YNR059W / MNT4

Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR059W / MNT4

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.34|P-value:3.51E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.15|P-value:6.41E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.11|P-value:7.47E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.35|P-value:3.40E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:5.49|P-value:1.22E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.88|P-value:9.97E-10 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.73|P-value:6.86E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:3.86|P-value:4.46E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.24|P-value:5.18E-8 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.12|P-value:7.61E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.42|P-value:3.59E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:5.03|P-value:1.57E-7 ID:SGTC_520|Compound:3584-0023|FD-Score:3.25|P-value:4.92E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.76|P-value:6.69E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.74|P-value:7.32E-5 ID:SGTC_732|Compound:3970-1727|FD-Score:3.10|P-value:8.32E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.07|P-value:9.02E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.01|P-value:1.59E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:4.27|P-value:7.05E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:3.37|P-value:3.13E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.21|P-value:5.18E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.16|P-value:6.66E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.11|P-value:7.95E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.09|P-value:1.50E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.16|P-value:6.78E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.03|P-value:9.77E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.26|P-value:4.72E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.90|P-value:3.76E-5 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.12|P-value:7.81E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.62|P-value:1.18E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.48|P-value:1.90E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.16|P-value:6.72E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.46|P-value:2.19E-4 ID:SGTC_1764|Compound:st044502|FD-Score:5.43|P-value:1.75E-8 ID:SGTC_1830|Compound:st055982|FD-Score:3.87|P-value:4.22E-5 ID:SGTC_1870|Compound:st057514|FD-Score:3.13|P-value:7.42E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.41|P-value:2.53E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.11|P-value:8.02E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.26|P-value:4.64E-4 ID:SGTC_1989|Compound:st071868|FD-Score:-3.10|P-value:7.63E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.55|P-value:1.45E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.09|P-value:8.54E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.90|P-value:3.24E-7 ID:SGTC_2022|Compound:5136654|FD-Score:3.60|P-value:1.27E-4 ID:SGTC_2120|Compound:5538279|FD-Score:-3.20|P-value:5.32E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.31|P-value:3.59E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.15|P-value:7.04E-4 ID:SGTC_2312|Compound:7706453|FD-Score:4.15|P-value:1.23E-5 ID:SGTC_2369|Compound:9071472|FD-Score:3.66|P-value:1.01E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.29|P-value:4.20E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.47|P-value:2.17E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.61|P-value:1.23E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-4.29|P-value:6.09E-6 ID:SGTC_2831|Compound:7999036|FD-Score:3.50|P-value:1.93E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.82|P-value:5.16E-5 ID:SGTC_3052|Compound:9092717|FD-Score:4.15|P-value:1.27E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.72|P-value:7.88E-5 ID:SGTC_3150|Compound:9097574|FD-Score:3.55|P-value:1.57E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-3.39|P-value:2.71E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-5.39|P-value:1.97E-8 ID:SGTC_3246|Compound:9135460|FD-Score:3.77|P-value:6.41E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.07|P-value:9.14E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.34|P-value:3.51E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.15|P-value:6.41E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.11|P-value:7.47E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.35|P-value:3.40E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:5.49|P-value:1.22E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.88|P-value:9.97E-10 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.73|P-value:6.86E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:3.86|P-value:4.46E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.24|P-value:5.18E-8 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.12|P-value:7.61E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.42|P-value:3.59E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:5.03|P-value:1.57E-7 ID:SGTC_520|Compound:3584-0023|FD-Score:3.25|P-value:4.92E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.76|P-value:6.69E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.74|P-value:7.32E-5 ID:SGTC_732|Compound:3970-1727|FD-Score:3.10|P-value:8.32E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.07|P-value:9.02E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.01|P-value:1.59E-7 ID:SGTC_969|Compound:1313-0238|FD-Score:4.27|P-value:7.05E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:3.37|P-value:3.13E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.21|P-value:5.18E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.16|P-value:6.66E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.11|P-value:7.95E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.09|P-value:1.50E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.16|P-value:6.78E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.03|P-value:9.77E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.26|P-value:4.72E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.90|P-value:3.76E-5 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.12|P-value:7.81E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.62|P-value:1.18E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.48|P-value:1.90E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.16|P-value:6.72E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.46|P-value:2.19E-4 ID:SGTC_1764|Compound:st044502|FD-Score:5.43|P-value:1.75E-8 ID:SGTC_1830|Compound:st055982|FD-Score:3.87|P-value:4.22E-5 ID:SGTC_1870|Compound:st057514|FD-Score:3.13|P-value:7.42E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.41|P-value:2.53E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.11|P-value:8.02E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.26|P-value:4.64E-4 ID:SGTC_1989|Compound:st071868|FD-Score:-3.10|P-value:7.63E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.55|P-value:1.45E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.09|P-value:8.54E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.90|P-value:3.24E-7 ID:SGTC_2022|Compound:5136654|FD-Score:3.60|P-value:1.27E-4 ID:SGTC_2120|Compound:5538279|FD-Score:-3.20|P-value:5.32E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.31|P-value:3.59E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.15|P-value:7.04E-4 ID:SGTC_2312|Compound:7706453|FD-Score:4.15|P-value:1.23E-5 ID:SGTC_2369|Compound:9071472|FD-Score:3.66|P-value:1.01E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.29|P-value:4.20E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.47|P-value:2.17E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.61|P-value:1.23E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-4.29|P-value:6.09E-6 ID:SGTC_2831|Compound:7999036|FD-Score:3.50|P-value:1.93E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.82|P-value:5.16E-5 ID:SGTC_3052|Compound:9092717|FD-Score:4.15|P-value:1.27E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.72|P-value:7.88E-5 ID:SGTC_3150|Compound:9097574|FD-Score:3.55|P-value:1.57E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-3.39|P-value:2.71E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-5.39|P-value:1.97E-8 ID:SGTC_3246|Compound:9135460|FD-Score:3.77|P-value:6.41E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.07|P-value:9.14E-4

Top fitness defect scores for YNR059W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_139 0099-0334 5.49 718.6 µM 1.22E-8 6 2.04E-8
2 SGTC_1764 st044502 5.43 93.5 µM 1.75E-8 11 2.89E-8
3 SGTC_243 5hr heat shock (37°C) + splitomicin 5.24 1.0 µM 5.18E-8 heat shock/prefoldin 20 8.24E-8
4 SGTC_353 1988-1175 5.03 58.3 µM 1.57E-7 unfolded protein response 11 2.41E-7
5 SGTC_2017 5132927 4.90 60.6 µM 3.24E-7 12 4.87E-7
6 SGTC_319 1348-1596 4.42 45.5 µM 3.59E-6 RSC & ERG11 13 4.99E-6
7 SGTC_969 1313-0238 4.27 134.0 µM 7.05E-6 mitochondrial processes 17 9.58E-6
8 SGTC_2312 7706453 4.15 155.7 µM 1.23E-5 24 1.65E-5
9 SGTC_3052 9092717 4.15 49.5 µM 1.27E-5 19 1.70E-5
10 SGTC_1433 4060-0023 3.90 7.6 µM 3.76E-5 tubulin folding & SWR complex 19 4.85E-5
11 SGTC_1830 st055982 3.87 50.3 µM 4.22E-5 21 5.41E-5
12 SGTC_171 k064-0041 3.86 9.7 µM 4.46E-5 heme requiring 28 5.71E-5
13 SGTC_2918 7977171 3.82 22.1 µM 5.16E-5 33 6.58E-5
14 SGTC_3246 9135460 3.77 33.0 µM 6.41E-5 6 8.13E-5
15 SGTC_624 k048-0052 3.76 28.0 µM 6.69E-5 Golgi 19 8.46E-5
16 SGTC_717 1532-0246 3.74 73.2 µM 7.32E-5 Golgi 41 9.24E-5
17 SGTC_3067 9117431 3.72 49.5 µM 7.88E-5 18 9.92E-5
18 SGTC_2369 9071472 3.66 200.0 µM 1.01E-4 22 1.26E-4
19 SGTC_1527 coumarin 3.62 137.0 µM 1.18E-4 35 1.47E-4
20 SGTC_2620 irigenin 3.61 100.0 µM 1.23E-4 48 1.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.46E-10 YPL113C_p YPL113C_p hom Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
0.107 5.71E-10 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.101 4.37E-9 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.099 1.01E-8 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.094 4.35E-8 YCR015C_p YCR015C_p hom Putative protein of unknown function; YCR015C is not an essential gene
0.086 5.57E-7 YPL250C ICY2 hom Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
0.084 1.01E-6 YNR070W_p PDR18_p hom Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.084 1.08E-6 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.084 1.11E-6 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.079 4.50E-6 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.078 6.70E-6 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.076 1.09E-5 YDR242W AMD2 hom Putative amidase
0.074 1.58E-5 YBR163W EXO5 hom Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2
0.074 1.62E-5 YMR215W GAS3 hom Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation
0.073 2.33E-5 YJL026W RNR2 het Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits