YNR024W / MPP6

Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR024W / MPP6

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:-4.03|P-value:2.43E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.60|P-value:1.43E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.13|P-value:8.04E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.68|P-value:1.02E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.27|P-value:4.85E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.74|P-value:8.12E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.11|P-value:8.71E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.15|P-value:7.54E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.52|P-value:1.93E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.23|P-value:5.64E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.50|P-value:2.09E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.16|P-value:7.16E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.92|P-value:3.92E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.81|P-value:6.10E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.40|P-value:3.08E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.22|P-value:5.81E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.10|P-value:8.95E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.47|P-value:2.34E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.45|P-value:2.49E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.33|P-value:3.93E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.25|P-value:5.24E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-6.10|P-value:3.75E-10 ID:SGTC_1724|Compound:st037281|FD-Score:-4.74|P-value:8.97E-7 ID:SGTC_1725|Compound:st036284|FD-Score:-4.55|P-value:2.27E-6 ID:SGTC_1735|Compound:st034310|FD-Score:4.83|P-value:5.65E-7 ID:SGTC_1758|Compound:st042942|FD-Score:4.54|P-value:2.38E-6 ID:SGTC_1937|Compound:st074714|FD-Score:-4.00|P-value:2.76E-5 ID:SGTC_2002|Compound:4023503|FD-Score:4.88|P-value:4.27E-7 ID:SGTC_2006|Compound:4011487|FD-Score:3.78|P-value:6.83E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.01|P-value:2.65E-5 ID:SGTC_2099|Compound:5377090|FD-Score:3.92|P-value:3.78E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.47|P-value:2.29E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.28|P-value:4.79E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.11|P-value:8.52E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-4.03|P-value:2.44E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-5.04|P-value:1.88E-7 ID:SGTC_2303|Compound:7774051|FD-Score:-3.96|P-value:3.31E-5 ID:SGTC_2307|Compound:7538926|FD-Score:3.64|P-value:1.20E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.56|P-value:1.68E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.11|P-value:1.73E-5 ID:SGTC_2707|Compound:st078556|FD-Score:4.00|P-value:2.76E-5 ID:SGTC_2708|Compound:st078559|FD-Score:4.66|P-value:1.33E-6 ID:SGTC_2714|Compound:st079313|FD-Score:-3.95|P-value:3.44E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.09|P-value:9.12E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.10|P-value:8.76E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.26|P-value:5.08E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.07|P-value:9.98E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.10|P-value:8.72E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.03|P-value:2.43E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.60|P-value:1.43E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.13|P-value:8.04E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.68|P-value:1.02E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.27|P-value:4.85E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.74|P-value:8.12E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.11|P-value:8.71E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.15|P-value:7.54E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.52|P-value:1.93E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.23|P-value:5.64E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.50|P-value:2.09E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.16|P-value:7.16E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.92|P-value:3.92E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.81|P-value:6.10E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.40|P-value:3.08E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.22|P-value:5.81E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.10|P-value:8.95E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.47|P-value:2.34E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.45|P-value:2.49E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.33|P-value:3.93E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.25|P-value:5.24E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-6.10|P-value:3.75E-10 ID:SGTC_1724|Compound:st037281|FD-Score:-4.74|P-value:8.97E-7 ID:SGTC_1725|Compound:st036284|FD-Score:-4.55|P-value:2.27E-6 ID:SGTC_1735|Compound:st034310|FD-Score:4.83|P-value:5.65E-7 ID:SGTC_1758|Compound:st042942|FD-Score:4.54|P-value:2.38E-6 ID:SGTC_1937|Compound:st074714|FD-Score:-4.00|P-value:2.76E-5 ID:SGTC_2002|Compound:4023503|FD-Score:4.88|P-value:4.27E-7 ID:SGTC_2006|Compound:4011487|FD-Score:3.78|P-value:6.83E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.01|P-value:2.65E-5 ID:SGTC_2099|Compound:5377090|FD-Score:3.92|P-value:3.78E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.47|P-value:2.29E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.28|P-value:4.79E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.11|P-value:8.52E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-4.03|P-value:2.44E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-5.04|P-value:1.88E-7 ID:SGTC_2303|Compound:7774051|FD-Score:-3.96|P-value:3.31E-5 ID:SGTC_2307|Compound:7538926|FD-Score:3.64|P-value:1.20E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.56|P-value:1.68E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.11|P-value:1.73E-5 ID:SGTC_2707|Compound:st078556|FD-Score:4.00|P-value:2.76E-5 ID:SGTC_2708|Compound:st078559|FD-Score:4.66|P-value:1.33E-6 ID:SGTC_2714|Compound:st079313|FD-Score:-3.95|P-value:3.44E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.09|P-value:9.12E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.10|P-value:8.76E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.26|P-value:5.08E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.07|P-value:9.98E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.10|P-value:8.72E-4

Top fitness defect scores for YNR024W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2002 4023503 4.88 131.0 µM 4.27E-7 mitochondrial processes 14 5.26E-7
2 SGTC_1735 st034310 4.83 56.8 µM 5.65E-7 Golgi 10 6.94E-7
3 SGTC_2708 st078559 4.66 56.0 µM 1.33E-6 1 1.62E-6
4 SGTC_1758 st042942 4.54 75.2 µM 2.38E-6 10 2.85E-6
5 SGTC_2008 4012253 4.01 172.0 µM 2.65E-5 24 3.06E-5
6 SGTC_2707 st078556 4.00 66.6 µM 2.76E-5 9 3.18E-5
7 SGTC_2099 5377090 3.92 177.4 µM 3.78E-5 22 4.34E-5
8 SGTC_2006 4011487 3.78 200.0 µM 6.83E-5 endomembrane recycling 88 7.77E-5
9 SGTC_654 1124-0271 3.74 80.9 µM 8.12E-5 27 9.21E-5
10 SGTC_588 3970-1144 3.68 52.9 µM 1.02E-4 32 1.15E-4
11 SGTC_2307 7538926 3.64 6.3 µM 1.20E-4 51 1.36E-4
12 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 3.60 4.6 µM 1.43E-4 heat shock/prefoldin 47 1.61E-4
13 SGTC_2563 tomatine 3.56 8.5 µM 1.68E-4 71 1.88E-4
14 SGTC_919 tnp00227 3.52 403.6 nM 1.93E-4 RNA pol III & RNase P/MRP 59 2.16E-4
15 SGTC_1031 k035-0009 3.50 16.0 µM 2.09E-4 45 2.34E-4
16 SGTC_2126 5251174 3.47 33.9 µM 2.29E-4 57 2.56E-4
17 SGTC_1587 estradiol valerate 3.47 56.1 µM 2.34E-4 22 2.61E-4
18 SGTC_1315 1237-0019 3.40 3.7 µM 3.08E-4 19 3.42E-4
19 SGTC_1660 st012960 3.33 28.1 µM 3.93E-4 iron homeostasis 60 4.35E-4
20 SGTC_593 1203-0218 3.27 61.7 µM 4.85E-4 28 5.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 3.46E-9 YKR046C PET10 hom Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
0.101 5.44E-9 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.095 3.12E-8 YNL092W_p YNL092W_p hom Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene
0.091 1.32E-7 YMR001C CDC5 het Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate
0.088 3.13E-7 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.088 3.26E-7 YPL149W ATG5 hom Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation
0.087 5.30E-7 YJL084C ALY2 hom Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication
0.084 1.05E-6 YBR239C_p ERT1_p hom Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition
0.084 1.30E-6 YKL168C KKQ8 hom Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication
0.084 1.28E-6 YDR487C RIB3 het 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
0.083 1.66E-6 YFR046C CNN1 hom Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T
0.082 2.17E-6 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.080 3.63E-6 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.078 5.45E-6 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.078 5.57E-6 YJL133W MRS3 hom Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication