YNR043W / MVD1

Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNR043W / MVD1

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:3.19|P-value:7.24E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:5.21|P-value:8.31E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:5.56|P-value:1.19E-8 ID:SGTC_154|Compound:3389-1638|FD-Score:3.20|P-value:6.97E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:7.76|P-value:2.80E-15 ID:SGTC_157|Compound:1348-1695|FD-Score:7.34|P-value:7.08E-14 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.65|P-value:8.54E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:4.16|P-value:1.54E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:3.32|P-value:4.55E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.82|P-value:4.26E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.11|P-value:6.70E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.96|P-value:3.76E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.92|P-value:2.80E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:-3.89|P-value:3.10E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:3.17|P-value:7.79E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.26|P-value:5.69E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-3.06|P-value:7.89E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.26|P-value:3.84E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.86|P-value:5.74E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:3.10|P-value:9.86E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-2.99|P-value:9.89E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.71|P-value:6.81E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.64|P-value:1.39E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.25|P-value:1.06E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.32|P-value:4.67E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:5.79|P-value:2.89E-9 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.61|P-value:1.54E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.24|P-value:4.14E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.16|P-value:5.61E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.74|P-value:5.94E-5 ID:SGTC_1491|Compound:4138-0063|FD-Score:5.09|P-value:1.62E-7 ID:SGTC_1719|Compound:st032227|FD-Score:4.62|P-value:1.84E-6 ID:SGTC_1817|Compound:st052116|FD-Score:-3.14|P-value:6.07E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.01|P-value:9.37E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.49|P-value:2.47E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.75|P-value:5.59E-5 ID:SGTC_1954|Compound:st077032|FD-Score:3.62|P-value:1.49E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.52|P-value:2.19E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.14|P-value:8.72E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.75|P-value:9.04E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.32|P-value:4.70E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.64|P-value:8.93E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-3.29|P-value:3.48E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.18|P-value:7.55E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.50|P-value:1.95E-6 ID:SGTC_2625|Compound:euphol|FD-Score:4.42|P-value:4.66E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.48|P-value:2.53E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.79|P-value:7.62E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.39|P-value:3.55E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.19|P-value:7.24E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:5.21|P-value:8.31E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:5.56|P-value:1.19E-8 ID:SGTC_154|Compound:3389-1638|FD-Score:3.20|P-value:6.97E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:7.76|P-value:2.80E-15 ID:SGTC_157|Compound:1348-1695|FD-Score:7.34|P-value:7.08E-14 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.65|P-value:8.54E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:4.16|P-value:1.54E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:3.32|P-value:4.55E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.82|P-value:4.26E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.11|P-value:6.70E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.96|P-value:3.76E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.92|P-value:2.80E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:-3.89|P-value:3.10E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:3.17|P-value:7.79E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.26|P-value:5.69E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-3.06|P-value:7.89E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.26|P-value:3.84E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.86|P-value:5.74E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:3.10|P-value:9.86E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-2.99|P-value:9.89E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.71|P-value:6.81E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.64|P-value:1.39E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.25|P-value:1.06E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.32|P-value:4.67E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:5.79|P-value:2.89E-9 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.61|P-value:1.54E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.24|P-value:4.14E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.16|P-value:5.61E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.74|P-value:5.94E-5 ID:SGTC_1491|Compound:4138-0063|FD-Score:5.09|P-value:1.62E-7 ID:SGTC_1719|Compound:st032227|FD-Score:4.62|P-value:1.84E-6 ID:SGTC_1817|Compound:st052116|FD-Score:-3.14|P-value:6.07E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.01|P-value:9.37E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.49|P-value:2.47E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.75|P-value:5.59E-5 ID:SGTC_1954|Compound:st077032|FD-Score:3.62|P-value:1.49E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.52|P-value:2.19E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.14|P-value:8.72E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.75|P-value:9.04E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.32|P-value:4.70E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.64|P-value:8.93E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-3.29|P-value:3.48E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.18|P-value:7.55E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.50|P-value:1.95E-6 ID:SGTC_2625|Compound:euphol|FD-Score:4.42|P-value:4.66E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.48|P-value:2.53E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.79|P-value:7.62E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.39|P-value:3.55E-4

Top fitness defect scores for YNR043W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_155 k072-0202 7.76 43.6 µM 2.80E-15 1 4.40E-15 1.90
2 SGTC_157 1348-1695 7.34 65.8 µM 7.08E-14 iron homeostasis 16 1.04E-13 0.85
3 SGTC_1183 1254-0324 5.79 198.0 µM 2.89E-9 1 3.43E-9 1.74
4 SGTC_151 3013-0144 5.56 2.3 µM 1.19E-8 iron homeostasis 4 1.38E-8 0.43
5 SGTC_149 3970-0822 5.21 46.1 µM 8.31E-8 tubulin folding & SWR complex 4 9.26E-8 0.17
6 SGTC_1491 4138-0063 5.09 26.5 µM 1.62E-7 2 1.79E-7 1.03
7 SGTC_1719 st032227 4.62 49.2 µM 1.84E-6 6 1.95E-6 0.24
8 SGTC_2625 euphol 4.42 100.0 µM 4.66E-6 6 4.85E-6 0.29
9 SGTC_1088 bifonazole 4.25 369.0 nM 1.06E-5 1 1.09E-5 0.41
10 SGTC_286 k060-0067 4.16 22.9 µM 1.54E-5 tubulin folding & SWR complex 4 1.57E-5 0.27
11 SGTC_480 am 92016 3.96 50.0 µM 3.76E-5 6 3.79E-5 0.07
12 SGTC_971 1315-0384 3.86 26.7 µM 5.74E-5 cell wall signaling 5 5.75E-5 0.17
13 SGTC_2691 st077356 3.79 60.2 µM 7.62E-5 10 7.61E-5 0.10
14 SGTC_2298 7976326 3.75 193.8 µM 9.04E-5 1 9.00E-5 0.83
15 SGTC_1080 nisoldipine 3.64 24.4 µM 1.39E-4 TSC3-RPN4 6 1.37E-4 0.08
16 SGTC_1954 st077032 3.62 68.9 µM 1.49E-4 8 1.47E-4 0.31
17 SGTC_1369 1866-0067 3.61 208.0 µM 1.54E-4 RPP1 & pyrimidine depletion 10 1.52E-4 0.12
18 SGTC_2019 4016004 3.52 108.0 µM 2.19E-4 14 2.15E-4 0.04
19 SGTC_1938 st074717 3.49 56.4 µM 2.47E-4 2 2.43E-4 0.31
20 SGTC_2626 ethyl orsellinate 3.48 100.0 µM 2.53E-4 14 2.49E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.189 2.54E-28 YBR101C FES1 hom Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.161 9.00E-21 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.138 7.88E-16 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 3.62E-9 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.101 5.36E-9 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.099 8.60E-9 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.097 2.04E-8 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.096 3.04E-8 YHR107C CDC12 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
0.095 3.40E-8 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.088 3.68E-7 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.087 4.80E-7 YER097W_d YER097W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 5.73E-7 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.085 7.40E-7 YGL086W MAD1 hom Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
0.085 8.64E-7 YPL270W MDL2 hom Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
0.084 1.02E-6 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p