YNR036C / MRPS12

Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR036C / MRPS12

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.75|P-value:1.75E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.61|P-value:5.51E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.42|P-value:5.59E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.92|P-value:9.47E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.17|P-value:3.55E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:6.12|P-value:2.58E-9 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.08|P-value:4.99E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:3.35|P-value:6.95E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.02|P-value:1.04E-11 ID:SGTC_187|Compound:1488-2104|FD-Score:3.87|P-value:1.11E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.41|P-value:5.86E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:5.94|P-value:7.10E-9 ID:SGTC_204|Compound:1543-0184|FD-Score:5.12|P-value:5.30E-7 ID:SGTC_206|Compound:4546-0025|FD-Score:3.83|P-value:1.32E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.91|P-value:1.43E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:5.12|P-value:5.16E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:12.20|P-value:1.00E-31 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.72|P-value:2.45E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:7.42|P-value:7.13E-13 ID:SGTC_338|Compound:4055-0136|FD-Score:3.26|P-value:9.58E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.53|P-value:7.16E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.44|P-value:4.95E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.86|P-value:1.67E-6 ID:SGTC_596|Compound:1155-0152|FD-Score:4.60|P-value:5.69E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:6.22|P-value:1.45E-9 ID:SGTC_602|Compound:3130-1533|FD-Score:3.39|P-value:6.22E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.66|P-value:2.39E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.81|P-value:1.39E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.32|P-value:7.25E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-6.05|P-value:3.51E-9 ID:SGTC_797|Compound:k781-0471|FD-Score:5.58|P-value:5.08E-8 ID:SGTC_799|Compound:1310-0557|FD-Score:3.62|P-value:2.79E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.05|P-value:4.00E-9 ID:SGTC_803|Compound:4488-1585|FD-Score:5.74|P-value:2.12E-8 ID:SGTC_809|Compound:3998-0021|FD-Score:-4.43|P-value:1.11E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.80|P-value:2.36E-6 ID:SGTC_838|Compound:0109-0203|FD-Score:3.42|P-value:5.49E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.45|P-value:5.00E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.24|P-value:2.58E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:4.98|P-value:1.00E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:-6.53|P-value:2.09E-10 ID:SGTC_1032|Compound:k061-1018|FD-Score:5.86|P-value:1.13E-8 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.55|P-value:7.25E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:6.84|P-value:3.34E-11 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.15|P-value:3.84E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.02|P-value:5.90E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.29|P-value:8.63E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.66|P-value:2.41E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.33|P-value:1.81E-7 ID:SGTC_1624|Compound:st003710|FD-Score:3.99|P-value:6.98E-5 ID:SGTC_1656|Compound:st012921|FD-Score:-3.42|P-value:5.30E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.47|P-value:4.43E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.58|P-value:2.98E-4 ID:SGTC_1742|Compound:st038235|FD-Score:8.87|P-value:1.31E-17 ID:SGTC_1754|Compound:st042065|FD-Score:-3.77|P-value:1.54E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.16|P-value:3.66E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:4.40|P-value:1.36E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-3.50|P-value:4.03E-4 ID:SGTC_1901|Compound:st060216|FD-Score:6.05|P-value:3.98E-9 ID:SGTC_2113|Compound:5491891|FD-Score:3.52|P-value:3.92E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.78|P-value:2.52E-6 ID:SGTC_2156|Compound:5649887|FD-Score:3.76|P-value:1.69E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.85|P-value:1.23E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.23|P-value:1.36E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.64|P-value:4.82E-6 ID:SGTC_2254|Compound:7938975|FD-Score:3.96|P-value:7.92E-5 ID:SGTC_2315|Compound:7733312|FD-Score:-4.93|P-value:1.21E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.53|P-value:7.82E-6 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.26|P-value:9.35E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.42|P-value:5.50E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.66|P-value:2.38E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.08|P-value:4.67E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.28|P-value:8.74E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.32|P-value:7.86E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.20|P-value:3.07E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.92|P-value:9.12E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.82|P-value:1.26E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.34|P-value:6.77E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.58|P-value:6.19E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-3.79|P-value:1.44E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.87|P-value:1.06E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.67|P-value:2.34E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.35|P-value:7.08E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.97|P-value:9.80E-7 ID:SGTC_3189|Compound:9110682|FD-Score:4.54|P-value:7.48E-6 ID:SGTC_3193|Compound:9111931|FD-Score:4.47|P-value:1.00E-5 ID:SGTC_3194|Compound:9111903|FD-Score:5.96|P-value:6.54E-9 ID:SGTC_3195|Compound:9113082|FD-Score:-4.39|P-value:1.31E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.50|P-value:4.23E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.60|P-value:5.29E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:3.75|P-value:1.75E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.61|P-value:5.51E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.42|P-value:5.59E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.92|P-value:9.47E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.17|P-value:3.55E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:6.12|P-value:2.58E-9 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.08|P-value:4.99E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:3.35|P-value:6.95E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.02|P-value:1.04E-11 ID:SGTC_187|Compound:1488-2104|FD-Score:3.87|P-value:1.11E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.41|P-value:5.86E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:5.94|P-value:7.10E-9 ID:SGTC_204|Compound:1543-0184|FD-Score:5.12|P-value:5.30E-7 ID:SGTC_206|Compound:4546-0025|FD-Score:3.83|P-value:1.32E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.91|P-value:1.43E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:5.12|P-value:5.16E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:12.20|P-value:1.00E-31 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.72|P-value:2.45E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:7.42|P-value:7.13E-13 ID:SGTC_338|Compound:4055-0136|FD-Score:3.26|P-value:9.58E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.53|P-value:7.16E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.44|P-value:4.95E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.86|P-value:1.67E-6 ID:SGTC_596|Compound:1155-0152|FD-Score:4.60|P-value:5.69E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:6.22|P-value:1.45E-9 ID:SGTC_602|Compound:3130-1533|FD-Score:3.39|P-value:6.22E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.66|P-value:2.39E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.81|P-value:1.39E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.32|P-value:7.25E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-6.05|P-value:3.51E-9 ID:SGTC_797|Compound:k781-0471|FD-Score:5.58|P-value:5.08E-8 ID:SGTC_799|Compound:1310-0557|FD-Score:3.62|P-value:2.79E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.05|P-value:4.00E-9 ID:SGTC_803|Compound:4488-1585|FD-Score:5.74|P-value:2.12E-8 ID:SGTC_809|Compound:3998-0021|FD-Score:-4.43|P-value:1.11E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.80|P-value:2.36E-6 ID:SGTC_838|Compound:0109-0203|FD-Score:3.42|P-value:5.49E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.45|P-value:5.00E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.24|P-value:2.58E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:4.98|P-value:1.00E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:-6.53|P-value:2.09E-10 ID:SGTC_1032|Compound:k061-1018|FD-Score:5.86|P-value:1.13E-8 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.55|P-value:7.25E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:6.84|P-value:3.34E-11 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.15|P-value:3.84E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.02|P-value:5.90E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.29|P-value:8.63E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.66|P-value:2.41E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.33|P-value:1.81E-7 ID:SGTC_1624|Compound:st003710|FD-Score:3.99|P-value:6.98E-5 ID:SGTC_1656|Compound:st012921|FD-Score:-3.42|P-value:5.30E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.47|P-value:4.43E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.58|P-value:2.98E-4 ID:SGTC_1742|Compound:st038235|FD-Score:8.87|P-value:1.31E-17 ID:SGTC_1754|Compound:st042065|FD-Score:-3.77|P-value:1.54E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.16|P-value:3.66E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:4.40|P-value:1.36E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-3.50|P-value:4.03E-4 ID:SGTC_1901|Compound:st060216|FD-Score:6.05|P-value:3.98E-9 ID:SGTC_2113|Compound:5491891|FD-Score:3.52|P-value:3.92E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.78|P-value:2.52E-6 ID:SGTC_2156|Compound:5649887|FD-Score:3.76|P-value:1.69E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.85|P-value:1.23E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.23|P-value:1.36E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.64|P-value:4.82E-6 ID:SGTC_2254|Compound:7938975|FD-Score:3.96|P-value:7.92E-5 ID:SGTC_2315|Compound:7733312|FD-Score:-4.93|P-value:1.21E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.53|P-value:7.82E-6 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.26|P-value:9.35E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.42|P-value:5.50E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.66|P-value:2.38E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.08|P-value:4.67E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.28|P-value:8.74E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.32|P-value:7.86E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.20|P-value:3.07E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.92|P-value:9.12E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.82|P-value:1.26E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.34|P-value:6.77E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.58|P-value:6.19E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-3.79|P-value:1.44E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.87|P-value:1.06E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.67|P-value:2.34E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.35|P-value:7.08E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.97|P-value:9.80E-7 ID:SGTC_3189|Compound:9110682|FD-Score:4.54|P-value:7.48E-6 ID:SGTC_3193|Compound:9111931|FD-Score:4.47|P-value:1.00E-5 ID:SGTC_3194|Compound:9111903|FD-Score:5.96|P-value:6.54E-9 ID:SGTC_3195|Compound:9113082|FD-Score:-4.39|P-value:1.31E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.50|P-value:4.23E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.60|P-value:5.29E-6

Top fitness defect scores for YNR036C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 12.20 5.3 µM 1.00E-31 147 1.33E-34
2 SGTC_1742 st038235 8.87 28.9 µM 1.31E-17 mitochondrial stress 17 3.82E-19
3 SGTC_310 1273-0058 7.42 1.1 µM 7.13E-13 mitochondrial stress 105 5.87E-14
4 SGTC_173 1273-0061 7.02 2.7 µM 1.04E-11 mitochondrial stress 85 1.11E-12
5 SGTC_1038 k292-0204 6.84 154.0 µM 3.34E-11 1 3.96E-12
6 SGTC_2232 chlorophetanol 6.23 41.5 µM 1.36E-9 TRP & mitochondrial translation 39 2.29E-10
7 SGTC_601 0986-0029 6.22 62.9 µM 1.45E-9 calcium & mitochondrial duress 8 2.45E-10
8 SGTC_119 0121-0043 6.12 24.8 µM 2.58E-9 mitochondrial stress 25 4.60E-10
9 SGTC_1901 st060216 6.05 58.6 µM 3.98E-9 5 7.40E-10
10 SGTC_800 3448-7362 6.05 155.0 µM 4.00E-9 translation 47 7.44E-10
11 SGTC_3194 9111903 5.96 49.5 µM 6.54E-9 7 1.27E-9
12 SGTC_195 4234-0266 5.94 16.6 µM 7.10E-9 8 1.39E-9
13 SGTC_1032 k061-1018 5.86 98.7 µM 1.13E-8 2 2.32E-9
14 SGTC_803 4488-1585 5.74 147.0 µM 2.12E-8 1 4.63E-9
15 SGTC_275 trichlorophene 5.72 5.7 µM 2.45E-8 mitochondrial stress 130 5.42E-9
16 SGTC_797 k781-0471 5.58 270.0 µM 5.08E-8 RPP1 & pyrimidine depletion 4 1.20E-8
17 SGTC_1623 st003709 5.33 20.3 µM 1.81E-7 calcium & mitochondrial duress 20 4.81E-8
18 SGTC_214 4373-3496 5.12 70.0 µM 5.16E-7 25 1.52E-7
19 SGTC_204 1543-0184 5.12 62.4 µM 5.30E-7 TRP & mitochondrial translation 15 1.56E-7
20 SGTC_947 3447-0010 4.98 211.0 µM 1.00E-6 5 3.13E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.443 3.17E-161 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.417 5.76E-141 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.407 1.70E-133 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.401 9.63E-130 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.394 1.38E-124 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.392 1.06E-123 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.392 7.74E-123 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.389 1.44E-121 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.388 5.18E-121 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.388 9.64E-121 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.386 3.89E-119 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.385 4.82E-119 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.384 5.09E-118 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.384 8.20E-118 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.380 2.84E-115 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing