YNR029C_p

Putative protein of unknown function, deletion confers reduced fitness in saline

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR029C / YNR029C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.20|P-value:4.59E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:4.06|P-value:9.53E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.77|P-value:4.78E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.20|P-value:3.62E-4 ID:SGTC_276|Compound:colchicine|FD-Score:5.60|P-value:1.95E-9 ID:SGTC_412|Compound:gemfibrozil|FD-Score:2.99|P-value:7.88E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.03|P-value:8.59E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.48|P-value:1.20E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:3.09|P-value:5.39E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:9.16|P-value:3.49E-22 ID:SGTC_588|Compound:3970-1144|FD-Score:3.04|P-value:6.57E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.34|P-value:2.79E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.53|P-value:1.29E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.18|P-value:5.07E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.02|P-value:8.87E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.34|P-value:2.12E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.99|P-value:7.44E-8 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.78|P-value:3.35E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.06|P-value:6.09E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:4.42|P-value:1.60E-6 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.83|P-value:2.70E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:-3.36|P-value:2.53E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.49|P-value:1.51E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.05|P-value:8.06E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.23|P-value:3.16E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.38|P-value:1.76E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.88|P-value:1.40E-7 ID:SGTC_1519|Compound:esterone|FD-Score:3.10|P-value:5.27E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.50|P-value:1.08E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.00|P-value:7.42E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.88|P-value:3.03E-10 ID:SGTC_2000|Compound:st075254|FD-Score:3.24|P-value:3.14E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.69|P-value:3.84E-7 ID:SGTC_2012|Compound:4023501|FD-Score:3.53|P-value:9.58E-5 ID:SGTC_2050|Compound:5263056|FD-Score:3.89|P-value:2.07E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-3.43|P-value:1.91E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.29|P-value:2.55E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.00|P-value:7.59E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.38|P-value:1.78E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.11|P-value:6.49E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.06|P-value:7.75E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.25|P-value:2.98E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.02|P-value:7.14E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.59|P-value:7.49E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.10|P-value:5.23E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.30|P-value:2.89E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.02|P-value:9.14E-4 ID:SGTC_2692|Compound:st077426|FD-Score:4.37|P-value:2.06E-6 ID:SGTC_2767|Compound:sibutramine|FD-Score:5.63|P-value:1.56E-9 ID:SGTC_2995|Compound:9067767|FD-Score:3.41|P-value:1.57E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-3.42|P-value:1.99E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.18|P-value:4.93E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.15|P-value:4.43E-4 ID:SGTC_3169|Compound:9102970|FD-Score:-3.67|P-value:7.33E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-3.29|P-value:3.26E-4 ID:SGTC_3185|Compound:9108267|FD-Score:-3.58|P-value:1.06E-4 ID:SGTC_3195|Compound:9113082|FD-Score:5.84|P-value:4.02E-10 ID:SGTC_3331|Compound:9141060|FD-Score:-3.89|P-value:2.81E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.20|P-value:4.59E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:4.06|P-value:9.53E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.77|P-value:4.78E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.20|P-value:3.62E-4 ID:SGTC_276|Compound:colchicine|FD-Score:5.60|P-value:1.95E-9 ID:SGTC_412|Compound:gemfibrozil|FD-Score:2.99|P-value:7.88E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.03|P-value:8.59E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.48|P-value:1.20E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:3.09|P-value:5.39E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:9.16|P-value:3.49E-22 ID:SGTC_588|Compound:3970-1144|FD-Score:3.04|P-value:6.57E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.34|P-value:2.79E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.53|P-value:1.29E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.18|P-value:5.07E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.02|P-value:8.87E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.34|P-value:2.12E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.99|P-value:7.44E-8 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.78|P-value:3.35E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.06|P-value:6.09E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:4.42|P-value:1.60E-6 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.83|P-value:2.70E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:-3.36|P-value:2.53E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.49|P-value:1.51E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.05|P-value:8.06E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.23|P-value:3.16E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.38|P-value:1.76E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.88|P-value:1.40E-7 ID:SGTC_1519|Compound:esterone|FD-Score:3.10|P-value:5.27E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.50|P-value:1.08E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.00|P-value:7.42E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.88|P-value:3.03E-10 ID:SGTC_2000|Compound:st075254|FD-Score:3.24|P-value:3.14E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.69|P-value:3.84E-7 ID:SGTC_2012|Compound:4023501|FD-Score:3.53|P-value:9.58E-5 ID:SGTC_2050|Compound:5263056|FD-Score:3.89|P-value:2.07E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-3.43|P-value:1.91E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.29|P-value:2.55E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.00|P-value:7.59E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.38|P-value:1.78E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.11|P-value:6.49E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.06|P-value:7.75E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.25|P-value:2.98E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.02|P-value:7.14E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.59|P-value:7.49E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.10|P-value:5.23E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.30|P-value:2.89E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.02|P-value:9.14E-4 ID:SGTC_2692|Compound:st077426|FD-Score:4.37|P-value:2.06E-6 ID:SGTC_2767|Compound:sibutramine|FD-Score:5.63|P-value:1.56E-9 ID:SGTC_2995|Compound:9067767|FD-Score:3.41|P-value:1.57E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-3.42|P-value:1.99E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.18|P-value:4.93E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.15|P-value:4.43E-4 ID:SGTC_3169|Compound:9102970|FD-Score:-3.67|P-value:7.33E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-3.29|P-value:3.26E-4 ID:SGTC_3185|Compound:9108267|FD-Score:-3.58|P-value:1.06E-4 ID:SGTC_3195|Compound:9113082|FD-Score:5.84|P-value:4.02E-10 ID:SGTC_3331|Compound:9141060|FD-Score:-3.89|P-value:2.81E-5

Top fitness defect scores for YNR029C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_545 4218-0007 9.16 221.0 µM 3.49E-22 2 2.58E-20
2 SGTC_1872 amphotericin b 5.88 148.0 nM 3.03E-10 RNA pol III & RNase P/MRP 11 1.99E-9
3 SGTC_3195 9113082 5.84 49.5 µM 4.02E-10 4 2.58E-9
4 SGTC_2767 sibutramine 5.63 71.5 µM 1.56E-9 4 8.88E-9
5 SGTC_276 colchicine 5.60 750.0 µM 1.95E-9 4 1.09E-8
6 SGTC_879 0831-1030 4.99 162.0 µM 7.44E-8 23 3.01E-7
7 SGTC_1505 k297-0037 4.88 20.6 µM 1.40E-7 9 5.35E-7
8 SGTC_2009 4012297 4.69 12.1 µM 3.84E-7 cell wall signaling 45 1.34E-6
9 SGTC_495 decylubiquinone 4.48 155.0 µM 1.20E-6 copper-dependent oxidative stress 13 3.79E-6
10 SGTC_1196 1588-0294 4.42 184.0 µM 1.60E-6 8 4.93E-6
11 SGTC_2692 st077426 4.37 47.7 µM 2.06E-6 18 6.22E-6
12 SGTC_2483 5729050 4.30 27.2 µM 2.89E-6 16 8.46E-6
13 SGTC_136 0097-0015 4.06 404.5 µM 9.53E-6 60S ribosome export 14 2.51E-5
14 SGTC_2050 5263056 3.89 171.0 µM 2.07E-5 fatty acid desaturase (OLE1) 46 5.08E-5
15 SGTC_1200 1643-0193 3.83 18.4 µM 2.70E-5 21 6.48E-5
16 SGTC_1016 4226-1401 3.78 38.0 µM 3.35E-5 RNA pol III & RNase P/MRP 21 7.89E-5
17 SGTC_2432 5630864 3.59 12.2 µM 7.49E-5 34 1.64E-4
18 SGTC_2012 4023501 3.53 200.0 µM 9.58E-5 48 2.05E-4
19 SGTC_8 0354-0001 3.52 70.0 µM 1.02E-4 99 2.17E-4
20 SGTC_1676 st018489 3.50 23.4 µM 1.08E-4 60S ribosome export 52 2.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 3.02E-21 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.157 6.96E-20 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.148 7.72E-18 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.133 8.94E-15 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.100 6.20E-9 YFL053W DAK2 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.098 1.14E-8 YNL282W POP3 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.097 1.55E-8 YGR227W DIE2 hom Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1
0.094 4.31E-8 YGR231C PHB2 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.094 5.49E-8 YKR067W GPT2 hom Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen
0.089 2.60E-7 YBL070C_d YBL070C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.087 4.19E-7 YNL046W_p YNL046W_p hom Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.086 5.42E-7 YGL001C ERG26 het C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
0.084 1.05E-6 YHR021C RPS27B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication
0.082 2.25E-6 YDR276C PMP3 hom Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
0.080 3.06E-6 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data