YNR045W / PET494

Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR045W / PET494

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-4.29|P-value:3.72E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:3.62|P-value:5.76E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.12|P-value:4.35E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.60|P-value:1.31E-12 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.63|P-value:7.78E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:3.55|P-value:7.90E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:4.93|P-value:8.50E-8 ID:SGTC_108|Compound:0509-0257|FD-Score:3.00|P-value:6.92E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:18.90|P-value:1.51E-88 ID:SGTC_143|Compound:4032-1194|FD-Score:2.99|P-value:7.03E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.17|P-value:4.88E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.71|P-value:2.78E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:3.65|P-value:5.18E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:20.30|P-value:7.87E-102 ID:SGTC_279|Compound:1273-0055|FD-Score:3.01|P-value:6.60E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.15|P-value:3.91E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:11.70|P-value:2.37E-35 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.07|P-value:5.38E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.62|P-value:5.86E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.60|P-value:7.77E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.55|P-value:1.08E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.41|P-value:1.41E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.07|P-value:6.96E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.77|P-value:2.97E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:2.91|P-value:9.40E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.32|P-value:2.06E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.32|P-value:2.05E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.32|P-value:2.74E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-4.35|P-value:2.85E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:2.99|P-value:7.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.27|P-value:4.17E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.78|P-value:4.12E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:4.50|P-value:8.96E-7 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.13|P-value:5.54E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.00|P-value:9.17E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.15|P-value:5.20E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.63|P-value:5.49E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.22|P-value:2.95E-4 ID:SGTC_1635|Compound:st007035|FD-Score:19.70|P-value:7.92E-96 ID:SGTC_1674|Compound:st016616|FD-Score:-3.42|P-value:1.85E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.42|P-value:1.35E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.49|P-value:9.91E-5 ID:SGTC_1903|Compound:st060211|FD-Score:3.28|P-value:2.38E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.08|P-value:5.02E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.11|P-value:6.36E-6 ID:SGTC_2625|Compound:euphol|FD-Score:2.98|P-value:7.42E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.05|P-value:7.46E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.12|P-value:4.34E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-4.05|P-value:1.21E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-3.81|P-value:3.58E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-3.00|P-value:8.95E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.02|P-value:8.58E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.38|P-value:1.58E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-4.17|P-value:6.91E-6 ID:SGTC_3304|Compound:9125678|FD-Score:-3.09|P-value:6.51E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-4.25|P-value:4.54E-6 ID:SGTC_3315|Compound:9136395|FD-Score:3.22|P-value:2.97E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-4.29|P-value:3.72E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:3.62|P-value:5.76E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.12|P-value:4.35E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.60|P-value:1.31E-12 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.63|P-value:7.78E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:3.55|P-value:7.90E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:4.93|P-value:8.50E-8 ID:SGTC_108|Compound:0509-0257|FD-Score:3.00|P-value:6.92E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:18.90|P-value:1.51E-88 ID:SGTC_143|Compound:4032-1194|FD-Score:2.99|P-value:7.03E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.17|P-value:4.88E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.71|P-value:2.78E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:3.65|P-value:5.18E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:20.30|P-value:7.87E-102 ID:SGTC_279|Compound:1273-0055|FD-Score:3.01|P-value:6.60E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.15|P-value:3.91E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:11.70|P-value:2.37E-35 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.07|P-value:5.38E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.62|P-value:5.86E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.60|P-value:7.77E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.55|P-value:1.08E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.41|P-value:1.41E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.07|P-value:6.96E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.77|P-value:2.97E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:2.91|P-value:9.40E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.32|P-value:2.06E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.32|P-value:2.05E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.32|P-value:2.74E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-4.35|P-value:2.85E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:2.99|P-value:7.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.27|P-value:4.17E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.78|P-value:4.12E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:4.50|P-value:8.96E-7 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.13|P-value:5.54E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.00|P-value:9.17E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.15|P-value:5.20E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.63|P-value:5.49E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.22|P-value:2.95E-4 ID:SGTC_1635|Compound:st007035|FD-Score:19.70|P-value:7.92E-96 ID:SGTC_1674|Compound:st016616|FD-Score:-3.42|P-value:1.85E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.42|P-value:1.35E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.49|P-value:9.91E-5 ID:SGTC_1903|Compound:st060211|FD-Score:3.28|P-value:2.38E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.08|P-value:5.02E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.11|P-value:6.36E-6 ID:SGTC_2625|Compound:euphol|FD-Score:2.98|P-value:7.42E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.05|P-value:7.46E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.12|P-value:4.34E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-4.05|P-value:1.21E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-3.81|P-value:3.58E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-3.00|P-value:8.95E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.02|P-value:8.58E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.38|P-value:1.58E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-4.17|P-value:6.91E-6 ID:SGTC_3304|Compound:9125678|FD-Score:-3.09|P-value:6.51E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-4.25|P-value:4.54E-6 ID:SGTC_3315|Compound:9136395|FD-Score:3.22|P-value:2.97E-4

Top fitness defect scores for YNR045W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 20.30 5.3 µM 7.87E-102 52 1.12E-91
2 SGTC_1635 st007035 19.70 42.4 µM 7.92E-96 22 2.82E-86
3 SGTC_134 0269-0018 18.90 6.9 µM 1.51E-88 9 1.01E-79
4 SGTC_386 1509-0011 11.70 3.1 µM 2.37E-35 35 7.21E-32
5 SGTC_70 0141-0289 6.60 43.3 µM 1.31E-12 mitochondrial stress 61 2.00E-11
6 SGTC_87 0100-0052 4.93 35.5 µM 8.50E-8 57 4.19E-7
7 SGTC_168 3970-0862 4.71 530.5 µM 2.78E-7 81 1.22E-6
8 SGTC_1219 1469-0211 4.50 33.1 µM 8.96E-7 15 3.47E-6
9 SGTC_650 1328-0195 4.41 38.0 µM 1.41E-6 12 5.20E-6
10 SGTC_1222 0366-0074 4.13 1.2 µM 5.54E-6 TSC3-RPN4 9 1.78E-5
11 SGTC_2309 7664088 4.11 163.9 µM 6.36E-6 22 2.02E-5
12 SGTC_807 1315-0151 3.77 48.0 µM 2.97E-5 34 8.04E-5
13 SGTC_214 4373-3496 3.65 70.0 µM 5.18E-5 76 1.33E-4
14 SGTC_1508 1080-0625 3.63 72.9 µM 5.49E-5 27 1.40E-4
15 SGTC_59 0330-0160 3.62 1.3 µM 5.76E-5 134 1.46E-4
16 SGTC_450 aminopyrene 3.62 156.0 nM 5.86E-5 40 1.48E-4
17 SGTC_81 0411-0046 3.55 10.0 µM 7.90E-5 29 1.94E-4
18 SGTC_1691 st019933 3.49 84.6 µM 9.91E-5 24 2.38E-4
19 SGTC_1686 st019653 3.42 115.5 µM 1.35E-4 mitochondrial processes 20 3.13E-4
20 SGTC_3010 9080089 3.38 71.4 µM 1.58E-4 33 3.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.748 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.711 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.711 0 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.705 0 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.688 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.686 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.685 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.680 0 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.676 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.676 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.675 0 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.674 0 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.667 0 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.666 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.662 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p