YNR064C

Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR064C / YNR064C

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.54|P-value:1.32E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.38|P-value:2.54E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.75|P-value:5.66E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:3.17|P-value:5.46E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:3.36|P-value:2.74E-4 ID:SGTC_222|Compound:nsc-310342|FD-Score:3.14|P-value:6.09E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.57|P-value:1.30E-6 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.37|P-value:2.57E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.51|P-value:1.49E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.22|P-value:4.57E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.43|P-value:2.09E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.19|P-value:5.10E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:5.88|P-value:7.25E-10 ID:SGTC_611|Compound:3453-1652|FD-Score:3.93|P-value:2.64E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:4.03|P-value:1.66E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:4.21|P-value:7.23E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:4.15|P-value:9.46E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:4.25|P-value:6.17E-6 ID:SGTC_715|Compound:0868-0130|FD-Score:3.90|P-value:3.03E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:3.29|P-value:3.47E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.06|P-value:1.49E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:5.48|P-value:8.17E-9 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.09|P-value:7.35E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:12.90|P-value:2.34E-40 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.03|P-value:9.07E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.70|P-value:6.51E-7 ID:SGTC_1068|Compound:loratadine|FD-Score:6.01|P-value:3.09E-10 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.08|P-value:7.68E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.31|P-value:3.24E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.45|P-value:1.90E-4 ID:SGTC_1609|Compound:st001574|FD-Score:4.38|P-value:3.28E-6 ID:SGTC_1613|Compound:st002381|FD-Score:5.15|P-value:5.80E-8 ID:SGTC_1666|Compound:st014829|FD-Score:3.65|P-value:8.73E-5 ID:SGTC_1673|Compound:st016611|FD-Score:5.10|P-value:7.38E-8 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.79|P-value:4.75E-5 ID:SGTC_1697|Compound:st025554|FD-Score:-3.50|P-value:1.58E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.27|P-value:3.76E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.73|P-value:6.24E-5 ID:SGTC_1773|Compound:st048542|FD-Score:3.46|P-value:1.84E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.13|P-value:6.29E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.07|P-value:7.95E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.18|P-value:5.25E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.31|P-value:3.25E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.02|P-value:1.74E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.62|P-value:9.81E-5 ID:SGTC_2090|Compound:5301565|FD-Score:3.11|P-value:6.93E-4 ID:SGTC_2135|Compound:5326629|FD-Score:6.89|P-value:6.53E-13 ID:SGTC_2157|Compound:5649910|FD-Score:4.21|P-value:7.28E-6 ID:SGTC_2242|Compound:6630449|FD-Score:3.01|P-value:9.71E-4 ID:SGTC_2259|Compound:7964009|FD-Score:-3.23|P-value:4.36E-4 ID:SGTC_2293|Compound:7624732|FD-Score:4.06|P-value:1.48E-5 ID:SGTC_2323|Compound:6148992|FD-Score:4.37|P-value:3.38E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.05|P-value:8.50E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.29|P-value:3.58E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.19|P-value:5.18E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.57|P-value:1.26E-6 ID:SGTC_2383|Compound:9036125|FD-Score:5.24|P-value:3.49E-8 ID:SGTC_2416|Compound:tofa|FD-Score:3.89|P-value:3.15E-5 ID:SGTC_2440|Compound:5628896|FD-Score:3.89|P-value:3.16E-5 ID:SGTC_2448|Compound:5185112|FD-Score:3.02|P-value:9.24E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.43|P-value:2.09E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.24|P-value:4.20E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.47|P-value:1.75E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.44|P-value:2.00E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.79|P-value:4.67E-5 ID:SGTC_2714|Compound:st079313|FD-Score:4.51|P-value:1.74E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.23|P-value:4.45E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.07|P-value:7.99E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.31|P-value:3.32E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.29|P-value:3.47E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.41|P-value:2.23E-4 ID:SGTC_2929|Compound:9013348|FD-Score:4.44|P-value:2.46E-6 ID:SGTC_2957|Compound:9076800|FD-Score:3.31|P-value:3.33E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.06|P-value:8.08E-4 ID:SGTC_3173|Compound:9105693|FD-Score:4.12|P-value:1.09E-5 ID:SGTC_3194|Compound:9111903|FD-Score:6.99|P-value:3.09E-13 ID:SGTC_3201|Compound:9113999|FD-Score:4.35|P-value:3.75E-6 ID:SGTC_3207|Compound:9114163|FD-Score:-3.48|P-value:1.72E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.53|P-value:1.38E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.54|P-value:1.32E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.38|P-value:2.54E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.75|P-value:5.66E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:3.17|P-value:5.46E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:3.36|P-value:2.74E-4 ID:SGTC_222|Compound:nsc-310342|FD-Score:3.14|P-value:6.09E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.57|P-value:1.30E-6 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.37|P-value:2.57E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.51|P-value:1.49E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.22|P-value:4.57E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.43|P-value:2.09E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.19|P-value:5.10E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:5.88|P-value:7.25E-10 ID:SGTC_611|Compound:3453-1652|FD-Score:3.93|P-value:2.64E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:4.03|P-value:1.66E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:4.21|P-value:7.23E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:4.15|P-value:9.46E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:4.25|P-value:6.17E-6 ID:SGTC_715|Compound:0868-0130|FD-Score:3.90|P-value:3.03E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:3.29|P-value:3.47E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.06|P-value:1.49E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:5.48|P-value:8.17E-9 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.09|P-value:7.35E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:12.90|P-value:2.34E-40 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.03|P-value:9.07E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.70|P-value:6.51E-7 ID:SGTC_1068|Compound:loratadine|FD-Score:6.01|P-value:3.09E-10 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.08|P-value:7.68E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.31|P-value:3.24E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.45|P-value:1.90E-4 ID:SGTC_1609|Compound:st001574|FD-Score:4.38|P-value:3.28E-6 ID:SGTC_1613|Compound:st002381|FD-Score:5.15|P-value:5.80E-8 ID:SGTC_1666|Compound:st014829|FD-Score:3.65|P-value:8.73E-5 ID:SGTC_1673|Compound:st016611|FD-Score:5.10|P-value:7.38E-8 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.79|P-value:4.75E-5 ID:SGTC_1697|Compound:st025554|FD-Score:-3.50|P-value:1.58E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.27|P-value:3.76E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.73|P-value:6.24E-5 ID:SGTC_1773|Compound:st048542|FD-Score:3.46|P-value:1.84E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.13|P-value:6.29E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.07|P-value:7.95E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.18|P-value:5.25E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.31|P-value:3.25E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.02|P-value:1.74E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.62|P-value:9.81E-5 ID:SGTC_2090|Compound:5301565|FD-Score:3.11|P-value:6.93E-4 ID:SGTC_2135|Compound:5326629|FD-Score:6.89|P-value:6.53E-13 ID:SGTC_2157|Compound:5649910|FD-Score:4.21|P-value:7.28E-6 ID:SGTC_2242|Compound:6630449|FD-Score:3.01|P-value:9.71E-4 ID:SGTC_2259|Compound:7964009|FD-Score:-3.23|P-value:4.36E-4 ID:SGTC_2293|Compound:7624732|FD-Score:4.06|P-value:1.48E-5 ID:SGTC_2323|Compound:6148992|FD-Score:4.37|P-value:3.38E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.05|P-value:8.50E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.29|P-value:3.58E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.19|P-value:5.18E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.57|P-value:1.26E-6 ID:SGTC_2383|Compound:9036125|FD-Score:5.24|P-value:3.49E-8 ID:SGTC_2416|Compound:tofa|FD-Score:3.89|P-value:3.15E-5 ID:SGTC_2440|Compound:5628896|FD-Score:3.89|P-value:3.16E-5 ID:SGTC_2448|Compound:5185112|FD-Score:3.02|P-value:9.24E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.43|P-value:2.09E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.24|P-value:4.20E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.47|P-value:1.75E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.44|P-value:2.00E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.79|P-value:4.67E-5 ID:SGTC_2714|Compound:st079313|FD-Score:4.51|P-value:1.74E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.23|P-value:4.45E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.07|P-value:7.99E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.31|P-value:3.32E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.29|P-value:3.47E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.41|P-value:2.23E-4 ID:SGTC_2929|Compound:9013348|FD-Score:4.44|P-value:2.46E-6 ID:SGTC_2957|Compound:9076800|FD-Score:3.31|P-value:3.33E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.06|P-value:8.08E-4 ID:SGTC_3173|Compound:9105693|FD-Score:4.12|P-value:1.09E-5 ID:SGTC_3194|Compound:9111903|FD-Score:6.99|P-value:3.09E-13 ID:SGTC_3201|Compound:9113999|FD-Score:4.35|P-value:3.75E-6 ID:SGTC_3207|Compound:9114163|FD-Score:-3.48|P-value:1.72E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.53|P-value:1.38E-4

Top fitness defect scores for YNR064C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_986 1493-0483 12.90 84.0 µM 2.34E-40 1 3.44E-38
2 SGTC_3194 9111903 6.99 49.5 µM 3.09E-13 3 1.37E-12
3 SGTC_2135 5326629 6.89 150.4 µM 6.53E-13 RPP1 & pyrimidine depletion 3 2.78E-12
4 SGTC_1068 loratadine 6.01 26.9 µM 3.09E-10 5 9.37E-10
5 SGTC_601 0986-0029 5.88 62.9 µM 7.25E-10 calcium & mitochondrial duress 10 2.10E-9
6 SGTC_976 1348-1067 5.48 47.6 µM 8.17E-9 60S ribosome export 5 2.07E-8
7 SGTC_2383 9036125 5.24 200.0 µM 3.49E-8 1 8.16E-8
8 SGTC_1613 st002381 5.15 52.1 µM 5.80E-8 7 1.32E-7
9 SGTC_1673 st016611 5.10 27.3 µM 7.38E-8 20 1.66E-7
10 SGTC_1060 3448-7350 4.70 82.0 µM 6.51E-7 Golgi 22 1.30E-6
11 SGTC_2378 9074213 4.57 121.4 µM 1.26E-6 RSC complex & mRNA processing 6 2.43E-6
12 SGTC_243 5hr heat shock (37°C) + splitomicin 4.57 1.0 µM 1.30E-6 heat shock/prefoldin 34 2.49E-6
13 SGTC_2714 st079313 4.51 56.9 µM 1.74E-6 4 3.29E-6
14 SGTC_2929 9013348 4.44 24.6 µM 2.46E-6 13 4.55E-6
15 SGTC_1609 st001574 4.38 46.4 µM 3.28E-6 7 5.97E-6
16 SGTC_2323 6148992 4.37 148.3 µM 3.38E-6 22 6.15E-6
17 SGTC_3201 9113999 4.35 49.5 µM 3.75E-6 25 6.79E-6
18 SGTC_692 k241-0027 4.25 77.8 µM 6.17E-6 5 1.09E-5
19 SGTC_684 1140-0066 4.21 328.0 µM 7.23E-6 Golgi 17 1.26E-5
20 SGTC_2157 5649910 4.21 96.4 µM 7.28E-6 18 1.27E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.66E-10 YOR127W RGA1 hom GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.106 7.23E-10 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.104 1.47E-9 YOR163W DDP1 hom Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
0.095 3.68E-8 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.093 6.16E-8 YLR308W CDA2 hom Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
0.089 2.10E-7 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.088 3.80E-7 YKR103W NFT1 hom Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
0.087 4.89E-7 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.084 1.23E-6 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.082 2.03E-6 YGL166W CUP2 hom Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
0.081 2.98E-6 YML131W YML131W hom Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.080 3.04E-6 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.080 3.10E-6 YLL027W ISA1 hom Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins
0.080 3.51E-6 YML012W ERV25 hom Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport
0.079 4.52E-6 YDR102C_d YDR102C_d hom Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index