YNR013C / PHO91

Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR013C / PHO91

Click on Significant Values for Screen Details ID:SGTC_115|Compound:0527-0192|FD-Score:-3.32|P-value:5.75E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.68|P-value:2.43E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.94|P-value:5.80E-5 ID:SGTC_401|Compound:neomycin|FD-Score:3.24|P-value:9.00E-4 ID:SGTC_442|Compound:cape|FD-Score:-3.20|P-value:8.54E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:4.05|P-value:4.65E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:3.45|P-value:4.43E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.65|P-value:1.75E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.23|P-value:7.90E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.21|P-value:8.44E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.57|P-value:2.89E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.82|P-value:1.18E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.24|P-value:9.21E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.05|P-value:4.72E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.51|P-value:3.58E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:4.52|P-value:6.61E-6 ID:SGTC_1486|Compound:3970-0793|FD-Score:5.72|P-value:1.64E-8 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.27|P-value:1.89E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:5.13|P-value:3.66E-7 ID:SGTC_1753|Compound:st043925|FD-Score:4.17|P-value:2.95E-5 ID:SGTC_1777|Compound:st045864|FD-Score:4.17|P-value:2.92E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.24|P-value:7.54E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.67|P-value:2.05E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.36|P-value:6.05E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.70|P-value:1.84E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.27|P-value:8.23E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.13|P-value:3.46E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.23|P-value:2.27E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.32|P-value:7.03E-4 ID:SGTC_3000|Compound:9075062|FD-Score:4.12|P-value:3.61E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-4.30|P-value:1.34E-5 ID:SGTC_3248|Compound:9135562|FD-Score:-3.52|P-value:2.90E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.32|P-value:5.75E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.68|P-value:2.43E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.94|P-value:5.80E-5 ID:SGTC_401|Compound:neomycin|FD-Score:3.24|P-value:9.00E-4 ID:SGTC_442|Compound:cape|FD-Score:-3.20|P-value:8.54E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:4.05|P-value:4.65E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:3.45|P-value:4.43E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.65|P-value:1.75E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.23|P-value:7.90E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.21|P-value:8.44E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.57|P-value:2.89E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.82|P-value:1.18E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.24|P-value:9.21E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.05|P-value:4.72E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.51|P-value:3.58E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:4.52|P-value:6.61E-6 ID:SGTC_1486|Compound:3970-0793|FD-Score:5.72|P-value:1.64E-8 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.27|P-value:1.89E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:5.13|P-value:3.66E-7 ID:SGTC_1753|Compound:st043925|FD-Score:4.17|P-value:2.95E-5 ID:SGTC_1777|Compound:st045864|FD-Score:4.17|P-value:2.92E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.24|P-value:7.54E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.67|P-value:2.05E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.36|P-value:6.05E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.70|P-value:1.84E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.27|P-value:8.23E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.13|P-value:3.46E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.23|P-value:2.27E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.32|P-value:7.03E-4 ID:SGTC_3000|Compound:9075062|FD-Score:4.12|P-value:3.61E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-4.30|P-value:1.34E-5 ID:SGTC_3248|Compound:9135562|FD-Score:-3.52|P-value:2.90E-4

Top fitness defect scores for YNR013C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1486 3970-0793 5.72 4.5 µM 1.64E-8 2 5.33E-9
2 SGTC_1527 coumarin 5.13 137.0 µM 3.66E-7 3 1.45E-7
3 SGTC_1477 0139-0234 4.52 16.0 µM 6.61E-6 5 3.16E-6
4 SGTC_1502 4534-4282 4.27 27.7 µM 1.89E-5 6 9.65E-6
5 SGTC_2575 plumbagin 4.23 510.0 nM 2.27E-5 superoxide 32 1.18E-5
6 SGTC_1777 st045864 4.17 34.8 µM 2.92E-5 8 1.53E-5
7 SGTC_1753 st043925 4.17 64.0 µM 2.95E-5 6 1.55E-5
8 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.13 100.0 µM 3.46E-5 17 1.84E-5
9 SGTC_3000 9075062 4.12 71.4 µM 3.61E-5 15 1.92E-5
10 SGTC_573 3702-0553 4.05 84.7 µM 4.65E-5 12 2.52E-5
11 SGTC_1448 4255-0083 4.05 152.0 µM 4.72E-5 ERG2 17 2.56E-5
12 SGTC_1268 0828-0275 3.82 2.5 µM 1.18E-4 23 6.78E-5
13 SGTC_2419 paclitaxel 3.70 166.5 µM 1.84E-4 54 1.09E-4
14 SGTC_2359 9039622 3.67 200.0 µM 2.05E-4 endomembrane recycling 29 1.22E-4
15 SGTC_1159 4092-0538 3.57 61.2 µM 2.89E-4 44 1.76E-4
16 SGTC_1452 4194-0072 3.51 190.0 µM 3.58E-4 24 2.21E-4
17 SGTC_932 2857-0803 3.45 154.0 µM 4.43E-4 43 2.78E-4
18 SGTC_2367 9070478 3.36 135.4 µM 6.05E-4 cell wall 64 3.87E-4
19 SGTC_2966 9084041 3.32 48.0 µM 7.03E-4 61 4.54E-4
20 SGTC_2427 5545055 3.27 42.8 µM 8.23E-4 40 5.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 7.80E-32 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.164 9.57E-22 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.160 1.17E-20 YDL087C LUC7 het Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA
0.135 3.35E-15 YIL099W SGA1 hom Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
0.124 5.63E-13 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.121 1.70E-12 YMR122C_d YMR122C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.117 9.41E-12 YGR039W_d YGR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
0.117 1.31E-11 YDR222W_p YDR222W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.108 3.40E-10 YGL242C_p YGL242C_p hom Putative protein of unknown function; deletion mutant is viable
0.103 2.01E-9 YGR099W TEL2 het Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
0.102 3.28E-9 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.100 7.20E-9 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.096 2.70E-8 YGR239C PEX21 hom Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress
0.090 1.56E-7 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.089 2.13E-7 YGL111W NSA1 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis