YNR041C / COQ2

Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR041C / COQ2

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:10.90|P-value:1.59E-28 ID:SGTC_64|Compound:000l-0018|FD-Score:13.50|P-value:1.66E-42 ID:SGTC_67|Compound:0335-0847|FD-Score:11.40|P-value:3.75E-31 ID:SGTC_81|Compound:0411-0046|FD-Score:4.00|P-value:2.65E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:24.50|P-value:1.26E-135 ID:SGTC_87|Compound:0100-0052|FD-Score:4.66|P-value:1.25E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:3.62|P-value:1.29E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.79|P-value:6.56E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:7.92|P-value:6.16E-16 ID:SGTC_149|Compound:3970-0822|FD-Score:3.43|P-value:2.69E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:22.70|P-value:7.28E-117 ID:SGTC_165|Compound:k038-0023|FD-Score:5.00|P-value:2.21E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:6.38|P-value:5.69E-11 ID:SGTC_200|Compound:k038-0079|FD-Score:5.59|P-value:8.31E-9 ID:SGTC_214|Compound:4373-3496|FD-Score:3.07|P-value:9.88E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:5.20|P-value:7.53E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:23.20|P-value:2.21E-121 ID:SGTC_294|Compound:k038-0071|FD-Score:6.07|P-value:4.25E-10 ID:SGTC_340|Compound:k038-0059|FD-Score:7.07|P-value:4.48E-13 ID:SGTC_367|Compound:0335-0881|FD-Score:6.25|P-value:1.37E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:11.00|P-value:3.40E-29 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.22|P-value:5.53E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:8.99|P-value:5.14E-20 ID:SGTC_642|Compound:0335-0876|FD-Score:6.90|P-value:1.62E-12 ID:SGTC_643|Compound:k048-0106|FD-Score:3.44|P-value:2.57E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.54|P-value:1.67E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:9.43|P-value:8.03E-22 ID:SGTC_837|Compound:0091-0265|FD-Score:3.24|P-value:5.42E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:4.26|P-value:8.45E-6 ID:SGTC_859|Compound:0439-0102|FD-Score:3.36|P-value:3.48E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.21|P-value:5.79E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.31|P-value:4.11E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.37|P-value:3.29E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.78|P-value:6.60E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.02|P-value:2.48E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.62|P-value:1.29E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.09|P-value:9.14E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.17|P-value:1.29E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.19|P-value:7.62E-8 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.88|P-value:4.46E-5 ID:SGTC_1563|Compound:conessine|FD-Score:3.21|P-value:6.05E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.26|P-value:5.05E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.28|P-value:4.57E-4 ID:SGTC_1635|Compound:st007035|FD-Score:20.80|P-value:2.63E-98 ID:SGTC_1739|Compound:st037196|FD-Score:-5.23|P-value:6.11E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.37|P-value:3.22E-4 ID:SGTC_1896|Compound:st058441|FD-Score:4.40|P-value:4.37E-6 ID:SGTC_1910|Compound:st062352|FD-Score:-3.58|P-value:1.46E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-4.08|P-value:1.86E-5 ID:SGTC_2060|Compound:5238662|FD-Score:-3.37|P-value:3.27E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.15|P-value:7.32E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.67|P-value:1.04E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.86|P-value:4.86E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.56|P-value:1.65E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.19|P-value:6.26E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.90|P-value:3.79E-7 ID:SGTC_2805|Compound:7950783|FD-Score:4.04|P-value:2.28E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.37|P-value:4.86E-6 ID:SGTC_3104|Compound:9120930|FD-Score:3.92|P-value:3.75E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.13|P-value:7.96E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.24|P-value:5.47E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:10.90|P-value:1.59E-28 ID:SGTC_64|Compound:000l-0018|FD-Score:13.50|P-value:1.66E-42 ID:SGTC_67|Compound:0335-0847|FD-Score:11.40|P-value:3.75E-31 ID:SGTC_81|Compound:0411-0046|FD-Score:4.00|P-value:2.65E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:24.50|P-value:1.26E-135 ID:SGTC_87|Compound:0100-0052|FD-Score:4.66|P-value:1.25E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:3.62|P-value:1.29E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.79|P-value:6.56E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:7.92|P-value:6.16E-16 ID:SGTC_149|Compound:3970-0822|FD-Score:3.43|P-value:2.69E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:22.70|P-value:7.28E-117 ID:SGTC_165|Compound:k038-0023|FD-Score:5.00|P-value:2.21E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:6.38|P-value:5.69E-11 ID:SGTC_200|Compound:k038-0079|FD-Score:5.59|P-value:8.31E-9 ID:SGTC_214|Compound:4373-3496|FD-Score:3.07|P-value:9.88E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:5.20|P-value:7.53E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:23.20|P-value:2.21E-121 ID:SGTC_294|Compound:k038-0071|FD-Score:6.07|P-value:4.25E-10 ID:SGTC_340|Compound:k038-0059|FD-Score:7.07|P-value:4.48E-13 ID:SGTC_367|Compound:0335-0881|FD-Score:6.25|P-value:1.37E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:11.00|P-value:3.40E-29 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.22|P-value:5.53E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:8.99|P-value:5.14E-20 ID:SGTC_642|Compound:0335-0876|FD-Score:6.90|P-value:1.62E-12 ID:SGTC_643|Compound:k048-0106|FD-Score:3.44|P-value:2.57E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.54|P-value:1.67E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:9.43|P-value:8.03E-22 ID:SGTC_837|Compound:0091-0265|FD-Score:3.24|P-value:5.42E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:4.26|P-value:8.45E-6 ID:SGTC_859|Compound:0439-0102|FD-Score:3.36|P-value:3.48E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.21|P-value:5.79E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.31|P-value:4.11E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.37|P-value:3.29E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.78|P-value:6.60E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.02|P-value:2.48E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.62|P-value:1.29E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.09|P-value:9.14E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.17|P-value:1.29E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.19|P-value:7.62E-8 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.88|P-value:4.46E-5 ID:SGTC_1563|Compound:conessine|FD-Score:3.21|P-value:6.05E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.26|P-value:5.05E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.28|P-value:4.57E-4 ID:SGTC_1635|Compound:st007035|FD-Score:20.80|P-value:2.63E-98 ID:SGTC_1739|Compound:st037196|FD-Score:-5.23|P-value:6.11E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.37|P-value:3.22E-4 ID:SGTC_1896|Compound:st058441|FD-Score:4.40|P-value:4.37E-6 ID:SGTC_1910|Compound:st062352|FD-Score:-3.58|P-value:1.46E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-4.08|P-value:1.86E-5 ID:SGTC_2060|Compound:5238662|FD-Score:-3.37|P-value:3.27E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.15|P-value:7.32E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.67|P-value:1.04E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.86|P-value:4.86E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.56|P-value:1.65E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.19|P-value:6.26E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.90|P-value:3.79E-7 ID:SGTC_2805|Compound:7950783|FD-Score:4.04|P-value:2.28E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.37|P-value:4.86E-6 ID:SGTC_3104|Compound:9120930|FD-Score:3.92|P-value:3.75E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.13|P-value:7.96E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.24|P-value:5.47E-4

Top fitness defect scores for YNR041C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_86 0417-1630 24.50 471.9 µM 1.26E-135 ubiquinone biosynthesis & proteasome 2 7.25E-133
2 SGTC_236 1509-0011 23.20 5.3 µM 2.21E-121 39 6.45E-119
3 SGTC_158 k038-0087 22.70 26.4 µM 7.28E-117 ubiquinone biosynthesis & proteasome 2 1.71E-114
4 SGTC_1635 st007035 20.80 42.4 µM 2.63E-98 21 2.53E-96
5 SGTC_64 000l-0018 13.50 272.1 µM 1.66E-42 ubiquinone biosynthesis & proteasome 24 1.11E-41
6 SGTC_67 0335-0847 11.40 266.0 µM 3.75E-31 ubiquinone biosynthesis & proteasome 15 1.46E-30
7 SGTC_386 1509-0011 11.00 3.1 µM 3.40E-29 39 1.21E-28
8 SGTC_36 0335-0881 10.90 14.2 µM 1.59E-28 ubiquinone biosynthesis & proteasome 19 5.50E-28
9 SGTC_794 k038-0031 9.43 316.0 µM 8.03E-22 ubiquinone biosynthesis & proteasome 20 2.02E-21
10 SGTC_635 k038-0028 8.99 24.7 µM 5.14E-20 ubiquinone biosynthesis & proteasome 6 1.19E-19
11 SGTC_142 0335-0849 7.92 62.7 µM 6.16E-16 ubiquinone biosynthesis & proteasome 45 1.18E-15
12 SGTC_340 k038-0059 7.07 454.0 µM 4.48E-13 ubiquinone biosynthesis & proteasome 11 7.51E-13
13 SGTC_642 0335-0876 6.90 158.0 µM 1.62E-12 ubiquinone biosynthesis & proteasome 10 2.64E-12
14 SGTC_168 3970-0862 6.38 530.5 µM 5.69E-11 35 8.65E-11
15 SGTC_367 0335-0881 6.25 7.1 µM 1.37E-10 ubiquinone biosynthesis & proteasome 24 2.05E-10
16 SGTC_294 k038-0071 6.07 157.0 µM 4.25E-10 ubiquinone biosynthesis & proteasome 14 6.21E-10
17 SGTC_200 k038-0079 5.59 37.5 µM 8.31E-9 ubiquinone biosynthesis & proteasome 31 1.14E-8
18 SGTC_216 k038-0035 5.20 28.4 µM 7.53E-8 ubiquinone biosynthesis & proteasome 32 9.91E-8
19 SGTC_165 k038-0023 5.00 64.4 µM 2.21E-7 ubiquinone biosynthesis & proteasome 42 2.85E-7
20 SGTC_2804 7954240 4.90 19.5 µM 3.79E-7 13 4.84E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.828 0 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.802 0 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.788 0 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.777 0 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.773 0 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.701 0 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.657 0 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.648 0 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.624 0 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.607 0 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.585 7.04E-307 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.566 4.93E-283 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.535 1.14E-247 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.525 1.10E-236 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.512 7.47E-224 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data