YNR009W / NRM1

Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR009W / NRM1

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:-2.99|P-value:8.36E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.01|P-value:1.21E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.01|P-value:7.62E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-4.75|P-value:2.83E-7 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-2.94|P-value:9.82E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.22|P-value:3.46E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-3.33|P-value:2.25E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.30|P-value:3.01E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.34|P-value:2.21E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:3.51|P-value:1.10E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.26|P-value:3.00E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.53|P-value:1.03E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.48|P-value:1.23E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.35|P-value:2.10E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.09|P-value:5.71E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.56|P-value:8.86E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.89|P-value:2.15E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:3.20|P-value:3.84E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.06|P-value:6.44E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:5.33|P-value:1.04E-8 ID:SGTC_923|Compound:1900-2434|FD-Score:3.12|P-value:5.13E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.15|P-value:6.10E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:4.76|P-value:2.65E-7 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.22|P-value:3.54E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.01|P-value:7.70E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.41|P-value:1.64E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.00|P-value:1.24E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.99|P-value:1.36E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.81|P-value:3.05E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.16|P-value:4.42E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.95|P-value:1.59E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.33|P-value:2.29E-4 ID:SGTC_1725|Compound:st036284|FD-Score:6.74|P-value:6.31E-13 ID:SGTC_1726|Compound:st035556|FD-Score:4.73|P-value:3.15E-7 ID:SGTC_1732|Compound:st034308|FD-Score:-4.37|P-value:2.18E-6 ID:SGTC_1736|Compound:st036774|FD-Score:4.04|P-value:1.05E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-3.30|P-value:2.61E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.96|P-value:8.82E-8 ID:SGTC_1770|Compound:st043884|FD-Score:-3.23|P-value:3.43E-4 ID:SGTC_1809|Compound:st050081|FD-Score:5.13|P-value:3.33E-8 ID:SGTC_2024|Compound:5144227|FD-Score:-3.27|P-value:2.94E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.07|P-value:6.04E-4 ID:SGTC_2370|Compound:9071495|FD-Score:2.95|P-value:9.54E-4 ID:SGTC_2382|Compound:9035899|FD-Score:-2.97|P-value:9.03E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.78|P-value:3.43E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.69|P-value:5.23E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.18|P-value:4.14E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.19|P-value:3.89E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.35|P-value:2.08E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:-3.11|P-value:5.31E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.14|P-value:4.74E-4 ID:SGTC_2922|Compound:7999257|FD-Score:2.97|P-value:8.97E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.19|P-value:5.09E-6 ID:SGTC_3082|Compound:9117008|FD-Score:3.86|P-value:2.43E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.79|P-value:3.31E-5 ID:SGTC_3156|Compound:9099931|FD-Score:3.76|P-value:3.74E-5 ID:SGTC_3299|Compound:9121982|FD-Score:-4.09|P-value:8.47E-6 ID:SGTC_3328|Compound:9140624|FD-Score:5.77|P-value:6.19E-10 ID:SGTC_3329|Compound:9141233|FD-Score:5.04|P-value:5.46E-8 ID:SGTC_21|Compound:0849-0113|FD-Score:-2.99|P-value:8.36E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.01|P-value:1.21E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.01|P-value:7.62E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-4.75|P-value:2.83E-7 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-2.94|P-value:9.82E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.22|P-value:3.46E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-3.33|P-value:2.25E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.30|P-value:3.01E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.34|P-value:2.21E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:3.51|P-value:1.10E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.26|P-value:3.00E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.53|P-value:1.03E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.48|P-value:1.23E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.35|P-value:2.10E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.09|P-value:5.71E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.56|P-value:8.86E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.89|P-value:2.15E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:3.20|P-value:3.84E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.06|P-value:6.44E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:5.33|P-value:1.04E-8 ID:SGTC_923|Compound:1900-2434|FD-Score:3.12|P-value:5.13E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.15|P-value:6.10E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:4.76|P-value:2.65E-7 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.22|P-value:3.54E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.01|P-value:7.70E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.41|P-value:1.64E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.00|P-value:1.24E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.99|P-value:1.36E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.81|P-value:3.05E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.16|P-value:4.42E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.95|P-value:1.59E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.33|P-value:2.29E-4 ID:SGTC_1725|Compound:st036284|FD-Score:6.74|P-value:6.31E-13 ID:SGTC_1726|Compound:st035556|FD-Score:4.73|P-value:3.15E-7 ID:SGTC_1732|Compound:st034308|FD-Score:-4.37|P-value:2.18E-6 ID:SGTC_1736|Compound:st036774|FD-Score:4.04|P-value:1.05E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-3.30|P-value:2.61E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.96|P-value:8.82E-8 ID:SGTC_1770|Compound:st043884|FD-Score:-3.23|P-value:3.43E-4 ID:SGTC_1809|Compound:st050081|FD-Score:5.13|P-value:3.33E-8 ID:SGTC_2024|Compound:5144227|FD-Score:-3.27|P-value:2.94E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.07|P-value:6.04E-4 ID:SGTC_2370|Compound:9071495|FD-Score:2.95|P-value:9.54E-4 ID:SGTC_2382|Compound:9035899|FD-Score:-2.97|P-value:9.03E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.78|P-value:3.43E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.69|P-value:5.23E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.18|P-value:4.14E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.19|P-value:3.89E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.35|P-value:2.08E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:-3.11|P-value:5.31E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.14|P-value:4.74E-4 ID:SGTC_2922|Compound:7999257|FD-Score:2.97|P-value:8.97E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.19|P-value:5.09E-6 ID:SGTC_3082|Compound:9117008|FD-Score:3.86|P-value:2.43E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.79|P-value:3.31E-5 ID:SGTC_3156|Compound:9099931|FD-Score:3.76|P-value:3.74E-5 ID:SGTC_3299|Compound:9121982|FD-Score:-4.09|P-value:8.47E-6 ID:SGTC_3328|Compound:9140624|FD-Score:5.77|P-value:6.19E-10 ID:SGTC_3329|Compound:9141233|FD-Score:5.04|P-value:5.46E-8

Top fitness defect scores for YNR009W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1725 st036284 6.74 20.6 µM 6.31E-13 4 7.74E-12
2 SGTC_3328 9140624 5.77 29.0 µM 6.19E-10 4 3.93E-9
3 SGTC_921 1561-0023 5.33 372.0 µM 1.04E-8 2 5.04E-8
4 SGTC_1809 st050081 5.13 57.6 µM 3.33E-8 8 1.45E-7
5 SGTC_3329 9141233 5.04 27.6 µM 5.46E-8 6 2.27E-7
6 SGTC_1745 st081495 4.96 74.0 µM 8.82E-8 RNA processing & uracil transport 38 3.50E-7
7 SGTC_932 2857-0803 4.76 154.0 µM 2.65E-7 18 9.50E-7
8 SGTC_1726 st035556 4.73 14.6 µM 3.15E-7 20 1.11E-6
9 SGTC_502 l-744,832 4.30 89.3 µM 3.01E-6 calcium & mitochondrial duress 32 8.58E-6
10 SGTC_2949 9072542 4.19 2.2 µM 5.09E-6 TSC3-RPN4 30 1.38E-5
11 SGTC_929 2805-0021 4.15 398.0 µM 6.10E-6 13 1.63E-5
12 SGTC_1736 st036774 4.04 51.0 µM 1.05E-5 31 2.66E-5
13 SGTC_1089 terbinafine 4.00 2.2 µM 1.24E-5 13 3.10E-5
14 SGTC_839 0122-0028 3.89 230.0 µM 2.15E-5 RSC complex & mRNA processing 39 5.09E-5
15 SGTC_3082 9117008 3.86 49.5 µM 2.43E-5 17 5.69E-5
16 SGTC_1182 1222-0449 3.81 220.0 µM 3.05E-5 24 7.00E-5
17 SGTC_3109 9122853 3.79 49.5 µM 3.31E-5 8 7.55E-5
18 SGTC_3156 9099931 3.76 49.5 µM 3.74E-5 11 8.42E-5
19 SGTC_2396 5342950 3.69 42.8 µM 5.23E-5 RSC complex & mRNA processing 54 1.14E-4
20 SGTC_815 1582-0027 3.56 36.9 µM 8.86E-5 43 1.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 8.07E-18 YLR267W_p BOP2_p hom Protein of unknown function
0.139 5.65E-16 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.134 5.65E-15 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.127 1.92E-13 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.124 6.00E-13 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.121 1.97E-12 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.118 6.57E-12 YGR032W GSC2 hom Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.111 1.38E-10 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.109 2.09E-10 YER011W TIR1 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
0.109 2.57E-10 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.104 1.47E-9 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.103 2.05E-9 YJR087W_d YJR087W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2
0.102 3.34E-9 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.100 5.86E-9 YPL221W FLC1 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
0.098 1.17E-8 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function