HIPHOP chemogenomics database
YNR023W / SNF12 
73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YNR023W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.088 | 3.89E-7 | YJR090C | GRR1 | hom | F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification |
| 0.085 | 9.30E-7 | YMR205C | PFK2 | hom | Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes |
| 0.083 | 1.39E-6 | YLL002W | RTT109 | hom | Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p |
| 0.079 | 4.45E-6 | YMR189W | GCV2 | hom | P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm |
| 0.075 | 1.34E-5 | YLR072W_p | YLR072W_p | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene |
| 0.074 | 1.83E-5 | YJL144W | YJL144W | hom | Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress |
| 0.072 | 3.30E-5 | YCL048W | SPS22 | hom | Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall |
| 0.070 | 4.79E-5 | YMR049C | ERB1 | het | Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 |
| 0.068 | 7.97E-5 | YEL018W | EAF5 | hom | Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex |
| 0.065 | 1.53E-4 | YML131W | YML131W | hom | Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress |
| 0.065 | 1.75E-4 | YOR242C | SSP2 | hom | Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis |
| 0.063 | 2.58E-4 | YHR121W | LSM12 | hom | Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress |
| 0.062 | 3.47E-4 | YLR372W | SUR4 | hom | Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis |
| 0.061 | 3.81E-4 | YNL063W | MTQ1 | hom | S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene |
| 0.061 | 3.98E-4 | YNL143C_p | YNL143C_p | hom | Protein of unknown function; expressed at both mRNA and protein levels |