YNR019W / ARE2

Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR019W / ARE2

Click on Significant Values for Screen Details ID:SGTC_144|Compound:4161-2749|FD-Score:-3.42|P-value:2.93E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:-3.41|P-value:3.09E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.31|P-value:4.67E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:5.53|P-value:1.62E-8 ID:SGTC_687|Compound:k029-0044|FD-Score:3.63|P-value:1.45E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.07|P-value:2.35E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.72|P-value:9.49E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.80|P-value:6.89E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.40|P-value:3.40E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.47|P-value:2.63E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.23|P-value:1.19E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.50|P-value:2.22E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-4.38|P-value:5.64E-6 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.81|P-value:7.12E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.40|P-value:3.45E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.40|P-value:3.44E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.10|P-value:9.81E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.71|P-value:1.03E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-4.19|P-value:1.32E-5 ID:SGTC_2329|Compound:6138490|FD-Score:4.80|P-value:7.77E-7 ID:SGTC_2415|Compound:st077333|FD-Score:3.13|P-value:8.87E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.28|P-value:5.00E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.16|P-value:7.49E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.62|P-value:9.35E-9 ID:SGTC_2602|Compound:kawain|FD-Score:3.10|P-value:9.70E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.13|P-value:1.82E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.25|P-value:1.08E-5 ID:SGTC_3038|Compound:9091290|FD-Score:3.95|P-value:3.97E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.11|P-value:9.39E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.68|P-value:1.47E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.42|P-value:2.93E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:-3.41|P-value:3.09E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.31|P-value:4.67E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:5.53|P-value:1.62E-8 ID:SGTC_687|Compound:k029-0044|FD-Score:3.63|P-value:1.45E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.07|P-value:2.35E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.72|P-value:9.49E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.80|P-value:6.89E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.40|P-value:3.40E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.47|P-value:2.63E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.23|P-value:1.19E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.50|P-value:2.22E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-4.38|P-value:5.64E-6 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.81|P-value:7.12E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.40|P-value:3.45E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.40|P-value:3.44E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.10|P-value:9.81E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.71|P-value:1.03E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-4.19|P-value:1.32E-5 ID:SGTC_2329|Compound:6138490|FD-Score:4.80|P-value:7.77E-7 ID:SGTC_2415|Compound:st077333|FD-Score:3.13|P-value:8.87E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.28|P-value:5.00E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.16|P-value:7.49E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.62|P-value:9.35E-9 ID:SGTC_2602|Compound:kawain|FD-Score:3.10|P-value:9.70E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.13|P-value:1.82E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.25|P-value:1.08E-5 ID:SGTC_3038|Compound:9091290|FD-Score:3.95|P-value:3.97E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.11|P-value:9.39E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.68|P-value:1.47E-6

Top fitness defect scores for YNR019W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 5.62 100.0 µM 9.35E-9 redox potentiating 181 9.39E-9
2 SGTC_686 1319-0111 5.53 510.0 µM 1.62E-8 60S ribosome export 3 1.63E-8
3 SGTC_2329 6138490 4.80 200.0 µM 7.77E-7 12 7.75E-7
4 SGTC_3157 9099274 4.68 49.5 µM 1.47E-6 10 1.46E-6
5 SGTC_2771 fluoxetine 4.25 41.0 µM 1.08E-5 13 1.08E-5
6 SGTC_1244 0416-0015 4.23 52.5 µM 1.19E-5 ERG2 28 1.19E-5
7 SGTC_2752 diclazuril 4.13 33.1 µM 1.82E-5 108 1.80E-5
8 SGTC_827 3253-0474 4.07 693.0 µM 2.35E-5 16 2.34E-5
9 SGTC_3038 9091290 3.95 49.5 µM 3.97E-5 14 3.94E-5
10 SGTC_1465 k213-0056 3.81 144.0 µM 7.12E-5 DNA intercalators 26 7.06E-5
11 SGTC_2055 5235184 3.71 200.0 µM 1.03E-4 ERG2 44 1.02E-4
12 SGTC_687 k029-0044 3.63 34.9 µM 1.45E-4 PDR1 24 1.44E-4
13 SGTC_1176 0848-0131 3.47 83.3 µM 2.63E-4 Golgi 34 2.60E-4
14 SGTC_967 1306-0166 3.40 352.0 µM 3.40E-4 61 3.36E-4
15 SGTC_1705 st027868 3.40 56.3 µM 3.44E-4 25 3.40E-4
16 SGTC_1521 st012942 3.40 49.4 µM 3.45E-4 53 3.41E-4
17 SGTC_676 falcarinol 3.31 140.0 µM 4.67E-4 77 4.62E-4
18 SGTC_2415 st077333 3.13 57.7 µM 8.87E-4 104 8.77E-4
19 SGTC_3063 1327-0034 3.11 4.0 µM 9.39E-4 67 9.28E-4
20 SGTC_2602 kawain 3.10 100.0 µM 9.70E-4 69 9.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.233 2.65E-42 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.170 3.01E-23 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.162 3.39E-21 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.159 1.75E-20 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.148 5.70E-18 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.148 6.62E-18 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.148 7.80E-18 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.146 2.17E-17 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.139 7.51E-16 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.138 9.86E-16 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.138 1.29E-15 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.137 1.59E-15 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.129 6.05E-14 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.126 2.76E-13 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.124 5.56E-13 YKR029C SET3 hom Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication