YNR023W / SNF12

73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR023W / SNF12

Click on Significant Values for Screen Details ID:SGTC_151|Compound:3013-0144|FD-Score:-3.14|P-value:4.98E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:4.62|P-value:9.45E-5 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.96|P-value:8.76E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:4.29|P-value:3.02E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.02|P-value:7.45E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.12|P-value:5.33E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.78|P-value:5.54E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:5.34|P-value:5.98E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:4.90|P-value:3.45E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:5.10|P-value:1.59E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.26|P-value:3.46E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.52|P-value:1.42E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.02|P-value:7.24E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.66|P-value:8.31E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.10|P-value:5.62E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:4.10|P-value:5.57E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.29|P-value:3.01E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.45|P-value:1.74E-4 ID:SGTC_1726|Compound:st035556|FD-Score:4.19|P-value:4.25E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.32|P-value:2.77E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.86|P-value:3.92E-5 ID:SGTC_1842|Compound:st055362|FD-Score:3.99|P-value:8.02E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.94|P-value:9.20E-4 ID:SGTC_1939|Compound:st074455|FD-Score:5.38|P-value:5.05E-6 ID:SGTC_1942|Compound:st076330|FD-Score:5.74|P-value:1.04E-6 ID:SGTC_2061|Compound:5245884|FD-Score:4.57|P-value:1.16E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.48|P-value:1.61E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.57|P-value:1.15E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.35|P-value:2.49E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.48|P-value:1.65E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-5.72|P-value:9.28E-9 ID:SGTC_2330|Compound:7979373|FD-Score:4.84|P-value:4.28E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.60|P-value:1.06E-4 ID:SGTC_2443|Compound:5493264|FD-Score:4.04|P-value:6.82E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.61|P-value:1.01E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.24|P-value:3.54E-4 ID:SGTC_2820|Compound:7989630|FD-Score:4.23|P-value:3.64E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.36|P-value:2.35E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.04|P-value:6.89E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.11|P-value:5.40E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.02|P-value:7.44E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.07|P-value:6.06E-4 ID:SGTC_3171|Compound:9103192|FD-Score:4.07|P-value:6.10E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-3.27|P-value:3.33E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.14|P-value:4.98E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:4.62|P-value:9.45E-5 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.96|P-value:8.76E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:4.29|P-value:3.02E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.02|P-value:7.45E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.12|P-value:5.33E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.78|P-value:5.54E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:5.34|P-value:5.98E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:4.90|P-value:3.45E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:5.10|P-value:1.59E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.26|P-value:3.46E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.52|P-value:1.42E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.02|P-value:7.24E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.66|P-value:8.31E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.10|P-value:5.62E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:4.10|P-value:5.57E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.29|P-value:3.01E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.45|P-value:1.74E-4 ID:SGTC_1726|Compound:st035556|FD-Score:4.19|P-value:4.25E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.32|P-value:2.77E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.86|P-value:3.92E-5 ID:SGTC_1842|Compound:st055362|FD-Score:3.99|P-value:8.02E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.94|P-value:9.20E-4 ID:SGTC_1939|Compound:st074455|FD-Score:5.38|P-value:5.05E-6 ID:SGTC_1942|Compound:st076330|FD-Score:5.74|P-value:1.04E-6 ID:SGTC_2061|Compound:5245884|FD-Score:4.57|P-value:1.16E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.48|P-value:1.61E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.57|P-value:1.15E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.35|P-value:2.49E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.48|P-value:1.65E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-5.72|P-value:9.28E-9 ID:SGTC_2330|Compound:7979373|FD-Score:4.84|P-value:4.28E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.60|P-value:1.06E-4 ID:SGTC_2443|Compound:5493264|FD-Score:4.04|P-value:6.82E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.61|P-value:1.01E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.24|P-value:3.54E-4 ID:SGTC_2820|Compound:7989630|FD-Score:4.23|P-value:3.64E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.36|P-value:2.35E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.04|P-value:6.89E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.11|P-value:5.40E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.02|P-value:7.44E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.07|P-value:6.06E-4 ID:SGTC_3171|Compound:9103192|FD-Score:4.07|P-value:6.10E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-3.27|P-value:3.33E-4

Top fitness defect scores for YNR023W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1942 st076330 5.74 65.2 µM 1.04E-6 5 4.61E-9
2 SGTC_1939 st074455 5.38 53.6 µM 5.05E-6 9 3.76E-8
3 SGTC_907 3448-6986 5.34 75.5 µM 5.98E-6 4 4.70E-8
4 SGTC_914 3820-6779 5.10 408.0 µM 1.59E-5 6 1.73E-7
5 SGTC_913 3487-1245 4.90 167.0 µM 3.45E-5 9 4.86E-7
6 SGTC_1826 st055655 4.86 41.6 µM 3.92E-5 ERG2 26 5.77E-7
7 SGTC_2330 7979373 4.84 200.0 µM 4.28E-5 60S ribosome export 17 6.48E-7
8 SGTC_1038 k292-0204 4.66 154.0 µM 8.31E-5 7 1.58E-6
9 SGTC_198 3454-2873 4.62 16.2 µM 9.45E-5 60S ribosome export 6 1.88E-6
10 SGTC_2498 4'-Methoxychalcone 4.61 54.6 µM 1.01E-4 RPP1 & pyrimidine depletion 19 2.06E-6
11 SGTC_2125 5246583 4.57 200.0 µM 1.15E-4 tubulin folding & SWR complex 30 2.44E-6
12 SGTC_2061 5245884 4.57 81.0 µM 1.16E-4 tubulin folding & SWR complex 15 2.46E-6
13 SGTC_1538 2',3',6-trimethoxyflavanone 4.45 63.6 µM 1.74E-4 11 4.28E-6
14 SGTC_2826 7992541 4.36 19.5 µM 2.35E-4 12 6.40E-6
15 SGTC_2239 6685329 4.35 187.6 µM 2.49E-4 19 6.92E-6
16 SGTC_1520 flindersine 4.29 88.0 µM 3.01E-4 24 8.92E-6
17 SGTC_657 3534-0529 4.29 86.7 µM 3.02E-4 9 8.97E-6
18 SGTC_2741 miltefosine 4.24 3.0 µM 3.54E-4 36 1.11E-5
19 SGTC_2820 7989630 4.23 71.4 µM 3.64E-4 ERG2 13 1.15E-5
20 SGTC_1726 st035556 4.19 14.6 µM 4.25E-4 31 1.42E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.088 3.89E-7 YJR090C GRR1 hom F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
0.085 9.30E-7 YMR205C PFK2 hom Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
0.083 1.39E-6 YLL002W RTT109 hom Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p
0.079 4.45E-6 YMR189W GCV2 hom P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
0.075 1.34E-5 YLR072W_p YLR072W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene
0.074 1.83E-5 YJL144W YJL144W hom Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress
0.072 3.30E-5 YCL048W SPS22 hom Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
0.070 4.79E-5 YMR049C ERB1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1
0.068 7.97E-5 YEL018W EAF5 hom Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex
0.065 1.53E-4 YML131W YML131W hom Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.065 1.75E-4 YOR242C SSP2 hom Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis
0.063 2.58E-4 YHR121W LSM12 hom Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress
0.062 3.47E-4 YLR372W SUR4 hom Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
0.061 3.81E-4 YNL063W MTQ1 hom S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene
0.061 3.98E-4 YNL143C_p YNL143C_p hom Protein of unknown function; expressed at both mRNA and protein levels