HIPHOP chemogenomics database

YNR035C / ARC35

Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin

Zygosity: Heterozygous strain

fixedexpanded
Profile for YNR035C / ARC35

Click on Significant Values for Screen Details

Top fitness defect scores for YNR035C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_748	0136-0228	22.20	77.9 µM	1.55E-79	redox potentiating	1	5.87E-110	5.89
2	SGTC_2666	tannic acid	11.30	100.0 µM	4.74E-22	iron homeostasis	1	5.39E-30	4.63
3	SGTC_2544	sphondin	8.34	68.5 µM	8.52E-13	RNA pol III & RNase P/MRP	9	3.80E-17	0.16
4	SGTC_285	1486-1325	8.14	46.0 µM	2.76E-12		1	1.93E-16	2.72
5	SGTC_525	k781-2675	7.15	26.7 µM	7.25E-10	redox potentiating	11	4.35E-13	0.17
6	SGTC_849	0386-0493	6.88	241.0 µM	2.88E-9		1	2.95E-12	1.14
7	SGTC_149	3970-0822	6.30	46.1 µM	4.86E-8	tubulin folding & SWR complex	2	1.46E-10	0.23
8	SGTC_344	k064-0035	6.24	6.4 µM	6.37E-8	60S ribosome export	2	2.13E-10	1.15
9	SGTC_1593	justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one	6.13	54.9 µM	1.09E-7	redox potentiating	2	4.45E-10	1.06
10	SGTC_2619	obliquin	5.46	87.9 µM	1.95E-6	cell wall	19	2.39E-8	0.12
11	SGTC_3188	9110789	5.41	49.5 µM	2.34E-6	iron homeostasis	3	3.09E-8	0.40
12	SGTC_2691	st077356	5.25	60.2 µM	4.56E-6		4	7.74E-8	0.43
13	SGTC_32	0928-0142	5.22	34.1 µM	5.16E-6	TSC3-RPN4	2	9.18E-8	0.45
14	SGTC_1872	amphotericin b	5.20	148.0 nM	5.49E-6	RNA pol III & RNase P/MRP	14	1.00E-7	0.22
15	SGTC_3233	9132340	5.11	49.5 µM	7.75E-6		3	1.61E-7	0.27
16	SGTC_2888	9058547	5.06	13.0 µM	9.49E-6		1	2.13E-7	1.66
17	SGTC_974	1326-0144	4.82	138.0 µM	2.31E-5	ERG2	2	7.25E-7	0.45
18	SGTC_943	3253-1379	4.57	105.0 µM	5.62E-5		3	2.46E-6	0.27
19	SGTC_2378	9074213	4.44	121.4 µM	8.81E-5	RSC complex & mRNA processing	17	4.56E-6	0.23
20	SGTC_2158	5657123	4.40	3.6 µM	9.83E-5		12	5.30E-6	0.59

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.287	1.25E-64	YKL013C	ARC19	het	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.191	8.72E-29	YPR173C	VPS4	hom	AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.173	7.47E-24	YKL041W	VPS24	hom	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
0.172	1.39E-23	YJR065C	ARP3	het	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.143	8.30E-17	YDR495C	VPS3	hom	Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.132	1.60E-14	YOR036W	PEP12	hom	Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.131	2.75E-14	YKL002W	DID4	hom	Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
0.119	4.46E-12	YOR382W	FIT2	hom	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.117	1.37E-11	YNR006W	VPS27	hom	Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.116	1.53E-11	YJR102C	VPS25	hom	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.112	9.12E-11	YDR323C	PEP7	hom	Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.107	4.66E-10	YLR119W	SRN2	hom	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.102	2.90E-9	YNL282W	POP3	het	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.102	3.95E-9	YEL014C_d	YEL014C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100	7.34E-9	YCL008C	STP22	hom	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype