HIPHOP chemogenomics database
YNR064C 
Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YNR064C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.110 | 1.66E-10 | YOR127W | RGA1 | hom | GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| 0.106 | 7.23E-10 | YCL046W_d | YCL046W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C |
| 0.104 | 1.47E-9 | YOR163W | DDP1 | hom | Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress |
| 0.095 | 3.68E-8 | YKR028W | SAP190 | hom | Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication |
| 0.093 | 6.16E-8 | YLR308W | CDA2 | hom | Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall |
| 0.089 | 2.10E-7 | YMR126C_p | DLT1_p | hom | Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA) |
| 0.088 | 3.80E-7 | YKR103W | NFT1 | hom | Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds. |
| 0.087 | 4.89E-7 | YPR029C | APL4 | hom | Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport |
| 0.084 | 1.23E-6 | YLL012W | YEH1 | hom | Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes |
| 0.082 | 2.03E-6 | YGL166W | CUP2 | hom | Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication |
| 0.081 | 2.98E-6 | YML131W | YML131W | hom | Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress |
| 0.080 | 3.04E-6 | YBR083W | TEC1 | hom | Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member |
| 0.080 | 3.10E-6 | YLL027W | ISA1 | hom | Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins |
| 0.080 | 3.51E-6 | YML012W | ERV25 | hom | Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport |
| 0.079 | 4.52E-6 | YDR102C_d | YDR102C_d | hom | Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index |