YNR011C / PRP2

RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNR011C / PRP2

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.36|P-value:3.45E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.32|P-value:3.91E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.08|P-value:7.91E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.70|P-value:9.13E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.96|P-value:3.03E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.61|P-value:1.31E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:-3.94|P-value:2.70E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:3.61|P-value:1.30E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-5.44|P-value:1.31E-8 ID:SGTC_462|Compound:ag-879|FD-Score:-4.79|P-value:4.74E-7 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.52|P-value:1.55E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.56|P-value:1.55E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:3.19|P-value:6.22E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.14|P-value:7.50E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.57|P-value:1.52E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.17|P-value:5.69E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.48|P-value:2.15E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.58|P-value:1.20E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.11|P-value:8.50E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.17|P-value:5.75E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.73|P-value:8.05E-5 ID:SGTC_873|Compound:0591-4978|FD-Score:3.51|P-value:1.89E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.19|P-value:5.29E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.06|P-value:9.96E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:8.28|P-value:2.01E-17 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.51|P-value:1.90E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.79|P-value:6.22E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.51|P-value:1.90E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.55|P-value:1.63E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.35|P-value:5.33E-6 ID:SGTC_1783|Compound:st039459|FD-Score:-3.97|P-value:2.36E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.26|P-value:4.85E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.16|P-value:1.26E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-3.48|P-value:1.80E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-4.94|P-value:2.16E-7 ID:SGTC_1961|Compound:st076550|FD-Score:6.28|P-value:9.27E-11 ID:SGTC_1969|Compound:st069479|FD-Score:5.65|P-value:5.01E-9 ID:SGTC_1970|Compound:st070122|FD-Score:5.80|P-value:2.05E-9 ID:SGTC_1975|Compound:st070967|FD-Score:4.95|P-value:2.58E-7 ID:SGTC_2008|Compound:4012253|FD-Score:4.14|P-value:1.40E-5 ID:SGTC_2258|Compound:7960471|FD-Score:3.45|P-value:2.45E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.08|P-value:7.94E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.50|P-value:1.63E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.17|P-value:5.74E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-4.82|P-value:4.05E-7 ID:SGTC_2591|Compound:skatole|FD-Score:-8.16|P-value:4.02E-17 ID:SGTC_2788|Compound:5282734|FD-Score:3.21|P-value:5.98E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.46|P-value:2.36E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.88|P-value:3.90E-7 ID:SGTC_2877|Compound:9040724|FD-Score:-3.64|P-value:9.34E-5 ID:SGTC_2894|Compound:9048625|FD-Score:4.34|P-value:5.60E-6 ID:SGTC_2921|Compound:7974240|FD-Score:3.40|P-value:2.94E-4 ID:SGTC_2940|Compound:9060638|FD-Score:5.02|P-value:1.80E-7 ID:SGTC_3053|Compound:9095903|FD-Score:-3.34|P-value:3.01E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.26|P-value:4.84E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.06|P-value:9.84E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.36|P-value:3.45E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.32|P-value:3.91E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.08|P-value:7.91E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.70|P-value:9.13E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.96|P-value:3.03E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.61|P-value:1.31E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:-3.94|P-value:2.70E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:3.61|P-value:1.30E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-5.44|P-value:1.31E-8 ID:SGTC_462|Compound:ag-879|FD-Score:-4.79|P-value:4.74E-7 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.52|P-value:1.55E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.56|P-value:1.55E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:3.19|P-value:6.22E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.14|P-value:7.50E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.57|P-value:1.52E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.17|P-value:5.69E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.48|P-value:2.15E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.58|P-value:1.20E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.11|P-value:8.50E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.17|P-value:5.75E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.73|P-value:8.05E-5 ID:SGTC_873|Compound:0591-4978|FD-Score:3.51|P-value:1.89E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.19|P-value:5.29E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.06|P-value:9.96E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:8.28|P-value:2.01E-17 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.51|P-value:1.90E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.79|P-value:6.22E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.51|P-value:1.90E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.55|P-value:1.63E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.35|P-value:5.33E-6 ID:SGTC_1783|Compound:st039459|FD-Score:-3.97|P-value:2.36E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.26|P-value:4.85E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.16|P-value:1.26E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-3.48|P-value:1.80E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-4.94|P-value:2.16E-7 ID:SGTC_1961|Compound:st076550|FD-Score:6.28|P-value:9.27E-11 ID:SGTC_1969|Compound:st069479|FD-Score:5.65|P-value:5.01E-9 ID:SGTC_1970|Compound:st070122|FD-Score:5.80|P-value:2.05E-9 ID:SGTC_1975|Compound:st070967|FD-Score:4.95|P-value:2.58E-7 ID:SGTC_2008|Compound:4012253|FD-Score:4.14|P-value:1.40E-5 ID:SGTC_2258|Compound:7960471|FD-Score:3.45|P-value:2.45E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.08|P-value:7.94E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.50|P-value:1.63E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.17|P-value:5.74E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-4.82|P-value:4.05E-7 ID:SGTC_2591|Compound:skatole|FD-Score:-8.16|P-value:4.02E-17 ID:SGTC_2788|Compound:5282734|FD-Score:3.21|P-value:5.98E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.46|P-value:2.36E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.88|P-value:3.90E-7 ID:SGTC_2877|Compound:9040724|FD-Score:-3.64|P-value:9.34E-5 ID:SGTC_2894|Compound:9048625|FD-Score:4.34|P-value:5.60E-6 ID:SGTC_2921|Compound:7974240|FD-Score:3.40|P-value:2.94E-4 ID:SGTC_2940|Compound:9060638|FD-Score:5.02|P-value:1.80E-7 ID:SGTC_3053|Compound:9095903|FD-Score:-3.34|P-value:3.01E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.26|P-value:4.84E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.06|P-value:9.84E-4

Top fitness defect scores for YNR011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_996 3970-0799 8.28 1.8 µM 2.01E-17 5 5.91E-17 0.45
2 SGTC_1961 st076550 6.28 68.7 µM 9.27E-11 1 1.67E-10 0.98
3 SGTC_1970 st070122 5.80 35.8 µM 2.05E-9 TSC3-RPN4 4 3.36E-9 0.23
4 SGTC_1969 st069479 5.65 40.1 µM 5.01E-9 1 7.96E-9 1.85
5 SGTC_2940 9060638 5.02 45.9 µM 1.80E-7 amide catabolism 2 2.57E-7 0.16
6 SGTC_1975 st070967 4.95 30.8 µM 2.58E-7 5 3.64E-7 0.22
7 SGTC_2850 9015429 4.88 58.4 µM 3.90E-7 2 5.43E-7 0.08
8 SGTC_1734 st037168 4.35 69.4 µM 5.33E-6 4 6.87E-6 0.38
9 SGTC_2894 9048625 4.34 32.5 µM 5.60E-6 6 7.20E-6 0.35
10 SGTC_1787 fluconazole 4.16 80.0 µM 1.26E-5 iron homeostasis 10 1.58E-5 0.13
11 SGTC_2008 4012253 4.14 172.0 µM 1.40E-5 11 1.75E-5 0.04
12 SGTC_115 0527-0192 3.96 112.0 µM 3.03E-5 23 3.71E-5 0.04
13 SGTC_1311 1190-0148 3.79 100.0 µM 6.22E-5 azole & statin 7 7.45E-5 0.02
14 SGTC_820 1582-0060 3.73 59.9 µM 8.05E-5 12 9.59E-5 0.16
15 SGTC_114 0364-0001 3.70 490.3 µM 9.13E-5 5 1.08E-4 0.04
16 SGTC_325 2810-4341 3.61 181.0 µM 1.30E-4 amide catabolism 9 1.52E-4 0.02
17 SGTC_214 4373-3496 3.61 70.0 µM 1.31E-4 24 1.54E-4 0.05
18 SGTC_673 1082-0474 3.57 110.0 µM 1.52E-4 RSC complex & mRNA processing 58 1.78E-4 0.00
19 SGTC_1342 1486-1464 3.55 234.0 µM 1.63E-4 3 1.90E-4 0.02
20 SGTC_873 0591-4978 3.51 488.0 µM 1.89E-4 6 2.20E-4 0.33

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 3.21E-45 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.191 6.02E-29 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.170 3.70E-23 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.167 2.58E-22 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.166 4.45E-22 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.155 1.29E-19 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.152 7.81E-19 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.150 2.43E-18 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.148 7.84E-18 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.142 1.08E-16 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.134 8.10E-15 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.129 5.47E-14 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.126 2.05E-13 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.122 1.26E-12 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.117 1.07E-11 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication