YNR038W / DBP6

Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNR038W / DBP6

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:3.27|P-value:7.58E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:5.53|P-value:4.15E-8 ID:SGTC_612|Compound:0302-0167|FD-Score:3.36|P-value:5.59E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:-4.12|P-value:3.23E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.55|P-value:2.88E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.63|P-value:2.18E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.26|P-value:7.82E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.45|P-value:4.12E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.91|P-value:7.56E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:3.38|P-value:5.36E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.17|P-value:2.66E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.24|P-value:8.33E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.75|P-value:2.04E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.72|P-value:1.52E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.87|P-value:8.51E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.26|P-value:7.78E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.40|P-value:4.93E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.30|P-value:6.84E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.86|P-value:8.89E-5 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.24|P-value:8.40E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.89|P-value:7.88E-5 ID:SGTC_1632|Compound:st005650|FD-Score:3.34|P-value:6.04E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.42|P-value:4.65E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.67|P-value:2.95E-6 ID:SGTC_2034|Compound:5197015|FD-Score:3.23|P-value:8.76E-4 ID:SGTC_2080|Compound:5212524|FD-Score:4.25|P-value:1.87E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:3.21|P-value:9.44E-4 ID:SGTC_2412|Compound:st077135|FD-Score:6.10|P-value:1.66E-9 ID:SGTC_2466|Compound:5983409|FD-Score:3.32|P-value:6.45E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.47|P-value:3.88E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.50|P-value:3.44E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.85|P-value:9.31E-5 ID:SGTC_2964|Compound:9083345|FD-Score:3.29|P-value:7.12E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.55|P-value:2.87E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.27|P-value:7.58E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:5.53|P-value:4.15E-8 ID:SGTC_612|Compound:0302-0167|FD-Score:3.36|P-value:5.59E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:-4.12|P-value:3.23E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.55|P-value:2.88E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.63|P-value:2.18E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.26|P-value:7.82E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.45|P-value:4.12E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.91|P-value:7.56E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:3.38|P-value:5.36E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.17|P-value:2.66E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.24|P-value:8.33E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.75|P-value:2.04E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.72|P-value:1.52E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.87|P-value:8.51E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.26|P-value:7.78E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.40|P-value:4.93E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.30|P-value:6.84E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.86|P-value:8.89E-5 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.24|P-value:8.40E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.89|P-value:7.88E-5 ID:SGTC_1632|Compound:st005650|FD-Score:3.34|P-value:6.04E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.42|P-value:4.65E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.67|P-value:2.95E-6 ID:SGTC_2034|Compound:5197015|FD-Score:3.23|P-value:8.76E-4 ID:SGTC_2080|Compound:5212524|FD-Score:4.25|P-value:1.87E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:3.21|P-value:9.44E-4 ID:SGTC_2412|Compound:st077135|FD-Score:6.10|P-value:1.66E-9 ID:SGTC_2466|Compound:5983409|FD-Score:3.32|P-value:6.45E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.47|P-value:3.88E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.50|P-value:3.44E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.85|P-value:9.31E-5 ID:SGTC_2964|Compound:9083345|FD-Score:3.29|P-value:7.12E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.55|P-value:2.87E-4

Top fitness defect scores for YNR038W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2412 st077135 6.10 33.4 µM 1.66E-9 2 5.24E-10 1.04
2 SGTC_527 4476-4215 5.53 268.0 µM 4.15E-8 PDR1 1 1.60E-8 1.52
3 SGTC_1929 genistein trimethyl ether 4.67 50.5 µM 2.95E-6 1 1.48E-6 0.48
4 SGTC_2080 5212524 4.25 12.4 µM 1.87E-5 copper-dependent oxidative stress 4 1.05E-5 0.08
5 SGTC_1014 4130-3005 4.17 69.3 µM 2.66E-5 4 1.53E-5 0.04
6 SGTC_865 0488-0499 3.91 301.0 µM 7.56E-5 3 4.62E-5 0.33
7 SGTC_674 0498-0004 3.63 451.0 µM 2.18E-4 heme requiring 28 1.42E-4 0.10
8 SGTC_3012 9080433 3.55 71.4 µM 2.87E-4 4 1.90E-4 0.12
9 SGTC_656 4090-1979 3.55 187.0 µM 2.88E-4 3 1.91E-4 0.20
10 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.47 63.6 µM 3.88E-4 16 2.62E-4 0.06
11 SGTC_1830 st055982 3.42 50.3 µM 4.65E-4 6 3.17E-4 0.06
12 SGTC_1177 0983-0204 3.40 23.6 µM 4.93E-4 19 3.37E-4 0.20
13 SGTC_978 1416-0512 3.38 87.4 µM 5.36E-4 redox potentiating 13 3.69E-4 0.13
14 SGTC_612 0302-0167 3.36 22.4 µM 5.59E-4 copper-dependent oxidative stress 12 3.85E-4 0.00
15 SGTC_1632 st005650 3.34 90.0 µM 6.04E-4 12 4.19E-4 0.10
16 SGTC_2466 5983409 3.32 37.1 µM 6.45E-4 14 4.49E-4 0.01
17 SGTC_1343 1487-0095 3.30 224.0 µM 6.84E-4 4 4.77E-4 8.92E-4
18 SGTC_2964 9083345 3.29 53.4 µM 7.12E-4 19 4.98E-4 0.02
19 SGTC_95 0471-0001 3.27 561.1 µM 7.58E-4 10 5.32E-4 0.08
20 SGTC_1121 fusaric acid 3.26 630.5 nM 7.78E-4 8 5.47E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.29E-11 YCR054C CTR86 het Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
0.111 1.02E-10 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.107 4.64E-10 YFR032C-A RPL29 hom Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog
0.096 2.31E-8 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.095 2.99E-8 YAL049C AIM2 hom Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor
0.090 1.69E-7 YGL065C ALG2 het Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
0.085 7.69E-7 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.084 1.18E-6 YOL164W-A_p YOL164W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.083 1.41E-6 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.081 2.86E-6 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.079 4.07E-6 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.079 4.23E-6 YMR270C RRN9 het Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.079 4.35E-6 YLR129W DIP2 het Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
0.078 5.44E-6 YMR087W YMR087W hom Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain
0.077 7.05E-6 YHR101C BIG1 het Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan