YNR063W_p

Putative zinc-cluster protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR063W / YNR063W

Click on Significant Values for Screen Details ID:SGTC_624|Compound:k048-0052|FD-Score:2.97|P-value:7.70E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-4.79|P-value:2.12E-7 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.19|P-value:3.83E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:2.99|P-value:7.22E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:6.92|P-value:9.87E-14 ID:SGTC_748|Compound:0136-0228|FD-Score:-4.83|P-value:1.71E-7 ID:SGTC_805|Compound:3852-0218|FD-Score:3.23|P-value:2.95E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.99|P-value:5.77E-8 ID:SGTC_864|Compound:0469-0573|FD-Score:3.99|P-value:1.09E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.56|P-value:7.76E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.25|P-value:2.72E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.64|P-value:5.46E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.25|P-value:2.75E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.16|P-value:4.93E-6 ID:SGTC_1719|Compound:st032227|FD-Score:-3.20|P-value:3.70E-4 ID:SGTC_1720|Compound:st037298|FD-Score:2.97|P-value:7.75E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.08|P-value:7.11E-6 ID:SGTC_1832|Compound:st054113|FD-Score:6.61|P-value:1.15E-12 ID:SGTC_1842|Compound:st055362|FD-Score:3.34|P-value:1.89E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.75|P-value:3.81E-5 ID:SGTC_1923|Compound:st058458|FD-Score:2.92|P-value:9.35E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.25|P-value:3.04E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.04|P-value:6.67E-4 ID:SGTC_1956|Compound:st077085|FD-Score:2.90|P-value:9.98E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.94|P-value:1.41E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.95|P-value:1.52E-5 ID:SGTC_2217|Compound:6934799|FD-Score:3.51|P-value:9.51E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.05|P-value:5.88E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.16|P-value:3.81E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.20|P-value:3.66E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.26|P-value:2.57E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:5.57|P-value:1.66E-9 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.96|P-value:1.28E-5 ID:SGTC_2551|Compound:apiole|FD-Score:4.69|P-value:3.08E-7 ID:SGTC_2557|Compound:derrustone|FD-Score:3.24|P-value:2.81E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.39|P-value:1.50E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.54|P-value:6.95E-7 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.48|P-value:1.20E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.51|P-value:1.05E-4 ID:SGTC_2863|Compound:9028737|FD-Score:-3.11|P-value:5.13E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.50|P-value:9.66E-5 ID:SGTC_2968|Compound:9090663|FD-Score:4.19|P-value:4.30E-6 ID:SGTC_3058|Compound:9093861|FD-Score:3.69|P-value:4.40E-5 ID:SGTC_3068|Compound:9116768|FD-Score:3.68|P-value:4.61E-5 ID:SGTC_3084|Compound:9116877|FD-Score:4.33|P-value:2.05E-6 ID:SGTC_3149|Compound:9097855|FD-Score:4.09|P-value:6.74E-6 ID:SGTC_3153|Compound:9100258|FD-Score:-3.31|P-value:2.34E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.25|P-value:3.07E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.29|P-value:2.60E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.57|P-value:8.06E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:2.97|P-value:7.70E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-4.79|P-value:2.12E-7 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.19|P-value:3.83E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:2.99|P-value:7.22E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:6.92|P-value:9.87E-14 ID:SGTC_748|Compound:0136-0228|FD-Score:-4.83|P-value:1.71E-7 ID:SGTC_805|Compound:3852-0218|FD-Score:3.23|P-value:2.95E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.99|P-value:5.77E-8 ID:SGTC_864|Compound:0469-0573|FD-Score:3.99|P-value:1.09E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.56|P-value:7.76E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.25|P-value:2.72E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.64|P-value:5.46E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.25|P-value:2.75E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.16|P-value:4.93E-6 ID:SGTC_1719|Compound:st032227|FD-Score:-3.20|P-value:3.70E-4 ID:SGTC_1720|Compound:st037298|FD-Score:2.97|P-value:7.75E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.08|P-value:7.11E-6 ID:SGTC_1832|Compound:st054113|FD-Score:6.61|P-value:1.15E-12 ID:SGTC_1842|Compound:st055362|FD-Score:3.34|P-value:1.89E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.75|P-value:3.81E-5 ID:SGTC_1923|Compound:st058458|FD-Score:2.92|P-value:9.35E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.25|P-value:3.04E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.04|P-value:6.67E-4 ID:SGTC_1956|Compound:st077085|FD-Score:2.90|P-value:9.98E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.94|P-value:1.41E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.95|P-value:1.52E-5 ID:SGTC_2217|Compound:6934799|FD-Score:3.51|P-value:9.51E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.05|P-value:5.88E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.16|P-value:3.81E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.20|P-value:3.66E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.26|P-value:2.57E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:5.57|P-value:1.66E-9 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.96|P-value:1.28E-5 ID:SGTC_2551|Compound:apiole|FD-Score:4.69|P-value:3.08E-7 ID:SGTC_2557|Compound:derrustone|FD-Score:3.24|P-value:2.81E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.39|P-value:1.50E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.54|P-value:6.95E-7 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.48|P-value:1.20E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.51|P-value:1.05E-4 ID:SGTC_2863|Compound:9028737|FD-Score:-3.11|P-value:5.13E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.50|P-value:9.66E-5 ID:SGTC_2968|Compound:9090663|FD-Score:4.19|P-value:4.30E-6 ID:SGTC_3058|Compound:9093861|FD-Score:3.69|P-value:4.40E-5 ID:SGTC_3068|Compound:9116768|FD-Score:3.68|P-value:4.61E-5 ID:SGTC_3084|Compound:9116877|FD-Score:4.33|P-value:2.05E-6 ID:SGTC_3149|Compound:9097855|FD-Score:4.09|P-value:6.74E-6 ID:SGTC_3153|Compound:9100258|FD-Score:-3.31|P-value:2.34E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.25|P-value:3.07E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.29|P-value:2.60E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.57|P-value:8.06E-5

Top fitness defect scores for YNR063W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_742 0kpi-0133 6.92 140.0 µM 9.87E-14 ERG2 3 2.21E-12
2 SGTC_1832 st054113 6.61 55.0 µM 1.15E-12 1 1.96E-11
3 SGTC_2528 xanthyletin 5.57 44.8 µM 1.66E-9 8 1.29E-8
4 SGTC_839 0122-0028 4.99 230.0 µM 5.77E-8 RSC complex & mRNA processing 13 3.05E-7
5 SGTC_2551 apiole 4.69 73.9 µM 3.08E-7 5 1.36E-6
6 SGTC_2633 5,7-dihydroxyisoflavone 4.54 100.0 µM 6.95E-7 22 2.80E-6
7 SGTC_2588 indole-3-carbinol 4.39 100.0 µM 1.50E-6 29 5.57E-6
8 SGTC_3084 9116877 4.33 49.5 µM 2.05E-6 6 7.34E-6
9 SGTC_2968 9090663 4.19 33.4 µM 4.30E-6 23 1.42E-5
10 SGTC_1149 3909-7961 4.16 23.3 µM 4.93E-6 14 1.61E-5
11 SGTC_3149 9097855 4.09 49.5 µM 6.74E-6 Golgi 26 2.13E-5
12 SGTC_1744 st037937 4.08 38.9 µM 7.11E-6 27 2.23E-5
13 SGTC_864 0469-0573 3.99 172.0 µM 1.09E-5 18 3.27E-5
14 SGTC_2529 gangaleoidin 3.96 93.6 µM 1.28E-5 16 3.77E-5
15 SGTC_2015 5119600 3.94 184.0 µM 1.41E-5 30 4.12E-5
16 SGTC_3058 9093861 3.69 49.5 µM 4.40E-5 26 1.13E-4
17 SGTC_3068 9116768 3.68 49.5 µM 4.61E-5 24 1.18E-4
18 SGTC_976 1348-1067 3.64 47.6 µM 5.46E-5 60S ribosome export 41 1.38E-4
19 SGTC_943 3253-1379 3.56 105.0 µM 7.76E-5 38 1.88E-4
20 SGTC_2217 6934799 3.51 96.1 µM 9.51E-5 TSC3-RPN4 12 2.26E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.091 1.15E-7 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.090 1.60E-7 YJR067C YAE1 het Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.089 2.58E-7 YBR259W YBR259W hom Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress
0.085 8.36E-7 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.084 1.04E-6 YDR046C BAP3 hom Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication
0.082 2.02E-6 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.081 2.47E-6 YJL105W SET4 hom Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication
0.081 2.95E-6 YPL107W_p YPL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene
0.079 4.43E-6 YJL122W ALB1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
0.076 1.04E-5 YLR457C NBP1 het Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication
0.076 1.16E-5 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.075 1.52E-5 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.074 1.62E-5 YOR345C_d YOR345C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.073 2.38E-5 YGL216W KIP3 hom Kinesin-related motor protein involved in mitotic spindle positioning
0.073 2.40E-5 YBL035C POL12 het B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation