YNR051C / BRE5

Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR051C / BRE5

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:3.18|P-value:8.11E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.78|P-value:9.20E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:5.47|P-value:3.18E-8 ID:SGTC_97|Compound:0535-0701|FD-Score:5.73|P-value:7.58E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:6.60|P-value:3.57E-11 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.05|P-value:3.48E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.47|P-value:4.98E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:6.86|P-value:6.17E-12 ID:SGTC_133|Compound:0724-0033|FD-Score:-4.20|P-value:1.84E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:3.41|P-value:3.68E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.50|P-value:2.63E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:4.96|P-value:4.69E-7 ID:SGTC_192|Compound:3455-0609|FD-Score:3.19|P-value:7.82E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.43|P-value:3.38E-4 ID:SGTC_263|Compound:alizarin|FD-Score:6.13|P-value:6.82E-10 ID:SGTC_268|Compound:camptothecin|FD-Score:3.38|P-value:4.05E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.51|P-value:4.63E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.16|P-value:9.76E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.44|P-value:3.27E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.91|P-value:4.53E-12 ID:SGTC_592|Compound:k241-0073|FD-Score:10.50|P-value:1.40E-25 ID:SGTC_638|Compound:3970-0837|FD-Score:3.91|P-value:5.57E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:3.87|P-value:6.57E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:4.06|P-value:2.93E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:4.42|P-value:6.13E-6 ID:SGTC_716|Compound:1683-5115|FD-Score:3.67|P-value:1.40E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.95|P-value:4.59E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:3.18|P-value:8.26E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:5.22|P-value:1.22E-7 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.37|P-value:4.79E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:5.40|P-value:4.68E-8 ID:SGTC_981|Compound:1488-1094|FD-Score:3.91|P-value:5.48E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.20|P-value:8.53E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:7.67|P-value:1.88E-14 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.44|P-value:5.73E-6 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.79|P-value:8.71E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.00|P-value:3.85E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:5.67|P-value:1.04E-8 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.56|P-value:3.28E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.17|P-value:8.63E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.82|P-value:7.88E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.54|P-value:2.34E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.70|P-value:1.27E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.83|P-value:8.89E-7 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.52|P-value:3.95E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.25|P-value:1.33E-5 ID:SGTC_1625|Compound:st003711|FD-Score:3.41|P-value:3.72E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.57|P-value:2.06E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.38|P-value:4.05E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.49|P-value:7.08E-11 ID:SGTC_1727|Compound:st034309|FD-Score:3.82|P-value:7.73E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-4.33|P-value:1.04E-5 ID:SGTC_1755|Compound:st041960|FD-Score:5.28|P-value:9.29E-8 ID:SGTC_1759|Compound:st043059|FD-Score:-4.02|P-value:3.90E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.37|P-value:4.30E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.70|P-value:1.26E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.57|P-value:2.03E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.71|P-value:1.61E-6 ID:SGTC_1959|Compound:st077091|FD-Score:-3.25|P-value:7.18E-4 ID:SGTC_1970|Compound:st070122|FD-Score:4.60|P-value:2.71E-6 ID:SGTC_1979|Compound:st071809|FD-Score:3.70|P-value:1.24E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.22|P-value:7.13E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.18|P-value:8.33E-4 ID:SGTC_2068|Compound:5226020|FD-Score:5.14|P-value:1.91E-7 ID:SGTC_2077|Compound:5212015|FD-Score:3.32|P-value:5.04E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.25|P-value:7.22E-4 ID:SGTC_2242|Compound:6630449|FD-Score:6.21|P-value:4.19E-10 ID:SGTC_2314|Compound:7727897|FD-Score:-3.58|P-value:2.20E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.54|P-value:3.56E-6 ID:SGTC_2348|Compound:9022543|FD-Score:4.14|P-value:2.13E-5 ID:SGTC_2399|Compound:5884133|FD-Score:5.84|P-value:4.05E-9 ID:SGTC_2402|Compound:5553605|FD-Score:3.18|P-value:8.10E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.49|P-value:2.74E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.47|P-value:5.66E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-6.85|P-value:7.81E-12 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.99|P-value:3.93E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.28|P-value:1.16E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.33|P-value:7.01E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.49|P-value:2.73E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.18|P-value:8.21E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.39|P-value:3.91E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.23|P-value:6.84E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.56|P-value:2.15E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.20|P-value:7.72E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.25|P-value:1.30E-5 ID:SGTC_2954|Compound:9074818|FD-Score:7.47|P-value:8.33E-14 ID:SGTC_2955|Compound:9076254|FD-Score:4.00|P-value:3.81E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-3.26|P-value:6.91E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.82|P-value:7.84E-5 ID:SGTC_3131|Compound:9127911|FD-Score:3.17|P-value:8.45E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.93|P-value:4.97E-5 ID:SGTC_3189|Compound:9110682|FD-Score:6.09|P-value:9.09E-10 ID:SGTC_3195|Compound:9113082|FD-Score:3.78|P-value:9.08E-5 ID:SGTC_3299|Compound:9121982|FD-Score:9.20|P-value:5.31E-20 ID:SGTC_61|Compound:0978-8327|FD-Score:3.18|P-value:8.11E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.78|P-value:9.20E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:5.47|P-value:3.18E-8 ID:SGTC_97|Compound:0535-0701|FD-Score:5.73|P-value:7.58E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:6.60|P-value:3.57E-11 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.05|P-value:3.48E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.47|P-value:4.98E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:6.86|P-value:6.17E-12 ID:SGTC_133|Compound:0724-0033|FD-Score:-4.20|P-value:1.84E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:3.41|P-value:3.68E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.50|P-value:2.63E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:4.96|P-value:4.69E-7 ID:SGTC_192|Compound:3455-0609|FD-Score:3.19|P-value:7.82E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.43|P-value:3.38E-4 ID:SGTC_263|Compound:alizarin|FD-Score:6.13|P-value:6.82E-10 ID:SGTC_268|Compound:camptothecin|FD-Score:3.38|P-value:4.05E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.51|P-value:4.63E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.16|P-value:9.76E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.44|P-value:3.27E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.91|P-value:4.53E-12 ID:SGTC_592|Compound:k241-0073|FD-Score:10.50|P-value:1.40E-25 ID:SGTC_638|Compound:3970-0837|FD-Score:3.91|P-value:5.57E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:3.87|P-value:6.57E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:4.06|P-value:2.93E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:4.42|P-value:6.13E-6 ID:SGTC_716|Compound:1683-5115|FD-Score:3.67|P-value:1.40E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.95|P-value:4.59E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:3.18|P-value:8.26E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:5.22|P-value:1.22E-7 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.37|P-value:4.79E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:5.40|P-value:4.68E-8 ID:SGTC_981|Compound:1488-1094|FD-Score:3.91|P-value:5.48E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.20|P-value:8.53E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:7.67|P-value:1.88E-14 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.44|P-value:5.73E-6 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.79|P-value:8.71E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.00|P-value:3.85E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:5.67|P-value:1.04E-8 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.56|P-value:3.28E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.17|P-value:8.63E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.82|P-value:7.88E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.54|P-value:2.34E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.70|P-value:1.27E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.83|P-value:8.89E-7 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.52|P-value:3.95E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.25|P-value:1.33E-5 ID:SGTC_1625|Compound:st003711|FD-Score:3.41|P-value:3.72E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.57|P-value:2.06E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.38|P-value:4.05E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.49|P-value:7.08E-11 ID:SGTC_1727|Compound:st034309|FD-Score:3.82|P-value:7.73E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-4.33|P-value:1.04E-5 ID:SGTC_1755|Compound:st041960|FD-Score:5.28|P-value:9.29E-8 ID:SGTC_1759|Compound:st043059|FD-Score:-4.02|P-value:3.90E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.37|P-value:4.30E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.70|P-value:1.26E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.57|P-value:2.03E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.71|P-value:1.61E-6 ID:SGTC_1959|Compound:st077091|FD-Score:-3.25|P-value:7.18E-4 ID:SGTC_1970|Compound:st070122|FD-Score:4.60|P-value:2.71E-6 ID:SGTC_1979|Compound:st071809|FD-Score:3.70|P-value:1.24E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.22|P-value:7.13E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.18|P-value:8.33E-4 ID:SGTC_2068|Compound:5226020|FD-Score:5.14|P-value:1.91E-7 ID:SGTC_2077|Compound:5212015|FD-Score:3.32|P-value:5.04E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.25|P-value:7.22E-4 ID:SGTC_2242|Compound:6630449|FD-Score:6.21|P-value:4.19E-10 ID:SGTC_2314|Compound:7727897|FD-Score:-3.58|P-value:2.20E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.54|P-value:3.56E-6 ID:SGTC_2348|Compound:9022543|FD-Score:4.14|P-value:2.13E-5 ID:SGTC_2399|Compound:5884133|FD-Score:5.84|P-value:4.05E-9 ID:SGTC_2402|Compound:5553605|FD-Score:3.18|P-value:8.10E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.49|P-value:2.74E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.47|P-value:5.66E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-6.85|P-value:7.81E-12 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.99|P-value:3.93E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.28|P-value:1.16E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.33|P-value:7.01E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.49|P-value:2.73E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.18|P-value:8.21E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.39|P-value:3.91E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.23|P-value:6.84E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.56|P-value:2.15E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.20|P-value:7.72E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.25|P-value:1.30E-5 ID:SGTC_2954|Compound:9074818|FD-Score:7.47|P-value:8.33E-14 ID:SGTC_2955|Compound:9076254|FD-Score:4.00|P-value:3.81E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-3.26|P-value:6.91E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.82|P-value:7.84E-5 ID:SGTC_3131|Compound:9127911|FD-Score:3.17|P-value:8.45E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.93|P-value:4.97E-5 ID:SGTC_3189|Compound:9110682|FD-Score:6.09|P-value:9.09E-10 ID:SGTC_3195|Compound:9113082|FD-Score:3.78|P-value:9.08E-5 ID:SGTC_3299|Compound:9121982|FD-Score:9.20|P-value:5.31E-20

Top fitness defect scores for YNR051C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_592 k241-0073 10.50 46.5 µM 1.40E-25 3 3.27E-26
2 SGTC_3299 9121982 9.20 43.1 µM 5.31E-20 2 1.77E-20
3 SGTC_999 4022-0066 7.67 22.7 µM 1.88E-14 Golgi 7 8.89E-15
4 SGTC_2954 9074818 7.47 52.7 µM 8.33E-14 4 4.11E-14
5 SGTC_528 3492-0019 6.91 172.0 µM 4.53E-12 calcium & mitochondrial duress 95 2.49E-12
6 SGTC_124 0136-0217 6.86 7.1 µM 6.17E-12 mitochondrial stress 19 3.42E-12
7 SGTC_103 0844-0104 6.60 51.8 µM 3.57E-11 ERAD & cell cycle 65 2.08E-11
8 SGTC_1687 st020778 6.49 55.4 µM 7.08E-11 101 4.19E-11
9 SGTC_2242 6630449 6.21 61.3 µM 4.19E-10 Golgi 17 2.60E-10
10 SGTC_263 alizarin 6.13 107.9 µM 6.82E-10 iron homeostasis 25 4.29E-10
11 SGTC_3189 9110682 6.09 49.5 µM 9.09E-10 9 5.75E-10
12 SGTC_2399 5884133 5.84 200.0 µM 4.05E-9 cell wall signaling 30 2.67E-9
13 SGTC_97 0535-0701 5.73 19.1 µM 7.58E-9 60S ribosome export 5 5.07E-9
14 SGTC_1195 1502-0147 5.67 41.1 µM 1.04E-8 5 7.05E-9
15 SGTC_70 0141-0289 5.47 43.3 µM 3.18E-8 mitochondrial stress 98 2.21E-8
16 SGTC_971 1315-0384 5.40 26.7 µM 4.68E-8 cell wall signaling 3 3.28E-8
17 SGTC_2612 dictamnine 5.33 15.5 µM 7.01E-8 RNA pol III & RNase P/MRP 20 4.97E-8
18 SGTC_1755 st041960 5.28 45.2 µM 9.29E-8 9 6.64E-8
19 SGTC_841 0251-0215 5.22 91.2 µM 1.22E-7 49 8.82E-8
20 SGTC_2068 5226020 5.14 147.0 µM 1.91E-7 10 1.39E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.324 8.99E-83 YER151C UBP3 hom Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.206 1.23E-33 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.194 8.62E-30 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.174 4.17E-24 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.165 6.82E-22 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.161 6.28E-21 YOR069W VPS5 hom Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes
0.156 8.45E-20 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.151 1.29E-18 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.150 2.08E-18 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.144 6.20E-17 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.136 3.08E-15 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.135 3.39E-15 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.132 1.60E-14 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.130 3.87E-14 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.129 8.02E-14 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif