YNR052C / POP2

RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR052C / POP2

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:-4.36|P-value:1.47E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.99|P-value:8.73E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.84|P-value:6.77E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:7.29|P-value:3.24E-9 ID:SGTC_197|Compound:4544-0043|FD-Score:5.35|P-value:1.18E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:4.09|P-value:6.60E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.53|P-value:1.79E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:4.19|P-value:4.98E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.19|P-value:8.78E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:5.15|P-value:2.33E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.36|P-value:8.11E-8 ID:SGTC_549|Compound:1661-1316|FD-Score:5.33|P-value:1.24E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:4.16|P-value:5.34E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.06|P-value:3.23E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:4.47|P-value:2.14E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:5.77|P-value:2.45E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:5.09|P-value:2.93E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.95|P-value:9.62E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.24|P-value:4.22E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:5.68|P-value:3.38E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:-4.50|P-value:9.52E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:5.63|P-value:4.08E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:5.08|P-value:2.95E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:4.83|P-value:6.88E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.02|P-value:7.92E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:8.81|P-value:1.04E-12 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.96|P-value:9.30E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:5.44|P-value:8.35E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:5.07|P-value:3.04E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.43|P-value:2.43E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:5.49|P-value:6.99E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:5.31|P-value:1.33E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.67|P-value:1.15E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.22|P-value:4.51E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.45|P-value:2.29E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:5.96|P-value:1.15E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.99|P-value:4.53E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.58|P-value:1.51E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:6.38|P-value:2.03E-7 ID:SGTC_1624|Compound:st003710|FD-Score:7.62|P-value:6.47E-10 ID:SGTC_1654|Compound:st012436|FD-Score:4.88|P-value:5.86E-5 ID:SGTC_1658|Compound:st012944|FD-Score:6.98|P-value:1.44E-8 ID:SGTC_1687|Compound:st020778|FD-Score:5.79|P-value:2.23E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:5.50|P-value:6.68E-6 ID:SGTC_1780|Compound:st038448|FD-Score:4.22|P-value:4.57E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.69|P-value:1.10E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.08|P-value:2.68E-7 ID:SGTC_1799|Compound:st045822|FD-Score:4.46|P-value:2.22E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.22|P-value:4.53E-4 ID:SGTC_1850|Compound:st056238|FD-Score:4.14|P-value:5.75E-4 ID:SGTC_1912|Compound:st060209|FD-Score:8.89|P-value:6.38E-13 ID:SGTC_2050|Compound:5263056|FD-Score:5.08|P-value:2.98E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-3.79|P-value:7.96E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.37|P-value:2.89E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.59|P-value:1.51E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.68|P-value:1.13E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-4.90|P-value:2.49E-5 ID:SGTC_2346|Compound:9031566|FD-Score:6.40|P-value:1.92E-7 ID:SGTC_2349|Compound:9023730|FD-Score:-3.72|P-value:9.47E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.36|P-value:3.04E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-4.43|P-value:1.16E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.28|P-value:3.79E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.73|P-value:9.31E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.87|P-value:6.25E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:5.84|P-value:1.87E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.07|P-value:7.04E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.26|P-value:4.00E-4 ID:SGTC_2789|Compound:5281112|FD-Score:5.78|P-value:2.29E-6 ID:SGTC_2873|Compound:9040596|FD-Score:5.25|P-value:1.63E-5 ID:SGTC_2894|Compound:9048625|FD-Score:-4.88|P-value:2.61E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-3.76|P-value:8.61E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.73|P-value:9.50E-5 ID:SGTC_3026|Compound:9090633|FD-Score:4.30|P-value:3.59E-4 ID:SGTC_3054|Compound:9094397|FD-Score:4.26|P-value:3.99E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-5.45|P-value:3.41E-6 ID:SGTC_3197|Compound:9113331|FD-Score:6.66|P-value:6.02E-8 ID:SGTC_57|Compound:miconazole|FD-Score:-4.36|P-value:1.47E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.99|P-value:8.73E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.84|P-value:6.77E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:7.29|P-value:3.24E-9 ID:SGTC_197|Compound:4544-0043|FD-Score:5.35|P-value:1.18E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:4.09|P-value:6.60E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.53|P-value:1.79E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:4.19|P-value:4.98E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.19|P-value:8.78E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:5.15|P-value:2.33E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.36|P-value:8.11E-8 ID:SGTC_549|Compound:1661-1316|FD-Score:5.33|P-value:1.24E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:4.16|P-value:5.34E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.06|P-value:3.23E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:4.47|P-value:2.14E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:5.77|P-value:2.45E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:5.09|P-value:2.93E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.95|P-value:9.62E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.24|P-value:4.22E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:5.68|P-value:3.38E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:-4.50|P-value:9.52E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:5.63|P-value:4.08E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:5.08|P-value:2.95E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:4.83|P-value:6.88E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.02|P-value:7.92E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:8.81|P-value:1.04E-12 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.96|P-value:9.30E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:5.44|P-value:8.35E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:5.07|P-value:3.04E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.43|P-value:2.43E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:5.49|P-value:6.99E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:5.31|P-value:1.33E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.67|P-value:1.15E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.22|P-value:4.51E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.45|P-value:2.29E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:5.96|P-value:1.15E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.99|P-value:4.53E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.58|P-value:1.51E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:6.38|P-value:2.03E-7 ID:SGTC_1624|Compound:st003710|FD-Score:7.62|P-value:6.47E-10 ID:SGTC_1654|Compound:st012436|FD-Score:4.88|P-value:5.86E-5 ID:SGTC_1658|Compound:st012944|FD-Score:6.98|P-value:1.44E-8 ID:SGTC_1687|Compound:st020778|FD-Score:5.79|P-value:2.23E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:5.50|P-value:6.68E-6 ID:SGTC_1780|Compound:st038448|FD-Score:4.22|P-value:4.57E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.69|P-value:1.10E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.08|P-value:2.68E-7 ID:SGTC_1799|Compound:st045822|FD-Score:4.46|P-value:2.22E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.22|P-value:4.53E-4 ID:SGTC_1850|Compound:st056238|FD-Score:4.14|P-value:5.75E-4 ID:SGTC_1912|Compound:st060209|FD-Score:8.89|P-value:6.38E-13 ID:SGTC_2050|Compound:5263056|FD-Score:5.08|P-value:2.98E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-3.79|P-value:7.96E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.37|P-value:2.89E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.59|P-value:1.51E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.68|P-value:1.13E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-4.90|P-value:2.49E-5 ID:SGTC_2346|Compound:9031566|FD-Score:6.40|P-value:1.92E-7 ID:SGTC_2349|Compound:9023730|FD-Score:-3.72|P-value:9.47E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.36|P-value:3.04E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-4.43|P-value:1.16E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.28|P-value:3.79E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.73|P-value:9.31E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.87|P-value:6.25E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:5.84|P-value:1.87E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.07|P-value:7.04E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.26|P-value:4.00E-4 ID:SGTC_2789|Compound:5281112|FD-Score:5.78|P-value:2.29E-6 ID:SGTC_2873|Compound:9040596|FD-Score:5.25|P-value:1.63E-5 ID:SGTC_2894|Compound:9048625|FD-Score:-4.88|P-value:2.61E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-3.76|P-value:8.61E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.73|P-value:9.50E-5 ID:SGTC_3026|Compound:9090633|FD-Score:4.30|P-value:3.59E-4 ID:SGTC_3054|Compound:9094397|FD-Score:4.26|P-value:3.99E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-5.45|P-value:3.41E-6 ID:SGTC_3197|Compound:9113331|FD-Score:6.66|P-value:6.02E-8

Top fitness defect scores for YNR052C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1912 st060209 8.89 90.8 µM 6.38E-13 1 3.00E-19
2 SGTC_1026 k007-1105 8.81 30.6 µM 1.04E-12 ERAD & cell cycle 15 6.37E-19
3 SGTC_1624 st003710 7.62 6.2 µM 6.47E-10 calcium & mitochondrial duress 7 1.27E-14
4 SGTC_146 3448-8650 7.29 53.1 µM 3.24E-9 NEO1-PIK1 33 1.51E-13
5 SGTC_1658 st012944 6.98 20.0 µM 1.44E-8 iron homeostasis 17 1.49E-12
6 SGTC_3197 9113331 6.66 49.5 µM 6.02E-8 3 1.35E-11
7 SGTC_2346 9031566 6.40 143.8 µM 1.92E-7 Golgi 3 8.03E-11
8 SGTC_1457 k015-0032 6.38 57.3 µM 2.03E-7 4 8.77E-11
9 SGTC_1272 0839-0021 5.96 27.0 µM 1.15E-6 5 1.26E-9
10 SGTC_2743 auranofin 5.84 4.3 µM 1.87E-6 RPP1 & pyrimidine depletion 12 2.67E-9
11 SGTC_1687 st020778 5.79 55.4 µM 2.23E-6 113 3.50E-9
12 SGTC_2789 5281112 5.78 71.4 µM 2.29E-6 7 3.65E-9
13 SGTC_756 0508-1999 5.77 28.3 µM 2.45E-6 RPP1 & pyrimidine depletion 3 4.05E-9
14 SGTC_838 0109-0203 5.68 71.4 µM 3.38E-6 2 6.64E-9
15 SGTC_849 0386-0493 5.63 241.0 µM 4.08E-6 4 8.85E-9
16 SGTC_1693 xanthone 5.50 101.9 µM 6.68E-6 DNA damage response 3 1.89E-8
17 SGTC_1174 0739-0097 5.49 51.1 µM 6.99E-6 redox potentiating 9 2.03E-8
18 SGTC_1070 indatraline 5.44 8.8 µM 8.35E-6 60S ribosome export 7 2.66E-8
19 SGTC_197 4544-0043 5.35 41.6 µM 1.18E-5 endomembrane recycling 21 4.50E-8
20 SGTC_549 1661-1316 5.33 519.0 µM 1.24E-5 3 4.91E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.271 9.74E-58 YAL021C CCR4 hom Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
0.232 2.69E-42 YLR268W SEC22 hom R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
0.176 1.08E-24 YDL041W_d YDL041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
0.173 6.99E-24 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.158 4.84E-20 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.156 9.63E-20 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.155 1.86E-19 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.146 1.98E-17 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.143 7.90E-17 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.142 1.10E-16 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.141 2.24E-16 YDL160C DHH1 hom Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress
0.141 2.89E-16 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.139 5.00E-16 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.138 1.09E-15 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.137 2.06E-15 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress