YNR034W / SOL1

Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR034W / SOL1

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:-3.30|P-value:1.13E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:2.73|P-value:7.45E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:2.82|P-value:5.24E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:2.74|P-value:7.28E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.03|P-value:1.64E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.38|P-value:7.65E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:-4.49|P-value:2.23E-7 ID:SGTC_368|Compound:fentichlor|FD-Score:5.42|P-value:2.11E-10 ID:SGTC_406|Compound:estrone|FD-Score:3.90|P-value:3.17E-6 ID:SGTC_555|Compound:4296-0685|FD-Score:-3.27|P-value:1.25E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.13|P-value:1.42E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.13|P-value:1.38E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.10|P-value:1.08E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.30|P-value:1.09E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.15|P-value:8.02E-7 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:2.66|P-value:9.89E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.68|P-value:8.90E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.02|P-value:2.30E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.15|P-value:1.26E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-3.47|P-value:5.05E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.20|P-value:6.24E-7 ID:SGTC_1749|Compound:st037932|FD-Score:-3.53|P-value:3.83E-5 ID:SGTC_1826|Compound:st055655|FD-Score:-2.97|P-value:4.47E-4 ID:SGTC_1839|Compound:st053978|FD-Score:2.76|P-value:6.50E-4 ID:SGTC_1927|Compound:st060202|FD-Score:2.85|P-value:4.55E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.61|P-value:1.48E-5 ID:SGTC_1989|Compound:st071868|FD-Score:2.93|P-value:3.37E-4 ID:SGTC_2075|Compound:5212009|FD-Score:2.87|P-value:4.28E-4 ID:SGTC_2166|Compound:5933061|FD-Score:5.40|P-value:2.58E-10 ID:SGTC_2285|Compound:7945142|FD-Score:3.44|P-value:3.31E-5 ID:SGTC_2341|Compound:7987486|FD-Score:2.75|P-value:6.87E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-2.96|P-value:4.79E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.18|P-value:6.81E-7 ID:SGTC_2383|Compound:9036125|FD-Score:-2.96|P-value:4.70E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.02|P-value:2.29E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.69|P-value:9.79E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.06|P-value:1.89E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-2.86|P-value:6.95E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-3.28|P-value:1.20E-4 ID:SGTC_2716|Compound:st080858|FD-Score:2.67|P-value:9.36E-4 ID:SGTC_2789|Compound:5281112|FD-Score:2.87|P-value:4.26E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.22|P-value:1.61E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.11|P-value:1.55E-4 ID:SGTC_2991|Compound:9074669|FD-Score:2.81|P-value:5.42E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.45|P-value:3.16E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-2.82|P-value:8.16E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.26|P-value:7.74E-5 ID:SGTC_3102|Compound:9121669|FD-Score:-3.06|P-value:3.11E-4 ID:SGTC_3106|Compound:9121286|FD-Score:2.71|P-value:8.14E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-3.96|P-value:4.39E-6 ID:SGTC_3177|Compound:9107506|FD-Score:3.42|P-value:3.73E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.35|P-value:2.55E-7 ID:SGTC_3296|Compound:9122258|FD-Score:-3.68|P-value:1.85E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.30|P-value:1.13E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:2.73|P-value:7.45E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:2.82|P-value:5.24E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:2.74|P-value:7.28E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.03|P-value:1.64E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.38|P-value:7.65E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:-4.49|P-value:2.23E-7 ID:SGTC_368|Compound:fentichlor|FD-Score:5.42|P-value:2.11E-10 ID:SGTC_406|Compound:estrone|FD-Score:3.90|P-value:3.17E-6 ID:SGTC_555|Compound:4296-0685|FD-Score:-3.27|P-value:1.25E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.13|P-value:1.42E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.13|P-value:1.38E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.10|P-value:1.08E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.30|P-value:1.09E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.15|P-value:8.02E-7 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:2.66|P-value:9.89E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.68|P-value:8.90E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.02|P-value:2.30E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.15|P-value:1.26E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-3.47|P-value:5.05E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.20|P-value:6.24E-7 ID:SGTC_1749|Compound:st037932|FD-Score:-3.53|P-value:3.83E-5 ID:SGTC_1826|Compound:st055655|FD-Score:-2.97|P-value:4.47E-4 ID:SGTC_1839|Compound:st053978|FD-Score:2.76|P-value:6.50E-4 ID:SGTC_1927|Compound:st060202|FD-Score:2.85|P-value:4.55E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.61|P-value:1.48E-5 ID:SGTC_1989|Compound:st071868|FD-Score:2.93|P-value:3.37E-4 ID:SGTC_2075|Compound:5212009|FD-Score:2.87|P-value:4.28E-4 ID:SGTC_2166|Compound:5933061|FD-Score:5.40|P-value:2.58E-10 ID:SGTC_2285|Compound:7945142|FD-Score:3.44|P-value:3.31E-5 ID:SGTC_2341|Compound:7987486|FD-Score:2.75|P-value:6.87E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-2.96|P-value:4.79E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.18|P-value:6.81E-7 ID:SGTC_2383|Compound:9036125|FD-Score:-2.96|P-value:4.70E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.02|P-value:2.29E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.69|P-value:9.79E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.06|P-value:1.89E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-2.86|P-value:6.95E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-3.28|P-value:1.20E-4 ID:SGTC_2716|Compound:st080858|FD-Score:2.67|P-value:9.36E-4 ID:SGTC_2789|Compound:5281112|FD-Score:2.87|P-value:4.26E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.22|P-value:1.61E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.11|P-value:1.55E-4 ID:SGTC_2991|Compound:9074669|FD-Score:2.81|P-value:5.42E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.45|P-value:3.16E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-2.82|P-value:8.16E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.26|P-value:7.74E-5 ID:SGTC_3102|Compound:9121669|FD-Score:-3.06|P-value:3.11E-4 ID:SGTC_3106|Compound:9121286|FD-Score:2.71|P-value:8.14E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-3.96|P-value:4.39E-6 ID:SGTC_3177|Compound:9107506|FD-Score:3.42|P-value:3.73E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.35|P-value:2.55E-7 ID:SGTC_3296|Compound:9122258|FD-Score:-3.68|P-value:1.85E-5

Top fitness defect scores for YNR034W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_368 fentichlor 5.42 4.6 µM 2.11E-10 5 2.92E-8
2 SGTC_2166 5933061 5.40 31.5 µM 2.58E-10 tubulin folding & SWR complex 17 3.40E-8
3 SGTC_3236 9132701 4.35 49.5 µM 2.55E-7 TSC3-RPN4 16 6.79E-6
4 SGTC_1742 st038235 4.20 28.9 µM 6.24E-7 mitochondrial stress 109 1.35E-5
5 SGTC_2378 9074213 4.18 121.4 µM 6.81E-7 RSC complex & mRNA processing 13 1.45E-5
6 SGTC_1510 1123-0200 4.15 71.5 µM 8.02E-7 37 1.64E-5
7 SGTC_1001 4048-4355 4.10 44.4 µM 1.08E-6 copper-dependent oxidative stress 30 2.06E-5
8 SGTC_87 0100-0052 4.03 35.5 µM 1.64E-6 101 2.84E-5
9 SGTC_406 estrone 3.90 100.0 µM 3.17E-6 9 4.73E-5
10 SGTC_2557 derrustone 3.69 83.8 µM 9.79E-6 46 1.13E-4
11 SGTC_1945 st075991 3.61 56.6 µM 1.48E-5 60S ribosome export 31 1.55E-4
12 SGTC_2997 9067075 3.45 71.4 µM 3.16E-5 unfolded protein response 73 2.77E-4
13 SGTC_2285 7945142 3.44 200.0 µM 3.31E-5 37 2.87E-4
14 SGTC_3177 9107506 3.42 49.5 µM 3.73E-5 ERG2 12 3.15E-4
15 SGTC_3040 9091894 3.26 49.5 µM 7.74E-5 DNA intercalators 35 5.53E-4
16 SGTC_1702 st027038 3.15 51.0 µM 1.26E-4 43 8.06E-4
17 SGTC_958 1222-0007 3.13 33.0 µM 1.38E-4 58 8.62E-4
18 SGTC_834 0312-0008 3.13 75.7 µM 1.42E-4 NEO1 78 8.81E-4
19 SGTC_2968 9090663 3.11 33.4 µM 1.55E-4 67 9.42E-4
20 SGTC_2578 7,8-dihydroxyflavone 3.06 64.4 µM 1.89E-4 75 0.00110

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 3.67E-12 YOR045W TOM6 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.111 1.08E-10 YDR438W THI74 hom Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication
0.104 1.44E-9 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.102 3.04E-9 YPL164C MLH3 hom Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
0.101 4.10E-9 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.091 1.21E-7 YPL211W NIP7 het Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
0.089 2.76E-7 YNL150W_d YNL150W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.088 2.95E-7 YPL265W DIP5 hom Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress
0.088 3.08E-7 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.087 5.07E-7 YMR172C-A_d YMR172C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.082 1.73E-6 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.082 2.18E-6 YLL029W FRA1 hom Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
0.081 2.71E-6 YDR029W_d YDR029W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.079 4.23E-6 YNL057W_d YNL057W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.078 6.28E-6 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress