YNR062C_p

Putative membrane protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR062C / YNR062C

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:5.34|P-value:8.91E-8 ID:SGTC_346|Compound:4513-0042|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-4.12|P-value:5.28E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:5.35|P-value:8.42E-8 ID:SGTC_426|Compound:0988-0037|FD-Score:4.44|P-value:6.72E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.31|P-value:9.87E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.54|P-value:2.41E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:7.68|P-value:4.07E-14 ID:SGTC_708|Compound:3448-5400|FD-Score:3.44|P-value:3.42E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.23|P-value:7.02E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.62|P-value:1.82E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.13|P-value:9.96E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.20|P-value:1.86E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.87|P-value:1.40E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.26|P-value:1.46E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.44|P-value:6.33E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.07|P-value:3.58E-7 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.25|P-value:6.67E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.23|P-value:7.10E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:5.20|P-value:1.79E-7 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.29|P-value:5.76E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:7.14|P-value:1.81E-12 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.37|P-value:7.97E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.03|P-value:3.73E-5 ID:SGTC_1615|Compound:st002656|FD-Score:3.55|P-value:2.37E-4 ID:SGTC_1669|Compound:st015249|FD-Score:3.37|P-value:4.41E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.97|P-value:4.78E-5 ID:SGTC_1738|Compound:st035555|FD-Score:4.08|P-value:3.09E-5 ID:SGTC_1848|Compound:st056003|FD-Score:5.73|P-value:1.09E-8 ID:SGTC_1919|Compound:st067113|FD-Score:5.47|P-value:4.52E-8 ID:SGTC_1933|Compound:st074711|FD-Score:3.14|P-value:9.38E-4 ID:SGTC_2026|Compound:5148700|FD-Score:8.81|P-value:5.91E-18 ID:SGTC_2035|Compound:5154463|FD-Score:-3.56|P-value:4.15E-4 ID:SGTC_2044|Compound:5102272|FD-Score:6.06|P-value:1.68E-9 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.52|P-value:2.56E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.73|P-value:1.22E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.17|P-value:8.73E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.72|P-value:4.26E-6 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.13|P-value:9.66E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.31|P-value:1.16E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.30|P-value:5.66E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.65|P-value:1.62E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.97|P-value:4.71E-5 ID:SGTC_2944|Compound:9067346|FD-Score:4.92|P-value:7.41E-7 ID:SGTC_2950|Compound:9072895|FD-Score:4.20|P-value:1.82E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.41|P-value:3.83E-4 ID:SGTC_3159|Compound:9100096|FD-Score:8.62|P-value:2.74E-17 ID:SGTC_3175|Compound:9106517|FD-Score:3.70|P-value:1.36E-4 ID:SGTC_3181|Compound:9108277|FD-Score:4.49|P-value:5.26E-6 ID:SGTC_3188|Compound:9110789|FD-Score:-5.18|P-value:4.79E-7 ID:SGTC_3190|Compound:9110366|FD-Score:3.42|P-value:3.73E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.33|P-value:9.30E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.70|P-value:2.59E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.31|P-value:5.46E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.32|P-value:5.21E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.59|P-value:3.74E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:5.34|P-value:8.91E-8 ID:SGTC_346|Compound:4513-0042|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-4.12|P-value:5.28E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:5.35|P-value:8.42E-8 ID:SGTC_426|Compound:0988-0037|FD-Score:4.44|P-value:6.72E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.31|P-value:9.87E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.54|P-value:2.41E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:7.68|P-value:4.07E-14 ID:SGTC_708|Compound:3448-5400|FD-Score:3.44|P-value:3.42E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.23|P-value:7.02E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.62|P-value:1.82E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.13|P-value:9.96E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.20|P-value:1.86E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.87|P-value:1.40E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.26|P-value:1.46E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.44|P-value:6.33E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.07|P-value:3.58E-7 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.25|P-value:6.67E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.23|P-value:7.10E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:5.20|P-value:1.79E-7 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.29|P-value:5.76E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:7.14|P-value:1.81E-12 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.37|P-value:7.97E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.03|P-value:3.73E-5 ID:SGTC_1615|Compound:st002656|FD-Score:3.55|P-value:2.37E-4 ID:SGTC_1669|Compound:st015249|FD-Score:3.37|P-value:4.41E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.97|P-value:4.78E-5 ID:SGTC_1738|Compound:st035555|FD-Score:4.08|P-value:3.09E-5 ID:SGTC_1848|Compound:st056003|FD-Score:5.73|P-value:1.09E-8 ID:SGTC_1919|Compound:st067113|FD-Score:5.47|P-value:4.52E-8 ID:SGTC_1933|Compound:st074711|FD-Score:3.14|P-value:9.38E-4 ID:SGTC_2026|Compound:5148700|FD-Score:8.81|P-value:5.91E-18 ID:SGTC_2035|Compound:5154463|FD-Score:-3.56|P-value:4.15E-4 ID:SGTC_2044|Compound:5102272|FD-Score:6.06|P-value:1.68E-9 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.52|P-value:2.56E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.73|P-value:1.22E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.17|P-value:8.73E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.72|P-value:4.26E-6 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.13|P-value:9.66E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.31|P-value:1.16E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.30|P-value:5.66E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.65|P-value:1.62E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.97|P-value:4.71E-5 ID:SGTC_2944|Compound:9067346|FD-Score:4.92|P-value:7.41E-7 ID:SGTC_2950|Compound:9072895|FD-Score:4.20|P-value:1.82E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.41|P-value:3.83E-4 ID:SGTC_3159|Compound:9100096|FD-Score:8.62|P-value:2.74E-17 ID:SGTC_3175|Compound:9106517|FD-Score:3.70|P-value:1.36E-4 ID:SGTC_3181|Compound:9108277|FD-Score:4.49|P-value:5.26E-6 ID:SGTC_3188|Compound:9110789|FD-Score:-5.18|P-value:4.79E-7 ID:SGTC_3190|Compound:9110366|FD-Score:3.42|P-value:3.73E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.33|P-value:9.30E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.70|P-value:2.59E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.31|P-value:5.46E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.32|P-value:5.21E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.59|P-value:3.74E-4

