YNR016C / ACC1

Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNR016C / ACC1

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:8.00|P-value:2.48E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:8.28|P-value:6.12E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:5.86|P-value:2.65E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:9.29|P-value:2.59E-13 ID:SGTC_93|Compound:0109-0045|FD-Score:4.48|P-value:2.50E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.59|P-value:7.01E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:4.45|P-value:2.69E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:8.28|P-value:6.18E-11 ID:SGTC_157|Compound:1348-1695|FD-Score:8.88|P-value:2.57E-12 ID:SGTC_159|Compound:3970-0959|FD-Score:-5.13|P-value:3.22E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-6.37|P-value:3.45E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:-5.03|P-value:4.37E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:13.60|P-value:1.79E-26 ID:SGTC_188|Compound:3229-0966|FD-Score:5.15|P-value:3.10E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:4.08|P-value:7.63E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.94|P-value:3.40E-8 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.03|P-value:8.75E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.84|P-value:2.80E-6 ID:SGTC_302|Compound:1094-0063|FD-Score:5.20|P-value:2.63E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:8.81|P-value:3.64E-12 ID:SGTC_351|Compound:caspofungin|FD-Score:9.24|P-value:3.30E-13 ID:SGTC_353|Compound:1988-1175|FD-Score:5.28|P-value:2.02E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:10.20|P-value:1.21E-15 ID:SGTC_360|Compound:0957-0399|FD-Score:4.86|P-value:8.07E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:4.05|P-value:8.33E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.63|P-value:1.60E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:4.02|P-value:8.94E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.44|P-value:2.79E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:-4.51|P-value:2.18E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:7.74|P-value:8.96E-10 ID:SGTC_606|Compound:k015-0008|FD-Score:6.52|P-value:2.03E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:4.78|P-value:1.03E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.67|P-value:5.16E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:14.20|P-value:1.39E-28 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.01|P-value:2.55E-8 ID:SGTC_690|Compound:glyoxal|FD-Score:6.08|P-value:1.16E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:8.37|P-value:3.90E-11 ID:SGTC_767|Compound:0929-0023|FD-Score:4.90|P-value:7.06E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:5.05|P-value:4.42E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:10.10|P-value:2.32E-15 ID:SGTC_839|Compound:0122-0028|FD-Score:6.78|P-value:6.73E-8 ID:SGTC_863|Compound:0466-0191|FD-Score:8.38|P-value:3.64E-11 ID:SGTC_871|Compound:0574-0004|FD-Score:9.39|P-value:1.42E-13 ID:SGTC_882|Compound:0843-0131|FD-Score:4.62|P-value:1.67E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:8.54|P-value:1.58E-11 ID:SGTC_916|Compound:4466-0038|FD-Score:5.48|P-value:1.01E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:5.06|P-value:4.20E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:4.73|P-value:1.20E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:7.49|P-value:2.91E-9 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.11|P-value:6.85E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:9.40|P-value:1.37E-13 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.95|P-value:1.87E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:12.90|P-value:3.75E-24 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.14|P-value:6.45E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:6.60|P-value:1.44E-7 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.18|P-value:5.77E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:5.93|P-value:2.01E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:6.93|P-value:3.59E-8 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.72|P-value:4.34E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:5.88|P-value:2.42E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:14.70|P-value:1.73E-30 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.08|P-value:7.69E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:9.29|P-value:2.56E-13 ID:SGTC_1547|Compound:harmine|FD-Score:4.99|P-value:5.21E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:6.98|P-value:2.84E-8 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:6.32|P-value:4.47E-7 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:6.49|P-value:2.31E-7 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:8.22|P-value:8.18E-11 ID:SGTC_1651|Compound:st011928|FD-Score:4.00|P-value:9.43E-4 ID:SGTC_1652|Compound:st011932|FD-Score:19.00|P-value:5.68E-50 ID:SGTC_1694|Compound:st024011|FD-Score:4.17|P-value:5.97E-4 ID:SGTC_1707|Compound:st032323|FD-Score:7.20|P-value:1.07E-8 ID:SGTC_1723|Compound:st034307|FD-Score:4.18|P-value:5.77E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.45|P-value:2.71E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.93|P-value:2.01E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.43|P-value:2.90E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.99|P-value:9.60E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.75|P-value:1.12E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.61|P-value:1.68E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-4.58|P-value:1.78E-4 ID:SGTC_1974|Compound:st069448|FD-Score:22.00|P-value:4.41E-66 ID:SGTC_2004|Compound:4023728|FD-Score:4.52|P-value:2.24E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.38|P-value:3.33E-4 ID:SGTC_2041|Compound:5107442|FD-Score:7.95|P-value:3.10E-10 ID:SGTC_2107|Compound:5363541|FD-Score:4.49|P-value:2.46E-4 ID:SGTC_2109|Compound:5483026|FD-Score:8.65|P-value:8.57E-12 ID:SGTC_2111|Compound:5486399|FD-Score:12.00|P-value:7.18E-21 ID:SGTC_2132|Compound:5317594|FD-Score:4.01|P-value:9.22E-4 ID:SGTC_2140|Compound:5586273|FD-Score:5.45|P-value:1.12E-5 ID:SGTC_2180|Compound:6301957|FD-Score:4.13|P-value:6.75E-4 ID:SGTC_2186|Compound:6124449|FD-Score:15.20|P-value:1.91E-32 ID:SGTC_2229|Compound:7354935|FD-Score:5.87|P-value:2.51E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.94|P-value:3.27E-10 ID:SGTC_2248|Compound:tofa|FD-Score:10.70|P-value:4.38E-17 ID:SGTC_2277|Compound:7947813|FD-Score:4.65|P-value:1.50E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.63|P-value:1.60E-4 ID:SGTC_2301|Compound:7769476|FD-Score:4.52|P-value:2.25E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.81|P-value:6.06E-8 ID:SGTC_2375|Compound:9072683|FD-Score:3.99|P-value:9.69E-4 ID:SGTC_2378|Compound:9074213|FD-Score:6.59|P-value:1.48E-7 ID:SGTC_2387|Compound:9077560|FD-Score:4.19|P-value:5.71E-4 ID:SGTC_2396|Compound:5342950|FD-Score:8.81|P-value:3.65E-12 ID:SGTC_2400|Compound:5203494|FD-Score:5.45|P-value:1.12E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:10.20|P-value:1.14E-15 ID:SGTC_2534|Compound:helenine|FD-Score:6.16|P-value:8.30E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:4.65|P-value:1.50E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:7.96|P-value:2.97E-10 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.25|P-value:6.04E-7 ID:SGTC_2662|Compound:daunorubicin|FD-Score:9.88|P-value:7.80E-15 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.21|P-value:6.86E-7 ID:SGTC_2738|Compound:aclarubicin|FD-Score:4.39|P-value:3.22E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:4.61|P-value:1.71E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:7.25|P-value:8.68E-9 ID:SGTC_2766|Compound:oltipraz|FD-Score:9.66|P-value:2.93E-14 ID:SGTC_2779|Compound:methotrexate|FD-Score:-7.24|P-value:8.44E-9 ID:SGTC_2809|Compound:7964133|FD-Score:4.26|P-value:4.65E-4 ID:SGTC_2845|Compound:9003024|FD-Score:9.93|P-value:5.56E-15 ID:SGTC_2867|Compound:9039098|FD-Score:-4.46|P-value:2.55E-4 ID:SGTC_2890|Compound:9046729|FD-Score:5.38|P-value:1.45E-5 ID:SGTC_2912|Compound:7964298|FD-Score:12.30|P-value:4.91E-22 ID:SGTC_2921|Compound:7974240|FD-Score:4.83|P-value:8.78E-5 ID:SGTC_2962|Compound:9082311|FD-Score:5.37|P-value:1.50E-5 ID:SGTC_2997|Compound:9067075|FD-Score:13.50|P-value:3.76E-26 ID:SGTC_3020|Compound:9089140|FD-Score:4.75|P-value:1.11E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:6.64|P-value:1.21E-7 ID:SGTC_3060|Compound:1327-0027|FD-Score:6.47|P-value:2.45E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:5.42|P-value:1.26E-5 ID:SGTC_3064|Compound:1327-0027|FD-Score:4.24|P-value:5.01E-4 ID:SGTC_3143|Compound:9086658|FD-Score:6.70|P-value:9.65E-8 ID:SGTC_3266|Compound:9136860|FD-Score:4.30|P-value:4.15E-4 ID:SGTC_3277|Compound:9138724|FD-Score:9.48|P-value:8.28E-14 ID:SGTC_3311|Compound:9131146|FD-Score:4.58|P-value:1.86E-4 ID:SGTC_3318|Compound:9139014|FD-Score:4.37|P-value:3.42E-4 ID:SGTC_3321|Compound:9137793|FD-Score:8.55|P-value:1.48E-11 ID:SGTC_22|Compound:0964-0034|FD-Score:8.00|P-value:2.48E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:8.28|P-value:6.12E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:5.86|P-value:2.65E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:9.29|P-value:2.59E-13 ID:SGTC_93|Compound:0109-0045|FD-Score:4.48|P-value:2.50E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.59|P-value:7.01E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:4.45|P-value:2.69E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:8.28|P-value:6.18E-11 ID:SGTC_157|Compound:1348-1695|FD-Score:8.88|P-value:2.57E-12 ID:SGTC_159|Compound:3970-0959|FD-Score:-5.13|P-value:3.22E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-6.37|P-value:3.45E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:-5.03|P-value:4.37E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:13.60|P-value:1.79E-26 ID:SGTC_188|Compound:3229-0966|FD-Score:5.15|P-value:3.10E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:4.08|P-value:7.63E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.94|P-value:3.40E-8 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.03|P-value:8.75E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.84|P-value:2.80E-6 ID:SGTC_302|Compound:1094-0063|FD-Score:5.20|P-value:2.63E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:8.81|P-value:3.64E-12 ID:SGTC_351|Compound:caspofungin|FD-Score:9.24|P-value:3.30E-13 ID:SGTC_353|Compound:1988-1175|FD-Score:5.28|P-value:2.02E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:10.20|P-value:1.21E-15 ID:SGTC_360|Compound:0957-0399|FD-Score:4.86|P-value:8.07E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:4.05|P-value:8.33E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.63|P-value:1.60E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:4.02|P-value:8.94E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.44|P-value:2.79E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:-4.51|P-value:2.18E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:7.74|P-value:8.96E-10 ID:SGTC_606|Compound:k015-0008|FD-Score:6.52|P-value:2.03E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:4.78|P-value:1.03E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.67|P-value:5.16E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:14.20|P-value:1.39E-28 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.01|P-value:2.55E-8 ID:SGTC_690|Compound:glyoxal|FD-Score:6.08|P-value:1.16E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:8.37|P-value:3.90E-11 ID:SGTC_767|Compound:0929-0023|FD-Score:4.90|P-value:7.06E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:5.05|P-value:4.42E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:10.10|P-value:2.32E-15 ID:SGTC_839|Compound:0122-0028|FD-Score:6.78|P-value:6.73E-8 ID:SGTC_863|Compound:0466-0191|FD-Score:8.38|P-value:3.64E-11 ID:SGTC_871|Compound:0574-0004|FD-Score:9.39|P-value:1.42E-13 ID:SGTC_882|Compound:0843-0131|FD-Score:4.62|P-value:1.67E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:8.54|P-value:1.58E-11 ID:SGTC_916|Compound:4466-0038|FD-Score:5.48|P-value:1.01E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:5.06|P-value:4.20E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:4.73|P-value:1.20E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:7.49|P-value:2.91E-9 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.11|P-value:6.85E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:9.40|P-value:1.37E-13 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.95|P-value:1.87E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:12.90|P-value:3.75E-24 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.14|P-value:6.45E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:6.60|P-value:1.44E-7 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.18|P-value:5.77E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:5.93|P-value:2.01E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:6.93|P-value:3.59E-8 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.72|P-value:4.34E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:5.88|P-value:2.42E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:14.70|P-value:1.73E-30 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.08|P-value:7.69E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:9.29|P-value:2.56E-13 ID:SGTC_1547|Compound:harmine|FD-Score:4.99|P-value:5.21E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:6.98|P-value:2.84E-8 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:6.32|P-value:4.47E-7 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:6.49|P-value:2.31E-7 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:8.22|P-value:8.18E-11 ID:SGTC_1651|Compound:st011928|FD-Score:4.00|P-value:9.43E-4 ID:SGTC_1652|Compound:st011932|FD-Score:19.00|P-value:5.68E-50 ID:SGTC_1694|Compound:st024011|FD-Score:4.17|P-value:5.97E-4 ID:SGTC_1707|Compound:st032323|FD-Score:7.20|P-value:1.07E-8 ID:SGTC_1723|Compound:st034307|FD-Score:4.18|P-value:5.77E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.45|P-value:2.71E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.93|P-value:2.01E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.43|P-value:2.90E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.99|P-value:9.60E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.75|P-value:1.12E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.61|P-value:1.68E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-4.58|P-value:1.78E-4 ID:SGTC_1974|Compound:st069448|FD-Score:22.00|P-value:4.41E-66 ID:SGTC_2004|Compound:4023728|FD-Score:4.52|P-value:2.24E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.38|P-value:3.33E-4 ID:SGTC_2041|Compound:5107442|FD-Score:7.95|P-value:3.10E-10 ID:SGTC_2107|Compound:5363541|FD-Score:4.49|P-value:2.46E-4 ID:SGTC_2109|Compound:5483026|FD-Score:8.65|P-value:8.57E-12 ID:SGTC_2111|Compound:5486399|FD-Score:12.00|P-value:7.18E-21 ID:SGTC_2132|Compound:5317594|FD-Score:4.01|P-value:9.22E-4 ID:SGTC_2140|Compound:5586273|FD-Score:5.45|P-value:1.12E-5 ID:SGTC_2180|Compound:6301957|FD-Score:4.13|P-value:6.75E-4 ID:SGTC_2186|Compound:6124449|FD-Score:15.20|P-value:1.91E-32 ID:SGTC_2229|Compound:7354935|FD-Score:5.87|P-value:2.51E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.94|P-value:3.27E-10 ID:SGTC_2248|Compound:tofa|FD-Score:10.70|P-value:4.38E-17 ID:SGTC_2277|Compound:7947813|FD-Score:4.65|P-value:1.50E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.63|P-value:1.60E-4 ID:SGTC_2301|Compound:7769476|FD-Score:4.52|P-value:2.25E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.81|P-value:6.06E-8 ID:SGTC_2375|Compound:9072683|FD-Score:3.99|P-value:9.69E-4 ID:SGTC_2378|Compound:9074213|FD-Score:6.59|P-value:1.48E-7 ID:SGTC_2387|Compound:9077560|FD-Score:4.19|P-value:5.71E-4 ID:SGTC_2396|Compound:5342950|FD-Score:8.81|P-value:3.65E-12 ID:SGTC_2400|Compound:5203494|FD-Score:5.45|P-value:1.12E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:10.20|P-value:1.14E-15 ID:SGTC_2534|Compound:helenine|FD-Score:6.16|P-value:8.30E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:4.65|P-value:1.50E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:7.96|P-value:2.97E-10 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.25|P-value:6.04E-7 ID:SGTC_2662|Compound:daunorubicin|FD-Score:9.88|P-value:7.80E-15 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.21|P-value:6.86E-7 ID:SGTC_2738|Compound:aclarubicin|FD-Score:4.39|P-value:3.22E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:4.61|P-value:1.71E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:7.25|P-value:8.68E-9 ID:SGTC_2766|Compound:oltipraz|FD-Score:9.66|P-value:2.93E-14 ID:SGTC_2779|Compound:methotrexate|FD-Score:-7.24|P-value:8.44E-9 ID:SGTC_2809|Compound:7964133|FD-Score:4.26|P-value:4.65E-4 ID:SGTC_2845|Compound:9003024|FD-Score:9.93|P-value:5.56E-15 ID:SGTC_2867|Compound:9039098|FD-Score:-4.46|P-value:2.55E-4 ID:SGTC_2890|Compound:9046729|FD-Score:5.38|P-value:1.45E-5 ID:SGTC_2912|Compound:7964298|FD-Score:12.30|P-value:4.91E-22 ID:SGTC_2921|Compound:7974240|FD-Score:4.83|P-value:8.78E-5 ID:SGTC_2962|Compound:9082311|FD-Score:5.37|P-value:1.50E-5 ID:SGTC_2997|Compound:9067075|FD-Score:13.50|P-value:3.76E-26 ID:SGTC_3020|Compound:9089140|FD-Score:4.75|P-value:1.11E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:6.64|P-value:1.21E-7 ID:SGTC_3060|Compound:1327-0027|FD-Score:6.47|P-value:2.45E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:5.42|P-value:1.26E-5 ID:SGTC_3064|Compound:1327-0027|FD-Score:4.24|P-value:5.01E-4 ID:SGTC_3143|Compound:9086658|FD-Score:6.70|P-value:9.65E-8 ID:SGTC_3266|Compound:9136860|FD-Score:4.30|P-value:4.15E-4 ID:SGTC_3277|Compound:9138724|FD-Score:9.48|P-value:8.28E-14 ID:SGTC_3311|Compound:9131146|FD-Score:4.58|P-value:1.86E-4 ID:SGTC_3318|Compound:9139014|FD-Score:4.37|P-value:3.42E-4 ID:SGTC_3321|Compound:9137793|FD-Score:8.55|P-value:1.48E-11

Top fitness defect scores for YNR016C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1974 st069448 22.00 26.9 µM 4.41E-66 1 9.49E-108 17.10
2 SGTC_1652 st011932 19.00 78.0 µM 5.68E-50 RSC complex & mRNA processing 3 3.51E-81 2.89
3 SGTC_2186 6124449 15.20 200.0 µM 1.91E-32 RSC complex & mRNA processing 2 2.69E-52 1.15
4 SGTC_1374 2889-5571 14.70 141.0 µM 1.73E-30 RSC complex & mRNA processing 5 4.53E-49 1.01
5 SGTC_673 1082-0474 14.20 110.0 µM 1.39E-28 RSC complex & mRNA processing 3 6.22E-46 1.18
6 SGTC_181 1447-1644 13.60 8.1 µM 1.79E-26 endomembrane recycling 1 1.86E-42 5.08
7 SGTC_2997 9067075 13.50 71.4 µM 3.76E-26 unfolded protein response 1 6.28E-42 2.49
8 SGTC_1133 3473-0247 12.90 50.0 µM 3.75E-24 RSC complex & mRNA processing 3 1.22E-38 1.31
9 SGTC_2912 7964298 12.30 10.9 µM 4.91E-22 cell wall 8 3.73E-35 0.41
10 SGTC_2111 5486399 12.00 200.0 µM 7.18E-21 6 3.08E-33 1.70
11 SGTC_2248 tofa 10.70 1.1 µM 4.38E-17 sphingolipid biosynthesis & PDR1 6 5.16E-27 0.44
12 SGTC_2408 sulbentine 10.20 18.4 µM 1.14E-15 5 1.10E-24 0.22
13 SGTC_354 2783-3500 10.20 4.9 µM 1.21E-15 cell wall 3 1.20E-24 1.33
14 SGTC_829 1635-0120 10.10 117.0 µM 2.32E-15 DNA damage response 7 3.49E-24 0.94
15 SGTC_2845 9003024 9.93 43.0 µM 5.56E-15 amide catabolism 1 1.47E-23 2.25
16 SGTC_2662 daunorubicin 9.88 22.4 µM 7.80E-15 anthracycline transcription coupled DNA repair 2 2.57E-23 0.17
17 SGTC_2766 oltipraz 9.66 83.9 µM 2.93E-14 heme requiring 4 2.25E-22 0.19
18 SGTC_3277 9138724 9.48 49.5 µM 8.28E-14 Golgi 2 1.24E-21 1.55
19 SGTC_1050 3232-1156 9.40 69.3 µM 1.37E-13 RSC complex & mRNA processing 2 2.82E-21 1.03
20 SGTC_871 0574-0004 9.39 149.0 µM 1.42E-13 6 3.02E-21 0.27

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.525 1.06E-236 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.486 4.08E-198 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.479 2.96E-192 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.446 2.55E-163 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.441 1.28E-159 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.423 1.34E-145 YAL001C TFC3 het Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
0.421 3.77E-144 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.392 8.04E-124 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.389 2.58E-121 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.388 6.50E-121 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.370 1.01E-109 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.366 4.40E-107 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.363 5.04E-105 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.359 1.99E-102 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.358 9.07E-102 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p