YNR035C / ARC35

Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNR035C / ARC35

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:5.22|P-value:5.16E-6 ID:SGTC_49|Compound:0717-0965|FD-Score:4.23|P-value:1.74E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:6.30|P-value:4.86E-8 ID:SGTC_285|Compound:1486-1325|FD-Score:8.14|P-value:2.76E-12 ID:SGTC_344|Compound:k064-0035|FD-Score:6.24|P-value:6.37E-8 ID:SGTC_348|Compound:k064-0012|FD-Score:3.78|P-value:7.10E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:7.15|P-value:7.25E-10 ID:SGTC_572|Compound:0960-0087|FD-Score:-4.15|P-value:2.08E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.87|P-value:5.38E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:4.21|P-value:1.89E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.78|P-value:6.92E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:4.01|P-value:3.48E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:22.20|P-value:1.55E-79 ID:SGTC_849|Compound:0386-0493|FD-Score:6.88|P-value:2.88E-9 ID:SGTC_874|Compound:0599-0792|FD-Score:3.68|P-value:9.26E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.57|P-value:5.62E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:4.82|P-value:2.31E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:4.09|P-value:2.74E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.19|P-value:1.98E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:-3.87|P-value:5.02E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:4.37|P-value:1.09E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.96|P-value:4.06E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.66|P-value:9.96E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.72|P-value:7.72E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.29|P-value:1.43E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-4.72|P-value:3.03E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.96|P-value:4.12E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.13|P-value:1.09E-7 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.77|P-value:7.13E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.74|P-value:7.90E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.38|P-value:1.06E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.65|P-value:9.66E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.96|P-value:4.08E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.20|P-value:5.49E-6 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-4.09|P-value:2.53E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.81|P-value:6.51E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-4.02|P-value:3.16E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.80|P-value:6.25E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.66|P-value:9.86E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.96|P-value:4.12E-4 ID:SGTC_2158|Compound:5657123|FD-Score:4.40|P-value:9.83E-5 ID:SGTC_2197|Compound:6588183|FD-Score:3.84|P-value:5.80E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.76|P-value:7.33E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.44|P-value:8.81E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.32|P-value:1.30E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.66|P-value:9.97E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.66|P-value:9.35E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:8.34|P-value:8.52E-13 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.90|P-value:4.55E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.88|P-value:5.22E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.89|P-value:5.00E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.75|P-value:7.16E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.46|P-value:1.95E-6 ID:SGTC_2666|Compound:tannic acid|FD-Score:11.30|P-value:4.74E-22 ID:SGTC_2691|Compound:st077356|FD-Score:5.25|P-value:4.56E-6 ID:SGTC_2695|Compound:st077686|FD-Score:-4.74|P-value:2.81E-5 ID:SGTC_2842|Compound:9000675|FD-Score:4.23|P-value:1.75E-4 ID:SGTC_2888|Compound:9058547|FD-Score:5.06|P-value:9.49E-6 ID:SGTC_2905|Compound:7799065|FD-Score:-4.67|P-value:3.66E-5 ID:SGTC_2917|Compound:7979103|FD-Score:-4.15|P-value:2.12E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-4.67|P-value:3.58E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-4.52|P-value:6.15E-5 ID:SGTC_3142|Compound:9086498|FD-Score:4.20|P-value:1.90E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.77|P-value:7.21E-4 ID:SGTC_3188|Compound:9110789|FD-Score:5.41|P-value:2.34E-6 ID:SGTC_3233|Compound:9132340|FD-Score:5.11|P-value:7.75E-6 ID:SGTC_32|Compound:0928-0142|FD-Score:5.22|P-value:5.16E-6 ID:SGTC_49|Compound:0717-0965|FD-Score:4.23|P-value:1.74E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:6.30|P-value:4.86E-8 ID:SGTC_285|Compound:1486-1325|FD-Score:8.14|P-value:2.76E-12 ID:SGTC_344|Compound:k064-0035|FD-Score:6.24|P-value:6.37E-8 ID:SGTC_348|Compound:k064-0012|FD-Score:3.78|P-value:7.10E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:7.15|P-value:7.25E-10 ID:SGTC_572|Compound:0960-0087|FD-Score:-4.15|P-value:2.08E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.87|P-value:5.38E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:4.21|P-value:1.89E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.78|P-value:6.92E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:4.01|P-value:3.48E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:22.20|P-value:1.55E-79 ID:SGTC_849|Compound:0386-0493|FD-Score:6.88|P-value:2.88E-9 ID:SGTC_874|Compound:0599-0792|FD-Score:3.68|P-value:9.26E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.57|P-value:5.62E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:4.82|P-value:2.31E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:4.09|P-value:2.74E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.19|P-value:1.98E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:-3.87|P-value:5.02E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:4.37|P-value:1.09E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.96|P-value:4.06E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.66|P-value:9.96E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.72|P-value:7.72E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.29|P-value:1.43E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-4.72|P-value:3.03E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.96|P-value:4.12E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.13|P-value:1.09E-7 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.77|P-value:7.13E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.74|P-value:7.90E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.38|P-value:1.06E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.65|P-value:9.66E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.96|P-value:4.08E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.20|P-value:5.49E-6 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-4.09|P-value:2.53E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.81|P-value:6.51E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-4.02|P-value:3.16E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.80|P-value:6.25E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.66|P-value:9.86E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.96|P-value:4.12E-4 ID:SGTC_2158|Compound:5657123|FD-Score:4.40|P-value:9.83E-5 ID:SGTC_2197|Compound:6588183|FD-Score:3.84|P-value:5.80E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.76|P-value:7.33E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.44|P-value:8.81E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.32|P-value:1.30E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.66|P-value:9.97E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.66|P-value:9.35E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:8.34|P-value:8.52E-13 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.90|P-value:4.55E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.88|P-value:5.22E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.89|P-value:5.00E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.75|P-value:7.16E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.46|P-value:1.95E-6 ID:SGTC_2666|Compound:tannic acid|FD-Score:11.30|P-value:4.74E-22 ID:SGTC_2691|Compound:st077356|FD-Score:5.25|P-value:4.56E-6 ID:SGTC_2695|Compound:st077686|FD-Score:-4.74|P-value:2.81E-5 ID:SGTC_2842|Compound:9000675|FD-Score:4.23|P-value:1.75E-4 ID:SGTC_2888|Compound:9058547|FD-Score:5.06|P-value:9.49E-6 ID:SGTC_2905|Compound:7799065|FD-Score:-4.67|P-value:3.66E-5 ID:SGTC_2917|Compound:7979103|FD-Score:-4.15|P-value:2.12E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-4.67|P-value:3.58E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-4.52|P-value:6.15E-5 ID:SGTC_3142|Compound:9086498|FD-Score:4.20|P-value:1.90E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.77|P-value:7.21E-4 ID:SGTC_3188|Compound:9110789|FD-Score:5.41|P-value:2.34E-6 ID:SGTC_3233|Compound:9132340|FD-Score:5.11|P-value:7.75E-6

Top fitness defect scores for YNR035C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_748 0136-0228 22.20 77.9 µM 1.55E-79 redox potentiating 1 5.87E-110 5.89
2 SGTC_2666 tannic acid 11.30 100.0 µM 4.74E-22 iron homeostasis 1 5.39E-30 4.63
3 SGTC_2544 sphondin 8.34 68.5 µM 8.52E-13 RNA pol III & RNase P/MRP 9 3.80E-17 0.16
4 SGTC_285 1486-1325 8.14 46.0 µM 2.76E-12 1 1.93E-16 2.72
5 SGTC_525 k781-2675 7.15 26.7 µM 7.25E-10 redox potentiating 11 4.35E-13 0.17
6 SGTC_849 0386-0493 6.88 241.0 µM 2.88E-9 1 2.95E-12 1.14
7 SGTC_149 3970-0822 6.30 46.1 µM 4.86E-8 tubulin folding & SWR complex 2 1.46E-10 0.23
8 SGTC_344 k064-0035 6.24 6.4 µM 6.37E-8 60S ribosome export 2 2.13E-10 1.15
9 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 6.13 54.9 µM 1.09E-7 redox potentiating 2 4.45E-10 1.06
10 SGTC_2619 obliquin 5.46 87.9 µM 1.95E-6 cell wall 19 2.39E-8 0.12
11 SGTC_3188 9110789 5.41 49.5 µM 2.34E-6 iron homeostasis 3 3.09E-8 0.40
12 SGTC_2691 st077356 5.25 60.2 µM 4.56E-6 4 7.74E-8 0.43
13 SGTC_32 0928-0142 5.22 34.1 µM 5.16E-6 TSC3-RPN4 2 9.18E-8 0.45
14 SGTC_1872 amphotericin b 5.20 148.0 nM 5.49E-6 RNA pol III & RNase P/MRP 14 1.00E-7 0.22
15 SGTC_3233 9132340 5.11 49.5 µM 7.75E-6 3 1.61E-7 0.27
16 SGTC_2888 9058547 5.06 13.0 µM 9.49E-6 1 2.13E-7 1.66
17 SGTC_974 1326-0144 4.82 138.0 µM 2.31E-5 ERG2 2 7.25E-7 0.45
18 SGTC_943 3253-1379 4.57 105.0 µM 5.62E-5 3 2.46E-6 0.27
19 SGTC_2378 9074213 4.44 121.4 µM 8.81E-5 RSC complex & mRNA processing 17 4.56E-6 0.23
20 SGTC_2158 5657123 4.40 3.6 µM 9.83E-5 12 5.30E-6 0.59

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.287 1.25E-64 YKL013C ARC19 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.191 8.72E-29 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.173 7.47E-24 YKL041W VPS24 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
0.172 1.39E-23 YJR065C ARP3 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.143 8.30E-17 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.132 1.60E-14 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.131 2.75E-14 YKL002W DID4 hom Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
0.119 4.46E-12 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.117 1.37E-11 YNR006W VPS27 hom Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.116 1.53E-11 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.112 9.12E-11 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.107 4.66E-10 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.102 2.90E-9 YNL282W POP3 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.102 3.95E-9 YEL014C_d YEL014C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 7.34E-9 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype