YNR037C / RSM19

Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR037C / RSM19

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.55|P-value:1.56E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:5.49|P-value:2.49E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:5.07|P-value:1.74E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:5.43|P-value:3.35E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:4.63|P-value:1.14E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:5.21|P-value:9.35E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:4.20|P-value:6.14E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:5.25|P-value:7.79E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:9.96|P-value:3.68E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.52|P-value:1.18E-9 ID:SGTC_283|Compound:0987-0079|FD-Score:5.10|P-value:1.53E-6 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.05|P-value:1.00E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.98|P-value:8.35E-11 ID:SGTC_363|Compound:0455-0021|FD-Score:3.77|P-value:2.82E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.72|P-value:7.77E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:7.43|P-value:5.17E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.84|P-value:2.10E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.42|P-value:8.89E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.88|P-value:1.93E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.84|P-value:2.21E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.58|P-value:5.37E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.31|P-value:5.71E-7 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.52|P-value:6.16E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:-4.03|P-value:1.05E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:7.21|P-value:2.00E-11 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.85|P-value:1.99E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:-4.11|P-value:7.79E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.39|P-value:9.81E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.76|P-value:2.90E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.26|P-value:7.26E-7 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.09|P-value:9.01E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.57|P-value:5.49E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.16|P-value:6.70E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.40|P-value:9.23E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.87|P-value:4.18E-6 ID:SGTC_1635|Compound:st007035|FD-Score:4.83|P-value:5.00E-6 ID:SGTC_1707|Compound:st032323|FD-Score:-3.46|P-value:7.42E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.02|P-value:1.79E-8 ID:SGTC_1750|Compound:st081859|FD-Score:-3.57|P-value:5.21E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.16|P-value:6.48E-5 ID:SGTC_1796|Compound:st049173|FD-Score:3.99|P-value:1.32E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.74|P-value:2.97E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.92|P-value:3.05E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.33|P-value:3.50E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.33|P-value:5.24E-7 ID:SGTC_1921|Compound:5740136|FD-Score:3.39|P-value:9.75E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.01|P-value:2.07E-6 ID:SGTC_2113|Compound:5491891|FD-Score:5.14|P-value:1.25E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.59|P-value:1.57E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.79|P-value:2.46E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.89|P-value:3.57E-6 ID:SGTC_2909|Compound:7941780|FD-Score:3.47|P-value:7.61E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.84|P-value:2.05E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.75|P-value:2.82E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-4.27|P-value:4.32E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.55|P-value:1.56E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:5.49|P-value:2.49E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:5.07|P-value:1.74E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:5.43|P-value:3.35E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:4.63|P-value:1.14E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:5.21|P-value:9.35E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:4.20|P-value:6.14E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:5.25|P-value:7.79E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:9.96|P-value:3.68E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.52|P-value:1.18E-9 ID:SGTC_283|Compound:0987-0079|FD-Score:5.10|P-value:1.53E-6 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.05|P-value:1.00E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.98|P-value:8.35E-11 ID:SGTC_363|Compound:0455-0021|FD-Score:3.77|P-value:2.82E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.72|P-value:7.77E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:7.43|P-value:5.17E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.84|P-value:2.10E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.42|P-value:8.89E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.88|P-value:1.93E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.84|P-value:2.21E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.58|P-value:5.37E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.31|P-value:5.71E-7 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.52|P-value:6.16E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:-4.03|P-value:1.05E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:7.21|P-value:2.00E-11 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.85|P-value:1.99E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:-4.11|P-value:7.79E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.39|P-value:9.81E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.76|P-value:2.90E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.26|P-value:7.26E-7 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.09|P-value:9.01E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.57|P-value:5.49E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.16|P-value:6.70E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.40|P-value:9.23E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.87|P-value:4.18E-6 ID:SGTC_1635|Compound:st007035|FD-Score:4.83|P-value:5.00E-6 ID:SGTC_1707|Compound:st032323|FD-Score:-3.46|P-value:7.42E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.02|P-value:1.79E-8 ID:SGTC_1750|Compound:st081859|FD-Score:-3.57|P-value:5.21E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.16|P-value:6.48E-5 ID:SGTC_1796|Compound:st049173|FD-Score:3.99|P-value:1.32E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.74|P-value:2.97E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.92|P-value:3.05E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.33|P-value:3.50E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.33|P-value:5.24E-7 ID:SGTC_1921|Compound:5740136|FD-Score:3.39|P-value:9.75E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.01|P-value:2.07E-6 ID:SGTC_2113|Compound:5491891|FD-Score:5.14|P-value:1.25E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.59|P-value:1.57E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.79|P-value:2.46E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.89|P-value:3.57E-6 ID:SGTC_2909|Compound:7941780|FD-Score:3.47|P-value:7.61E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.84|P-value:2.05E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.75|P-value:2.82E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-4.27|P-value:4.32E-5

Top fitness defect scores for YNR037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.96 5.3 µM 3.68E-20 197 1.18E-23
2 SGTC_386 1509-0011 7.43 3.1 µM 5.17E-12 73 5.57E-14
3 SGTC_1036 k216-0215 7.21 33.5 µM 2.00E-11 mitochondrial response to ROS 8 2.78E-13
4 SGTC_310 1273-0058 6.98 1.1 µM 8.35E-11 mitochondrial stress 118 1.51E-12
5 SGTC_275 trichlorophene 6.52 5.7 µM 1.18E-9 mitochondrial stress 100 3.50E-11
6 SGTC_1742 st038235 6.02 28.9 µM 1.79E-8 mitochondrial stress 45 8.84E-10
7 SGTC_2232 chlorophetanol 5.59 41.5 µM 1.57E-7 TRP & mitochondrial translation 52 1.16E-8
8 SGTC_63 0099-0242 5.49 26.7 µM 2.49E-7 mitochondrial stress 38 1.99E-8
9 SGTC_70 0141-0289 5.43 43.3 µM 3.35E-7 mitochondrial stress 101 2.84E-8
10 SGTC_1883 5-benzylidenerhodanine 5.33 20.0 µM 5.24E-7 TRP & mitochondrial translation 23 4.82E-8
11 SGTC_908 3448-7491 5.31 47.7 µM 5.71E-7 mitochondrial stress 68 5.33E-8
12 SGTC_1240 0356-0016 5.26 42.1 µM 7.26E-7 mitochondrial response to ROS 13 7.09E-8
13 SGTC_173 1273-0061 5.25 2.7 µM 7.79E-7 mitochondrial stress 138 7.71E-8
14 SGTC_134 0269-0018 5.21 6.9 µM 9.35E-7 101 9.57E-8
15 SGTC_2113 5491891 5.14 107.0 µM 1.25E-6 TSC3-RPN4 7 1.35E-7
16 SGTC_283 0987-0079 5.10 11.7 µM 1.53E-6 8 1.72E-7
17 SGTC_68 0986-0284 5.07 82.8 µM 1.74E-6 28 2.00E-7
18 SGTC_1371 2421-0008 4.87 32.7 µM 4.18E-6 mitochondrial processes 17 5.64E-7
19 SGTC_1635 st007035 4.83 42.4 µM 5.00E-6 174 6.96E-7
20 SGTC_365 0121-0052 4.72 13.6 µM 7.77E-6 mitochondrial response to ROS 34 1.17E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.512 3.27E-224 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.509 1.37E-220 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.502 2.12E-213 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.493 4.82E-205 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.493 8.90E-205 YKL068W-A_p YKL068W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii
0.490 5.53E-202 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.489 1.07E-201 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.477 1.06E-190 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.472 5.32E-186 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.470 6.20E-184 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.469 1.51E-182 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.464 3.46E-178 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.453 2.09E-169 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.452 9.23E-169 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.452 3.64E-168 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport