HIPHOP chemogenomics database

YNR034W / SOL1

Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YNR034W / SOL1

Click on Significant Values for Screen Details

Top fitness defect scores for YNR034W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_368	fentichlor	5.42	4.6 µM	2.11E-10		5	2.92E-8
2	SGTC_2166	5933061	5.40	31.5 µM	2.58E-10	tubulin folding & SWR complex	17	3.40E-8
3	SGTC_3236	9132701	4.35	49.5 µM	2.55E-7	TSC3-RPN4	16	6.79E-6
4	SGTC_1742	st038235	4.20	28.9 µM	6.24E-7	mitochondrial stress	109	1.35E-5
5	SGTC_2378	9074213	4.18	121.4 µM	6.81E-7	RSC complex & mRNA processing	13	1.45E-5
6	SGTC_1510	1123-0200	4.15	71.5 µM	8.02E-7		37	1.64E-5
7	SGTC_1001	4048-4355	4.10	44.4 µM	1.08E-6	copper-dependent oxidative stress	30	2.06E-5
8	SGTC_87	0100-0052	4.03	35.5 µM	1.64E-6		101	2.84E-5
9	SGTC_406	estrone	3.90	100.0 µM	3.17E-6		9	4.73E-5
10	SGTC_2557	derrustone	3.69	83.8 µM	9.79E-6		46	1.13E-4
11	SGTC_1945	st075991	3.61	56.6 µM	1.48E-5	60S ribosome export	31	1.55E-4
12	SGTC_2997	9067075	3.45	71.4 µM	3.16E-5	unfolded protein response	73	2.77E-4
13	SGTC_2285	7945142	3.44	200.0 µM	3.31E-5		37	2.87E-4
14	SGTC_3177	9107506	3.42	49.5 µM	3.73E-5	ERG2	12	3.15E-4
15	SGTC_3040	9091894	3.26	49.5 µM	7.74E-5	DNA intercalators	35	5.53E-4
16	SGTC_1702	st027038	3.15	51.0 µM	1.26E-4		43	8.06E-4
17	SGTC_958	1222-0007	3.13	33.0 µM	1.38E-4		58	8.62E-4
18	SGTC_834	0312-0008	3.13	75.7 µM	1.42E-4	NEO1	78	8.81E-4
19	SGTC_2968	9090663	3.11	33.4 µM	1.55E-4		67	9.42E-4
20	SGTC_2578	7,8-dihydroxyflavone	3.06	64.4 µM	1.89E-4		75	0.00110

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.120	3.67E-12	YOR045W	TOM6	hom	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.111	1.08E-10	YDR438W	THI74	hom	Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication
0.104	1.44E-9	YNL134C	YNL134C	hom	Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.102	3.04E-9	YPL164C	MLH3	hom	Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
0.101	4.10E-9	YIL032C_d	YIL032C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.091	1.21E-7	YPL211W	NIP7	het	Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
0.089	2.76E-7	YNL150W_d	YNL150W_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.088	2.95E-7	YPL265W	DIP5	hom	Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress
0.088	3.08E-7	YDR050C	TPI1	het	Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.087	5.07E-7	YMR172C-A_d	YMR172C-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.082	1.73E-6	YHR168W	MTG2	hom	Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.082	2.18E-6	YLL029W	FRA1	hom	Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
0.081	2.71E-6	YDR029W_d	YDR029W_d	hom	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.079	4.23E-6	YNL057W_d	YNL057W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.078	6.28E-6	YLR149C	YLR149C	hom	Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress