YNR040W_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR040W / YNR040W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:5.19|P-value:2.15E-7 ID:SGTC_8|Compound:0354-0001|FD-Score:3.76|P-value:1.26E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.28|P-value:1.54E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.58|P-value:2.39E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-4.03|P-value:4.17E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.65|P-value:1.85E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.90|P-value:7.11E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.33|P-value:5.76E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.56|P-value:4.32E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:6.43|P-value:1.93E-10 ID:SGTC_122|Compound:0236-0016|FD-Score:4.23|P-value:1.90E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.15|P-value:2.62E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:8.69|P-value:1.34E-17 ID:SGTC_263|Compound:alizarin|FD-Score:-3.71|P-value:1.51E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:5.66|P-value:1.81E-8 ID:SGTC_346|Compound:4513-0042|FD-Score:3.73|P-value:1.43E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.11|P-value:3.12E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:5.92|P-value:4.16E-9 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.49|P-value:3.39E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.53|P-value:2.91E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:7.30|P-value:5.78E-13 ID:SGTC_514|Compound:4466-0038|FD-Score:5.71|P-value:1.38E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:8.00|P-value:3.33E-15 ID:SGTC_559|Compound:1550-0661|FD-Score:4.04|P-value:4.23E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:-3.39|P-value:4.72E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.54|P-value:2.83E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.17|P-value:9.96E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.31|P-value:1.37E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.52|P-value:2.97E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:-3.37|P-value:5.01E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:7.83|P-value:1.17E-14 ID:SGTC_922|Compound:1866-0035|FD-Score:5.47|P-value:5.08E-8 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.21|P-value:8.76E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.46|P-value:3.79E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.83|P-value:1.25E-6 ID:SGTC_1090|Compound:efavirenz|FD-Score:5.19|P-value:2.21E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:-4.07|P-value:3.58E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.26|P-value:7.29E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-6.10|P-value:1.35E-9 ID:SGTC_1249|Compound:0481-0015|FD-Score:-9.46|P-value:1.49E-20 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.28|P-value:7.01E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.48|P-value:3.58E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.50|P-value:3.24E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.23|P-value:8.30E-4 ID:SGTC_1712|Compound:st032288|FD-Score:6.25|P-value:5.92E-10 ID:SGTC_1774|Compound:st048371|FD-Score:4.32|P-value:1.28E-5 ID:SGTC_1779|Compound:st039427|FD-Score:4.27|P-value:1.58E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.48|P-value:3.40E-4 ID:SGTC_1800|Compound:st050079|FD-Score:6.94|P-value:6.85E-12 ID:SGTC_1803|Compound:st050068|FD-Score:4.65|P-value:2.98E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-3.41|P-value:4.34E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:4.96|P-value:6.81E-7 ID:SGTC_2317|Compound:5986382|FD-Score:3.55|P-value:2.78E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.91|P-value:6.97E-5 ID:SGTC_2376|Compound:9072922|FD-Score:4.09|P-value:3.42E-5 ID:SGTC_2385|Compound:9074692|FD-Score:-4.09|P-value:3.30E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.28|P-value:6.91E-4 ID:SGTC_2421|Compound:5690543|FD-Score:-3.30|P-value:6.43E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.43|P-value:7.77E-6 ID:SGTC_2460|Compound:5552655|FD-Score:-3.87|P-value:7.94E-5 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.21|P-value:2.04E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-7.28|P-value:6.40E-13 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.71|P-value:1.50E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.32|P-value:6.23E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:6.57|P-value:8.06E-11 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-4.11|P-value:3.10E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:4.87|P-value:1.08E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.42|P-value:8.57E-6 ID:SGTC_2701|Compound:st077767|FD-Score:3.23|P-value:8.28E-4 ID:SGTC_2704|Compound:st078022|FD-Score:5.39|P-value:7.86E-8 ID:SGTC_2916|Compound:7875993|FD-Score:-3.84|P-value:9.02E-5 ID:SGTC_2922|Compound:7999257|FD-Score:3.67|P-value:1.76E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.22|P-value:8.32E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.85|P-value:8.81E-5 ID:SGTC_3185|Compound:9108267|FD-Score:5.31|P-value:1.15E-7 ID:SGTC_3190|Compound:9110366|FD-Score:-4.09|P-value:3.29E-5 ID:SGTC_3311|Compound:9131146|FD-Score:12.40|P-value:6.40E-34 ID:SGTC_3321|Compound:9137793|FD-Score:9.38|P-value:3.26E-20 ID:SGTC_3326|Compound:9140064|FD-Score:-3.19|P-value:9.25E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.36|P-value:5.37E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:5.19|P-value:2.15E-7 ID:SGTC_8|Compound:0354-0001|FD-Score:3.76|P-value:1.26E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.28|P-value:1.54E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.58|P-value:2.39E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-4.03|P-value:4.17E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.65|P-value:1.85E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.90|P-value:7.11E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.33|P-value:5.76E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.56|P-value:4.32E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:6.43|P-value:1.93E-10 ID:SGTC_122|Compound:0236-0016|FD-Score:4.23|P-value:1.90E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.15|P-value:2.62E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:8.69|P-value:1.34E-17 ID:SGTC_263|Compound:alizarin|FD-Score:-3.71|P-value:1.51E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:5.66|P-value:1.81E-8 ID:SGTC_346|Compound:4513-0042|FD-Score:3.73|P-value:1.43E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.11|P-value:3.12E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:5.92|P-value:4.16E-9 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.49|P-value:3.39E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.53|P-value:2.91E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:7.30|P-value:5.78E-13 ID:SGTC_514|Compound:4466-0038|FD-Score:5.71|P-value:1.38E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:8.00|P-value:3.33E-15 ID:SGTC_559|Compound:1550-0661|FD-Score:4.04|P-value:4.23E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:-3.39|P-value:4.72E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.54|P-value:2.83E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.17|P-value:9.96E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.31|P-value:1.37E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.52|P-value:2.97E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:-3.37|P-value:5.01E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:7.83|P-value:1.17E-14 ID:SGTC_922|Compound:1866-0035|FD-Score:5.47|P-value:5.08E-8 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.21|P-value:8.76E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.46|P-value:3.79E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.83|P-value:1.25E-6 ID:SGTC_1090|Compound:efavirenz|FD-Score:5.19|P-value:2.21E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:-4.07|P-value:3.58E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.26|P-value:7.29E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-6.10|P-value:1.35E-9 ID:SGTC_1249|Compound:0481-0015|FD-Score:-9.46|P-value:1.49E-20 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.28|P-value:7.01E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.48|P-value:3.58E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.50|P-value:3.24E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.23|P-value:8.30E-4 ID:SGTC_1712|Compound:st032288|FD-Score:6.25|P-value:5.92E-10 ID:SGTC_1774|Compound:st048371|FD-Score:4.32|P-value:1.28E-5 ID:SGTC_1779|Compound:st039427|FD-Score:4.27|P-value:1.58E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.48|P-value:3.40E-4 ID:SGTC_1800|Compound:st050079|FD-Score:6.94|P-value:6.85E-12 ID:SGTC_1803|Compound:st050068|FD-Score:4.65|P-value:2.98E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-3.41|P-value:4.34E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:4.96|P-value:6.81E-7 ID:SGTC_2317|Compound:5986382|FD-Score:3.55|P-value:2.78E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.91|P-value:6.97E-5 ID:SGTC_2376|Compound:9072922|FD-Score:4.09|P-value:3.42E-5 ID:SGTC_2385|Compound:9074692|FD-Score:-4.09|P-value:3.30E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.28|P-value:6.91E-4 ID:SGTC_2421|Compound:5690543|FD-Score:-3.30|P-value:6.43E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.43|P-value:7.77E-6 ID:SGTC_2460|Compound:5552655|FD-Score:-3.87|P-value:7.94E-5 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.21|P-value:2.04E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-7.28|P-value:6.40E-13 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.71|P-value:1.50E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.32|P-value:6.23E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:6.57|P-value:8.06E-11 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-4.11|P-value:3.10E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:4.87|P-value:1.08E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.42|P-value:8.57E-6 ID:SGTC_2701|Compound:st077767|FD-Score:3.23|P-value:8.28E-4 ID:SGTC_2704|Compound:st078022|FD-Score:5.39|P-value:7.86E-8 ID:SGTC_2916|Compound:7875993|FD-Score:-3.84|P-value:9.02E-5 ID:SGTC_2922|Compound:7999257|FD-Score:3.67|P-value:1.76E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.22|P-value:8.32E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.85|P-value:8.81E-5 ID:SGTC_3185|Compound:9108267|FD-Score:5.31|P-value:1.15E-7 ID:SGTC_3190|Compound:9110366|FD-Score:-4.09|P-value:3.29E-5 ID:SGTC_3311|Compound:9131146|FD-Score:12.40|P-value:6.40E-34 ID:SGTC_3321|Compound:9137793|FD-Score:9.38|P-value:3.26E-20 ID:SGTC_3326|Compound:9140064|FD-Score:-3.19|P-value:9.25E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.36|P-value:5.37E-4

Top fitness defect scores for YNR040W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3311 9131146 12.40 2.9 µM 6.40E-34 cell wall 10 1.22E-35
2 SGTC_3321 9137793 9.38 26.8 µM 3.26E-20 cell wall 7 3.33E-21
3 SGTC_188 3229-0966 8.69 278.5 µM 1.34E-17 2 1.88E-18
4 SGTC_528 3492-0019 8.00 172.0 µM 3.33E-15 calcium & mitochondrial duress 71 6.27E-16
5 SGTC_863 0466-0191 7.83 129.0 µM 1.17E-14 cell wall 18 2.36E-15
6 SGTC_467 ro 31-8220 7.30 72.8 µM 5.78E-13 calcium & mitochondrial duress 19 1.43E-13
7 SGTC_1800 st050079 6.94 29.1 µM 6.85E-12 NEO1-PIK1 25 1.93E-12
8 SGTC_2584 androsterone 6.57 48.7 µM 8.06E-11 cell wall 45 2.59E-11
9 SGTC_121 0557-0495 6.43 61.3 µM 1.93E-10 calcium & mitochondrial duress 14 6.50E-11
10 SGTC_1712 st032288 6.25 53.4 µM 5.92E-10 calcium & mitochondrial duress 73 2.11E-10
11 SGTC_363 0455-0021 5.92 3.1 µM 4.16E-9 azole & statin 33 1.64E-9
12 SGTC_514 4466-0038 5.71 2.6 nM 1.38E-8 cell wall 84 5.82E-9
13 SGTC_304 1310-0298 5.66 97.0 µM 1.81E-8 cell wall 23 7.70E-9
14 SGTC_922 1866-0035 5.47 480.0 µM 5.08E-8 excess fatty acid 25 2.29E-8
15 SGTC_2704 st078022 5.39 71.1 µM 7.86E-8 6 3.62E-8
16 SGTC_3185 9108267 5.31 49.5 µM 1.15E-7 60S ribosome export 3 5.39E-8
17 SGTC_6 0844-0013 5.19 19.8 µM 2.15E-7 31 1.04E-7
18 SGTC_1090 efavirenz 5.19 20.7 µM 2.21E-7 6 1.07E-7
19 SGTC_2091 4-phenylthiadiazole 4.96 200.0 µM 6.81E-7 5 3.51E-7
20 SGTC_2619 obliquin 4.87 87.9 µM 1.08E-6 cell wall 101 5.72E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.375 2.34E-112 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.330 4.30E-86 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.325 3.40E-83 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.301 3.10E-71 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.296 6.58E-69 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.289 2.23E-65 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.280 2.90E-61 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.276 7.99E-60 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.265 6.44E-55 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.263 4.10E-54 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.260 4.01E-53 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.260 6.10E-53 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.260 8.09E-53 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.256 2.70E-51 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.246 2.84E-47 YJL073W JEM1 hom DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2