Top fitness defect scores for YNR062C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2026 5148700 8.81 152.0 µM 5.91E-18 1 6.46E-19
2 SGTC_3159 9100096 8.62 49.5 µM 2.74E-17 1 3.33E-18
3 SGTC_622 1348-1566 7.68 26.3 µM 4.07E-14 1 8.17E-15
4 SGTC_1464 k208-0027 7.14 110.0 µM 1.81E-12 7 4.69E-13
5 SGTC_2044 5102272 6.06 200.0 µM 1.68E-9 1 6.82E-10
6 SGTC_1848 st056003 5.73 16.4 µM 1.09E-8 2 4.97E-9
7 SGTC_1919 st067113 5.47 52.3 µM 4.52E-8 TSC3-RPN4 12 2.26E-8
8 SGTC_361 000s-0510 5.35 1.4 µM 8.42E-8 11 4.38E-8
9 SGTC_35 0133-0054 5.34 64.1 µM 8.91E-8 6 4.65E-8
10 SGTC_1278 0874-0585 5.20 172.0 µM 1.79E-7 3 9.77E-8
11 SGTC_1118 chelidonine 5.07 707.5 nM 3.58E-7 7 2.04E-7
12 SGTC_2944 9067346 4.92 25.6 µM 7.41E-7 11 4.41E-7
13 SGTC_3181 9108277 4.49 49.5 µM 5.26E-6 iron homeostasis 7 3.51E-6
14 SGTC_426 0988-0037 4.44 14.6 µM 6.72E-6 ERAD & cell cycle 22 4.56E-6
15 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 4.31 66.7 µM 1.16E-5 12 8.14E-6
16 SGTC_965 1291-5240 4.26 308.0 µM 1.46E-5 24 1.04E-5
17 SGTC_2950 9072895 4.20 21.5 µM 1.82E-5 31 1.31E-5
18 SGTC_950 1165-0508 4.20 94.1 µM 1.86E-5 22 1.34E-5
19 SGTC_1738 st035555 4.08 74.0 µM 3.09E-5 TSC3-RPN4 30 2.29E-5
20 SGTC_1573 oleylamine 4.03 1.1 µM 3.73E-5 26 2.79E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.083 1.46E-6 YNL272C SEC2 het Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
0.081 2.99E-6 YIR024C YIR024C hom Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect
0.079 5.17E-6 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.078 5.80E-6 YPR138C MEP3 hom Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease
0.076 9.38E-6 YPL076W GPI2 het Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein
0.076 1.03E-5 YCR004C YCP4 hom Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.075 1.36E-5 YER085C_p YER085C_p hom Putative protein of unknown function
0.074 1.57E-5 YOL039W RPP2A hom Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.073 2.51E-5 YDR045C RPC11 het RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
0.073 2.56E-5 YDR540C IRC4 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.071 4.02E-5 YER032W FIR1 hom Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
0.069 6.46E-5 YNR057C BIO4 hom Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels
0.068 8.24E-5 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.068 8.46E-5 YGR287C IMA1 hom Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family
0.067 1.02E-4 YBR128C ATG14 hom Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor