|FD-Score:4.33|P-value:6.52E-6 ID:SGTC_3211|Compound:9128781|FD-Score:7.95|P-value:5.66E-16 ID:SGTC_3307|Compound:9126885|FD-Score:-3.12|P-value:7.63E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.67|P-value:1.11E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.79|P-value:7.02E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.35|P-value:3.88E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:47.30|P-value:0 ID:SGTC_53|Compound:0973-0023|FD-Score:5.99|P-value:7.89E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.13|P-value:7.33E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:7.35|P-value:6.59E-14 ID:SGTC_86|Compound:0417-1630|FD-Score:4.37|P-value:5.50E-6 ID:SGTC_96|Compound:0929-0093|FD-Score:9.20|P-value:9.19E-21 ID:SGTC_115|Compound:0527-0192|FD-Score:18.80|P-value:2.69E-80 ID:SGTC_143|Compound:4032-1194|FD-Score:21.50|P-value:2.14E-104 ID:SGTC_150|Compound:3970-0969|FD-Score:3.27|P-value:5.05E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:4.70|P-value:1.10E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:3.82|P-value:6.09E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:8.30|P-value:2.96E-17 ID:SGTC_198|Compound:3454-2873|FD-Score:3.34|P-value:3.94E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:5.08|P-value:1.56E-7 ID:SGTC_284|Compound:0988-0104|FD-Score:4.31|P-value:7.17E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:9.47|P-value:6.36E-22 ID:SGTC_350|Compound:k064-0020|FD-Score:23.30|P-value:1.45E-122 ID:SGTC_352|Compound:k048-0007|FD-Score:16.10|P-value:7.95E-60 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:25.10|P-value:1.26E-141 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:29.30|P-value:2.06E-192 ID:SGTC_508|Compound:roscovitine|FD-Score:3.23|P-value:5.81E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.85|P-value:5.33E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:5.48|P-value:1.75E-8 ID:SGTC_628|Compound:1636-0253|FD-Score:19.50|P-value:9.40E-87 ID:SGTC_653|Compound:0203-0016|FD-Score:3.61|P-value:1.42E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:7.43|P-value:3.62E-14 ID:SGTC_710|Compound:3448-4187|FD-Score:4.40|P-value:4.81E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:29.00|P-value:2.36E-188 ID:SGTC_759|Compound:3486-0358|FD-Score:5.17|P-value:9.65E-8 ID:SGTC_769|Compound:0302-0231|FD-Score:8.54|P-value:3.56E-18 ID:SGTC_804|Compound:1595-0054|FD-Score:6.09|P-value:4.24E-10 ID:SGTC_823|Compound:0417-1665|FD-Score:4.08|P-value:2.08E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:20.70|P-value:8.58E-97 ID:SGTC_922|Compound:1866-0035|FD-Score:21.40|P-value:5.53E-104 ID:SGTC_979|Compound:1426-2828|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.32|P-value:3.70E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.62|P-value:1.63E-6 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.52|P-value:1.99E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.81|P-value:6.38E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.55|P-value:2.38E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:-6.58|P-value:1.36E-11 ID:SGTC_1163|Compound:k060-0048|FD-Score:5.70|P-value:4.83E-9 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.43|P-value:2.85E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.39|P-value:2.90E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.10|P-value:9.36E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:5.65|P-value:6.46E-9 ID:SGTC_1511|Compound:0906-3109|FD-Score:45.60|P-value:0 ID:SGTC_1619|Compound:st003326|FD-Score:3.56|P-value:1.73E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-4.05|P-value:1.98E-5 ID:SGTC_1815|Compound:st051655|FD-Score:4.05|P-value:2.31E-5 ID:SGTC_1820|Compound:st053765|FD-Score:3.45|P-value:2.60E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.81|P-value:6.45E-5 ID:SGTC_1941|Compound:st076221|FD-Score:14.30|P-value:1.00E-47 ID:SGTC_1953|Compound:st076800|FD-Score:4.74|P-value:9.29E-7 ID:SGTC_2067|Compound:5224629|FD-Score:3.62|P-value:1.38E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.96|P-value:2.86E-5 ID:SGTC_2071|Compound:5230951|FD-Score:-3.98|P-value:2.66E-5 ID:SGTC_2086|Compound:5274770|FD-Score:3.12|P-value:8.63E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-3.31|P-value:3.89E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.52|P-value:2.05E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.51|P-value:2.10E-4 ID:SGTC_2393|Compound:9031399|FD-Score:4.10|P-value:1.87E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.23|P-value:5.91E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.86|P-value:1.77E-9 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.96|P-value:3.38E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.12|P-value:8.63E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.30|P-value:4.62E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.33|P-value:9.15E-11 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.02|P-value:2.66E-5 ID:SGTC_2840|Compound:9008771|FD-Score:-3.17|P-value:6.41E-4 ID:SGTC_2858|Compound:9025781|FD-Score:21.80|P-value:1.17E-107 ID:SGTC_2956|Compound:9076196|FD-Score:3.81|P-value:6.28E-5 ID:SGTC_2962|Compound:9082311|FD-Score:4.72|P-value:1.01E-6 ID:SGTC_3022|Compound:9087993|FD-Score:4.33|P-value:6.52E-6 ID:SGTC_3211|Compound:9128781|FD-Score:7.95|P-value:5.66E-16 ID:SGTC_3307|Compound:9126885|FD-Score:-3.12|P-value:7.63E-4

Top fitness defect scores for YNR008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_45 0kpi-0036 47.30 14.9 µM 0 excess fatty acid 1 0
2 SGTC_1511 0906-3109 45.60 28.5 µM 0 excess fatty acid 1 0
3 SGTC_475 α-linolenic acid 29.30 10.0 µM 2.06E-192 excess fatty acid 1 7.98E-189
4 SGTC_743 1275-0778 29.00 158.0 µM 2.36E-188 excess fatty acid 2 7.60E-185
5 SGTC_410 α-linolenic acid 25.10 100.0 µM 1.26E-141 excess fatty acid 1 5.01E-139
6 SGTC_350 k064-0020 23.30 19.8 µM 1.45E-122 heme requiring 1 2.48E-120
7 SGTC_2858 9025781 21.80 9.0 µM 1.17E-107 sphingolipid biosynthesis & PDR1 4 1.03E-105
8 SGTC_143 4032-1194 21.50 15.7 µM 2.14E-104 1 1.64E-102
9 SGTC_922 1866-0035 21.40 480.0 µM 5.53E-104 excess fatty acid 1 4.14E-102
10 SGTC_852 0418-0143 20.70 439.0 µM 8.58E-97 calcium & mitochondrial duress 3 4.68E-95
11 SGTC_628 1636-0253 19.50 16.0 µM 9.40E-87 sphingolipid biosynthesis & PDR1 1 3.29E-85
12 SGTC_115 0527-0192 18.80 112.0 µM 2.69E-80 1 7.08E-79
13 SGTC_352 k048-0007 16.10 5.1 µM 7.95E-60 ERAD & cell cycle 2 8.54E-59
14 SGTC_1941 st076221 14.30 61.8 µM 1.00E-47 sphingolipid biosynthesis & PDR1 3 6.36E-47
15 SGTC_348 k064-0012 9.47 10.7 µM 6.36E-22 60S ribosome export 1 1.35E-21
16 SGTC_96 0929-0093 9.20 37.3 µM 9.19E-21 calcium & mitochondrial duress 2 1.86E-20
17 SGTC_769 0302-0231 8.54 76.0 µM 3.56E-18 2 6.46E-18
18 SGTC_188 3229-0966 8.30 278.5 µM 2.96E-17 3 5.18E-17
19 SGTC_3211 9128781 7.95 49.5 µM 5.66E-16 11 9.40E-16
20 SGTC_683 panaxydol 7.43 45.0 µM 3.62E-14 sphingolipid biosynthesis & PDR1 6 5.59E-14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.297 1.49E-69 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.245 4.06E-47 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.203 2.05E-32 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.185 3.53E-27 YDR155C CPR1 hom Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress
0.177 3.79E-25 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.160 1.46E-20 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.160 1.43E-20 YJL128C PBS2 hom MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition
0.157 5.27E-20 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.154 2.40E-19 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.154 2.54E-19 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.152 1.06E-18 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.149 4.38E-18 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.145 2.42E-17 YKR029C SET3 hom Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication
0.138 1.13E-15 YOL001W PHO80 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
0.138 1.23E-15 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay