HIPHOP chemogenomics database

YNR025C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase

Zygosity: Homozygous strain

fixedexpanded
Profile for YNR025C / YNR025C

Click on Significant Values for Screen Details

Top fitness defect scores for YNR025C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_937	3122-0005	5.79	46.7 µM	4.66E-10		7	3.57E-9
2	SGTC_617	3770-0098	5.29	35.0 µM	1.13E-8	exosome	6	6.13E-8
3	SGTC_930	2810-3379	5.27	265.0 µM	1.25E-8		1	6.70E-8
4	SGTC_1133	3473-0247	4.95	50.0 µM	8.55E-8	RSC complex & mRNA processing	21	3.74E-7
5	SGTC_178	4092-0806	4.71	87.5 µM	3.33E-7	ergosterol depletion effects on membrane	62	1.26E-6
6	SGTC_2835	9006588	4.52	71.4 µM	8.99E-7		27	3.06E-6
7	SGTC_870	0573-2213	4.37	57.6 µM	1.97E-6	ERG2	12	6.17E-6
8	SGTC_2117	5521686	4.35	200.0 µM	2.18E-6		8	6.75E-6
9	SGTC_858	0438-0351	4.24	2.8 µM	3.79E-6	copper-dependent oxidative stress	15	1.11E-5
10	SGTC_1644	st010134	4.11	20.9 µM	7.23E-6	mitochondrial processes	12	1.98E-5
11	SGTC_414	piperonyl butoxide	4.06	100.0 µM	9.34E-6		5	2.48E-5
12	SGTC_756	0508-1999	4.01	28.3 µM	1.15E-5	RPP1 & pyrimidine depletion	22	3.00E-5
13	SGTC_3038	9091290	3.97	49.5 µM	1.39E-5		13	3.55E-5
14	SGTC_362	0310-0100	3.90	9.0 µM	1.93E-5	RPP1 & pyrimidine depletion	35	4.75E-5
15	SGTC_382	3229-0966	3.90	23.2 µM	1.95E-5		22	4.81E-5
16	SGTC_369	0957-0393	3.84	4.5 µM	2.62E-5	cell wall signaling	27	6.26E-5
17	SGTC_934	2950-0684	3.82	338.0 µM	2.88E-5		25	6.80E-5
18	SGTC_938	3126-1755	3.79	342.0 µM	3.22E-5		14	7.52E-5
19	SGTC_2282	7944268	3.78	200.0 µM	3.40E-5	RPP1 & pyrimidine depletion	37	7.91E-5
20	SGTC_87	0100-0052	3.77	35.5 µM	3.52E-5		120	8.16E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.153	6.19E-19	YDR056C_p	YDR056C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.129	5.20E-14	YKL202W_d	YKL202W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126	2.13E-13	YKL004W	AUR1	het	Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.109	2.28E-10	YDR510W	SMT3	het	Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2
0.105	9.51E-10	YNL134C	YNL134C	hom	Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.096	2.44E-8	YDR026C	NSI1	hom	RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication
0.096	2.79E-8	YNL140C_p	YNL140C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.091	1.34E-7	YDR308C	SRB7	het	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
0.090	1.88E-7	YER064C	VHR2	hom	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.089	2.57E-7	YBR277C_d	YBR277C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W
0.087	4.54E-7	YIL146C	ATG32	hom	Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane
0.086	6.83E-7	YBL004W	UTP20	het	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.081	2.89E-6	YNR028W	CPR8	hom	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.080	3.33E-6	YDR094W_d	YDR094W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.080	3.52E-6	YDL167C	NRP1	hom	Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis